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The map label for this gene is yngG [H]

Identifier: 91783081

GI number: 91783081

Start: 1926414

End: 1927424

Strand: Direct

Name: yngG [H]

Synonym: Bxe_A2729

Alternate gene names: 91783081

Gene position: 1926414-1927424 (Clockwise)

Preceding gene: 91783080

Following gene: 91783082

Centisome position: 39.35

GC content: 60.93

Gene sequence:

>1011_bases
ATGAACATCTGGGATGGTGGACGCCGGCGCGTCTATATGCAGGAGGTGGGTACGCGCGACGGCTTCCAGTCGGAAGGGAT
CTTCGTCGAGACACGGGACAAGATCGCGCTGATTGACATGCTTTCGAAGACAGGCATGGCGAAAATCGAGGTGACCGCGT
TCGTGTCGCCGCAGGCGATACCCGCGTTACGCGATGCCGAGATTGTGCTGCGCGAGATCGAACGCAATCCAGGTGTTATC
TACACGGCGCTGGTTCCAAACGTGCGTGGTGCCGAACGCGCGATCGACGCGCATGCGGACGAGCTGAACCTGGTGATGTC
GGCGAGTGAAAGCCACAATCTGTCCAATCTGAGAATGACACGCGACCAGTCATTTAATGCGCTGAAGCAGGTCGCGGCCA
TTGCTCGCGATGCTGGCCTCCCTGTTAACATCTCTCTGTCTTGTGCATTCGGGTGCCCAATGGAAGGTGATGTGTCTGCG
AGCACCGTTCTCGAGTGGGCGGAACGCTTCGTCGAGGAGATCGGCTCACGGGGTGTCACTTTGTGCGACACGACGGGTAT
GGCGTATCCGCGGCAGGTTGCGGAGCTGACGTCACAATGTGTCGAGCGCTGGCCCCAGACTGAACTCACGCTGCACTTCC
ACAACACGCGCGGCATGGGCCTCGCCAACGTACTCGCCGCAATCGATGCCGGCGCCAACCGCTTCGACGCATCACTGGGT
GGGATCGGTGGATGCCCGTACGCGCCAGGCGCGAGCGGCAACGTGTGCAGCGAGGAGATCGTGCACGCGTTGGAGTTGAT
GGGCTACGACACTGGCGTTGATCTCGACGCGCTGATCGCCGCTGCGAGGTGCCTTCCGCCGCTGATTGGTCATGATACGC
CCAGCCAGATCGTGAAGGCGGGGCGGCGGCTCGACTTGCATCCGCTGCCGGCCGACTTTGCCGCGGTCCGCGAACGGACT
ATGCAGGGAAAGCTCAAGCCTAAACCGCATTATGGGATGAATATCGGCTAA

Upstream 100 bases:

>100_bases
CATCGGCGCCTAAGCTCGGCGACGATACAGATGGCGTCCTGCGCGAGATCGGTATTTCCGAAACGCGGATTGCCGAACTT
CGTGACAAAGGAGCAATTGC

Downstream 100 bases:

>100_bases
GGGGGTGACGTCGGATCCAAGCTGGTTCCCGACGTTCCCAACCGAAATTTTGGGGGCGGTACAGGAAAATACAGTTCATG
CAACAAACGCTAATTTAATG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNIWDGGRRRVYMQEVGTRDGFQSEGIFVETRDKIALIDMLSKTGMAKIEVTAFVSPQAIPALRDAEIVLREIERNPGVI
YTALVPNVRGAERAIDAHADELNLVMSASESHNLSNLRMTRDQSFNALKQVAAIARDAGLPVNISLSCAFGCPMEGDVSA
STVLEWAERFVEEIGSRGVTLCDTTGMAYPRQVAELTSQCVERWPQTELTLHFHNTRGMGLANVLAAIDAGANRFDASLG
GIGGCPYAPGASGNVCSEEIVHALELMGYDTGVDLDALIAAARCLPPLIGHDTPSQIVKAGRRLDLHPLPADFAAVRERT
MQGKLKPKPHYGMNIG

Sequences:

>Translated_336_residues
MNIWDGGRRRVYMQEVGTRDGFQSEGIFVETRDKIALIDMLSKTGMAKIEVTAFVSPQAIPALRDAEIVLREIERNPGVI
YTALVPNVRGAERAIDAHADELNLVMSASESHNLSNLRMTRDQSFNALKQVAAIARDAGLPVNISLSCAFGCPMEGDVSA
STVLEWAERFVEEIGSRGVTLCDTTGMAYPRQVAELTSQCVERWPQTELTLHFHNTRGMGLANVLAAIDAGANRFDASLG
GIGGCPYAPGASGNVCSEEIVHALELMGYDTGVDLDALIAAARCLPPLIGHDTPSQIVKAGRRLDLHPLPADFAAVRERT
MQGKLKPKPHYGMNIG
>Mature_336_residues
MNIWDGGRRRVYMQEVGTRDGFQSEGIFVETRDKIALIDMLSKTGMAKIEVTAFVSPQAIPALRDAEIVLREIERNPGVI
YTALVPNVRGAERAIDAHADELNLVMSASESHNLSNLRMTRDQSFNALKQVAAIARDAGLPVNISLSCAFGCPMEGDVSA
STVLEWAERFVEEIGSRGVTLCDTTGMAYPRQVAELTSQCVERWPQTELTLHFHNTRGMGLANVLAAIDAGANRFDASLG
GIGGCPYAPGASGNVCSEEIVHALELMGYDTGVDLDALIAAARCLPPLIGHDTPSQIVKAGRRLDLHPLPADFAAVRERT
MQGKLKPKPHYGMNIG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=38.5135135135135, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI109150422, Length=290, Percent_Identity=36.551724137931, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI109150427, Length=290, Percent_Identity=36.551724137931, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI260654708, Length=132, Percent_Identity=36.3636363636364, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17510563, Length=289, Percent_Identity=36.3321799307958, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320019, Length=227, Percent_Identity=26.431718061674, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320071, Length=227, Percent_Identity=26.431718061674, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=36.7697594501718, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 36298; Mature: 36298

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIWDGGRRRVYMQEVGTRDGFQSEGIFVETRDKIALIDMLSKTGMAKIEVTAFVSPQAI
CCCCCCCCCEEEHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEEEEEECCCCC
PALRDAEIVLREIERNPGVIYTALVPNVRGAERAIDAHADELNLVMSASESHNLSNLRMT
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHEEEEECCCCCCCCCEEEC
RDQSFNALKQVAAIARDAGLPVNISLSCAFGCPMEGDVSASTVLEWAERFVEEIGSRGVT
HHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
LCDTTGMAYPRQVAELTSQCVERWPQTELTLHFHNTRGMGLANVLAAIDAGANRFDASLG
EEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCC
GIGGCPYAPGASGNVCSEEIVHALELMGYDTGVDLDALIAAARCLPPLIGHDTPSQIVKA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCCCHHHHHHC
GRRLDLHPLPADFAAVRERTMQGKLKPKPHYGMNIG
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIWDGGRRRVYMQEVGTRDGFQSEGIFVETRDKIALIDMLSKTGMAKIEVTAFVSPQAI
CCCCCCCCCEEEHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEEEEEECCCCC
PALRDAEIVLREIERNPGVIYTALVPNVRGAERAIDAHADELNLVMSASESHNLSNLRMT
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHEEEEECCCCCCCCCEEEC
RDQSFNALKQVAAIARDAGLPVNISLSCAFGCPMEGDVSASTVLEWAERFVEEIGSRGVT
HHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
LCDTTGMAYPRQVAELTSQCVERWPQTELTLHFHNTRGMGLANVLAAIDAGANRFDASLG
EEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCC
GIGGCPYAPGASGNVCSEEIVHALELMGYDTGVDLDALIAAARCLPPLIGHDTPSQIVKA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCCCHHHHHHC
GRRLDLHPLPADFAAVRERTMQGKLKPKPHYGMNIG
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]