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The map label for this gene is parE [H]

Identifier: 91782490

GI number: 91782490

Start: 1242497

End: 1244482

Strand: Direct

Name: parE [H]

Synonym: Bxe_A3339

Alternate gene names: 91782490

Gene position: 1242497-1244482 (Clockwise)

Preceding gene: 91782489

Following gene: 91782491

Centisome position: 25.38

GC content: 63.6

Gene sequence:

>1986_bases
ATGTCTACGAAAAAGCCAAACGCCGCGTATAGCGAAGCGTCGATCAAGGTGTTGAAGGGTCTGGAGCCGGTCAAGCAACG
GCCCGGCATGTACACCCGCACCGAGAATCCGCTGCACATCATCCAGGAAGTCATCGACAACGCGTCGGACGAGGCCCTCG
GCGGCCACGGCCGGCAAATCACGGTCACGCTGCACGTCGACCATTCGGTCTCGGTGGAAGACGACGGCCGCGGCATTCCG
TTCGGCCTGCATCCGGAAGAAGGCGTGCCGGTCGTCGAAATCGTTTTCACGCGCCTGCACGCGGGCGGCAAGTTCGATAA
AGCCGCCGGCGGCGCGTACACGTTCTCGGGCGGCCTGCACGGCGTGGGCGTGTCGGTCACCAACGCGCTGTCCACGCGCC
TCGACGTCACCGTGTGGCGTGAAGGCAAGGTTGCCGAGCTGAGTTTCGCCAATGGCGACGTCGCCAGGGAACTCGAAGTG
CGCCCTGCCACGAAAGGCGACAAGAAGTCCGGCACGCGCGTCACCGCGTGGGCCAATCCGAAATACTTCGATTCGCCGAA
CCTGCCGCTCGGCGAATTGCAGCGTCTGCTGCGCTCGAAAGCGGTGCTGCTGCCGGGCGTGGAAGTCACGCTGATCAACG
AGAAAACCGGCGAACAGCAAAGCTGGAAATACGAAGACGGCTTGCGCGGCTATCTGCTAGAAGGCATGAACGGCAGCGAT
CTGCTGATTCCGCTGTTCGAGGGCGAGCGTTATGTCGAGAACTCGCGCGCGAGCGAAGAGACCTTCGCGGAAGGCGAGGG
CGCGTCGTGGGTCGTCGCGTGGAGCGAAGAAGGCACGCTCATGCGCGAGTCGTACGTGAACCTGATTCCGACGCCCGCGG
GCGGCACGCACGAATCCGGTTTGCGCGACGGTCTCTATCAGGCGGTGAAGAGCTTCGTCGAGTTGCACAACCTGCAGCCG
AAGGGCGTCAAGCTGCTCGCCGAAGACGTGTTCGCGCGCGTGTCGTTCGTGCTGTCGGCGAAGGTGCTCGATCCGCAATT
CCAAGGGCAGATCAAGGAGCGACTGAATAGCCGCGACGCGGTCAAGCTGGTGTCGTCGTTCGCGCGGCCGGCGCTGGAGC
TGTGGCTGAATCAGCACGTCGAGCACGGCAAGAAGCTCGCGGACCTCGTCATCAAGCAGGCGCAGGCGCGCACGCGTGCC
GGGCAGAAAGTCGAGAAGCGCAAGAGCTCGGGCGTGGCGGTGTTGCCGGGCAAGCTGACCGATTGCGAATCGACGGAAAT
CGGCCGCAACGAACTGTTCCTCGTGGAAGGCGATTCGGCGGGCGGCTCCGCGAAGATGGGCCGCGACAAGGAATATCAGG
CCATCCTGCCGCTGCGCGGCAAGGTGCTGAACACGTGGGAAACTGAGCGTGACCGGCTGTTCGCCAACAACGAAGTGCAC
GACATTTCGGTGGCGATCGGCGTCGATCCGCATAGCCCGGACGACAAGGTCGATCTGTCCAATCTCCGCTACGGCAAGAT
CTGCATTCTGTCGGATGCGGACGTCGACGGTTCGCATATTCAGGTGCTGCTGCTCACGCTGTTCTTCAAGCATTTCCCGC
AGCTGATCGAACGTGGCCACGTGTGTGTGGCGCGTCCGCCGCTGTTCCGGGTCGACGCGCCCGCGCGCGGCAAGAAGCCG
GCGCAGAAGCTCTATGCGCTCGACGAAGGCGAGCTCGAAGCGATTCTCGACAAGCTGCGCAAGGACGGCGTGCGCGACAC
GCAGTGGTCGATCAGCCGCTTCAAGGGCCTCGGCGAAATGAGCGCGGAGCAGTTGTGGGACACCACGATGAATCCCGACA
CGCGGCGGCTGACTCCCGTGGCGCTCGGCGAGCTCGACTACGACGCCACGGTCGCGCGCATGACGATGCTGATGGGCAAG
GGCGAAGCGGCATCGCGGCGCAGCTGGCTGGAAGAAAAGGGCAACGAAGTAGAAGCGGATATCTGA

Upstream 100 bases:

>100_bases
TCATTGTTTCGTTTCGCTTTTTTTGAAAACTCAACGCATTGTCCACGGACCTGTCCACAGGAGCTGTGGACAACGATGAA
CCGACGCACCCGAGTCAACC

Downstream 100 bases:

>100_bases
GCGCGCTCATAGCGCTCATGGCGCTCATGACAAATAGCGCGCGCATCGGTATCGAAAACGCACGGCAACTTCACGCCAAA
CACGGATACGGAATCTAGAT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSTKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGRQITVTLHVDHSVSVEDDGRGIP
FGLHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALSTRLDVTVWREGKVAELSFANGDVARELEV
RPATKGDKKSGTRVTAWANPKYFDSPNLPLGELQRLLRSKAVLLPGVEVTLINEKTGEQQSWKYEDGLRGYLLEGMNGSD
LLIPLFEGERYVENSRASEETFAEGEGASWVVAWSEEGTLMRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQP
KGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRA
GQKVEKRKSSGVAVLPGKLTDCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
DISVAIGVDPHSPDDKVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVCVARPPLFRVDAPARGKKP
AQKLYALDEGELEAILDKLRKDGVRDTQWSISRFKGLGEMSAEQLWDTTMNPDTRRLTPVALGELDYDATVARMTMLMGK
GEAASRRSWLEEKGNEVEADI

Sequences:

>Translated_661_residues
MSTKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGRQITVTLHVDHSVSVEDDGRGIP
FGLHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALSTRLDVTVWREGKVAELSFANGDVARELEV
RPATKGDKKSGTRVTAWANPKYFDSPNLPLGELQRLLRSKAVLLPGVEVTLINEKTGEQQSWKYEDGLRGYLLEGMNGSD
LLIPLFEGERYVENSRASEETFAEGEGASWVVAWSEEGTLMRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQP
KGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRA
GQKVEKRKSSGVAVLPGKLTDCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
DISVAIGVDPHSPDDKVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVCVARPPLFRVDAPARGKKP
AQKLYALDEGELEAILDKLRKDGVRDTQWSISRFKGLGEMSAEQLWDTTMNPDTRRLTPVALGELDYDATVARMTMLMGK
GEAASRRSWLEEKGNEVEADI
>Mature_660_residues
STKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGRQITVTLHVDHSVSVEDDGRGIPF
GLHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLHGVGVSVTNALSTRLDVTVWREGKVAELSFANGDVARELEVR
PATKGDKKSGTRVTAWANPKYFDSPNLPLGELQRLLRSKAVLLPGVEVTLINEKTGEQQSWKYEDGLRGYLLEGMNGSDL
LIPLFEGERYVENSRASEETFAEGEGASWVVAWSEEGTLMRESYVNLIPTPAGGTHESGLRDGLYQAVKSFVELHNLQPK
GVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDAVKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRAG
QKVEKRKSSGVAVLPGKLTDCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVHD
ISVAIGVDPHSPDDKVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGHVCVARPPLFRVDAPARGKKPA
QKLYALDEGELEAILDKLRKDGVRDTQWSISRFKGLGEMSAEQLWDTTMNPDTRRLTPVALGELDYDATVARMTMLMGKG
EAASRRSWLEEKGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=657, Percent_Identity=24.3531202435312, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI19913406, Length=652, Percent_Identity=25, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789408, Length=654, Percent_Identity=50.3058103975535, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=643, Percent_Identity=36.7029548989114, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI212645845, Length=608, Percent_Identity=23.8486842105263, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17535065, Length=648, Percent_Identity=23.7654320987654, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=215, Percent_Identity=29.3023255813954, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=652, Percent_Identity=25, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17136538, Length=668, Percent_Identity=26.0479041916168, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72768; Mature: 72637

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGRQI
CCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHVDHSVSVEDDGRGIPFGLHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEEECCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALSTRLDVTVWREGKVAELSFANGDVARELEVRPATKGDKKSGTRVTAWANP
CCCHHHHHHHHCCEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVTLINEKTGEQQSWKYEDGLRGYLLEGMNGSD
CCCCCCCCCHHHHHHHHHHCCEECCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCC
LLIPLFEGERYVENSRASEETFAEGEGASWVVAWSEEGTLMRESYVNLIPTPAGGTHESG
EEEEEECCCHHHHCCCCCHHHHHCCCCCEEEEEECCCCCEEHHCCCCEECCCCCCCCCHH
LRDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
VKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRAGQKVEKRKSSGVAVLPGKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
DCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCHHEECCCCEE
DISVAIGVDPHSPDDKVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGH
EEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
VCVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRDTQWSISRFKGLGEM
EEEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCH
SAEQLWDTTMNPDTRRLTPVALGELDYDATVARMTMLMGKGEAASRRSWLEEKGNEVEAD
HHHHHHCCCCCCCCCEECEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCC
I
C
>Mature Secondary Structure 
STKKPNAAYSEASIKVLKGLEPVKQRPGMYTRTENPLHIIQEVIDNASDEALGGHGRQI
CCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEE
TVTLHVDHSVSVEDDGRGIPFGLHPEEGVPVVEIVFTRLHAGGKFDKAAGGAYTFSGGLH
EEEEEECCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
GVGVSVTNALSTRLDVTVWREGKVAELSFANGDVARELEVRPATKGDKKSGTRVTAWANP
CCCHHHHHHHHCCEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECCC
KYFDSPNLPLGELQRLLRSKAVLLPGVEVTLINEKTGEQQSWKYEDGLRGYLLEGMNGSD
CCCCCCCCCHHHHHHHHHHCCEECCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCC
LLIPLFEGERYVENSRASEETFAEGEGASWVVAWSEEGTLMRESYVNLIPTPAGGTHESG
EEEEEECCCHHHHCCCCCHHHHHCCCCCEEEEEECCCCCEEHHCCCCEECCCCCCCCCHH
LRDGLYQAVKSFVELHNLQPKGVKLLAEDVFARVSFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
VKLVSSFARPALELWLNQHVEHGKKLADLVIKQAQARTRAGQKVEKRKSSGVAVLPGKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
DCESTEIGRNELFLVEGDSAGGSAKMGRDKEYQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCHHEECCCCEE
DISVAIGVDPHSPDDKVDLSNLRYGKICILSDADVDGSHIQVLLLTLFFKHFPQLIERGH
EEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
VCVARPPLFRVDAPARGKKPAQKLYALDEGELEAILDKLRKDGVRDTQWSISRFKGLGEM
EEEECCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCH
SAEQLWDTTMNPDTRRLTPVALGELDYDATVARMTMLMGKGEAASRRSWLEEKGNEVEAD
HHHHHHCCCCCCCCCEECEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]