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The map label for this gene is iscS [H]

Identifier: 91784248

GI number: 91784248

Start: 3194913

End: 3196136

Strand: Reverse

Name: iscS [H]

Synonym: Bxe_A1553

Alternate gene names: 91784248

Gene position: 3196136-3194913 (Counterclockwise)

Preceding gene: 91784249

Following gene: 91784247

Centisome position: 65.28

GC content: 60.95

Gene sequence:

>1224_bases
ATGAATAACGACACTCTCCATCTGCCCATCTACATGGACTACAGCGCGACGACGCCGATCGATCCGCGCGTGGTGGACAA
GATGATTCCGTACCTGCGTGAGCAGTTCGGCAATCCCGCATCGCGCAGCCACTCGTATGGCTGGGACGCGGAGCGCGCGG
TCGAAGAAGCGCGTGAGAACGTCGCCGCGCTGGTGAACGCAGACCCGCGCGAAATCATCTGGACCTCGGGTGCAACGGAG
TCGGACAACCTCGCGCTCAAGGGTGCCGCGCACTTCTACAAGAGCAAGGGCAAGCACATCGTCACGGTGAAGACCGAGCA
CAAGGCCGTGCTCGACACCTGCCGCGAACTTGAACGCGAAGGCTTCGAAGTCACGTATCTGGACGTCAGGGACGATGGCC
TGCTCGACCTCGACAAGTTCAAGGCCGCGCTGCGTCCGGACACGATTCTGGTGTCGGTCATGTCGGTGAACAACGAGATC
GGCGTGATCCAGGACATCGAGGCGATCGGCGAGATCACCCGTGAAAAGGGCATCGTTTTCCACGTCGACGCGGCGCAAGC
CACCGGCAAGATCGCGATCGACCTGCAAAAGCTGAAGGTCGACCTGATGTCGTTCTCGGCGCACAAGACGTACGGTCCGA
AGGGCATCGGCGCGCTGTACGTGCGCCGCAAGCCGCGTATCCGTATCGAAGCGCAGATGCACGGCGGCGGTCACGAGCGC
GGCATGCGTTCGGGCACGCTGGCTACGCACCAGATCGTCGGCATGGGCGAGGCATTCCGTATCGCGCGTGAAGAAATGGC
GACGGAAAACGAACGTATCCGCATGCTGCGCGACCGTCTGCTGCGCGGCCTGTCGGAAATGGAAGAAGTGTATGTGAACG
GCGACATGGAAAAGCGTGTGCCGCACAACCTGAACATCAGCTTCAATTTCGTGGAAGGCGAATCGCTGATCATGGCGGTG
AAAGACGTGGCGGTGTCGTCGGGCTCGGCCTGTACGTCGGCTTCGCTGGAACCGTCGTACGTGCTGCGGGCGTTGGGCCG
TAACGACGAACTGGCGCACAGCTCGATCCGCTTCACGGTGGGCCGCTTCACGACCGAGCAGGATGTCGATTACGTGATCA
ACCTGCTGAAGACCAAGATTTCGAAGCTGCGCGACTTGTCGCCGCTGTGGGAAATGCACAAGGACGGGATCGATATTTCG
ACCATCCAGTGGGCAGCGCACTGA

Upstream 100 bases:

>100_bases
CGTTTTCAACATGGCCGGTTCCTAGGCACGGTAGAGAGCAGTCACCGCAGCCTGATCAGAAACCCAGAAGCCAGAGCACA
TGACGTCCCCGGAGCAATTG

Downstream 100 bases:

>100_bases
CGCGCCGTCTGGACGAAGTCGAATTCATCGAATTGCAAATTGCAGGTTGAAACGGATCAAGGAGTTTAATCATGGCTTAT
AGCGACAAGGTTCTGGACCA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNNDTLHLPIYMDYSATTPIDPRVVDKMIPYLREQFGNPASRSHSYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLALKGAAHFYKSKGKHIVTVKTEHKAVLDTCRELEREGFEVTYLDVRDDGLLDLDKFKAALRPDTILVSVMSVNNEI
GVIQDIEAIGEITREKGIVFHVDAAQATGKIAIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDRLLRGLSEMEEVYVNGDMEKRVPHNLNISFNFVEGESLIMAV
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVINLLKTKISKLRDLSPLWEMHKDGIDIS
TIQWAAH

Sequences:

>Translated_407_residues
MNNDTLHLPIYMDYSATTPIDPRVVDKMIPYLREQFGNPASRSHSYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLALKGAAHFYKSKGKHIVTVKTEHKAVLDTCRELEREGFEVTYLDVRDDGLLDLDKFKAALRPDTILVSVMSVNNEI
GVIQDIEAIGEITREKGIVFHVDAAQATGKIAIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDRLLRGLSEMEEVYVNGDMEKRVPHNLNISFNFVEGESLIMAV
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVINLLKTKISKLRDLSPLWEMHKDGIDIS
TIQWAAH
>Mature_407_residues
MNNDTLHLPIYMDYSATTPIDPRVVDKMIPYLREQFGNPASRSHSYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLALKGAAHFYKSKGKHIVTVKTEHKAVLDTCRELEREGFEVTYLDVRDDGLLDLDKFKAALRPDTILVSVMSVNNEI
GVIQDIEAIGEITREKGIVFHVDAAQATGKIAIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDRLLRGLSEMEEVYVNGDMEKRVPHNLNISFNFVEGESLIMAV
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQDVDYVINLLKTKISKLRDLSPLWEMHKDGIDIS
TIQWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=58.25, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=32.8502415458937, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI48994898, Length=404, Percent_Identity=71.5346534653465, Blast_Score=623, Evalue=1e-180,
Organism=Escherichia coli, GI1789175, Length=396, Percent_Identity=24.7474747474747, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787970, Length=218, Percent_Identity=27.9816513761468, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=59.6009975062344, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=32.4159021406728, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=57.3934837092732, Blast_Score=502, Evalue=1e-143,
Organism=Drosophila melanogaster, GI20129463, Length=407, Percent_Identity=55.5282555282555, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45593; Mature: 45593

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDTLHLPIYMDYSATTPIDPRVVDKMIPYLREQFGNPASRSHSYGWDAERAVEEAREN
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLALKGAAHFYKSKGKHIVTVKTEHKAVLDTCRELERE
HHEEECCCCHHEEEECCCCCCCCEEEEHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHC
GFEVTYLDVRDDGLLDLDKFKAALRPDTILVSVMSVNNEIGVIQDIEAIGEITREKGIVF
CCEEEEEEECCCCCEEHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEE
HVDAAQATGKIAIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHER
EEECCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDRLLRGLSEMEEVYVNGDMEKRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHCC
PHNLNISFNFVEGESLIMAVKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQDVDYVINLLKTKISKLRDLSPLWEMHKDGIDISTIQWAAH
ECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MNNDTLHLPIYMDYSATTPIDPRVVDKMIPYLREQFGNPASRSHSYGWDAERAVEEAREN
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLALKGAAHFYKSKGKHIVTVKTEHKAVLDTCRELERE
HHEEECCCCHHEEEECCCCCCCCEEEEHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHC
GFEVTYLDVRDDGLLDLDKFKAALRPDTILVSVMSVNNEIGVIQDIEAIGEITREKGIVF
CCEEEEEEECCCCCEEHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEE
HVDAAQATGKIAIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRIRIEAQMHGGGHER
EEECCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMATENERIRMLRDRLLRGLSEMEEVYVNGDMEKRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHCC
PHNLNISFNFVEGESLIMAVKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQDVDYVINLLKTKISKLRDLSPLWEMHKDGIDISTIQWAAH
ECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA