Click here to switch to the map view.

The map label for this gene is pcm [H]

Identifier: 91783464

GI number: 91783464

Start: 2307855

End: 2308814

Strand: Direct

Name: pcm [H]

Synonym: Bxe_A2352

Alternate gene names: 91783464

Gene position: 2307855-2308814 (Clockwise)

Preceding gene: 91783463

Following gene: 91783465

Centisome position: 47.14

GC content: 67.08

Gene sequence:

>960_bases
GTGAAAAACTCGCCGCCCGGGTCCGCGGGTAAGTCCCAGTCCCGGCAGGCGAATGCGCAAACTGCGGCGCCGGCGAAGCC
GCAGGCGAGGCCATCCGCGGCAACTCCGCCGAAGCCACTGGCGGCGCCTTCCGCCAAAGCGCCGGTGAAAGCACCGCTAC
AAGCACCGCTGAATGCATCGGTGAAAGCGCCGGCCAGGAGCGCCGCGCAGAATTCCACCGCGCGTCCCTCGCCGCAGCCG
GCGGCATCCGCCAAACCTGCGGCCCGCGCCACCGAGCGCAGCGCCGCGCCGAACGTTGCTTTGAACGGCGCATTGGCGCT
GACTTCGGAACGGGTTCGCGAACGGATGGTCGAACGCCTGCGTGCGAACGGTGTGACCGATCAGCGCGTGTTGAACGCGA
TGTCGGTCGTGCCGCGCCATATGTTCGTCGACCCGGGTCTCGCGGCGCAGGCCTACGAAGATGCCGCATTGCCGATCGGT
CATCACCAGACGATCTCCAAACCCTCGGTCGTGGCCCGGATGATCGAACTGGCCGCCGCCGGCCGCGCGCTGAACAACGT
GCTCGAAATCGGCACGGGCTGCGGTTATCAGGCGGCCGTGCTGAGCCAGGTCGCGCGCGAGGTTTACTCGATCGAGCGCA
TCAGGCCGCTGTCGGAGCGCGCCAAGACAAATTTGCGTCCGCTGCGCATTCCGAACATCCGGCTGCACTATGGAGACGGG
CGGTTGGGTCTGCCCTCGGCGGCACCGTTCGACGCGATCGTGATCGCCGCGGCGGGGCTCGACGTACCGCAAGCGTTACT
TGAACAACTCGCGATCGGCGGCCGCCTGGTCGCGCCGGTCGGCTCGCAGGAGGGCCAAAGCCAGGTGCTGACTCTGGTCG
AGCGCCTCGGACCCGCGCAGTGGCGCGAGTCGCGGCTTGATCGCGTTTTCTTTGTACCCTTAAAATCCGGAGTGATTTGA

Upstream 100 bases:

>100_bases
GGACCTGGTGCGCGAACCGCGCCGGGCCGAAGGGCGTCCGGGCGAAATTCGCGCGGCGGCGCTTGCCGCGAGCGCGGCGT
TGAACGCACGTCAGCAGCCG

Downstream 100 bases:

>100_bases
CACCGATGAGTATGTTGCGCGCGATGCAAAGAACCAGACTGAATGCCCCCATGACCGTAACCCAGCGTAGCGTGTGCGTG
CTCGCCTTGTCCCTGTTGAT

Product: protein-L-isoaspartate(D-aspartate) O- methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKNSPPGSAGKSQSRQANAQTAAPAKPQARPSAATPPKPLAAPSAKAPVKAPLQAPLNASVKAPARSAAQNSTARPSPQP
AASAKPAARATERSAAPNVALNGALALTSERVRERMVERLRANGVTDQRVLNAMSVVPRHMFVDPGLAAQAYEDAALPIG
HHQTISKPSVVARMIELAAAGRALNNVLEIGTGCGYQAAVLSQVAREVYSIERIRPLSERAKTNLRPLRIPNIRLHYGDG
RLGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGSQEGQSQVLTLVERLGPAQWRESRLDRVFFVPLKSGVI

Sequences:

>Translated_319_residues
MKNSPPGSAGKSQSRQANAQTAAPAKPQARPSAATPPKPLAAPSAKAPVKAPLQAPLNASVKAPARSAAQNSTARPSPQP
AASAKPAARATERSAAPNVALNGALALTSERVRERMVERLRANGVTDQRVLNAMSVVPRHMFVDPGLAAQAYEDAALPIG
HHQTISKPSVVARMIELAAAGRALNNVLEIGTGCGYQAAVLSQVAREVYSIERIRPLSERAKTNLRPLRIPNIRLHYGDG
RLGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGSQEGQSQVLTLVERLGPAQWRESRLDRVFFVPLKSGVI
>Mature_319_residues
MKNSPPGSAGKSQSRQANAQTAAPAKPQARPSAATPPKPLAAPSAKAPVKAPLQAPLNASVKAPARSAAQNSTARPSPQP
AASAKPAARATERSAAPNVALNGALALTSERVRERMVERLRANGVTDQRVLNAMSVVPRHMFVDPGLAAQAYEDAALPIG
HHQTISKPSVVARMIELAAAGRALNNVLEIGTGCGYQAAVLSQVAREVYSIERIRPLSERAKTNLRPLRIPNIRLHYGDG
RLGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGSQEGQSQVLTLVERLGPAQWRESRLDRVFFVPLKSGVI

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=213, Percent_Identity=31.924882629108, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1789100, Length=211, Percent_Identity=43.6018957345972, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71983477, Length=216, Percent_Identity=33.7962962962963, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI193207222, Length=211, Percent_Identity=33.175355450237, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17981723, Length=216, Percent_Identity=31.9444444444444, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 33432; Mature: 33432

Theoretical pI: Translated: 11.55; Mature: 11.55

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSPPGSAGKSQSRQANAQTAAPAKPQARPSAATPPKPLAAPSAKAPVKAPLQAPLNAS
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VKAPARSAAQNSTARPSPQPAASAKPAARATERSAAPNVALNGALALTSERVRERMVERL
CCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
RANGVTDQRVLNAMSVVPRHMFVDPGLAAQAYEDAALPIGHHQTISKPSVVARMIELAAA
HHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GRALNNVLEIGTGCGYQAAVLSQVAREVYSIERIRPLSERAKTNLRPLRIPNIRLHYGDG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEECCCEEEEECCC
RLGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGSQEGQSQVLTLVERLGPAQ
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCHHH
WRESRLDRVFFVPLKSGVI
HHHHHCCEEEEEECCCCCC
>Mature Secondary Structure
MKNSPPGSAGKSQSRQANAQTAAPAKPQARPSAATPPKPLAAPSAKAPVKAPLQAPLNAS
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VKAPARSAAQNSTARPSPQPAASAKPAARATERSAAPNVALNGALALTSERVRERMVERL
CCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
RANGVTDQRVLNAMSVVPRHMFVDPGLAAQAYEDAALPIGHHQTISKPSVVARMIELAAA
HHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GRALNNVLEIGTGCGYQAAVLSQVAREVYSIERIRPLSERAKTNLRPLRIPNIRLHYGDG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEECCCEEEEECCC
RLGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGSQEGQSQVLTLVERLGPAQ
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCHHH
WRESRLDRVFFVPLKSGVI
HHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA