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The map label for this gene is hemD [H]

Identifier: 91782421

GI number: 91782421

Start: 1163556

End: 1165574

Strand: Direct

Name: hemD [H]

Synonym: Bxe_A3410

Alternate gene names: 91782421

Gene position: 1163556-1165574 (Clockwise)

Preceding gene: 91782420

Following gene: 91782422

Centisome position: 23.77

GC content: 66.62

Gene sequence:

>2019_bases
ATGGCGGCCGATATCCCCGGCAACGCATCTCCATCCGTCGACAAGGCGGCGTTCACGGTCGTGATTACGCGACCGGCCGG
TCAGTCAAACGAACTGATCGCACGGCTCGCCGCCGCAGGCATCGCCACGCTCGACTTTCCGCTGATCGACGTCGCGCCCG
TCACGGACGAGGCTCCATTGCGCGCGGCGTTGAGTTCGCTCGAACGCTATGCGCTCGTCGTGTTCGTGTCGCCGAATGCC
GTCGATTACGCCTTCGCCCGCAGCGATACGATCTGGCCGCATGCGCTGCCGATCGGCGTGGTCGGTCCGGGCAGCGTGCA
GGCGCTGGCGCGTCACGGCGTGACCTCGCCGGCATACAACGTGATCAGCCCGCCGTCCGGCACCGACGAAGAAACCGCGC
GCTTCGATTCCGAAGGCCTCTTCGCGGCGATCGACACGGCGCTCGGCGCGACGAACCTGGAAGGCAAACGCGTGCTGATC
GTGCGCGGCGACGGTGGGCGCGAGTGGCTGGCCGAGCGTCTGCGCGAAGCCGGCGCCGAAGTCGAGACCGTCGCGGCGTA
CCGGCGCCTCGTGCCGGAACCGTCGATAGGCGGCTGGGCGCGTGTGCACGAATTGCTCGCGGGCGCGCCGCACGCGTGGC
TGCTCACCAGTTCCGAAGGCGTGCGCAATCTGCACGAACTGGCGCAAGACCACCTCACCGCCGACGAAATCTCTCAACTC
AAACGCGCCGCGCTCGTCACGCCGCATCCCCGGATCGCGCAGACCGCGCGGGCATTGGGTTTTGATAGCATTACGGTGTC
CGGCGCGGGCGACGAGCGCATTGTCCGCACCCTGCTTGCCGCCGTCCCGACCGTAGTTCAACCGGTACCGTCCAACCCGG
CTCATTCACCGGCTAAATCACGCATGACTGAAACGAACGCATCCACGAACGCTTCACCCCAGCCTGCCGCGACCACTGCG
TTGCCGCCGAATCCACCCTTCACGCCCTACGAAGCGCAAAAGCGCCATAGCGCGAGCGGACCGCTGCTGTGGTTTGTCGT
CGTGATCATTGCTTGTGCTGCGGGCGTGGGCGGCTATGCGCTCAATCGCAAGGTGGAGCGCACCGAGCAGCAACTGGTGC
AGCGCCAGCAGGCCAACGACACGCAGACCAACGAGCTGCGCATCAAGACGGAGCAGGCGCTCGCCACCGTGCATCAGTCG
GACTCGCAGGTCGCGCAACTCGAAGGCAAGCTCGCCGATGCGCAAACCGCGCAGCAGGCGTTACAACAGCAATACGCGGA
TCTCGCGCGCAATCGCGACGACTGGACGCTCGCCGAAGTCGGCCAGATGCTCTCCGCCGCCAGCCAGCAGTTGCAGCTCA
CCGGCAACACGCAGCTCGCGCTGTTCGCGCTGCAAAGCGCCGACACGCGCCTCGCCGCGTCGGACAGCCCGCAGGCGATC
GCCGTGCGCAAGGCCATCGCGCAGGACATCGACAAATTGAAGGCCGCGCCTTCCACCGACCTCACGGGCATGGCCATCAA
GCTCGACAACGCGATCGACCAGGTGGACAGCCTGCCGCTCTCGGGCGAAGCCCCGATCGCCCATGCCACGCCGCACGCCG
CGACGTGGGCCGATACGGCCAAGGTGGCCGCGGCCACCGGCGAGCCGCGCTGGAAGGTGTGGTGGCGCGAGGTGAGCACC
GGCATCGGCCAGCAGTTGACTAGCCTCGTGCAGGTGCGCCGTATCGACAACGCCGACGCGATGCTGGTCACGCCCGATCA
GGGCTACTTCGTGCGCGAGAATCTGAAGCTGCGTTTGCTGTCCGCGCGCCTCGCCTTGCTTTCGCGCAACGAGACCACGC
TGAAGTCCGACCTGCTCGCGGCGCAGAATGCGCTCACGCGCTACTTCGACAACTCGTCGAAGAAAACGCAGACCGTGAGC
GATCTCGTCAAGCAGGTGCAGGCGGGCTCGGCCGCGGTTGAGCTGCCGAATCTGAACACGAGCCTGCAGGCCGTCAATCA
ATACCGGAGCCGGGGTTAA

Upstream 100 bases:

>100_bases
TCGCGGGCGCGCTCGAGCAGCAAGGCGCGATGGAGATCGTTCGCGCACTCGGCGCCGCCAACGGCGCGGCTGCGGCGGAC
AGCGCGGTGACCGGCGAGTG

Downstream 100 bases:

>100_bases
TCATGGCGATCCGGGGACTTCTATGGCTTGCGTTGCTGTTCGTCATCGCGGTGGTGCTGGCGGTGGTGGGACGCTTCGAC
ATGGGCCAGGTGCTGCTGAT

Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MAADIPGNASPSVDKAAFTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVSPNA
VDYAFARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETARFDSEGLFAAIDTALGATNLEGKRVLI
VRGDGGREWLAERLREAGAEVETVAAYRRLVPEPSIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQL
KRAALVTPHPRIAQTARALGFDSITVSGAGDERIVRTLLAAVPTVVQPVPSNPAHSPAKSRMTETNASTNASPQPAATTA
LPPNPPFTPYEAQKRHSASGPLLWFVVVIIACAAGVGGYALNRKVERTEQQLVQRQQANDTQTNELRIKTEQALATVHQS
DSQVAQLEGKLADAQTAQQALQQQYADLARNRDDWTLAEVGQMLSAASQQLQLTGNTQLALFALQSADTRLAASDSPQAI
AVRKAIAQDIDKLKAAPSTDLTGMAIKLDNAIDQVDSLPLSGEAPIAHATPHAATWADTAKVAAATGEPRWKVWWREVST
GIGQQLTSLVQVRRIDNADAMLVTPDQGYFVRENLKLRLLSARLALLSRNETTLKSDLLAAQNALTRYFDNSSKKTQTVS
DLVKQVQAGSAAVELPNLNTSLQAVNQYRSRG

Sequences:

>Translated_672_residues
MAADIPGNASPSVDKAAFTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVSPNA
VDYAFARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETARFDSEGLFAAIDTALGATNLEGKRVLI
VRGDGGREWLAERLREAGAEVETVAAYRRLVPEPSIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQL
KRAALVTPHPRIAQTARALGFDSITVSGAGDERIVRTLLAAVPTVVQPVPSNPAHSPAKSRMTETNASTNASPQPAATTA
LPPNPPFTPYEAQKRHSASGPLLWFVVVIIACAAGVGGYALNRKVERTEQQLVQRQQANDTQTNELRIKTEQALATVHQS
DSQVAQLEGKLADAQTAQQALQQQYADLARNRDDWTLAEVGQMLSAASQQLQLTGNTQLALFALQSADTRLAASDSPQAI
AVRKAIAQDIDKLKAAPSTDLTGMAIKLDNAIDQVDSLPLSGEAPIAHATPHAATWADTAKVAAATGEPRWKVWWREVST
GIGQQLTSLVQVRRIDNADAMLVTPDQGYFVRENLKLRLLSARLALLSRNETTLKSDLLAAQNALTRYFDNSSKKTQTVS
DLVKQVQAGSAAVELPNLNTSLQAVNQYRSRG
>Mature_671_residues
AADIPGNASPSVDKAAFTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVSPNAV
DYAFARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETARFDSEGLFAAIDTALGATNLEGKRVLIV
RGDGGREWLAERLREAGAEVETVAAYRRLVPEPSIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQLK
RAALVTPHPRIAQTARALGFDSITVSGAGDERIVRTLLAAVPTVVQPVPSNPAHSPAKSRMTETNASTNASPQPAATTAL
PPNPPFTPYEAQKRHSASGPLLWFVVVIIACAAGVGGYALNRKVERTEQQLVQRQQANDTQTNELRIKTEQALATVHQSD
SQVAQLEGKLADAQTAQQALQQQYADLARNRDDWTLAEVGQMLSAASQQLQLTGNTQLALFALQSADTRLAASDSPQAIA
VRKAIAQDIDKLKAAPSTDLTGMAIKLDNAIDQVDSLPLSGEAPIAHATPHAATWADTAKVAAATGEPRWKVWWREVSTG
IGQQLTSLVQVRRIDNADAMLVTPDQGYFVRENLKLRLLSARLALLSRNETTLKSDLLAAQNALTRYFDNSSKKTQTVSD
LVKQVQAGSAAVELPNLNTSLQAVNQYRSRG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790235, Length=287, Percent_Identity=26.4808362369338, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790236, Length=269, Percent_Identity=28.6245353159851, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 71697; Mature: 71566

