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The map label for this gene is argH [H]

Identifier: 91782416

GI number: 91782416

Start: 1155550

End: 1156956

Strand: Reverse

Name: argH [H]

Synonym: Bxe_A3415

Alternate gene names: 91782416

Gene position: 1156956-1155550 (Counterclockwise)

Preceding gene: 91782417

Following gene: 91782415

Centisome position: 23.63

GC content: 64.18

Gene sequence:

>1407_bases
ATGACGTCCCAACTGCACAAAAAAGGCGAAGCCTGGTCGGCTCGCTTCTCGGAGCCGATGTCGGAGCTCGTCAAACGCTA
CACGTCGTCGGTTTTCTTCGACAAGCGATTGGCGCTCGTCGATATCGAAGGGTCGCTCGCGCACGCCTCCATGCTGGCCG
CGCAGAAGATCATCGCCGCCGACGACCTCACCGCGATCCAACGCGGCATGGCGCAGATCAAGGGTGAAATCGAGCGCGGC
GAATTCGAGTGGCAACTCGATCTGGAAGACGTCCACCTGAATATCGAAGCGCGCCTGACCGCGCTGATCGGCGACGCCGG
CAAGCGCCTGCACACCGGCCGCTCGCGCAACGACCAGGTCGCAACAGACATTCGCCTGTGGCTGCGCGGCGAGATCGACC
GCATCGGCGGCCTGCTCACGGAACTGCGCACGGCCCTGCTCGACATGGCGGAGAAGAACGCCGCGACTATCATGCCGGGC
TTCACGCACTTGCAGGTGGCGCAGCCGGTCACGTTCGGCCATCACCTGCTCGCTTACGTCGAGATGTTTTCGCGCGACGC
CGAGCGCATGATCGATTGCCGCAAGCGCGTGAACCGCCTGCCGCTCGGCGCGGCCGCGCTCGCCGGCACCAGCTATCCGA
TCGACCGCTACGCAGTGGCGAAGACGCTGGGCTTCGACGGCATCTGCGCGAACTCGCTGGACGCGGTGTCCGACCGCGAC
TTCGCGATCGAATTCACGGCGGCGTCGGCACTCGTCATGACGCACATCTCGCGCTTCTCCGAAGAACTGGTGCTGTGGAT
GAGCCCGCGCGTCGGCTTCATCGATCTGGCCGACCGCTTCTGCACCGGTTCGTCGATCATGCCGCAGAAGAAGAACCCGG
ACGTGCCCGAACTCGCGCGCGGCAAGACCGGCCGCGTGAACGGCCATCTGATCGCGCTGCTCACGCTGATGAAAGGCCAG
CCGCTCGCGTACAACAAAGACAATCAGGAAGACAAGGAACCGCTGTTCGATACTGTCGATACGGTCGCGGATACGCTGCG
CATCTTCGCTGAAATGGTCGCCGGTATTTCGGTGAAGCCGCAAGCCATGCGCGACGCTGCGTTGCAAGGCTTCTCGACGG
CAACGGATCTGGCCGACTACCTCGTCAAGCGCGGCCTGCCGTTCCGCGACGCGCACGAAGCAGTGGCGCTCGCCGTGCGC
GTATGCGCGGATCGCGGCTGCGATCTGGCGGATCTGACGCTCGAAGAAATGCGCAAGGAACTGTCGAACGTCGCGCATCT
GATTGGCGAGGACGTGTTTTCGTATCTGACGCTGGAAGGGTCGGTGGCGAGCCGCAATCATCCGGGCGGCACGGCGCCGG
AGCAGGTGCTCGCAGCGGTGAAGGCGGCGCGCGAAGCGTTGAAGTAA

Upstream 100 bases:

>100_bases
CAGTCTTTCTTCGCTTCGGCGGCTGCTTTTGCACGGCGGGTGCATTCGCGTCGTCAGCCTCCTTACCGCTCGCTCAACTG
CCGCTTAACTGCCCAACACC

Downstream 100 bases:

>100_bases
AGGCGGCGTGCGATGAGGTGAGATTACAAACTCATCGCTTGCGCCAGACTTGCTTGGTGTTCGAGGTTTGGCAGCCTTGC
AAACAGAAAGGCGAACTCGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIIAADDLTAIQRGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLTELRTALLDMAEKNAATIMPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMIDCRKRVNRLPLGAAALAGTSYPIDRYAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHISRFSEELVLWMSPRVGFIDLADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGISVKPQAMRDAALQGFSTATDLADYLVKRGLPFRDAHEAVALAVR
VCADRGCDLADLTLEEMRKELSNVAHLIGEDVFSYLTLEGSVASRNHPGGTAPEQVLAAVKAAREALK

Sequences:

>Translated_468_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIIAADDLTAIQRGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLTELRTALLDMAEKNAATIMPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMIDCRKRVNRLPLGAAALAGTSYPIDRYAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHISRFSEELVLWMSPRVGFIDLADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGISVKPQAMRDAALQGFSTATDLADYLVKRGLPFRDAHEAVALAVR
VCADRGCDLADLTLEEMRKELSNVAHLIGEDVFSYLTLEGSVASRNHPGGTAPEQVLAAVKAAREALK
>Mature_467_residues
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIIAADDLTAIQRGMAQIKGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLTELRTALLDMAEKNAATIMPGF
THLQVAQPVTFGHHLLAYVEMFSRDAERMIDCRKRVNRLPLGAAALAGTSYPIDRYAVAKTLGFDGICANSLDAVSDRDF
AIEFTAASALVMTHISRFSEELVLWMSPRVGFIDLADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGISVKPQAMRDAALQGFSTATDLADYLVKRGLPFRDAHEAVALAVRV
CADRGCDLADLTLEEMRKELSNVAHLIGEDVFSYLTLEGSVASRNHPGGTAPEQVLAAVKAAREALK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=462, Percent_Identity=39.3939393939394, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI68303542, Length=462, Percent_Identity=39.3939393939394, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI68303547, Length=462, Percent_Identity=37.2294372294372, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI68303549, Length=462, Percent_Identity=36.7965367965368, Blast_Score=303, Evalue=3e-82,
Organism=Escherichia coli, GI1790398, Length=460, Percent_Identity=45.2173913043478, Blast_Score=394, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=41.6846652267819, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI221473854, Length=461, Percent_Identity=38.3947939262473, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI78706858, Length=461, Percent_Identity=38.3947939262473, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51406; Mature: 51274

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIIAA
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
DDLTAIQRGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGGLLTELRTALLDMAEKNAATIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEECCCCHHHHHHHHHHH
EMFSRDAERMIDCRKRVNRLPLGAAALAGTSYPIDRYAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHISRFSEELVLWMSPRVGFIDLADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGISVKP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QAMRDAALQGFSTATDLADYLVKRGLPFRDAHEAVALAVRVCADRGCDLADLTLEEMRKE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LSNVAHLIGEDVFSYLTLEGSVASRNHPGGTAPEQVLAAVKAAREALK
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIEGSLAHASMLAAQKIIAA
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
DDLTAIQRGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGGLLTELRTALLDMAEKNAATIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEECCCCHHHHHHHHHHH
EMFSRDAERMIDCRKRVNRLPLGAAALAGTSYPIDRYAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHISRFSEELVLWMSPRVGFIDLADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGISVKP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QAMRDAALQGFSTATDLADYLVKRGLPFRDAHEAVALAVRVCADRGCDLADLTLEEMRKE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LSNVAHLIGEDVFSYLTLEGSVASRNHPGGTAPEQVLAAVKAAREALK
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA