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The map label for this gene is uvrB [H]

Identifier: 91782672

GI number: 91782672

Start: 1453746

End: 1455851

Strand: Direct

Name: uvrB [H]

Synonym: Bxe_A3153

Alternate gene names: 91782672

Gene position: 1453746-1455851 (Clockwise)

Preceding gene: 91782670

Following gene: 91782673

Centisome position: 29.69

GC content: 62.39

Gene sequence:

>2106_bases
ATGCCGCCCCACATGTCCGAACAACATCTGACTGAAGCCGAAGATACGCTCGACGAATCCAAATTCGTCAGTTTCGAAGG
CTCGCCGTTCCAGCTTTACCAGCCGTATCCGCCCGCCGGCGATCAGCCCACGGCGATCGACACGCTCGTCGAAGGCGTGG
AGGACGGCCTCGCGTTCCAGACGCTGCTTGGCGTGACCGGCTCAGGCAAGACGTTCACAATGGCGAACACGATCGCGCGG
CTTGGCCGCCCGGCTATCGTGTTCGCGCCGAACAAGACGCTCGCCGCGCAGCTCTATTCGGAGTTCCGCGAGTTCTTCCC
GCGCAATGCGGTCGAGTACTTCGTCTCGTACTACGACTATTACCAGCCGGAAGCGTACGTGCCGCAGCGCGACCTGTTCA
TCGAGAAGGACTCGTCGATCAACGAACACATCGAGCAGATGCGGCTGTCGGCTACCAAGAGCCTGATGGAACGGCGCGAC
GTGGTGATCGTGGCAACGGTGTCGGCCATTTACGGTATCGGCAATCCGTCCGAATACCACCGGATGATCCTGACGCTGCG
CACCGGCGACAAACTCGGCCAGCGCGACATCATCGCGCGGCTGATCGCGATGCAGTACAACCGCAACGAAGCCGACTTCC
AGCGCGGCTCGTTTCGCGTGCGCGGCGATACGATCGATATTTTCCCGGCCGAGCATGCCGAGATGGCGGTGCGCGTCGAA
CTGTTCGACGACGAAGTCGAAACGCTGCAGCTGTTCGATCCGCTTACCGGACGCGTGCGTCAGAAGATTCCGCGTTTCAC
AGTGTATCCGTCGTCGCACTATGTGACGCCGCGCGATACCGTGGTGCGCGCGGTCGAAACGATCAAGACCGAACTGCGCG
AGCGGCTCGAATTCTTCTATGCCGGCGGCAAGCTGGTCGAAGCGCAGCGGCTCGAACAGCGCACCCGCTTCGACCTGGAA
ATGCTCCAGGAGCTGGGTTTCTGCAAGGGCATCGAGAACTACTCGCGGCACTTTTCCGGCGCGGCGCCCGGCGAGCCGCC
GCCTACGTTGGTCGATTACCTGCCGCCGGACGCGATCATGATGCTCGACGAGTCGCACGTGCTGATCGGGCAGTTGAACG
GCATGTATAACGGCGACCGGGCGCGTAAGGAAAATCTGGTCGACTACGGTTTCCGCCTGCCGTCGGCGCTCGACAACCGG
CCGCTCAAGTTCAACGAGTTCGAGCGCAAGATGCGCCAGGTGGTGTTCGTGTCGGCCACGCCGGCCGACTACGAGCAGAA
GACAGCAGGGCAGGTGGCCGAACAGCTAGTGCGTCCCACCGGCCTCGTCGATCCGGAAATCGAGGTGCGGCCGGCGCGCA
GCCAGGTCGACGACGTGCTGGGCGAGATCAACGAGCGCGTCAAGGTGGGCGACCGCGTGCTGGTTACGGTGCTGACCAAG
CGCATGGCCGAACAGTTGACCGAGTTTCTGGCCGACCACGGCGTCAAGGTGCGTTATCTGCACAGCGACATCGACACCGT
GGAGCGGGTCGAAATCATCCGCGATCTACGGCTCGGCACCTTCGACGTGCTGGTCGGGATCAACCTGTTGCGCGAAGGGC
TGGATATCCCGGAAGTGTCGCTGGTCGCGATTCTCGACGCGGACAAGGAAGGCTTTCTGCGCGCCGAGCGTTCGCTGATC
CAGACCATCGGCCGGGCGGCGCGGAATGTGAACGGCAAGGCGATTCTCTATGCGGACAGGGTCACGGATTCGATGCGCCG
CGCGATCGACGAAACCGAGCGGCGCCGTAACAAGCAGATCGCCTTCAACCTCGAGAACGGTATTACGCCGCGCGGGGTGG
TCAAGCGGATTCGAGACATTATCGACGGCGTGTACAACGTCGACGACGCCCGCGCCGAACTGAAGGAACAGCAGGCGCGC
GCGAAATTCGAAGACATGTCCGAGAAGCAGCTCGCCAGGGAACTCAAGCGGCTCGAAAAGCAGATGATGGAGCACGCCAA
AAACCTCGAGTTCGAAAAGGCCGCGCAAACGCGCGATCAGCTCGCACTGCTGCGCCAGCGGGTGTTCGGCGCGAACGTCG
GCGATCACGTCTCCGGCGTCGAATAA

Upstream 100 bases:

