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The map label for this gene is envZ [H]

Identifier: 91782445

GI number: 91782445

Start: 1189775

End: 1191094

Strand: Direct

Name: envZ [H]

Synonym: Bxe_A3386

Alternate gene names: 91782445

Gene position: 1189775-1191094 (Clockwise)

Preceding gene: 91782444

Following gene: 91782448

Centisome position: 24.3

GC content: 68.79

Gene sequence:

>1320_bases
ATGCGTCGGCCCATTGATTCGCTGTTCGGGCGGCTGGCGCTGCTAGTCGTCGCGGTATTGCTGCTGTCGCATTTCGCGTG
GTACGCGCTCATGCGCCTCGAGCGCAGTCAACTGCAAACGCGCTACGCGGTCGAAGAAGCCACCTTCCTCGTCGACGCGG
TGCGTCAGCACGTCGCGCGGACGCCGGATCAGCCGTTGCCGTCACGCGTGAAGCTGGTCGATCCGGCGAGCCCGGAAGTG
CCGCCGGAAACAGCGGACATGCCGCCGCCAATGGAGCGTTTCGTCGAAGACGTGCGCGACCGCATGCCGTCCGGCACGCA
GGTGCGCGTCGGCCTGCCCGGCCGTCCGCCCACGCTGTGGGTGCGCGCCACGTCGGATCGAAGCTGGATCGTCGTGCCGG
TGCAGCCGTTGCGCACGCCGCGCTCGCTCGACCGCACGGTGTTGTGGCTCGCCATCATTTTCTCGTTTGCGGTCATGGCG
GCGCTCTTTGCCGCGTGGGCGCTCCAGCAGCCGTTGCGCTCGCTCGCCCAGGCGGTGGCGCGCTTCGGGCGCGGCCTGCC
GGTGCCGCCGGTGCCTGAGCGCGGCCCGCGCGAGTTGCGTCAATTGACACACGGGTTCAACCAGATGGTCCAGGAAGTGG
CGCGCACGGAGAACGACCGCGCCGTGATGCTGGCGGGTGTCGCGCACGATCTGAAAACGCCGCTCGCGCGTTTGAGGCTG
CGCGCCGAGATGATGGAAGAAGTGAAGATGCGCGACGGCGTGGTGCGCGACGTCGACTCCATGACGCATATCGTCGACCA
GTTCCTGGTGTTCGCCCACGACGGCGCCGATCGCAGCGAAGCGGTCGAAGTGGATGCGCAGTGCGAGCGGGTGGTGCGCA
GTTATCGCGCGGTGGCTTCCGGCACGCCGACCGTGCAGACCGAACTCAACGCGGGGCCGGCGTTCCTGTTGCCGGCCGCC
ACGCTCGACCGGATTCTGTCGAACCTGCTCGACAATGCGCACGCGTACGGCGCGCCGCCCATCGTCGTCGCCACGGCGCG
TACTCCGCAAGGCTTCACCTTGTCGGTGAGCGACAGCGGCGGCGGCATCGCGGCGCAGGATCTGATCAACGCCAGCCGGC
CGTTCGTGCGGCTCGATCCGGCGCGCGGCGGCAATGGCCATAGCGGCCTCGGGCTCGCCATTGTCGAGCGGCTGGTGCGG
CGTGCGGGTGGGGAGTGGGAGATCGGCAACCACGGCGGGCGTGGCTTGCGCGTCTTGATGAGCTTTCCGTTCGACGTGTT
GCCGCGGGTCGCGGCCACTTCGGAGAACGCCTGGTCATGA

Upstream 100 bases:

>100_bases
TGGCGTCTGCGCCGCATTCTCGAAACCGACCCGTCCACGCCGCGCTTCATTCAAACCGTGCGCGGCCGCGGCTACGTGTT
CGTGCCAGACGGCGAACAGC

Downstream 100 bases:

>100_bases
TGGGGGGCGCGGCGCCGGCTCCTGTAGCCTGCACCGCGCGCCGAGATCCGGATGCAAGGTCCAGCGGCGCGGTGTGGCCA
GGGGGCGGCGCGCTAGTCTG

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MRRPIDSLFGRLALLVVAVLLLSHFAWYALMRLERSQLQTRYAVEEATFLVDAVRQHVARTPDQPLPSRVKLVDPASPEV
PPETADMPPPMERFVEDVRDRMPSGTQVRVGLPGRPPTLWVRATSDRSWIVVPVQPLRTPRSLDRTVLWLAIIFSFAVMA
ALFAAWALQQPLRSLAQAVARFGRGLPVPPVPERGPRELRQLTHGFNQMVQEVARTENDRAVMLAGVAHDLKTPLARLRL
RAEMMEEVKMRDGVVRDVDSMTHIVDQFLVFAHDGADRSEAVEVDAQCERVVRSYRAVASGTPTVQTELNAGPAFLLPAA
TLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLSVSDSGGGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVR
RAGGEWEIGNHGGRGLRVLMSFPFDVLPRVAATSENAWS

Sequences:

>Translated_439_residues
MRRPIDSLFGRLALLVVAVLLLSHFAWYALMRLERSQLQTRYAVEEATFLVDAVRQHVARTPDQPLPSRVKLVDPASPEV
PPETADMPPPMERFVEDVRDRMPSGTQVRVGLPGRPPTLWVRATSDRSWIVVPVQPLRTPRSLDRTVLWLAIIFSFAVMA
ALFAAWALQQPLRSLAQAVARFGRGLPVPPVPERGPRELRQLTHGFNQMVQEVARTENDRAVMLAGVAHDLKTPLARLRL
RAEMMEEVKMRDGVVRDVDSMTHIVDQFLVFAHDGADRSEAVEVDAQCERVVRSYRAVASGTPTVQTELNAGPAFLLPAA
TLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLSVSDSGGGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVR
RAGGEWEIGNHGGRGLRVLMSFPFDVLPRVAATSENAWS
>Mature_439_residues
MRRPIDSLFGRLALLVVAVLLLSHFAWYALMRLERSQLQTRYAVEEATFLVDAVRQHVARTPDQPLPSRVKLVDPASPEV
PPETADMPPPMERFVEDVRDRMPSGTQVRVGLPGRPPTLWVRATSDRSWIVVPVQPLRTPRSLDRTVLWLAIIFSFAVMA
ALFAAWALQQPLRSLAQAVARFGRGLPVPPVPERGPRELRQLTHGFNQMVQEVARTENDRAVMLAGVAHDLKTPLARLRL
RAEMMEEVKMRDGVVRDVDSMTHIVDQFLVFAHDGADRSEAVEVDAQCERVVRSYRAVASGTPTVQTELNAGPAFLLPAA
TLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLSVSDSGGGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVR
RAGGEWEIGNHGGRGLRVLMSFPFDVLPRVAATSENAWS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=341, Percent_Identity=31.3782991202346, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=28.8461538461538, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=28.8389513108614, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=30.0411522633745, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=317, Percent_Identity=26.813880126183, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786783, Length=299, Percent_Identity=24.0802675585284, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=290, Percent_Identity=24.1379310344828, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=24.1666666666667, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48232; Mature: 48232

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPIDSLFGRLALLVVAVLLLSHFAWYALMRLERSQLQTRYAVEEATFLVDAVRQHVAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVKLVDPASPEVPPETADMPPPMERFVEDVRDRMPSGTQVRVGLPGRPPTLW
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEE
VRATSDRSWIVVPVQPLRTPRSLDRTVLWLAIIFSFAVMAALFAAWALQQPLRSLAQAVA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGLPVPPVPERGPRELRQLTHGFNQMVQEVARTENDRAVMLAGVAHDLKTPLARLRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMEEVKMRDGVVRDVDSMTHIVDQFLVFAHDGADRSEAVEVDAQCERVVRSYRAVAS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHHHC
GTPTVQTELNAGPAFLLPAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLSVSDSG
CCCCEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCCC
GGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVRRAGGEWEIGNHGGRGLRVLM
CCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHH
SFPFDVLPRVAATSENAWS
HCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRRPIDSLFGRLALLVVAVLLLSHFAWYALMRLERSQLQTRYAVEEATFLVDAVRQHVAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVKLVDPASPEVPPETADMPPPMERFVEDVRDRMPSGTQVRVGLPGRPPTLW
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEE
VRATSDRSWIVVPVQPLRTPRSLDRTVLWLAIIFSFAVMAALFAAWALQQPLRSLAQAVA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGLPVPPVPERGPRELRQLTHGFNQMVQEVARTENDRAVMLAGVAHDLKTPLARLRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMEEVKMRDGVVRDVDSMTHIVDQFLVFAHDGADRSEAVEVDAQCERVVRSYRAVAS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHHHC
GTPTVQTELNAGPAFLLPAATLDRILSNLLDNAHAYGAPPIVVATARTPQGFTLSVSDSG
CCCCEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCCC
GGIAAQDLINASRPFVRLDPARGGNGHSGLGLAIVERLVRRAGGEWEIGNHGGRGLRVLM
CCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHH
SFPFDVLPRVAATSENAWS
HCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]