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The map label for this gene is hisM [H]

Identifier: 91782896

GI number: 91782896

Start: 1691035

End: 1691748

Strand: Direct

Name: hisM [H]

Synonym: Bxe_A2926

Alternate gene names: 91782896

Gene position: 1691035-1691748 (Clockwise)

Preceding gene: 91782895

Following gene: 91782897

Centisome position: 34.54

GC content: 62.89

Gene sequence:

>714_bases
ATGATCGATATTCTCAATCAGTTCTGGCGCGCGTTCCTCTACTGGGACGGCCAGCGCATGTCGGGTCTCGCGGTCACGCT
GTGGCTGCTGGTGGCATCGGTCGGGATCGGCTTCTGCGCGGCGATTCCGCTGGCGGTGGCGCGGGTGTCGAAGAAGCGCT
GGCTCTCCACGCCCGTGCGTCTTTACACTTACGTGTTTCGCGGCACGCCGCTGTACGTGCAACTGCTGCTGATCTATACC
GGCATGTACAGCCTCGAATTCGTGCGCTCGCATCAATTGCTGGACGCGTTTTTCCGCAGCGGTTTTCACTGCGCGATTCT
CGCTTTCGCACTGAACACCTGCGCGTACACCACGGAGATTTTCGCCGGCGCGATCCGTTCGACCTCGCACGGCGAAGTGG
AGGCGGCGCGCGCCTACGGCATGAGCGGGTTCACGATGTACCGCCGCATTGTGATACCGTCCGCGCTGCGCCGGGCCTTG
CCGTTGTACAGTAACGAAGTGATCCTGATGCTGCACGCCACCACGGTCGCCTTCACGGCCACGGTGCCGGACATCCTGAA
AGTGGCGCGCGACGCGAATTCGGCCACTTACCAGTCGTTCGACGCGTTCGGCCTCGCGGCGCTGATTTACCTGGTGGTGT
CGTTCGCGCTGGTGGCGCTGTTTCGCCGCGCGGAGCGTCATTGGCTGGGATATCTCGCGGTGCGCACGCATTGA

Upstream 100 bases:

>100_bases
GCGCTGATCTATCTGGCTATCACCACCGTGTCGAATCTCGTGCTGATCTGGCTGGAAAAGCGCTATTCGACCGGCGTGCG
GCACGCGGAGCTCTGAGACC

Downstream 100 bases:

>100_bases
AACGCGCCGTGCTGGCAGTGGGCGGCGGTTTGCGTGGGCGCCGTCATGAAGATTGATCCGTATTTTCAAAGGGAGAGCAT
CTTGCTCCACACGACTCAAA

Product: ABC lysine/arginine/ornithine transporter, innermembrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIDILNQFWRAFLYWDGQRMSGLAVTLWLLVASVGIGFCAAIPLAVARVSKKRWLSTPVRLYTYVFRGTPLYVQLLLIYT
GMYSLEFVRSHQLLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRSTSHGEVEAARAYGMSGFTMYRRIVIPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYQSFDAFGLAALIYLVVSFALVALFRRAERHWLGYLAVRTH

Sequences:

>Translated_237_residues
MIDILNQFWRAFLYWDGQRMSGLAVTLWLLVASVGIGFCAAIPLAVARVSKKRWLSTPVRLYTYVFRGTPLYVQLLLIYT
GMYSLEFVRSHQLLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRSTSHGEVEAARAYGMSGFTMYRRIVIPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYQSFDAFGLAALIYLVVSFALVALFRRAERHWLGYLAVRTH
>Mature_237_residues
MIDILNQFWRAFLYWDGQRMSGLAVTLWLLVASVGIGFCAAIPLAVARVSKKRWLSTPVRLYTYVFRGTPLYVQLLLIYT
GMYSLEFVRSHQLLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRSTSHGEVEAARAYGMSGFTMYRRIVIPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYQSFDAFGLAALIYLVVSFALVALFRRAERHWLGYLAVRTH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=232, Percent_Identity=62.9310344827586, Blast_Score=316, Evalue=8e-88,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=35.0467289719626, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788226, Length=213, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=27.7511961722488, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788646, Length=199, Percent_Identity=29.1457286432161, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787087, Length=219, Percent_Identity=26.027397260274, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786873, Length=207, Percent_Identity=27.536231884058, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26645; Mature: 26645

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDILNQFWRAFLYWDGQRMSGLAVTLWLLVASVGIGFCAAIPLAVARVSKKRWLSTPVR
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LYTYVFRGTPLYVQLLLIYTGMYSLEFVRSHQLLDAFFRSGFHCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGAIRSTSHGEVEAARAYGMSGFTMYRRIVIPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYQSFDAFGLAALIYLVVSFALVALFRRAERHWLGYLAVRTH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MIDILNQFWRAFLYWDGQRMSGLAVTLWLLVASVGIGFCAAIPLAVARVSKKRWLSTPVR
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LYTYVFRGTPLYVQLLLIYTGMYSLEFVRSHQLLDAFFRSGFHCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGAIRSTSHGEVEAARAYGMSGFTMYRRIVIPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYQSFDAFGLAALIYLVVSFALVALFRRAERHWLGYLAVRTH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]