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The map label for this gene is moaA [H]

Identifier: 91782007

GI number: 91782007

Start: 707718

End: 708788

Strand: Direct

Name: moaA [H]

Synonym: Bxe_A3837

Alternate gene names: 91782007

Gene position: 707718-708788 (Clockwise)

Preceding gene: 91782006

Following gene: 91782009

Centisome position: 14.46

GC content: 63.4

Gene sequence:

>1071_bases
ATGGCATCCCGCTTTGGCGTAACCGCCGGCGGGGTTGTGTCCACGTTCGACAAGCTCGGTCGTCCGCTGCGGGATCTGCG
TCTGTCCGTCATCGATCAATGCAATTTCCGCTGTACGTACTGCATGCCGCGAGAAACTTTCGGCGCGGACTATCCGTTCC
TGGCGTCTTCGGAACGCATGTCGTTCGAACAGATTCTCAAGCTCGCGAAAGCGTTCACGCTTCTCGGTGTGGAGAAGATC
CGCATCACCGGCGGCGAGCCGCTCCTGCGGCGCGGGCTCGAATCCCTGATCGAACAGCTCGCGAAACTGACGACTGCGAG
CGGCAAGCCGGTCGAACTCGCATTGACGACCAACGGCTCGCTGCTCGCCGCGAAGGCGCGCTCGCTGCGCGACGCCGGCC
TCGGTCGGGTGACCGTGAGCCTCGACGCTGTGGAGGACGCCGTGTTTCGCCGGATGAGTGACGTCGACATGTCCGTTGCA
CGAATACTGGATGGGATCGAGGCAGCGCGCGCAGTGGGACTCGAACCGATCAAGGTCAATTCAGTGATCGAGCGGGGCGT
GAACGAGAGTCAGATCCTGCCGCTCGTGCGGCAGTTCAGAGGCACCGGCGTAGCGGTGCGTTTCATCGAATATATGGACG
TGGGCGGCGCGGGCGGCTGGTCGAACACGAAGGTAATGACCGCCCGCGAGATACGCGGGATCGTCGAATCGGAGTTTCCT
CTGGTGCCCGTCGTCGTTCGTGAGCAGAGCGGCACCGCCGTCAATTATCTCCATGCCGACGGCGCGGGCGAAGTCGGATT
CATAGCGAGCGTGTCGCAACCGTTCTGCGGGTCCTGTTCGCGCGCCCGCGTATCCGCCGACGGTCAGCTTTATTCCTGTC
TGTTCGCCACACATGGCACGGATCTCAGGCCCTGGCTTACCGACACCGCCACTGCCGGCCAACTGGCGGAGCGTGTGCGC
AGCCGCTGGACGCAACGCGACGATCGCTACTCGGAGCTACGCTCGACACAGCGCAAGCCGGCATCGGGAAAAGTCTATCC
GACGGTGCGCATGTCGCTGGTCGGCGGTTGA

Upstream 100 bases:

>100_bases
TGCTGTCAGCCAGGTTGACCGCCACCGTTTCGTATCCCGCCGCACGCTGCCCACTTCCGGATAGACCGTGACCATCATCG
ACCTGCCAGTAGCCGCTGAT

Downstream 100 bases:

>100_bases
GGCTTCGTCGGTCTTTGTGAAGGACGCCGGGCACAACGTGCAGAGCCGCCATGAAAGCGCGGGCGGCGACGGCCGGCATA
CCGCTAACTGGCACACATCG

Product: GTP cyclohydrolase subunit MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MASRFGVTAGGVVSTFDKLGRPLRDLRLSVIDQCNFRCTYCMPRETFGADYPFLASSERMSFEQILKLAKAFTLLGVEKI
RITGGEPLLRRGLESLIEQLAKLTTASGKPVELALTTNGSLLAAKARSLRDAGLGRVTVSLDAVEDAVFRRMSDVDMSVA
RILDGIEAARAVGLEPIKVNSVIERGVNESQILPLVRQFRGTGVAVRFIEYMDVGGAGGWSNTKVMTAREIRGIVESEFP
LVPVVVREQSGTAVNYLHADGAGEVGFIASVSQPFCGSCSRARVSADGQLYSCLFATHGTDLRPWLTDTATAGQLAERVR
SRWTQRDDRYSELRSTQRKPASGKVYPTVRMSLVGG

Sequences:

>Translated_356_residues
MASRFGVTAGGVVSTFDKLGRPLRDLRLSVIDQCNFRCTYCMPRETFGADYPFLASSERMSFEQILKLAKAFTLLGVEKI
RITGGEPLLRRGLESLIEQLAKLTTASGKPVELALTTNGSLLAAKARSLRDAGLGRVTVSLDAVEDAVFRRMSDVDMSVA
RILDGIEAARAVGLEPIKVNSVIERGVNESQILPLVRQFRGTGVAVRFIEYMDVGGAGGWSNTKVMTAREIRGIVESEFP
LVPVVVREQSGTAVNYLHADGAGEVGFIASVSQPFCGSCSRARVSADGQLYSCLFATHGTDLRPWLTDTATAGQLAERVR
SRWTQRDDRYSELRSTQRKPASGKVYPTVRMSLVGG
>Mature_355_residues
ASRFGVTAGGVVSTFDKLGRPLRDLRLSVIDQCNFRCTYCMPRETFGADYPFLASSERMSFEQILKLAKAFTLLGVEKIR
ITGGEPLLRRGLESLIEQLAKLTTASGKPVELALTTNGSLLAAKARSLRDAGLGRVTVSLDAVEDAVFRRMSDVDMSVAR
ILDGIEAARAVGLEPIKVNSVIERGVNESQILPLVRQFRGTGVAVRFIEYMDVGGAGGWSNTKVMTAREIRGIVESEFPL
VPVVVREQSGTAVNYLHADGAGEVGFIASVSQPFCGSCSRARVSADGQLYSCLFATHGTDLRPWLTDTATAGQLAERVRS
RWTQRDDRYSELRSTQRKPASGKVYPTVRMSLVGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=299, Percent_Identity=35.7859531772575, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI22027536, Length=299, Percent_Identity=35.7859531772575, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1786999, Length=307, Percent_Identity=33.5504885993485, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17561210, Length=349, Percent_Identity=30.6590257879656, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=343, Percent_Identity=30.9037900874636, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI32566331, Length=322, Percent_Identity=31.3664596273292, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI28574490, Length=342, Percent_Identity=31.5789473684211, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI28574488, Length=296, Percent_Identity=33.7837837837838, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38675; Mature: 38544

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRFGVTAGGVVSTFDKLGRPLRDLRLSVIDQCNFRCTYCMPRETFGADYPFLASSERM
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCC
SFEQILKLAKAFTLLGVEKIRITGGEPLLRRGLESLIEQLAKLTTASGKPVELALTTNGS
CHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
LLAAKARSLRDAGLGRVTVSLDAVEDAVFRRMSDVDMSVARILDGIEAARAVGLEPIKVN
EEHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
SVIERGVNESQILPLVRQFRGTGVAVRFIEYMDVGGAGGWSNTKVMTAREIRGIVESEFP
HHHHCCCCHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCCCCCEEEEHHHHHHHHHCCCC
LVPVVVREQSGTAVNYLHADGAGEVGFIASVSQPFCGSCSRARVSADGQLYSCLFATHGT
EEEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEEECCCCC
DLRPWLTDTATAGQLAERVRSRWTQRDDRYSELRSTQRKPASGKVYPTVRMSLVGG
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
ASRFGVTAGGVVSTFDKLGRPLRDLRLSVIDQCNFRCTYCMPRETFGADYPFLASSERM
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCC
SFEQILKLAKAFTLLGVEKIRITGGEPLLRRGLESLIEQLAKLTTASGKPVELALTTNGS
CHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
LLAAKARSLRDAGLGRVTVSLDAVEDAVFRRMSDVDMSVARILDGIEAARAVGLEPIKVN
EEHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
SVIERGVNESQILPLVRQFRGTGVAVRFIEYMDVGGAGGWSNTKVMTAREIRGIVESEFP
HHHHCCCCHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCCCCCEEEEHHHHHHHHHCCCC
LVPVVVREQSGTAVNYLHADGAGEVGFIASVSQPFCGSCSRARVSADGQLYSCLFATHGT
EEEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEEECCCCC
DLRPWLTDTATAGQLAERVRSRWTQRDDRYSELRSTQRKPASGKVYPTVRMSLVGG
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]