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The map label for this gene is hutU [H]

Identifier: 91782878

GI number: 91782878

Start: 1667233

End: 1668921

Strand: Direct

Name: hutU [H]

Synonym: Bxe_A2945

Alternate gene names: 91782878

Gene position: 1667233-1668921 (Clockwise)

Preceding gene: 91782877

Following gene: 91782879

Centisome position: 34.05

GC content: 64.18

Gene sequence:

>1689_bases
ATGAACAACCCGAAACACATCGACCCGCGTCTCGATCCGACCCGCACGATCCGCGCACCGCGCGGCGCGGAAAAGACCTG
CAAGACCTGGATCGCGGAAGCCGCGTACCGGATGATCCAGAACAATCTGGACCCGGAAGTCGCCGAGCATCCGCATGCGC
TGGTCGTGTACGGTGGCATTGGCCGTGCGGCGCGCAACTGGGACTGCTTCGATCAGATTCTCAAGTCGCTGAAGGATCTC
GAGGAAAACGAAACGCTGTTGATTCAATCCGGCAAGCCGGTCGGCGTGTTCCACACGCATGCCGACGCGCCGCGCGTGCT
GCTGGCGAATTCGAATCTGGTGCCGCATTGGGCGACGTGGGAACACTTCCACGAACTCGACCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCGGGCAGCTGGATTTACATCGGCAGCCAGGGCATCGTGCAGGGCACCTACGAGACGTTCTTCTCG
GTGGCGAACCAGCATTTCAACGGCGAGCCGAAGGGCCGCTGGATCCTGACCGGCGGCCTCGGCGGCATGGGCGGCGCGCA
GCCGCTCGCGGCCACGATGGCCGGTTTCTCGATGATCGCGGTGGAATGCGACGAGACGCGCATCGACTTCCGCCTGAAGA
CGCGCTACGTCGACAGGAAAGCGCAGACGCTCGATGAGGCGCTCGCCATGCTCGACGAAGCGAAGCTGGCCGGCAAGCCG
GTTTCGATCGGCCTGCTGGGCAATGCCGCCGACGTGTTCGCCGAGTGCGTGACGCGTGGCATCACGCCGGATTGCGTGAC
CGATCAGACCAGCGCGCACGATCCGATTCACGGCTACCTCCCGCAAGGCTGGAATGTCGAAGACTGGCGTGAGCGTATGA
AGACCGCGCCGGATTCGATCATCACGCCGGCCAAACAGTCGATGGCCAACCAGGTGCAAGCCATGCTGACGCTGCAGGAA
CGCGGCGCGGCCACGCTCGACTACGGCAACAACATCCGTCAGATGGCGCTGGAAATGGGCGTGAAAAACGCGTTCGATTT
CCCGGGTTTCGTGCCGGCGTATATCCGCCCGCTGTTCTGCGAAGGCAAGGGCCCGTTCCGCTGGGTCGCGCTGTCGGGCG
ATCCTGAGGATATCTACAAGACCGATGCGAAGGTCAAGGAACTGATCCCCGACGATCCGCATCTGCACAACTGGCTCGAC
ATGGCGCGCGAACGCATCGCGTTCCAGGGCTTGCCCGCGCGGATCTGCTGGGTCGGCGTGAAGGACCGCTATCGTCTGGG
CCAGGCGTTCAACGAAATGGTCAGGAACGGCGAACTGAAGGCGCCGATCGTGATCGGCCGCGATCACCTCGACACCGGTT
CGGTGGCGAGCCCGAATCGCGAAACCGAATCGATGAAGGACGGCTCGGACGCGGTCAGCGACTGGCCGCTGCTCAACGCG
CTGCTGAATACGGCGGGCGGCGCCTCGTGGGTGTCGCTGCATCACGGCGGCGGAGTCGGCATGGGCTTTAGCCAGCACGC
GGGCGTCGTGATCGTCGCCGATGGCACGGATGCCGCAAAAGAGCGCCTCGGCCGCGTACTGTTCAACGATCCGGCTACCG
GCGTGATGCGTCACGCGGATGCGGGCTATGAACTCGCGCAGCAAACCGCGCGCGAGGCTGGTCTCAATCTGCCGATGCTG
GGCCGCTGA

Upstream 100 bases:

>100_bases
ATCCCGGCAGCCGCTATCGCTTCACCGGACATTTCTGACTACGCCGTCTTTTCCGAACCCGAATCTTTTTCGACCATCTT
CAAGCATTCCGAGGGCCATC

Downstream 100 bases:

>100_bases
TCGTGGCGCTTCACGGCACGCTCGTGGTCAGCGGGGCAACCGTCACGCTGATTCGCGGCGCCGAACTCGTGGCGGCGCCC
TGGAAGAACGGCGGCGGCGT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNNPKHIDPRLDPTRTIRAPRGAEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILKSLKDL
EENETLLIQSGKPVGVFHTHADAPRVLLANSNLVPHWATWEHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGEPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDRKAQTLDEALAMLDEAKLAGKP
VSIGLLGNAADVFAECVTRGITPDCVTDQTSAHDPIHGYLPQGWNVEDWRERMKTAPDSIITPAKQSMANQVQAMLTLQE
RGAATLDYGNNIRQMALEMGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAKERLGRVLFNDPATGVMRHADAGYELAQQTAREAGLNLPML
GR

Sequences:

>Translated_562_residues
MNNPKHIDPRLDPTRTIRAPRGAEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILKSLKDL
EENETLLIQSGKPVGVFHTHADAPRVLLANSNLVPHWATWEHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGEPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDRKAQTLDEALAMLDEAKLAGKP
VSIGLLGNAADVFAECVTRGITPDCVTDQTSAHDPIHGYLPQGWNVEDWRERMKTAPDSIITPAKQSMANQVQAMLTLQE
RGAATLDYGNNIRQMALEMGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAKERLGRVLFNDPATGVMRHADAGYELAQQTAREAGLNLPML
GR
>Mature_562_residues
MNNPKHIDPRLDPTRTIRAPRGAEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILKSLKDL
EENETLLIQSGKPVGVFHTHADAPRVLLANSNLVPHWATWEHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGEPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDRKAQTLDEALAMLDEAKLAGKP
VSIGLLGNAADVFAECVTRGITPDCVTDQTSAHDPIHGYLPQGWNVEDWRERMKTAPDSIITPAKQSMANQVQAMLTLQE
RGAATLDYGNNIRQMALEMGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAKERLGRVLFNDPATGVMRHADAGYELAQQTAREAGLNLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=34.0277777777778, Blast_Score=301, Evalue=8e-82,
Organism=Homo sapiens, GI260306182, Length=636, Percent_Identity=32.0754716981132, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71997891, Length=581, Percent_Identity=33.5628227194492, Blast_Score=304, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61758; Mature: 61758

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPKHIDPRLDPTRTIRAPRGAEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCFDQILKSLKDLEENETLLIQSGKPVGVFHTHADAPRVLLANSNLVPHWATW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCH
EHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGEPKGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDRKAQTLDEALAMLDEAKLAGKP
CCCCCCHHHHHHHHCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSIGLLGNAADVFAECVTRGITPDCVTDQTSAHDPIHGYLPQGWNVEDWRERMKTAPDSI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHH
ITPAKQSMANQVQAMLTLQERGAATLDYGNNIRQMALEMGVKNAFDFPGFVPAYIRPLFC
CCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDAKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVRNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAKERLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREAGLNLPMLGR
CCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNNPKHIDPRLDPTRTIRAPRGAEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCFDQILKSLKDLEENETLLIQSGKPVGVFHTHADAPRVLLANSNLVPHWATW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCH
EHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGEPKGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDRKAQTLDEALAMLDEAKLAGKP
CCCCCCHHHHHHHHCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSIGLLGNAADVFAECVTRGITPDCVTDQTSAHDPIHGYLPQGWNVEDWRERMKTAPDSI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHH
ITPAKQSMANQVQAMLTLQERGAATLDYGNNIRQMALEMGVKNAFDFPGFVPAYIRPLFC
CCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDAKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVRNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAKERLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREAGLNLPMLGR
CCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]