Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 91782420

GI number: 91782420

Start: 1162699

End: 1163556

Strand: Direct

Name: hemC [H]

Synonym: Bxe_A3411

Alternate gene names: 91782420

Gene position: 1162699-1163556 (Clockwise)

Preceding gene: 91782418

Following gene: 91782421

Centisome position: 23.75

GC content: 68.41

Gene sequence:

>858_bases
ATGACAACACGTGGCGATCAAATTCTCGATCGCACTTTGTCGAAGGTTGGCGGCAAGGGCCTCTTCGTCAAGGAACTGGA
AGCCGCGCTTGCCGACGGCCGCGCCGATCTCGCCGTGCATTCGCTCAAAGACGTGCCGATGGCATTGCCCGAAGGCTTTG
CGCTATCCACCATCATGGAACGCGAAGATCCGCGCGACGCACTGGTTTCCAATACGTACGACTCGCTTGCCGCGTTGCCG
GAAGGCGCCGTGGTCGGCACCTCCAGCCTGCGCCGCGAGGCGATGCTGCGCATGCGCTATCCGCATCTCGAAGTGCGGCC
TTTGCGCGGCAATCTGGACACGCGCCTCGCCAAACTCGATCGCGGCGATTACGCGGCGATCATTCTGGCGGCGGCCGGGC
TGAAGCGCCTGGGTCTCGGCGAGCGTATCCGCGCGTTGCTCGATCCCGAAGACAGCTTGCCCGCAGCGGGGCAAGGCGCG
CTCGGCATCGAGATTCGCGCCGACCGCGCGGAACTCGCGGCATGGCTCGCGCCGCTGCATCACGAACACACGGCCGCAGC
CGTCGAAGCGGAGCGCATGGTCTCGCGCGCGCTCGGCGGCAGTTGCGAAGTGCCGCTCGCCGCCTATGCCACATGGCATG
ACGGCGCGCTGCATCTGCGCGGCATCGTGGCGACGCCGGACGGCCAGCGCGTGCTGAGCGCGCAGGCGTCGGCGCCGGCA
ACCAGCGTCGAGCAGGCTATCGCGCTCGGCCAGGAAGTCGCGGGCGCGCTCGAGCAGCAAGGCGCGATGGAGATCGTTCG
CGCACTCGGCGCCGCCAACGGCGCGGCTGCGGCGGACAGCGCGGTGACCGGCGAGTGA

Upstream 100 bases:

>100_bases
GATTGCGTCGCGAGAGAGCCGCCTGGCCATGTGGCAAGCGGAGCATGTGCGATGTGCGCTGCACAAATTATATCCATCTT
GTGACGTAAAAATCCTCGGA

Downstream 100 bases:

>100_bases
TGGCGGCCGATATCCCCGGCAACGCATCTCCATCCGTCGACAAGGCGGCGTTCACGGTCGTGATTACGCGACCGGCCGGT
CAGTCAAACGAACTGATCGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPEGFALSTIMEREDPRDALVSNTYDSLAALP
EGAVVGTSSLRREAMLRMRYPHLEVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLGERIRALLDPEDSLPAAGQGA
LGIEIRADRAELAAWLAPLHHEHTAAAVEAERMVSRALGGSCEVPLAAYATWHDGALHLRGIVATPDGQRVLSAQASAPA
TSVEQAIALGQEVAGALEQQGAMEIVRALGAANGAAAADSAVTGE

Sequences:

>Translated_285_residues
MTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPEGFALSTIMEREDPRDALVSNTYDSLAALP
EGAVVGTSSLRREAMLRMRYPHLEVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLGERIRALLDPEDSLPAAGQGA
LGIEIRADRAELAAWLAPLHHEHTAAAVEAERMVSRALGGSCEVPLAAYATWHDGALHLRGIVATPDGQRVLSAQASAPA
TSVEQAIALGQEVAGALEQQGAMEIVRALGAANGAAAADSAVTGE
>Mature_284_residues
TTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPEGFALSTIMEREDPRDALVSNTYDSLAALPE
GAVVGTSSLRREAMLRMRYPHLEVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLGERIRALLDPEDSLPAAGQGAL
GIEIRADRAELAAWLAPLHHEHTAAAVEAERMVSRALGGSCEVPLAAYATWHDGALHLRGIVATPDGQRVLSAQASAPAT
SVEQAIALGQEVAGALEQQGAMEIVRALGAANGAAAADSAVTGE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=248, Percent_Identity=47.9838709677419, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI66933009, Length=248, Percent_Identity=47.9838709677419, Blast_Score=218, Evalue=4e-57,
Organism=Escherichia coli, GI48994974, Length=267, Percent_Identity=56.9288389513109, Blast_Score=281, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6319996, Length=278, Percent_Identity=39.9280575539568, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20130425, Length=265, Percent_Identity=44.1509433962264, Blast_Score=201, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 29809; Mature: 29678

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPEGFALSTIME
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
REDPRDALVSNTYDSLAALPEGAVVGTSSLRREAMLRMRYPHLEVRPLRGNLDTRLAKLD
CCCCHHHHHHCCHHHHHHCCCCCEECHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHC
RGDYAAIILAAAGLKRLGLGERIRALLDPEDSLPAAGQGALGIEIRADRAELAAWLAPLH
CCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
HEHTAAAVEAERMVSRALGGSCEVPLAAYATWHDGALHLRGIVATPDGQRVLSAQASAPA
HHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCEEEEEEEECCCCCHHHHHCCCCCH
TSVEQAIALGQEVAGALEQQGAMEIVRALGAANGAAAADSAVTGE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPEGFALSTIME
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
REDPRDALVSNTYDSLAALPEGAVVGTSSLRREAMLRMRYPHLEVRPLRGNLDTRLAKLD
CCCCHHHHHHCCHHHHHHCCCCCEECHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHC
RGDYAAIILAAAGLKRLGLGERIRALLDPEDSLPAAGQGALGIEIRADRAELAAWLAPLH
CCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
HEHTAAAVEAERMVSRALGGSCEVPLAAYATWHDGALHLRGIVATPDGQRVLSAQASAPA
HHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCEEEEEEEECCCCCHHHHHCCCCCH
TSVEQAIALGQEVAGALEQQGAMEIVRALGAANGAAAADSAVTGE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA