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The map label for this gene is virB11 [H]

Identifier: 91783156

GI number: 91783156

Start: 2002341

End: 2003459

Strand: Direct

Name: virB11 [H]

Synonym: Bxe_A2649

Alternate gene names: 91783156

Gene position: 2002341-2003459 (Clockwise)

Preceding gene: 91783155

Following gene: 91783157

Centisome position: 40.9

GC content: 62.2

Gene sequence:

>1119_bases
ATGACACCCCGCACGGACATGCCGGATTCGTCCCGCGACCCGGGTCTCGCCCGGTTGCCCGAAGACGCCTCCGTGCGCGA
GTTGATGCGGCCGTTCGCGCCGCTGCTCGAGGATGCCGACGTGACAGAACTCGTGATCAACCGGCCGCAGCGCGTCCTGA
CCGAAGACTCGCGTGGTTGGCATGGCTACGACTGCCCGGATCTTGATTTCGACCGGCTGGTGTCTTTCGCCGTGGCAGTC
GCTACCCTGACGAATCAGGAGGTCTCGTCCCAGCATCCGATCCTGTCAGCGTTGCTGCCAGGGGATGCACGCATTCAGAT
CGTGGTGCCGCCCGTCGTACCGCCGCGCACGGTCTCAATTACGATCCGCCGTCCGTCGGCACGCGAAAAGACCCTCGACG
AATATCCTGGTGAAGGGCTGTTCGACGACACAGTCTGGCATCGTCCGGATGGTCTTGACGCAGTGTTGGCAGTGTTGCGG
CCGACAGACCGGAAGCTCATCCAGTGCCTGGAGGCACGGAACTGGGGTGCGTTTTTTGAGCTGGCTGTCATCGATCGTCT
GAATATCGCGATCGTCGGCAATACGGGTTCCGGCAAGACCAGTTTCATGAAGACCCTCTGTCGTTCGATTCCATCGAACG
AGCGGGTCATCACGATTGAGGATGTCAGGGAACTCTTCATCCGGCATATCGAGAACTGTGCCCATTTGCTCTATAGCAAA
GGGGGGCGTGGTCAGGCGCGTGTAACACCCGCTGACCTGATCGCCAGTACGATGCGGATGCGTCCCGATCGCGTGCTGCT
GGCCGAGCTGCGCGGCGCCGAAGCCTATGACTTCCTGAAGCTCCTGACGACGGGCCATGCGGGTTCGATCACGAGCTACC
ACGCGCCCAATACCGCGGTTGCGATCGAGCGTTTCGCGCTGATGGCCAAGGAACACCCGGAGGCTGCCGCCTGGGACGAT
GCCGCGCTCAAGCGCCTGCTGTTCCTGACCATCGATGTCGTCGCACACATGGAGTCGCGTTCGTTCTTCAATGCAGCGGG
CGAGCAGACAGGCAGGCGCTGGGGCATGACGGAAGTCTGGTTCGACCCGGTGCGCAAGGCACGCACCGCGTTCGTGTAG

Upstream 100 bases:

>100_bases
CGCCGACGCTGAAGCAGAACCAGGGCGCGGAGTTCACGATCGTGGTCGCGCGCGATCTCGACTTCGGATCGGTCTATACG
CTGCAGCCGGAAGGTGCGCA

Downstream 100 bases:

>100_bases
GGAGCGGCCATGATCCAGTCGCCTTCTCACCTTCAGCATATGCGGACCGCCGCCGTAACGCTTGCCGTGCTGGCTTGCCT
GTTCGGCGGACTGGCGGCAT

Product: putative type IV secretion system protein VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTPRTDMPDSSRDPGLARLPEDASVRELMRPFAPLLEDADVTELVINRPQRVLTEDSRGWHGYDCPDLDFDRLVSFAVAV
ATLTNQEVSSQHPILSALLPGDARIQIVVPPVVPPRTVSITIRRPSAREKTLDEYPGEGLFDDTVWHRPDGLDAVLAVLR
PTDRKLIQCLEARNWGAFFELAVIDRLNIAIVGNTGSGKTSFMKTLCRSIPSNERVITIEDVRELFIRHIENCAHLLYSK
GGRGQARVTPADLIASTMRMRPDRVLLAELRGAEAYDFLKLLTTGHAGSITSYHAPNTAVAIERFALMAKEHPEAAAWDD
AALKRLLFLTIDVVAHMESRSFFNAAGEQTGRRWGMTEVWFDPVRKARTAFV

Sequences:

>Translated_372_residues
MTPRTDMPDSSRDPGLARLPEDASVRELMRPFAPLLEDADVTELVINRPQRVLTEDSRGWHGYDCPDLDFDRLVSFAVAV
ATLTNQEVSSQHPILSALLPGDARIQIVVPPVVPPRTVSITIRRPSAREKTLDEYPGEGLFDDTVWHRPDGLDAVLAVLR
PTDRKLIQCLEARNWGAFFELAVIDRLNIAIVGNTGSGKTSFMKTLCRSIPSNERVITIEDVRELFIRHIENCAHLLYSK
GGRGQARVTPADLIASTMRMRPDRVLLAELRGAEAYDFLKLLTTGHAGSITSYHAPNTAVAIERFALMAKEHPEAAAWDD
AALKRLLFLTIDVVAHMESRSFFNAAGEQTGRRWGMTEVWFDPVRKARTAFV
>Mature_371_residues
TPRTDMPDSSRDPGLARLPEDASVRELMRPFAPLLEDADVTELVINRPQRVLTEDSRGWHGYDCPDLDFDRLVSFAVAVA
TLTNQEVSSQHPILSALLPGDARIQIVVPPVVPPRTVSITIRRPSAREKTLDEYPGEGLFDDTVWHRPDGLDAVLAVLRP
TDRKLIQCLEARNWGAFFELAVIDRLNIAIVGNTGSGKTSFMKTLCRSIPSNERVITIEDVRELFIRHIENCAHLLYSKG
GRGQARVTPADLIASTMRMRPDRVLLAELRGAEAYDFLKLLTTGHAGSITSYHAPNTAVAIERFALMAKEHPEAAAWDDA
ALKRLLFLTIDVVAHMESRSFFNAAGEQTGRRWGMTEVWFDPVRKARTAFV

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 41503; Mature: 41372

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRTDMPDSSRDPGLARLPEDASVRELMRPFAPLLEDADVTELVINRPQRVLTEDSRGW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHCCCCCCC
HGYDCPDLDFDRLVSFAVAVATLTNQEVSSQHPILSALLPGDARIQIVVPPVVPPRTVSI
CCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCHHEEECCCCCEEEEEECCCCCCCEEEE
TIRRPSAREKTLDEYPGEGLFDDTVWHRPDGLDAVLAVLRPTDRKLIQCLEARNWGAFFE
EEECCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEE
LAVIDRLNIAIVGNTGSGKTSFMKTLCRSIPSNERVITIEDVRELFIRHIENCAHLLYSK
EEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCC
GGRGQARVTPADLIASTMRMRPDRVLLAELRGAEAYDFLKLLTTGHAGSITSYHAPNTAV
CCCCCEEECHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECCCCHHH
AIERFALMAKEHPEAAAWDDAALKRLLFLTIDVVAHMESRSFFNAAGEQTGRRWGMTEVW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
FDPVRKARTAFV
HHHHHHHHHCCC
>Mature Secondary Structure 
TPRTDMPDSSRDPGLARLPEDASVRELMRPFAPLLEDADVTELVINRPQRVLTEDSRGW
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHCCCCCCC
HGYDCPDLDFDRLVSFAVAVATLTNQEVSSQHPILSALLPGDARIQIVVPPVVPPRTVSI
CCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCHHEEECCCCCEEEEEECCCCCCCEEEE
TIRRPSAREKTLDEYPGEGLFDDTVWHRPDGLDAVLAVLRPTDRKLIQCLEARNWGAFFE
EEECCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEE
LAVIDRLNIAIVGNTGSGKTSFMKTLCRSIPSNERVITIEDVRELFIRHIENCAHLLYSK
EEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCC
GGRGQARVTPADLIASTMRMRPDRVLLAELRGAEAYDFLKLLTTGHAGSITSYHAPNTAV
CCCCCEEECHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECCCCHHH
AIERFALMAKEHPEAAAWDDAALKRLLFLTIDVVAHMESRSFFNAAGEQTGRRWGMTEVW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
FDPVRKARTAFV
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]