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The map label for this gene is parC [H]

Identifier: 91782491

GI number: 91782491

Start: 1244581

End: 1246905

Strand: Direct

Name: parC [H]

Synonym: Bxe_A3338

Alternate gene names: 91782491

Gene position: 1244581-1246905 (Clockwise)

Preceding gene: 91782490

Following gene: 91782492

Centisome position: 25.42

GC content: 64.09

Gene sequence:

>2325_bases
ATGGACGACGATAACACTCTCGACCTTTTCACCGAGCCGCCGCCTCCGGAAGGCGACTTTCTCACGCTCGGCAATTATGC
GGAGCGCGCGTACCTCGACTATGCGGTGAGCGTGGTCAAGGGTCGCGCGCTGCCGGATGTGTGCGACGGCCAGAAGCCGG
TGCAGCGCCGCATCCTGTTCGCGATGAACGACATGGGTCTCTCCGACAACGCGAAGCCGGTCAAATCGGCGCGCGTGGTC
GGTGACGTGCTCGGTAAGTATCACCCGCACGGCGACCAGTCCGCGTATGACGCGCTGGTGCGGCTCGCGCAAGACTTTTC
GATGCGCTATCCGCTGATCGACGGGCAGGGCAATTTCGGTTCGCGCGACGGCGACGGCGCAGCGGCCATGCGGTACACGG
AAGCGCGCCTCACGCCGATCGCGAAACTGCTGCTCGATGAAATCAACCAGGGCACGGTCGATTTCATGAAGAACTACGAC
GGCGAGTTCGACGAGCCGAGGCTGCTGCCCGCCCGCTTGCCGTTCGTGCTGCTGAACGGCGCGTCCGGCATTGCGGTGGG
TCTGGCCACGGAAATTCCGTCGCACAATCTGCGCGAAGTCGCGGCGGCCGCGGTTGCGATGATCCGCAATCCGAAGCTCC
AGCACGCCGAATTGATGCAGTACATTCCCGGCCCGGACTTTCCGGGCGGCGGCCAGATCATTTCGAGCGAAGCGGAAATC
TCCGCCGCCTACGAATCCGGCCGCGGCAGCCTGAAAGTGCGCGCGCGCTGGAAGATCGAAGAACTCGCGCGCGGCCAGTG
GCAACTGGTCATCACCGAACTGCCGCCGAGCACGGCCGCGCAAAAGGTGCTGGAGGAAATCGAAGAGCAGACCAATCCGA
AGATCAAGCTCGGCAAGAAAACGCTCACGCCCGAACAGTTGCAGACCAAGCAGACCATGCTGGCGCTGCTCGACGCGGTG
CGCGACGAGTCCGGCAAGGACGCGCCGGTGCGCCTCGTGTTCGAGCCGAAGTCGAGCCGTATCGATCAGACCGATTTCGT
CAACACGCTGCTCGCGCATACGAGCCTCGAATCGAACGCGTCGCTGAATCTGGTCATGGTGGGCGGCGACGGCCGGCCGC
GTCAGAAGGGCTTGAGCGAAATCCTGCACGAGTGGATCGCGTTCCGCTTCGCCACGGTCACGCGTCGCACGCGGCATCGT
TTGAGCAAGGTCGACGACCGGATTCATATCCTCGAAGGCCGGATGATCGTCTTTTTGAATATCGACGAAGTCATCCGCAT
CATTCGCGAATCGGACGAACCGAAGGTCGCGTTGATGGCCGCGTTCGGCTTGTCCGACCGTCAGGCCGAAGACATTCTTG
AAATCCGGCTGCGCCAGCTGGCGCGGCTCGAGAAGATCAAGATCGAGAAGGAACTGGCCGAACTCAAAGACGAGAAGGCC
AGGCTGGAAGAACTGCTCGGCAGCGAGTCGGCCATGAAGCGGCTGCTCATCAAGGAAATAGAAGGCGACGCCAAGCAGTA
TGGCGACGAGCGCCGCACGCTCATCCAGCAGGAAAAGCGCGCGACGTTCGAAGCGCGCGTGGTCGACGAACCGGTCACGG
TCGTGGTGTCGCAGAAGGGTTGGGTGCGCGCGCTGAAGGGCCACGGGCTCGACGCGGCGGGCTTCACGTTCAAGGCCGGC
GACGGGCTCTACGCGGCGTTCCAGTGCCGCACGCCGGACACGCTGGTCGCGTGGGGCAGCAATGGCCGTGTCTATTCGGT
GGCGGTCGCCATGCTGCCGGGCGGCCGCGGCGACGGTGTACCGGTCACGTCGCTGATCGAGCTGGAGTCGGGCAGCCATC
TGATGCATTACTACGCGGCGTCCGCGGATCAGGCGTTGCTGCTCGCTTCGAGCAACGGCTTTGGCTTCATTGCCAGGGTC
GGCGATATGGTGAGCCGTGTGAAGGCCGGCAAGTCGTTCATGACGATCGACGCCGGCGCTCAACCGCTCGCGCCGATGCC
GATGCTGCCGGATGCGACGCACATTGCGTGTCTCTCCTCGAACGGGCGTCTGCTGGTGTTCGGCCTCGACGAGATGAAGA
CGCTTTCGGGCGGCGGCCGCGGCGTCACGCTAATGGCGCTCGACGAGAAGGAAACGCTGGTGCAGGCGCTCTCGATCAAC
AACGCGGGTGTGGTGTTGATCGGCACGCGCCGCGGCGGCCGTGTGGACGAGGAAAAGGTGAGCGGCGCGGCGCTTGCGCC
GCATATCGGCAAGCGGGCGCGCAAGGGGCGTGCGCCTGAGAGCAAGATGAAGCTCGAAAGCATGCGTCCGGTGCTGGCCG
TTTAA

Upstream 100 bases:

>100_bases
GAGCGCGCTCATAGCGCTCATGGCGCTCATGACAAATAGCGCGCGCATCGGTATCGAAAACGCACGGCAACTTCACGCCA
AACACGGATACGGAATCTAG

Downstream 100 bases:

>100_bases
CAAAGATTGACGTGGGAACACGGCAAGCGTCTGCTAGCATGCGGGACGCTTGCCGTGCGCAGTACGGGGAGCCGCGTCGC
CACGCCATTACGGCGGAGGT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 774; Mature: 774

Protein sequence:

>774_residues
MDDDNTLDLFTEPPPPEGDFLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILFAMNDMGLSDNAKPVKSARVV
GDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEINQGTVDFMKNYD
GEFDEPRLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRNPKLQHAELMQYIPGPDFPGGGQIISSEAEI
SAAYESGRGSLKVRARWKIEELARGQWQLVITELPPSTAAQKVLEEIEEQTNPKIKLGKKTLTPEQLQTKQTMLALLDAV
RDESGKDAPVRLVFEPKSSRIDQTDFVNTLLAHTSLESNASLNLVMVGGDGRPRQKGLSEILHEWIAFRFATVTRRTRHR
LSKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKVALMAAFGLSDRQAEDILEIRLRQLARLEKIKIEKELAELKDEKA
RLEELLGSESAMKRLLIKEIEGDAKQYGDERRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDAAGFTFKAG
DGLYAAFQCRTPDTLVAWGSNGRVYSVAVAMLPGGRGDGVPVTSLIELESGSHLMHYYAASADQALLLASSNGFGFIARV
GDMVSRVKAGKSFMTIDAGAQPLAPMPMLPDATHIACLSSNGRLLVFGLDEMKTLSGGGRGVTLMALDEKETLVQALSIN
NAGVVLIGTRRGGRVDEEKVSGAALAPHIGKRARKGRAPESKMKLESMRPVLAV

Sequences:

>Translated_774_residues
MDDDNTLDLFTEPPPPEGDFLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILFAMNDMGLSDNAKPVKSARVV
GDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEINQGTVDFMKNYD
GEFDEPRLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRNPKLQHAELMQYIPGPDFPGGGQIISSEAEI
SAAYESGRGSLKVRARWKIEELARGQWQLVITELPPSTAAQKVLEEIEEQTNPKIKLGKKTLTPEQLQTKQTMLALLDAV
RDESGKDAPVRLVFEPKSSRIDQTDFVNTLLAHTSLESNASLNLVMVGGDGRPRQKGLSEILHEWIAFRFATVTRRTRHR
LSKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKVALMAAFGLSDRQAEDILEIRLRQLARLEKIKIEKELAELKDEKA
RLEELLGSESAMKRLLIKEIEGDAKQYGDERRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDAAGFTFKAG
DGLYAAFQCRTPDTLVAWGSNGRVYSVAVAMLPGGRGDGVPVTSLIELESGSHLMHYYAASADQALLLASSNGFGFIARV
GDMVSRVKAGKSFMTIDAGAQPLAPMPMLPDATHIACLSSNGRLLVFGLDEMKTLSGGGRGVTLMALDEKETLVQALSIN
NAGVVLIGTRRGGRVDEEKVSGAALAPHIGKRARKGRAPESKMKLESMRPVLAV
>Mature_774_residues
MDDDNTLDLFTEPPPPEGDFLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILFAMNDMGLSDNAKPVKSARVV
GDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEINQGTVDFMKNYD
GEFDEPRLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRNPKLQHAELMQYIPGPDFPGGGQIISSEAEI
SAAYESGRGSLKVRARWKIEELARGQWQLVITELPPSTAAQKVLEEIEEQTNPKIKLGKKTLTPEQLQTKQTMLALLDAV
RDESGKDAPVRLVFEPKSSRIDQTDFVNTLLAHTSLESNASLNLVMVGGDGRPRQKGLSEILHEWIAFRFATVTRRTRHR
LSKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKVALMAAFGLSDRQAEDILEIRLRQLARLEKIKIEKELAELKDEKA
RLEELLGSESAMKRLLIKEIEGDAKQYGDERRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDAAGFTFKAG
DGLYAAFQCRTPDTLVAWGSNGRVYSVAVAMLPGGRGDGVPVTSLIELESGSHLMHYYAASADQALLLASSNGFGFIARV
GDMVSRVKAGKSFMTIDAGAQPLAPMPMLPDATHIACLSSNGRLLVFGLDEMKTLSGGGRGVTLMALDEKETLVQALSIN
NAGVVLIGTRRGGRVDEEKVSGAALAPHIGKRARKGRAPESKMKLESMRPVLAV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=254, Percent_Identity=29.5275590551181, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI19913406, Length=288, Percent_Identity=28.8194444444444, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789396, Length=682, Percent_Identity=47.3607038123167, Blast_Score=620, Evalue=1e-179,
Organism=Escherichia coli, GI1788562, Length=757, Percent_Identity=35.1387054161163, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI212645845, Length=391, Percent_Identity=28.1329923273657, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17535065, Length=286, Percent_Identity=30.4195804195804, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=290, Percent_Identity=30, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534553, Length=183, Percent_Identity=30.6010928961749, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=287, Percent_Identity=28.9198606271777, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=255, Percent_Identity=28.2352941176471, Blast_Score=92, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84670; Mature: 84670

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDDNTLDLFTEPPPPEGDFLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILF
CCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AMNDMGLSDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFG
HEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCC
SRDGDGAAAMRYTEARLTPIAKLLLDEINQGTVDFMKNYDGEFDEPRLLPARLPFVLLNG
CCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEECCCCCEEEEEC
ASGIAVGLATEIPSHNLREVAAAAVAMIRNPKLQHAELMQYIPGPDFPGGGQIISSEAEI
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEECCCHHH
SAAYESGRGSLKVRARWKIEELARGQWQLVITELPPSTAAQKVLEEIEEQTNPKIKLGKK
HHHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEECCC
TLTPEQLQTKQTMLALLDAVRDESGKDAPVRLVFEPKSSRIDQTDFVNTLLAHTSLESNA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
SLNLVMVGGDGRPRQKGLSEILHEWIAFRFATVTRRTRHRLSKVDDRIHILEGRMIVFLN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEE
IDEVIRIIRESDEPKVALMAAFGLSDRQAEDILEIRLRQLARLEKIKIEKELAELKDEKA
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEELLGSESAMKRLLIKEIEGDAKQYGDERRTLIQQEKRATFEARVVDEPVTVVVSQKG
HHHHHHCCHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCEEEEEECCCEEEEEECCC
WVRALKGHGLDAAGFTFKAGDGLYAAFQCRTPDTLVAWGSNGRVYSVAVAMLPGGRGDGV
HHHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCC
PVTSLIELESGSHLMHYYAASADQALLLASSNGFGFIARVGDMVSRVKAGKSFMTIDAGA
CEEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
QPLAPMPMLPDATHIACLSSNGRLLVFGLDEMKTLSGGGRGVTLMALDEKETLVQALSIN
CCCCCCCCCCCCCEEEEECCCCEEEEEECHHHHHCCCCCCEEEEEEECCHHHHHHHHCCC
NAGVVLIGTRRGGRVDEEKVSGAALAPHIGKRARKGRAPESKMKLESMRPVLAV
CCCEEEEECCCCCCCCHHHCCCCHHCHHHHHHHHCCCCCHHHHHHHHCCCHHCC
>Mature Secondary Structure
MDDDNTLDLFTEPPPPEGDFLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILF
CCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AMNDMGLSDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFG
HEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCC
SRDGDGAAAMRYTEARLTPIAKLLLDEINQGTVDFMKNYDGEFDEPRLLPARLPFVLLNG
CCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEECCCCCEEEEEC
ASGIAVGLATEIPSHNLREVAAAAVAMIRNPKLQHAELMQYIPGPDFPGGGQIISSEAEI
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEECCCHHH
SAAYESGRGSLKVRARWKIEELARGQWQLVITELPPSTAAQKVLEEIEEQTNPKIKLGKK
HHHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEECCC
TLTPEQLQTKQTMLALLDAVRDESGKDAPVRLVFEPKSSRIDQTDFVNTLLAHTSLESNA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
SLNLVMVGGDGRPRQKGLSEILHEWIAFRFATVTRRTRHRLSKVDDRIHILEGRMIVFLN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEE
IDEVIRIIRESDEPKVALMAAFGLSDRQAEDILEIRLRQLARLEKIKIEKELAELKDEKA
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEELLGSESAMKRLLIKEIEGDAKQYGDERRTLIQQEKRATFEARVVDEPVTVVVSQKG
HHHHHHCCHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCEEEEEECCCEEEEEECCC
WVRALKGHGLDAAGFTFKAGDGLYAAFQCRTPDTLVAWGSNGRVYSVAVAMLPGGRGDGV
HHHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCC
PVTSLIELESGSHLMHYYAASADQALLLASSNGFGFIARVGDMVSRVKAGKSFMTIDAGA
CEEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
QPLAPMPMLPDATHIACLSSNGRLLVFGLDEMKTLSGGGRGVTLMALDEKETLVQALSIN
CCCCCCCCCCCCCEEEEECCCCEEEEEECHHHHHCCCCCCEEEEEEECCHHHHHHHHCCC
NAGVVLIGTRRGGRVDEEKVSGAALAPHIGKRARKGRAPESKMKLESMRPVLAV
CCCEEEEECCCCCCCCHHHCCCCHHCHHHHHHHHCCCCCHHHHHHHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]