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The map label for this gene is rfbD [H]

Identifier: 91782042

GI number: 91782042

Start: 743057

End: 743974

Strand: Direct

Name: rfbD [H]

Synonym: Bxe_A3802

Alternate gene names: 91782042

Gene position: 743057-743974 (Clockwise)

Preceding gene: 91782041

Following gene: 91782043

Centisome position: 15.18

GC content: 60.78

Gene sequence:

>918_bases
ATGCGTGATAAGGCCAGTTCGGTGCCCATCCTCCTTGTTACCGGAAGTCGAGGCCAAGTTGGCTTTGAGTTGCGCCGGAG
TTTGGCTTCGCTCGGCAACGTGGTAGCGCTCGACCGTTCGGTCTGCGATCTGAGGAGTCCCGACTCCATCCGTAGCGTGG
TGCGAGAAGTGCAGCCGGACGTGATTGTGAACCCGGCCGCGTACACGGCCGTTGACGCAGCGGAAAACGACGCGGAACTC
GCATACGCCATAAACGGCGTGGCCGCCGGCGTGCTGGCTGAAGAAGCAAAGTCGCTTGGCGGCCTCCTGGTGCACTATTC
GACCGACTATGTTTTCGATGGTCGGAAGGATGGTCCATACGTCGAGACCGACGTTGTCAATCCCCAATCTGTCTATGGCA
AAAGTAAGCTTGCCGGCGAGCAGGCTATTGCGGAAAGAGGTGCAACGGCAATCGTGCTGCGCACTTGTTGGGTAGCTGGT
GCGCATGGCAGCAACTTCGCCAAGACTATGCTGAGGCTCGGTCGCGAACGCGACAGCCTGCGCGTGATCGCTGACCAATA
CGGAGCGCCGACGACAGCGGCGTTGATCGCCGACGTGACCGCGCAGATCGTCGCGCGCCACTGGCTTCACGGGGATCGCG
CGGCATTCGCGTCGGGTGTCTACCATCTTGCTGCGGCCGGCCAAACATCGTGGCATGGCTACGCAACCGAGGTGCTGCAA
TTTGCTGCGGCGCGCGGCGTCGAACTGAAAGTCGATCTCGCCCGTATCGAGCCCATTGCTACAGCTGACTATCCGCTACC
CGCTCCGCGTCCGGCCAATTCCCGTCTCGATACGCACAAGCTGCGCCAAACCTTCGGTATCAATCTCCCCGATTGGCGCG
ACGGTGTGCACCACCTGCTAGAACAGATTCTTCCGTGA

Upstream 100 bases:

>100_bases
GAAACGGGTCTCGCGAAGACGGTCCAGTGGTATCTGGACAATCAGGCGTGGTCGGACGAAGTCGCCTCGGGCGAGTACCG
CAAGTGGGTGGCCAAGCAAT

Downstream 100 bases:

>100_bases
GTAAAAAACATGCGTAAAGGCATTATCCTAGCCGGTGGGTCCGGCACGCGTCTTTACCCGATCACGCGGTCGGTGTCGAA
GCAACTGCTACCCGTCTACG

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRDKASSVPILLVTGSRGQVGFELRRSLASLGNVVALDRSVCDLRSPDSIRSVVREVQPDVIVNPAAYTAVDAAENDAEL
AYAINGVAAGVLAEEAKSLGGLLVHYSTDYVFDGRKDGPYVETDVVNPQSVYGKSKLAGEQAIAERGATAIVLRTCWVAG
AHGSNFAKTMLRLGRERDSLRVIADQYGAPTTAALIADVTAQIVARHWLHGDRAAFASGVYHLAAAGQTSWHGYATEVLQ
FAAARGVELKVDLARIEPIATADYPLPAPRPANSRLDTHKLRQTFGINLPDWRDGVHHLLEQILP

Sequences:

>Translated_305_residues
MRDKASSVPILLVTGSRGQVGFELRRSLASLGNVVALDRSVCDLRSPDSIRSVVREVQPDVIVNPAAYTAVDAAENDAEL
AYAINGVAAGVLAEEAKSLGGLLVHYSTDYVFDGRKDGPYVETDVVNPQSVYGKSKLAGEQAIAERGATAIVLRTCWVAG
AHGSNFAKTMLRLGRERDSLRVIADQYGAPTTAALIADVTAQIVARHWLHGDRAAFASGVYHLAAAGQTSWHGYATEVLQ
FAAARGVELKVDLARIEPIATADYPLPAPRPANSRLDTHKLRQTFGINLPDWRDGVHHLLEQILP
>Mature_305_residues
MRDKASSVPILLVTGSRGQVGFELRRSLASLGNVVALDRSVCDLRSPDSIRSVVREVQPDVIVNPAAYTAVDAAENDAEL
AYAINGVAAGVLAEEAKSLGGLLVHYSTDYVFDGRKDGPYVETDVVNPQSVYGKSKLAGEQAIAERGATAIVLRTCWVAG
AHGSNFAKTMLRLGRERDSLRVIADQYGAPTTAALIADVTAQIVARHWLHGDRAAFASGVYHLAAAGQTSWHGYATEVLQ
FAAARGVELKVDLARIEPIATADYPLPAPRPANSRLDTHKLRQTFGINLPDWRDGVHHLLEQILP

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=273, Percent_Identity=30.4029304029304, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI33519455, Length=273, Percent_Identity=30.4029304029304, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1788352, Length=302, Percent_Identity=45.6953642384106, Blast_Score=270, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32753; Mature: 32753

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKASSVPILLVTGSRGQVGFELRRSLASLGNVVALDRSVCDLRSPDSIRSVVREVQPD
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEECHHHHCCCCCHHHHHHHHHCCCC
VIVNPAAYTAVDAAENDAELAYAINGVAAGVLAEEAKSLGGLLVHYSTDYVFDGRKDGPY
EEECCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEECCCCCCCE
VETDVVNPQSVYGKSKLAGEQAIAERGATAIVLRTCWVAGAHGSNFAKTMLRLGRERDSL
EEECCCCHHHHHCHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHHHHHHCCCCCHH
RVIADQYGAPTTAALIADVTAQIVARHWLHGDRAAFASGVYHLAAAGQTSWHGYATEVLQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FAAARGVELKVDLARIEPIATADYPLPAPRPANSRLDTHKLRQTFGINLPDWRDGVHHLL
HHHHCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
EQILP
HHHCC
>Mature Secondary Structure
MRDKASSVPILLVTGSRGQVGFELRRSLASLGNVVALDRSVCDLRSPDSIRSVVREVQPD
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEECHHHHCCCCCHHHHHHHHHCCCC
VIVNPAAYTAVDAAENDAELAYAINGVAAGVLAEEAKSLGGLLVHYSTDYVFDGRKDGPY
EEECCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEECCCCCCCE
VETDVVNPQSVYGKSKLAGEQAIAERGATAIVLRTCWVAGAHGSNFAKTMLRLGRERDSL
EEECCCCHHHHHCHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHHHHHHCCCCCHH
RVIADQYGAPTTAALIADVTAQIVARHWLHGDRAAFASGVYHLAAAGQTSWHGYATEVLQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FAAARGVELKVDLARIEPIATADYPLPAPRPANSRLDTHKLRQTFGINLPDWRDGVHHLL
HHHHCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
EQILP
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]