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The map label for this gene is virB10 [H]

Identifier: 91783155

GI number: 91783155

Start: 2001112

End: 2002344

Strand: Direct

Name: virB10 [H]

Synonym: Bxe_A2650

Alternate gene names: 91783155

Gene position: 2001112-2002344 (Clockwise)

Preceding gene: 91783154

Following gene: 91783156

Centisome position: 40.87

GC content: 66.34

Gene sequence:

>1233_bases
ATGAATGACGATACCCCGAGAAATCTGATTGAGCCCGACGATTCCGCTGGGGCGCGGCCCGGACGCAACCCGAACGATAG
TGCATCAGGGGCATCCGCGGCTCGCGGAATGCCGGCGGTGGGCCAATACCGTAGTGCCCGCACGCGCGCCTGGTGGCTGA
CGCCGATCGTGATCGTTCTGGTCGTCGGTGCCGGTGCGGTCTGGACCGTCCATGGTTTCCTCGCGCGTCACGATGCCGAA
GCCAAGGCACGGCGCGATTCGGTGGCCGACGCGTCGAGCCAGGGCCGGGTGTTCAAGGATCTTCCTGCGTCCGCCATCGG
TGCGGCATCCGGTCCGGTGCCTACGAGCATTGCTGTACGCCCCGTACCGGCTTCGGCAGTGGCTGTTGCGCCTGTTGGCG
TCACGCACGCCGTGACGCCTCGTAGCTACTACGACGCGCCCCTGCTGGTCTCGGGCGGCGGGCAGGAGACGGCAGCTGCG
TTGCACGGTGTGCTGGAGGCGGGTGGCGCGGCAGGTGTTGCATCGTCGGTGGCCGCAGCAGTATCCGGTGGCGCAGGCGC
CCCATCAGAGGTGGCGGGACCGGCAGGAGGCGCGCTTGCCCAGGCGTTGACGCCGACTGCGACCCCTCGTGTGCGTGCCG
GCATGCTCGGCAACCGCAGTCTGGTGCTCGCGCAGGGCGCCAAGATCGACTGCGTGGGCGATACGGCCTTCGATTCGACC
GAGGCCGGCATCTCGACCTGCACGGTCACGAAGAACGTGTACTCCGACGATGGTCGCGTGGTGCTGATCGAGCGCGGTTC
GCAGATCGACAGCCAGTACCGGTCGAACCTGTCGCCGGGCCAGAAGCGAGTGTTCATGTTGTCGGCACGTGTCAAGACGC
CGCACGGCGTCACGGTCGAGATTGATTCGCCTGCAGCCGACGCACTCGGCCGCATGGGCATGGACGGTTATGTGGACAAC
CACTGGGGCCAGCGCATTGGTGCCGCGATGCTGCTCGGCCTGACCCAGGACGCGATCGGTTATCTGGCGACGCGCGGCGG
CAATAGCAATGGATCCGTCGTGTACGAGAACACGCAGCAGCAGGGCAACGACATGGCCACGCGCGTACTCGACAGCACGA
TCAACATTCCGCCGACGCTGAAGCAGAACCAGGGCGCGGAGTTCACGATCGTGGTCGCGCGCGATCTCGACTTCGGATCG
GTCTATACGCTGCAGCCGGAAGGTGCGCAATGA

Upstream 100 bases:

>100_bases
GTCGTCGGTATCTGGAACGACGCCTATGACATGGACGGCGTACCGCCGCGTGACGGCACCTCAGTCGGCGGTGTGAAGCG
TGTCCTGCGGAGCCACAACG

Downstream 100 bases:

>100_bases
CACCCCGCACGGACATGCCGGATTCGTCCCGCGACCCGGGTCTCGCCCGGTTGCCCGAAGACGCCTCCGTGCGCGAGTTG
ATGCGGCCGTTCGCGCCGCT

Product: putative type IV secretion system protein VirB10

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNDDTPRNLIEPDDSAGARPGRNPNDSASGASAARGMPAVGQYRSARTRAWWLTPIVIVLVVGAGAVWTVHGFLARHDAE
AKARRDSVADASSQGRVFKDLPASAIGAASGPVPTSIAVRPVPASAVAVAPVGVTHAVTPRSYYDAPLLVSGGGQETAAA
LHGVLEAGGAAGVASSVAAAVSGGAGAPSEVAGPAGGALAQALTPTATPRVRAGMLGNRSLVLAQGAKIDCVGDTAFDST
EAGISTCTVTKNVYSDDGRVVLIERGSQIDSQYRSNLSPGQKRVFMLSARVKTPHGVTVEIDSPAADALGRMGMDGYVDN
HWGQRIGAAMLLGLTQDAIGYLATRGGNSNGSVVYENTQQQGNDMATRVLDSTINIPPTLKQNQGAEFTIVVARDLDFGS
VYTLQPEGAQ

Sequences:

>Translated_410_residues
MNDDTPRNLIEPDDSAGARPGRNPNDSASGASAARGMPAVGQYRSARTRAWWLTPIVIVLVVGAGAVWTVHGFLARHDAE
AKARRDSVADASSQGRVFKDLPASAIGAASGPVPTSIAVRPVPASAVAVAPVGVTHAVTPRSYYDAPLLVSGGGQETAAA
LHGVLEAGGAAGVASSVAAAVSGGAGAPSEVAGPAGGALAQALTPTATPRVRAGMLGNRSLVLAQGAKIDCVGDTAFDST
EAGISTCTVTKNVYSDDGRVVLIERGSQIDSQYRSNLSPGQKRVFMLSARVKTPHGVTVEIDSPAADALGRMGMDGYVDN
HWGQRIGAAMLLGLTQDAIGYLATRGGNSNGSVVYENTQQQGNDMATRVLDSTINIPPTLKQNQGAEFTIVVARDLDFGS
VYTLQPEGAQ
>Mature_410_residues
MNDDTPRNLIEPDDSAGARPGRNPNDSASGASAARGMPAVGQYRSARTRAWWLTPIVIVLVVGAGAVWTVHGFLARHDAE
AKARRDSVADASSQGRVFKDLPASAIGAASGPVPTSIAVRPVPASAVAVAPVGVTHAVTPRSYYDAPLLVSGGGQETAAA
LHGVLEAGGAAGVASSVAAAVSGGAGAPSEVAGPAGGALAQALTPTATPRVRAGMLGNRSLVLAQGAKIDCVGDTAFDST
EAGISTCTVTKNVYSDDGRVVLIERGSQIDSQYRSNLSPGQKRVFMLSARVKTPHGVTVEIDSPAADALGRMGMDGYVDN
HWGQRIGAAMLLGLTQDAIGYLATRGGNSNGSVVYENTQQQGNDMATRVLDSTINIPPTLKQNQGAEFTIVVARDLDFGS
VYTLQPEGAQ

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 41891; Mature: 41891

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDTPRNLIEPDDSAGARPGRNPNDSASGASAARGMPAVGQYRSARTRAWWLTPIVIVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHCCCCCEEHHHHHHHHH
VVGAGAVWTVHGFLARHDAEAKARRDSVADASSQGRVFKDLPASAIGAASGPVPTSIAVR
HHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHCCCHHHCCCCCCCCCCEEEE
PVPASAVAVAPVGVTHAVTPRSYYDAPLLVSGGGQETAAALHGVLEAGGAAGVASSVAAA
CCCCCCEEEECCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHH
VSGGAGAPSEVAGPAGGALAQALTPTATPRVRAGMLGNRSLVLAQGAKIDCVGDTAFDST
HCCCCCCCHHCCCCCCCHHHHHCCCCCCCCHHHCCCCCCEEEEECCCEEEEECCCCCCCC
EAGISTCTVTKNVYSDDGRVVLIERGSQIDSQYRSNLSPGQKRVFMLSARVKTPHGVTVE
CCCCEEEEEECCEECCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEE
IDSPAADALGRMGMDGYVDNHWGQRIGAAMLLGLTQDAIGYLATRGGNSNGSVVYENTQQ
ECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCEEECCCHH
QGNDMATRVLDSTINIPPTLKQNQGAEFTIVVARDLDFGSVYTLQPEGAQ
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCC
>Mature Secondary Structure
MNDDTPRNLIEPDDSAGARPGRNPNDSASGASAARGMPAVGQYRSARTRAWWLTPIVIVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHCCCCCEEHHHHHHHHH
VVGAGAVWTVHGFLARHDAEAKARRDSVADASSQGRVFKDLPASAIGAASGPVPTSIAVR
HHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHCCCHHHCCCCCCCCCCEEEE
PVPASAVAVAPVGVTHAVTPRSYYDAPLLVSGGGQETAAALHGVLEAGGAAGVASSVAAA
CCCCCCEEEECCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHH
VSGGAGAPSEVAGPAGGALAQALTPTATPRVRAGMLGNRSLVLAQGAKIDCVGDTAFDST
HCCCCCCCHHCCCCCCCHHHHHCCCCCCCCHHHCCCCCCEEEEECCCEEEEECCCCCCCC
EAGISTCTVTKNVYSDDGRVVLIERGSQIDSQYRSNLSPGQKRVFMLSARVKTPHGVTVE
CCCCEEEEEECCEECCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEE
IDSPAADALGRMGMDGYVDNHWGQRIGAAMLLGLTQDAIGYLATRGGNSNGSVVYENTQQ
ECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCEEECCCHH
QGNDMATRVLDSTINIPPTLKQNQGAEFTIVVARDLDFGSVYTLQPEGAQ
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]