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The map label for this gene is phbA [H]

Identifier: 91783474

GI number: 91783474

Start: 2319075

End: 2320256

Strand: Direct

Name: phbA [H]

Synonym: Bxe_A2342

Alternate gene names: 91783474

Gene position: 2319075-2320256 (Clockwise)

Preceding gene: 91783473

Following gene: 91783475

Centisome position: 47.37

GC content: 66.5

Gene sequence:

>1182_bases
ATGACTGATGTTGTGATCGTATCGGCCGCCCGTACGGCAGTGGGCAAATTCGGTGGGTCGCTGGCGAAAATCGCCGCGCC
CGATCTCGGCGCCGCGGTGATTCGCGCCGTTCTCGAGCGTGCCGGTCTGAAGCCCGAGCAGGTGAGCGAAGTGATCCTGG
GCCAGGTGCTGACGGCAGGCTCGGGCCAGAATCCGGCGCGTCAATCGCTGATCAAGGCGGGTCTGCCTTCGGCGGTGCCG
GGCATGACGATCAACAAGGTCTGCGGCTCCGGCCTGAAGGCCGTGATGCTCGCGGCCAATGCCATTATCGCGGGCGACGC
GGACATCGTGATCGCCGGCGGGCAGGAAAACATGAGCGCCGCGCCGCACGTGCTGCCGGGCTCGCGCGACGGCTTCCGCA
TGGGCGACGCGAAGCTGGTCGACTCGATGATCGTCGATGGCCTGTGGGACGTCTACAACCAGTATCACATGGGCGTGACG
GCGGAAAACGTCGCGAAGGAATACGGCATCACGCGCGAACAGCAGGACGCGTTCGCGGCGTTGTCGCAGAACAAGGCGGA
AGCCGCGCAGAAGTCGGGCCGGTTCGACGACGAAATCGTGCCGATCGAGATTCCGCAACGCAAGGGCGAGCCGCTGCGTT
TCGCGACCGACGAATTCGTGCGTCACGGCGTGACGGCCGAGTCGCTCGCGGGCCTGAAGCCGGCCTTCTCGAAGGAAGGC
ACGGTGACGGCGGCCAATGCCTCCGGTCTTAACGACGGTGCTGCGGCCGTGCTGGTGATGTCGGCGAAGAAGGCCGAAGC
GCTCGGCCTCACGCCGCTCGCGCGCATCAAGGCGTATGCGAACGCCGGCGTGGATCCGAAGGTGATGGGCATGGGCCCGG
TGCCGGCTTCGCGCCGTTGCCTCGAACGCGCGGGCTGGACGCCGGCCGACCTCGACCTGATGGAAATCAACGAAGCGTTT
GCCGCGCAGGCGCTCGCCGTGCATCAGCAGATGGGCTGGGACACGTCGAAGGTCAACGTGAACGGCGGCGCGATTGCGAT
CGGCCATCCGATCGGCGCGTCCGGCTGCCGGATTCTCGTCACGCTGCTGCACGAAATGCAGAAGCGCGATGCGAAGAAGG
GTTTGGCCTCGCTGTGTATCGGCGGTGGCATGGGTGTGGCGCTGGCGGTCGAGCGCGCCTGA

Upstream 100 bases:

>100_bases
AACGCGTAGCTGACCGGGTCAGGGCGCAAGCAGAAGGAACGAGATTTTTTAACTTGACGGGCTGCGGCGCATTTGGCCGA
CTCGCCCGGAGGATATGGAA

Downstream 100 bases:

>100_bases
GTATCGTCGCGCGACCGGAGCCTGCTGCGTCGGTCGCGCGACACACAGAGCGTTGCCGCGCGCCGAGGCGTGCGGTCAGC
GGTGGCCTCGTCGGCCGGTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPDLGAAVIRAVLERAGLKPEQVSEVILGQVLTAGSGQNPARQSLIKAGLPSAVP
GMTINKVCGSGLKAVMLAANAIIAGDADIVIAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNQYHMGVT
AENVAKEYGITREQQDAFAALSQNKAEAAQKSGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFSKEG
TVTAANASGLNDGAAAVLVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRCLERAGWTPADLDLMEINEAF
AAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERA

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPDLGAAVIRAVLERAGLKPEQVSEVILGQVLTAGSGQNPARQSLIKAGLPSAVP
GMTINKVCGSGLKAVMLAANAIIAGDADIVIAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNQYHMGVT
AENVAKEYGITREQQDAFAALSQNKAEAAQKSGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFSKEG
TVTAANASGLNDGAAAVLVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRCLERAGWTPADLDLMEINEAF
AAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERA
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPDLGAAVIRAVLERAGLKPEQVSEVILGQVLTAGSGQNPARQSLIKAGLPSAVPG
MTINKVCGSGLKAVMLAANAIIAGDADIVIAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNQYHMGVTA
ENVAKEYGITREQQDAFAALSQNKAEAAQKSGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFSKEGT
VTAANASGLNDGAAAVLVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRCLERAGWTPADLDLMEINEAFA
AQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=54.7314578005115, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.0203562340967, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=43.8461538461538, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=42.7848101265823, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.6037735849057, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.6326530612245, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=63.0102040816327, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.559796437659, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=46.2871287128713, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.6065162907268, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=35.2078239608802, Blast_Score=205, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.6410256410256, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.1188630490956, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=40.6565656565657, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.7102803738318, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=32.48730964467, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=43.0730478589421, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.1002506265664, Blast_Score=236, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=58.1632653061224, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.0559796437659, Blast_Score=328, Evalue=3e-90,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.8235294117647, Blast_Score=177, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40576; Mature: 40445

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPDLGAAVIRAVLERAGLKPEQVSEVILGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQSLIKAGLPSAVPGMTINKVCGSGLKAVMLAANAIIAGDADIVIAGGQENMSA
CCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHCEEEECCCCEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNQYHMGVTAENVAKEYGITREQQDAFAA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHH
LSQNKAEAAQKSGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFSKEG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGLNDGAAAVLVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LERAGWTPADLDLMEINEAFAAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPDLGAAVIRAVLERAGLKPEQVSEVILGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQSLIKAGLPSAVPGMTINKVCGSGLKAVMLAANAIIAGDADIVIAGGQENMSA
CCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHCEEEECCCCEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNQYHMGVTAENVAKEYGITREQQDAFAA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHH
LSQNKAEAAQKSGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFSKEG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGLNDGAAAVLVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LERAGWTPADLDLMEINEAFAAQALAVHQQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]