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADIPGNASPSVDKAAFTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPL
CCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCHHEECCCCEEECCCCCCHHH
RAALSSLERYALVVFVSPNAVDYAFARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYN
HHHHHHHCCEEEEEEECCCCEEEHECCCCCCCCCCCEECEECCCHHHHHHHCCCCCCCCC
VISPPSGTDEETARFDSEGLFAAIDTALGATNLEGKRVLIVRGDGGREWLAERLREAGAE
CCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCC
VETVAAYRRLVPEPSIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQL
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHH
KRAALVTPHPRIAQTARALGFDSITVSGAGDERIVRTLLAAVPTVVQPVPSNPAHSPAKS
HHHHCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RMTETNASTNASPQPAATTALPPNPPFTPYEAQKRHSASGPLLWFVVVIIACAAGVGGYA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCHH
LNRKVERTEQQLVQRQQANDTQTNELRIKTEQALATVHQSDSQVAQLEGKLADAQTAQQA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LQQQYADLARNRDDWTLAEVGQMLSAASQQLQLTGNTQLALFALQSADTRLAASDSPQAI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCEEECCCCCHHH
AVRKAIAQDIDKLKAAPSTDLTGMAIKLDNAIDQVDSLPLSGEAPIAHATPHAATWADTA
HHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
KVAAATGEPRWKVWWREVSTGIGQQLTSLVQVRRIDNADAMLVTPDQGYFVRENLKLRLL
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCHHHHH
SARLALLSRNETTLKSDLLAAQNALTRYFDNSSKKTQTVSDLVKQVQAGSAAVELPNLNT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCH
SLQAVNQYRSRG
HHHHHHHHHHCC
>Mature Secondary Structure 
AADIPGNASPSVDKAAFTVVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPL
CCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCHHEECCCCEEECCCCCCHHH
RAALSSLERYALVVFVSPNAVDYAFARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYN
HHHHHHHCCEEEEEEECCCCEEEHECCCCCCCCCCCEECEECCCHHHHHHHCCCCCCCCC
VISPPSGTDEETARFDSEGLFAAIDTALGATNLEGKRVLIVRGDGGREWLAERLREAGAE
CCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCC
VETVAAYRRLVPEPSIGGWARVHELLAGAPHAWLLTSSEGVRNLHELAQDHLTADEISQL
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHH
KRAALVTPHPRIAQTARALGFDSITVSGAGDERIVRTLLAAVPTVVQPVPSNPAHSPAKS
HHHHCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RMTETNASTNASPQPAATTALPPNPPFTPYEAQKRHSASGPLLWFVVVIIACAAGVGGYA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCHH
LNRKVERTEQQLVQRQQANDTQTNELRIKTEQALATVHQSDSQVAQLEGKLADAQTAQQA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LQQQYADLARNRDDWTLAEVGQMLSAASQQLQLTGNTQLALFALQSADTRLAASDSPQAI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCEEECCCCCHHH
AVRKAIAQDIDKLKAAPSTDLTGMAIKLDNAIDQVDSLPLSGEAPIAHATPHAATWADTA
HHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
KVAAATGEPRWKVWWREVSTGIGQQLTSLVQVRRIDNADAMLVTPDQGYFVRENLKLRLL
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCHHHHH
SARLALLSRNETTLKSDLLAAQNALTRYFDNSSKKTQTVSDLVKQVQAGSAAVELPNLNT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCH
SLQAVNQYRSRG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]