>100_bases
GCATGCGGCCACACCCGCGCGAACCCTCGAAAGCCTACGCAGACCCGCTCGATCGTCGATTCCCGCAACCCGTTAGAATA
GTTCTTTGCCCCAAGGCCCG

Downstream 100 bases:

>100_bases
TGCGTCTTCACGCCGCTGGGCGCGGCAATGTGCCGCGCCCATGTCAATGACTGCCGGCTGCCCGCCGCGTCATCGCACGC
ATTTCCTTAAAAGCGCCTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 701; Mature: 700

Protein sequence:

>701_residues
MPPHMSEQHLTEAEDTLDESKFVSFEGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLAFQTLLGVTGSGKTFTMANTIAR
LGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRD
VVIVATVSAIYGIGNPSEYHRMILTLRTGDKLGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVE
LFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVVRAVETIKTELRERLEFFYAGGKLVEAQRLEQRTRFDLE
MLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDAIMMLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNR
PLKFNEFERKMRQVVFVSATPADYEQKTAGQVAEQLVRPTGLVDPEIEVRPARSQVDDVLGEINERVKVGDRVLVTVLTK
RMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLI
QTIGRAARNVNGKAILYADRVTDSMRRAIDETERRRNKQIAFNLENGITPRGVVKRIRDIIDGVYNVDDARAELKEQQAR
AKFEDMSEKQLARELKRLEKQMMEHAKNLEFEKAAQTRDQLALLRQRVFGANVGDHVSGVE

Sequences:

>Translated_701_residues
MPPHMSEQHLTEAEDTLDESKFVSFEGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLAFQTLLGVTGSGKTFTMANTIAR
LGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRD
VVIVATVSAIYGIGNPSEYHRMILTLRTGDKLGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVE
LFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVVRAVETIKTELRERLEFFYAGGKLVEAQRLEQRTRFDLE
MLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDAIMMLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNR
PLKFNEFERKMRQVVFVSATPADYEQKTAGQVAEQLVRPTGLVDPEIEVRPARSQVDDVLGEINERVKVGDRVLVTVLTK
RMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLI
QTIGRAARNVNGKAILYADRVTDSMRRAIDETERRRNKQIAFNLENGITPRGVVKRIRDIIDGVYNVDDARAELKEQQAR
AKFEDMSEKQLARELKRLEKQMMEHAKNLEFEKAAQTRDQLALLRQRVFGANVGDHVSGVE
>Mature_700_residues
PPHMSEQHLTEAEDTLDESKFVSFEGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLAFQTLLGVTGSGKTFTMANTIARL
GRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDV
VIVATVSAIYGIGNPSEYHRMILTLRTGDKLGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVEL
FDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVVRAVETIKTELRERLEFFYAGGKLVEAQRLEQRTRFDLEM
LQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDAIMMLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRP
LKFNEFERKMRQVVFVSATPADYEQKTAGQVAEQLVRPTGLVDPEIEVRPARSQVDDVLGEINERVKVGDRVLVTVLTKR
MAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQ
TIGRAARNVNGKAILYADRVTDSMRRAIDETERRRNKQIAFNLENGITPRGVVKRIRDIIDGVYNVDDARAELKEQQARA
KFEDMSEKQLARELKRLEKQMMEHAKNLEFEKAAQTRDQLALLRQRVFGANVGDHVSGVE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=65.7228017883756, Blast_Score=873, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=21.8241042345277, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79876; Mature: 79745

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPHMSEQHLTEAEDTLDESKFVSFEGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLAFQ
CCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
TLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDY
HHHCCCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYH
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHE
RMILTLRTGDKLGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVE
EEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECCEEEECCCCCCCEEEEEE
LFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVVRAVETIKTELRERLEFFY
EECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDAIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEE
MLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFNEFERKMRQVVFVSAT
EECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECC
PADYEQKTAGQVAEQLVRPTGLVDPEIEVRPARSQVDDVLGEINERVKVGDRVLVTVLTK
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
RMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVS
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEE
LVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADRVTDSMRRAIDETERRRNKQI
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCE
AFNLENGITPRGVVKRIRDIIDGVYNVDDARAELKEQQARAKFEDMSEKQLARELKRLEK
EEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QMMEHAKNLEFEKAAQTRDQLALLRQRVFGANVGDHVSGVE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PPHMSEQHLTEAEDTLDESKFVSFEGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLAFQ
CCCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
TLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDY
HHHCCCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYH
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHE
RMILTLRTGDKLGQRDIIARLIAMQYNRNEADFQRGSFRVRGDTIDIFPAEHAEMAVRVE
EEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEECCEEEECCCCCCCEEEEEE
LFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVVRAVETIKTELRERLEFFY
EECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDAIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEE
MLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFNEFERKMRQVVFVSAT
EECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECC
PADYEQKTAGQVAEQLVRPTGLVDPEIEVRPARSQVDDVLGEINERVKVGDRVLVTVLTK
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
RMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVS
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEE
LVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADRVTDSMRRAIDETERRRNKQI
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCE
AFNLENGITPRGVVKRIRDIIDGVYNVDDARAELKEQQARAKFEDMSEKQLARELKRLEK
EEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QMMEHAKNLEFEKAAQTRDQLALLRQRVFGANVGDHVSGVE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA