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The map label for this gene is lpxD [H]

Identifier: 91784109

GI number: 91784109

Start: 3035400

End: 3036512

Strand: Reverse

Name: lpxD [H]

Synonym: Bxe_A1692

Alternate gene names: 91784109

Gene position: 3036512-3035400 (Counterclockwise)

Preceding gene: 91784110

Following gene: 91784108

Centisome position: 62.02

GC content: 64.33

Gene sequence:

>1113_bases
ATGGCATTTACGCTCGAGGACATCGTCCAACGGTTCGGCGGTGAAGTAGTCGGAAACGGTTCGCAGCGCGTCGGCAGTCT
TGCGCCGCTCGACCAGGCAGGCCCGGACCAGCTGGCGTTCCTCGCCAATCCGAAGTACCTGTCGCAGGTCGAAACGACCC
GTGCGGGCGCCGTGTTGATCAACGCCGAAGACCTCGCCAGGCTCGCTTCCCGCGAGAGTCGTAACTTCATCGTCACGCCG
AATCCGTACGCTTACTTCGCGCGCGTCGCGCAAACCTTTATCGACCTCGCTGCGCCCAAGGCGGTGCCCGGCGTGCACCC
GAGCGCAACCATCGACCCGTCGGCGCAGATTGCCGCGAGCGCGGTGATCGGCCCGCATGTCACGGTGGAGGCGGGCGCGG
TGATCGGCGAAAACGTGCGGCTCGACGCCAATGTCGTGATCGGCCGTGGAACGCGCATCGGCGCGGACTCGCACCTTTAT
CCCAATGTCGCGGTGTACTACGGTTGCAAGCTGGGCGAGCGCGTGATCGTGCACGCGGGCGCGGTGATCGGCTCGGACGG
TTTCGGCTTCGCGCCGGATTTCGTCGGCGAGGGTGACGCGCGTACCGGCAGCTGGGTGAAGATTCCGCAGGTGGGCGGCG
TGTCGATCGCGGCAGACGTGGAAATCGGCGCGAACACCACCATCGACCGTGGCGCAATGGCCGATACCATCATCGAAGAG
TGCGTGAAGATCGACAATCTCGTACAGATCGGCCACAACTGCAAGGTCGGAGCCTATACGGTGATTGCCGGCTGCGCGGG
CATCGCGGGCAGCACCACGATCGGCCGGCATTGCATGATCGGCGGCGCCGTCGGGATTGCCGGCCACGTCACGCTGGCCG
ATTACGTGATCGTCACGGCAAAGTCGGGCGTGTCGAAGTCGCTGTTGAAGCCTGGTATGTACACGAGTGCCTTCCCGGCC
GTGAACCATGCAGACTGGAACAAAAGTGCAGCGTTGCTGCGCAATATCGACAAACTGCGCGATCGTATCAAGGCGCTCGA
AAACGCCGCGGCCGGACGGCAAGACGGCCCGGCGGCCAATGCAGCAAGCAGTTCTGCAGGCGACAAGGCCTGA

Upstream 100 bases:

>100_bases
GCTGGCGGCGTCGGGTAACTGAACGCGGCAGCGGGGCCGCACGCGGCCCGGTAGCAGAAGATCTGACAAGTTGGACTGAA
CGGTAGGAGACAGGATAGGC

Downstream 100 bases:

>100_bases
GAAACCTCAGGACAACTTGAAGGACGACCTTCAGGCCGATTCACGAGCCCGGGTCGAAGACCGGGTCGCGGAACAATTCA
CCAGGCAATTCGCAGGGCAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAFTLEDIVQRFGGEVVGNGSQRVGSLAPLDQAGPDQLAFLANPKYLSQVETTRAGAVLINAEDLARLASRESRNFIVTP
NPYAYFARVAQTFIDLAAPKAVPGVHPSATIDPSAQIAASAVIGPHVTVEAGAVIGENVRLDANVVIGRGTRIGADSHLY
PNVAVYYGCKLGERVIVHAGAVIGSDGFGFAPDFVGEGDARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEE
CVKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTAKSGVSKSLLKPGMYTSAFPA
VNHADWNKSAALLRNIDKLRDRIKALENAAAGRQDGPAANAASSSAGDKA

Sequences:

>Translated_370_residues
MAFTLEDIVQRFGGEVVGNGSQRVGSLAPLDQAGPDQLAFLANPKYLSQVETTRAGAVLINAEDLARLASRESRNFIVTP
NPYAYFARVAQTFIDLAAPKAVPGVHPSATIDPSAQIAASAVIGPHVTVEAGAVIGENVRLDANVVIGRGTRIGADSHLY
PNVAVYYGCKLGERVIVHAGAVIGSDGFGFAPDFVGEGDARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEE
CVKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTAKSGVSKSLLKPGMYTSAFPA
VNHADWNKSAALLRNIDKLRDRIKALENAAAGRQDGPAANAASSSAGDKA
>Mature_369_residues
AFTLEDIVQRFGGEVVGNGSQRVGSLAPLDQAGPDQLAFLANPKYLSQVETTRAGAVLINAEDLARLASRESRNFIVTPN
PYAYFARVAQTFIDLAAPKAVPGVHPSATIDPSAQIAASAVIGPHVTVEAGAVIGENVRLDANVVIGRGTRIGADSHLYP
NVAVYYGCKLGERVIVHAGAVIGSDGFGFAPDFVGEGDARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEEC
VKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTAKSGVSKSLLKPGMYTSAFPAV
NHADWNKSAALLRNIDKLRDRIKALENAAAGRQDGPAANAASSSAGDKA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=346, Percent_Identity=39.5953757225434, Blast_Score=249, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 38083; Mature: 37951

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTLEDIVQRFGGEVVGNGSQRVGSLAPLDQAGPDQLAFLANPKYLSQVETTRAGAVLI
CCCCHHHHHHHHCCEEECCCHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEE
NAEDLARLASRESRNFIVTPNPYAYFARVAQTFIDLAAPKAVPGVHPSATIDPSAQIAAS
CHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
AVIGPHVTVEAGAVIGENVRLDANVVIGRGTRIGADSHLYPNVAVYYGCKLGERVIVHAG
HHCCCCEEEECCCEECCCEEEECEEEEECCCEECCCCCCCCCEEEEEECCCCCEEEEEEC
AVIGSDGFGFAPDFVGEGDARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEE
EEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
CVKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTA
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEEE
KSGVSKSLLKPGMYTSAFPAVNHADWNKSAALLRNIDKLRDRIKALENAAAGRQDGPAAN
CCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AASSSAGDKA
CCCCCCCCCC
>Mature Secondary Structure 
AFTLEDIVQRFGGEVVGNGSQRVGSLAPLDQAGPDQLAFLANPKYLSQVETTRAGAVLI
CCCHHHHHHHHCCEEECCCHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEE
NAEDLARLASRESRNFIVTPNPYAYFARVAQTFIDLAAPKAVPGVHPSATIDPSAQIAAS
CHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
AVIGPHVTVEAGAVIGENVRLDANVVIGRGTRIGADSHLYPNVAVYYGCKLGERVIVHAG
HHCCCCEEEECCCEECCCEEEECEEEEECCCEECCCCCCCCCEEEEEECCCCCEEEEEEC
AVIGSDGFGFAPDFVGEGDARTGSWVKIPQVGGVSIAADVEIGANTTIDRGAMADTIIEE
EEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
CVKIDNLVQIGHNCKVGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLADYVIVTA
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEEE
KSGVSKSLLKPGMYTSAFPAVNHADWNKSAALLRNIDKLRDRIKALENAAAGRQDGPAAN
CCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AASSSAGDKA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA