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The map label for this gene is dctA [H]

Identifier: 91782475

GI number: 91782475

Start: 1225596

End: 1226969

Strand: Direct

Name: dctA [H]

Synonym: Bxe_A3356

Alternate gene names: 91782475

Gene position: 1225596-1226969 (Clockwise)

Preceding gene: 91782474

Following gene: 91782476

Centisome position: 25.03

GC content: 58.15

Gene sequence:

>1374_bases
ATGCGGGTTTCGAAGATCGGGAAATCTCTTTCCCATCTCTATGTACAGGTGTTGATCGGCATTGTCGCCGGCGTGCTCGT
CGGACACTTCTATCCTGACACAGGTTCACAGTTAAAGCCGCTCGGAGACCTGTTCATCAAGCTGATCCGGATGCTGCTCG
CGCCGATCATTTTCGCGTCGGTCGTCGTTGGTATTGCCCGCATGAACGACCTTCACGAGGCGGGCCGGGTGGGCGTGAAA
GCGGTGCTGTATTTCGAAGTCGCCTCGACGATTGCGCTCGCGGTGGGCCTCGTGATCGTGAACGTGATCAGGCCGGGCAG
CGGTATGAACATCGACCCCGCGAAAATCGACAGTTCGGCCATAGCCACTTATACCCATGCGGCGCAACAGCACGGCATGC
TCGATTTCTTCATGAGCATCGTTCCGAATAGCGTTGTCGGCGCATTCGCCAATGGCGACATTCTGCCCATCATCTTCTTT
TCGGTCCTGTTCGCAATCTCGCTCGCGAGGCTGGGCCCCCGTGCCGCGCCGTTCGTCGACATGCTCGACATGTTCCTTCA
GGGCATGTTCGGCGTGGTCAGGATCGTGATGTACGTGGCCCCTATCGGTGCTTTTGGCGGCATGGCATTCACGATCGCGA
GATATGGAATCGGCACGCTTGCCTCGTTCGGCCAATTGATGCTGTGTCTTTATCTGACCTCAGTTTTCTTCGTGGTGGTG
GTGCTCGGTCTCGTCATGCGCATGTGCGGACTGTCGCTATGGAAGTTTCTCCGGTATATCAGGGATGAGATCTTCATTAC
GCTCGGCACGGCTTCGACCGAAGCGGTCCTTCCGCAGATGCTCATCAAAATGGAGAAGCTGGGATGTTCACGGCCCGTGG
TCGGCATGGTGTTGCCTACGGGCTACACGTTCAATGCGGATGGGACGGCGATCTATCTGACAATGGCCGCCCTGTTCATT
GCGCAAGCAATGAATATCCATCTGACGATCTGGGACCAGTTGCTGTTGCTCGGTGTAATGCTGTTGACATCCAAGGGTTC
GGCGGGTGTGGCCGGAGCCGGATTCGTGGCGCTGGCCGCCACGCTCGCCACCATGCACAAAGTACCCGTGTCCGGGCTGG
TGCTGTTGCTGGGCGTCGATCGATTCCTCAACGAGGCGCGTGCCGTCACGAACCTGATTGGCAACGGTGTGGCGACCATT
GTCGTGGCGCGATGGGAAGGCGCGCTCGATATGAACCAGGCCCGATCGATGCTGAACGGCAATGCCGATACGGGCATTGA
TGCGCCGGAGTCCATGAGCCAGGAGCCGACCGTTGGAACGGCTCCGGCGAAAGAGACCGTTATTCGACCGAACACGCAAC
CCAACACGCACTGA

Upstream 100 bases:

>100_bases
GAGGAATGCCGGCGGATTCGATTCGGGCTCACGGTAGCGGCATATGCCGCTACCGTGCTTGCGCCGATTCTACTAAAAAT
GCCACGCATAGGAGACAGTC

Downstream 100 bases:

>100_bases
CCCCTTGGGTCATTTCTATTCCAGACATCGCCACCATGACAAAGCAATCTGGCACGACGAGTTTTCGCGAAGCCGCCCTC
GATTACCACGAGTTCCCCAC

Product: Sodium/dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MRVSKIGKSLSHLYVQVLIGIVAGVLVGHFYPDTGSQLKPLGDLFIKLIRMLLAPIIFASVVVGIARMNDLHEAGRVGVK
AVLYFEVASTIALAVGLVIVNVIRPGSGMNIDPAKIDSSAIATYTHAAQQHGMLDFFMSIVPNSVVGAFANGDILPIIFF
SVLFAISLARLGPRAAPFVDMLDMFLQGMFGVVRIVMYVAPIGAFGGMAFTIARYGIGTLASFGQLMLCLYLTSVFFVVV
VLGLVMRMCGLSLWKFLRYIRDEIFITLGTASTEAVLPQMLIKMEKLGCSRPVVGMVLPTGYTFNADGTAIYLTMAALFI
AQAMNIHLTIWDQLLLLGVMLLTSKGSAGVAGAGFVALAATLATMHKVPVSGLVLLLGVDRFLNEARAVTNLIGNGVATI
VVARWEGALDMNQARSMLNGNADTGIDAPESMSQEPTVGTAPAKETVIRPNTQPNTH

Sequences:

>Translated_457_residues
MRVSKIGKSLSHLYVQVLIGIVAGVLVGHFYPDTGSQLKPLGDLFIKLIRMLLAPIIFASVVVGIARMNDLHEAGRVGVK
AVLYFEVASTIALAVGLVIVNVIRPGSGMNIDPAKIDSSAIATYTHAAQQHGMLDFFMSIVPNSVVGAFANGDILPIIFF
SVLFAISLARLGPRAAPFVDMLDMFLQGMFGVVRIVMYVAPIGAFGGMAFTIARYGIGTLASFGQLMLCLYLTSVFFVVV
VLGLVMRMCGLSLWKFLRYIRDEIFITLGTASTEAVLPQMLIKMEKLGCSRPVVGMVLPTGYTFNADGTAIYLTMAALFI
AQAMNIHLTIWDQLLLLGVMLLTSKGSAGVAGAGFVALAATLATMHKVPVSGLVLLLGVDRFLNEARAVTNLIGNGVATI
VVARWEGALDMNQARSMLNGNADTGIDAPESMSQEPTVGTAPAKETVIRPNTQPNTH
>Mature_457_residues
MRVSKIGKSLSHLYVQVLIGIVAGVLVGHFYPDTGSQLKPLGDLFIKLIRMLLAPIIFASVVVGIARMNDLHEAGRVGVK
AVLYFEVASTIALAVGLVIVNVIRPGSGMNIDPAKIDSSAIATYTHAAQQHGMLDFFMSIVPNSVVGAFANGDILPIIFF
SVLFAISLARLGPRAAPFVDMLDMFLQGMFGVVRIVMYVAPIGAFGGMAFTIARYGIGTLASFGQLMLCLYLTSVFFVVV
VLGLVMRMCGLSLWKFLRYIRDEIFITLGTASTEAVLPQMLIKMEKLGCSRPVVGMVLPTGYTFNADGTAIYLTMAALFI
AQAMNIHLTIWDQLLLLGVMLLTSKGSAGVAGAGFVALAATLATMHKVPVSGLVLLLGVDRFLNEARAVTNLIGNGVATI
VVARWEGALDMNQARSMLNGNADTGIDAPESMSQEPTVGTAPAKETVIRPNTQPNTH

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=469, Percent_Identity=24.0938166311301, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI169790839, Length=418, Percent_Identity=24.8803827751196, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI40254478, Length=471, Percent_Identity=23.9915074309979, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI5032093, Length=312, Percent_Identity=26.6025641025641, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223468566, Length=268, Percent_Identity=27.6119402985075, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=27.6119402985075, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI66773030, Length=455, Percent_Identity=23.2967032967033, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI21314632, Length=437, Percent_Identity=23.5697940503432, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4827012, Length=390, Percent_Identity=25.3846153846154, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=24.8663101604278, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=55.0480769230769, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=40.632603406326, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1788024, Length=406, Percent_Identity=19.4581280788177, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789473, Length=320, Percent_Identity=25.625, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=432, Percent_Identity=27.7777777777778, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983099, Length=466, Percent_Identity=27.6824034334764, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=466, Percent_Identity=27.6824034334764, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71996953, Length=476, Percent_Identity=25.6302521008403, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193206654, Length=452, Percent_Identity=23.8938053097345, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193206505, Length=464, Percent_Identity=26.0775862068966, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=415, Percent_Identity=25.5421686746988, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24583025, Length=436, Percent_Identity=22.9357798165138, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137668, Length=436, Percent_Identity=22.9357798165138, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24583023, Length=436, Percent_Identity=22.9357798165138, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360481, Length=453, Percent_Identity=22.9580573951435, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281360483, Length=453, Percent_Identity=22.9580573951435, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17137666, Length=453, Percent_Identity=22.9580573951435, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48698; Mature: 48698

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCHHCCCCCCCCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCHHCCCCCCCCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA