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The map label for this gene is liaR [H]

Identifier: 91783993

GI number: 91783993

Start: 2905568

End: 2906209

Strand: Reverse

Name: liaR [H]

Synonym: Bxe_A1815

Alternate gene names: 91783993

Gene position: 2906209-2905568 (Counterclockwise)

Preceding gene: 91783994

Following gene: 91783990

Centisome position: 59.36

GC content: 62.15

Gene sequence:

>642_bases
ATGAAATTCACGGTCTTGCTGGTCGACGATCACGCCGTTGTGCGGCAGGGTCTGGTGAGTATCCTGACGATGACCGACGA
CTTCACACTGGTCGGTGAAGCGGGCGACGGCGTGCACGCCATCGAACTCGCGCGCGAACACCAGCCCGATCTCATCGTGC
TGGATCTGCTGATGCCAGGCATGGATGCGGCCGCAACGATCCGCTCGCTGCGCTCGCTCAGTCCGAACTCCCGGATTGCG
GTCCTGACATCATCGGACGACGACAACCTCGCGTTCTCGGCAATCGAAGCCGGCGCGCACTCCTTCCTGCTCAAGTCGAT
GTCCGGCGACGCACTGCTCGACACGCTGCGCCGCCTCGCGGAGGGTGAAGCGGTGATTCACCCTGACGTCGCGCATCGAA
TCCTGCGCAGCGTGCGGACCGCGCGCGAACGCGTGACGGATCCTTTCGCGTCATTGACTGAACGGGAAATGGATGTATTG
CGGGCGTTGGCCGAAGGGTCGAGTAACGGCCGGATCGGGAAGATGCTGAACATCAGCGAGAGCACGGTGAAAACCCATAT
CGGCAACGTGCTGGCCAAGTTGGATCTGCGTGACCGCACTCAGGCGGTTGCGTTTGCGTGGCGTCACGGTCTGATCGGTT
GA

Upstream 100 bases:

>100_bases
AGGGCCAACAGTTTGCCGCACGGAGAACTTCACCTGGCGAGCAGCCCGGGAAAAGGCGCCGAAATCACTGTCTCGTTCCA
ATTAACGCTTTGAGGGTTCG

Downstream 100 bases:

>100_bases
ACAGAGCAGACCGGCGCGAGGCAGCGCGCCAGCTGCGCACGCACTCCGCCGATCCGCGCTGCGTCACATTTGCGCGATCG
TACCGTTTCCTGTCCGGTTC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKFTVLLVDDHAVVRQGLVSILTMTDDFTLVGEAGDGVHAIELAREHQPDLIVLDLLMPGMDAAATIRSLRSLSPNSRIA
VLTSSDDDNLAFSAIEAGAHSFLLKSMSGDALLDTLRRLAEGEAVIHPDVAHRILRSVRTARERVTDPFASLTEREMDVL
RALAEGSSNGRIGKMLNISESTVKTHIGNVLAKLDLRDRTQAVAFAWRHGLIG

Sequences:

>Translated_213_residues
MKFTVLLVDDHAVVRQGLVSILTMTDDFTLVGEAGDGVHAIELAREHQPDLIVLDLLMPGMDAAATIRSLRSLSPNSRIA
VLTSSDDDNLAFSAIEAGAHSFLLKSMSGDALLDTLRRLAEGEAVIHPDVAHRILRSVRTARERVTDPFASLTEREMDVL
RALAEGSSNGRIGKMLNISESTVKTHIGNVLAKLDLRDRTQAVAFAWRHGLIG
>Mature_213_residues
MKFTVLLVDDHAVVRQGLVSILTMTDDFTLVGEAGDGVHAIELAREHQPDLIVLDLLMPGMDAAATIRSLRSLSPNSRIA
VLTSSDDDNLAFSAIEAGAHSFLLKSMSGDALLDTLRRLAEGEAVIHPDVAHRILRSVRTARERVTDPFASLTEREMDVL
RALAEGSSNGRIGKMLNISESTVKTHIGNVLAKLDLRDRTQAVAFAWRHGLIG

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=42.3809523809524, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1787473, Length=206, Percent_Identity=39.3203883495146, Blast_Score=116, Evalue=9e-28,
Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=30, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=24.8803827751196, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=30.6122448979592, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=21.3592233009709, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787277, Length=134, Percent_Identity=31.3432835820896, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23112; Mature: 23112

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTVLLVDDHAVVRQGLVSILTMTDDFTLVGEAGDGVHAIELAREHQPDLIVLDLLMPG
CEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEHHCCC
MDAAATIRSLRSLSPNSRIAVLTSSDDDNLAFSAIEAGAHSFLLKSMSGDALLDTLRRLA
CCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EGEAVIHPDVAHRILRSVRTARERVTDPFASLTEREMDVLRALAEGSSNGRIGKMLNISE
CCCEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCH
STVKTHIGNVLAKLDLRDRTQAVAFAWRHGLIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFTVLLVDDHAVVRQGLVSILTMTDDFTLVGEAGDGVHAIELAREHQPDLIVLDLLMPG
CEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEHHCCC
MDAAATIRSLRSLSPNSRIAVLTSSDDDNLAFSAIEAGAHSFLLKSMSGDALLDTLRRLA
CCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EGEAVIHPDVAHRILRSVRTARERVTDPFASLTEREMDVLRALAEGSSNGRIGKMLNISE
CCCEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCH
STVKTHIGNVLAKLDLRDRTQAVAFAWRHGLIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]