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The map label for this gene is degS [H]

Identifier: 91783960

GI number: 91783960

Start: 2873369

End: 2874721

Strand: Direct

Name: degS [H]

Synonym: Bxe_A1851

Alternate gene names: 91783960

Gene position: 2873369-2874721 (Clockwise)

Preceding gene: 91783959

Following gene: 91783961

Centisome position: 58.69

GC content: 66.3

Gene sequence:

>1353_bases
ATGCACATGCCCGTCAGCGGTAAGACGCCCACATCGCGCAGTGCCGTTTTGCGTGAGCGAGCCGGCTCACTCGTGGCCCA
GCCCGCAACTGCGGCCGCTGCCGCGTTCGTCGTGACGCTCACCGCCATGCTGGCCGCCCGGCACTGGTTCGACCCGGCGT
TCTTCATTTGCGTCGCCGCCGCCCTGCTTCTGGCCACGAGCGTGTTTCTGCTCGTGCGCGCGCGGCGCGACGGCCTGTCC
GCACGCAGCGAGGAACACGCCCGCCACAGCCAGTCTGCCGTGAATGAAGCGCGCATGATGGCGATCATCCGTTCGTCAAT
GGAGGCGATCATCACCATCGACGAGCAGCAGCGGATCGTCATCTTCAATCCGATGGCGGAACAGGTTTTCGGCTGCTCCG
CGATGGACGCGATCGGCGCGCCGCTGGCCCGCTTCATCCCGGATCGCTTTCGGGCGGCGCACGCACAGCATGTTGCGCAG
TTCGGCGTAACGGGCGTGTCGGACCGGCAGATGGGCAAGCAGCGCGTGCTGGCGGGCTTGCGCGCCAACGGCGAGGAATT
TCCGCTGGAGGCTTCGATTTCGCAGATCCGCGACGGCAACATCCGCCTCTATACGGTCATGCTGCGCGACATCACGGAGC
GCGTCAAAGCGGAACGTGCGCAACGCCAGGCGCGTGAGGAACTGCGCGAGCTGTCGGCCAATTTGCAGAACATCCGCGAA
GACGAAAAAACGCGTATTGCGCGCGAACTGCACGACGATCTCGGCCAGCAGCTCACCGCGCTGAAAATGGACATTTCGTC
GGTCGAACAGGCGCTGGACGGCGCGGCAAGCGGGCCGGTGCGCGAGCAGTTGCAAGGCATGCGCCGCTTGATCGACGTGA
CCGTGGCCTCGGTGCGCCGCATCGCGGCCGATCTGCGGCCGGTCATGCTCGACGACCTCGGCCTGATTCCCGCAATCGAG
TGGCTCGCCACCGACTTCACCAACCGCTACGGCATCGACGTGGAGCGCGATATCGAAACCGGCGACGCGCGCTTCAGCCC
GGCAGGCGCCACCGCGCTGTTCCGGATCGTGCAGGAGGCGCTCACAAACGTGGCGCGCCATGCCGATGCCACGCTGGTCA
CGCTGAGCCTGCGCGCGGGCGATCAGACCTTCGTGCTGCGCATCGCCGATAATGGCCAGGGCGTGCATCGCGCGGCCGAG
CCGGGCACCAAGTCCTTCGGCCTGCTCGGCGTTCGCGAACGCGCCCACATGCTCGGCGGCGCGGTCGACATTCATACCGC
GCATGGCCAGGGCTTTGCGCTCACCGTCACCATTCCGGCAGAAACCGTGCAGATGCAGGAGATGCAAACATGA

Upstream 100 bases:

>100_bases
ACCCTGGAACCACCCGGAACAGACGTGCTTGCCGTGCGCGCCGCCGTACCGACGTCGTCGGGCGGCGCGTCCGATCCTTG
TTCGCAGTCATTCCAAAGAG

Downstream 100 bases:

>100_bases
CCCGCGTCCTGATTGCCGACGACCACGCGCTGGTGCGCGACGGTCTGCGCCATATCCTCAAGGGCGCAAGCGGCTTCGAA
GTGGTCGGCGAAGCGGACGA

Product: multi-sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MHMPVSGKTPTSRSAVLRERAGSLVAQPATAAAAAFVVTLTAMLAARHWFDPAFFICVAAALLLATSVFLLVRARRDGLS
ARSEEHARHSQSAVNEARMMAIIRSSMEAIITIDEQQRIVIFNPMAEQVFGCSAMDAIGAPLARFIPDRFRAAHAQHVAQ
FGVTGVSDRQMGKQRVLAGLRANGEEFPLEASISQIRDGNIRLYTVMLRDITERVKAERAQRQAREELRELSANLQNIRE
DEKTRIARELHDDLGQQLTALKMDISSVEQALDGAASGPVREQLQGMRRLIDVTVASVRRIAADLRPVMLDDLGLIPAIE
WLATDFTNRYGIDVERDIETGDARFSPAGATALFRIVQEALTNVARHADATLVTLSLRAGDQTFVLRIADNGQGVHRAAE
PGTKSFGLLGVRERAHMLGGAVDIHTAHGQGFALTVTIPAETVQMQEMQT

Sequences:

>Translated_450_residues
MHMPVSGKTPTSRSAVLRERAGSLVAQPATAAAAAFVVTLTAMLAARHWFDPAFFICVAAALLLATSVFLLVRARRDGLS
ARSEEHARHSQSAVNEARMMAIIRSSMEAIITIDEQQRIVIFNPMAEQVFGCSAMDAIGAPLARFIPDRFRAAHAQHVAQ
FGVTGVSDRQMGKQRVLAGLRANGEEFPLEASISQIRDGNIRLYTVMLRDITERVKAERAQRQAREELRELSANLQNIRE
DEKTRIARELHDDLGQQLTALKMDISSVEQALDGAASGPVREQLQGMRRLIDVTVASVRRIAADLRPVMLDDLGLIPAIE
WLATDFTNRYGIDVERDIETGDARFSPAGATALFRIVQEALTNVARHADATLVTLSLRAGDQTFVLRIADNGQGVHRAAE
PGTKSFGLLGVRERAHMLGGAVDIHTAHGQGFALTVTIPAETVQMQEMQT
>Mature_450_residues
MHMPVSGKTPTSRSAVLRERAGSLVAQPATAAAAAFVVTLTAMLAARHWFDPAFFICVAAALLLATSVFLLVRARRDGLS
ARSEEHARHSQSAVNEARMMAIIRSSMEAIITIDEQQRIVIFNPMAEQVFGCSAMDAIGAPLARFIPDRFRAAHAQHVAQ
FGVTGVSDRQMGKQRVLAGLRANGEEFPLEASISQIRDGNIRLYTVMLRDITERVKAERAQRQAREELRELSANLQNIRE
DEKTRIARELHDDLGQQLTALKMDISSVEQALDGAASGPVREQLQGMRRLIDVTVASVRRIAADLRPVMLDDLGLIPAIE
WLATDFTNRYGIDVERDIETGDARFSPAGATALFRIVQEALTNVARHADATLVTLSLRAGDQTFVLRIADNGQGVHRAAE
PGTKSFGLLGVRERAHMLGGAVDIHTAHGQGFALTVTIPAETVQMQEMQT

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=208, Percent_Identity=30.2884615384615, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082311, Length=237, Percent_Identity=32.9113924050633, Blast_Score=88, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49166; Mature: 49166

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMPVSGKTPTSRSAVLRERAGSLVAQPATAAAAAFVVTLTAMLAARHWFDPAFFICVAA
CCCCCCCCCCCHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALLLATSVFLLVRARRDGLSARSEEHARHSQSAVNEARMMAIIRSSMEAIITIDEQQRIV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEE
IFNPMAEQVFGCSAMDAIGAPLARFIPDRFRAAHAQHVAQFGVTGVSDRQMGKQRVLAGL
EECCHHHHHHCCHHHHHHCCCHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RANGEEFPLEASISQIRDGNIRLYTVMLRDITERVKAERAQRQAREELRELSANLQNIRE
HCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEKTRIARELHDDLGQQLTALKMDISSVEQALDGAASGPVREQLQGMRRLIDVTVASVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IAADLRPVMLDDLGLIPAIEWLATDFTNRYGIDVERDIETGDARFSPAGATALFRIVQEA
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
LTNVARHADATLVTLSLRAGDQTFVLRIADNGQGVHRAAEPGTKSFGLLGVRERAHMLGG
HHHHHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
AVDIHTAHGQGFALTVTIPAETVQMQEMQT
CEEEEEECCCCEEEEEEECHHHHHHHHCCC
>Mature Secondary Structure
MHMPVSGKTPTSRSAVLRERAGSLVAQPATAAAAAFVVTLTAMLAARHWFDPAFFICVAA
CCCCCCCCCCCHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALLLATSVFLLVRARRDGLSARSEEHARHSQSAVNEARMMAIIRSSMEAIITIDEQQRIV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEE
IFNPMAEQVFGCSAMDAIGAPLARFIPDRFRAAHAQHVAQFGVTGVSDRQMGKQRVLAGL
EECCHHHHHHCCHHHHHHCCCHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RANGEEFPLEASISQIRDGNIRLYTVMLRDITERVKAERAQRQAREELRELSANLQNIRE
HCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEKTRIARELHDDLGQQLTALKMDISSVEQALDGAASGPVREQLQGMRRLIDVTVASVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IAADLRPVMLDDLGLIPAIEWLATDFTNRYGIDVERDIETGDARFSPAGATALFRIVQEA
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
LTNVARHADATLVTLSLRAGDQTFVLRIADNGQGVHRAAEPGTKSFGLLGVRERAHMLGG
HHHHHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
AVDIHTAHGQGFALTVTIPAETVQMQEMQT
CEEEEEECCCCEEEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]