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The map label for this gene is pcaK [H]

Identifier: 91781942

GI number: 91781942

Start: 624502

End: 625866

Strand: Direct

Name: pcaK [H]

Synonym: Bxe_A3901

Alternate gene names: 91781942

Gene position: 624502-625866 (Clockwise)

Preceding gene: 91781940

Following gene: 91781943

Centisome position: 12.76

GC content: 66.81

Gene sequence:

>1365_bases
ATGAGCGCGAAACCGGCCGCGGCCGCCACCAATGTGATCGAAGTCGAGCGCGTGCTCGCCGAAACGCATCACCCGGCATT
CCAGTTGATGCTGCTCGTGCTATGCGGGCTGTGCCTCGTGATCGACGGGTTCGACGCACAGGCTATGGGCTACGTCGCGC
CGAGCGTGATCGGCGAATGGCACGTCTCGAAAGCCGCGCTCGGTCCGGTGTTCAGCGCCAGTCTGTTCGGCATGCTGCTC
GGCGCGCTCGGGCTGTCGGTGCTGGCTGACCGCGTGGGCCGCCGGCCGGTGCTGATCGGCTCCACGTTCTTCTTCGCGCT
GGCAATGCTTACCACGCCTTTCGTCACGACGATCCCCGCCTTGATCGCGCTGCGCTTCGTCACCGGTCTCGGGCTCGGCT
GCATCATGCCGAACGCGATGGCGCTGGTCGGCGAATTCTCGACGCCTGTGCATCGCGTCAAGCGCATGATGCTGGTGTCG
TGCGGCTTTACGCTGGGCGCGGCGCTCGGCGGCTTTATCAGCGCCGCGCTGATTCCGGCCTATGGCTGGCGCTCGGTTTT
CTGGGTCGGCGGTGCGGCGCCGTTGCTGCTGGCGCTGGCGATGCTCGTCGCGCTGCCGGAGTCGCTGCAATTCCTGGTTC
TCAAAGGCCACAACGAGCGCGCGTTGCGCTGGCTCGCGAAGTTCAACCCAATGCTGCCGATCGACGCGAACACGCGTCTC
GTCGTGCGTGAAAAGGGCAATGACGGCGCGCCGGTGGCCGAACTGTTCCGCGCCGGCCGTGGCCCGGTGACGTTGATTCT
GTGGGCGATCAGTTTCATGAACCTGATCGATCTGTACTTCCTGTCGAACTGGCTGCCCACCGTGATGCGCGACGCCGGCT
ATTCGCCGAGCACCGCCGTGCTCGTCGGCACGGTGCTACAGACGGGCGGCGTGGTCGGCACCTTGCTGCTCGGCTGGTTC
ATCGAACGGTTTGGCTTTGTGCGCGTGCTGTTCGTGTGCTTCGCGGGCGCGGCGCTGGCAGTCAGCACGATCGGCACGGT
GGCGCATATGCTGCCGTGGCTGCTGATCGTCGTATTCGCGGGCGGCTTCTGCGTGGTCGGCGGACAGCCGGCGGTCAACG
CGCTGGCCGGCCATTTTTATCCAACCGCGCTGCGCTCGACGGGGATTGGCTGGAGCCTTGGCATCGGCCGGATCGGTTCG
GTGATCGGACCGCTGATCGGCGGTCAGCTGATCGCGCTCAACTGGTCGAATGCTTCGCTGTTTCATGCGGCGGCGGTGCC
GGTGCTGTGCTCCGCGCTGCTGGTGATCGGACTGGCCGCCGCGACGCGCCAGCGCGGCCGGCCGTCCGAGCCGCGCACCG
CCTGA

Upstream 100 bases:

>100_bases
CGCATGCACCGTGCGCACCGCATGCGCCGACCTCCGGGGTTCTCCGGGCGTTCGGGCCGCACGCCACTCAACAATCCAGT
CAGCAGGAGGGGACGACCCA

Downstream 100 bases:

>100_bases
GATGACGAGATCGAGTATCAACGGAGAACCTTGCATGGATACCCAAACACGTACGCCGAACACTGTCAGTTCGCGGCTCG
AGATCGAGCCCGGCTATCAG

Product: major facilitator superfamily 4- hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSAKPAAAATNVIEVERVLAETHHPAFQLMLLVLCGLCLVIDGFDAQAMGYVAPSVIGEWHVSKAALGPVFSASLFGMLL
GALGLSVLADRVGRRPVLIGSTFFFALAMLTTPFVTTIPALIALRFVTGLGLGCIMPNAMALVGEFSTPVHRVKRMMLVS
CGFTLGAALGGFISAALIPAYGWRSVFWVGGAAPLLLALAMLVALPESLQFLVLKGHNERALRWLAKFNPMLPIDANTRL
VVREKGNDGAPVAELFRAGRGPVTLILWAISFMNLIDLYFLSNWLPTVMRDAGYSPSTAVLVGTVLQTGGVVGTLLLGWF
IERFGFVRVLFVCFAGAALAVSTIGTVAHMLPWLLIVVFAGGFCVVGGQPAVNALAGHFYPTALRSTGIGWSLGIGRIGS
VIGPLIGGQLIALNWSNASLFHAAAVPVLCSALLVIGLAAATRQRGRPSEPRTA

Sequences:

>Translated_454_residues
MSAKPAAAATNVIEVERVLAETHHPAFQLMLLVLCGLCLVIDGFDAQAMGYVAPSVIGEWHVSKAALGPVFSASLFGMLL
GALGLSVLADRVGRRPVLIGSTFFFALAMLTTPFVTTIPALIALRFVTGLGLGCIMPNAMALVGEFSTPVHRVKRMMLVS
CGFTLGAALGGFISAALIPAYGWRSVFWVGGAAPLLLALAMLVALPESLQFLVLKGHNERALRWLAKFNPMLPIDANTRL
VVREKGNDGAPVAELFRAGRGPVTLILWAISFMNLIDLYFLSNWLPTVMRDAGYSPSTAVLVGTVLQTGGVVGTLLLGWF
IERFGFVRVLFVCFAGAALAVSTIGTVAHMLPWLLIVVFAGGFCVVGGQPAVNALAGHFYPTALRSTGIGWSLGIGRIGS
VIGPLIGGQLIALNWSNASLFHAAAVPVLCSALLVIGLAAATRQRGRPSEPRTA
>Mature_453_residues
SAKPAAAATNVIEVERVLAETHHPAFQLMLLVLCGLCLVIDGFDAQAMGYVAPSVIGEWHVSKAALGPVFSASLFGMLLG
ALGLSVLADRVGRRPVLIGSTFFFALAMLTTPFVTTIPALIALRFVTGLGLGCIMPNAMALVGEFSTPVHRVKRMMLVSC
GFTLGAALGGFISAALIPAYGWRSVFWVGGAAPLLLALAMLVALPESLQFLVLKGHNERALRWLAKFNPMLPIDANTRLV
VREKGNDGAPVAELFRAGRGPVTLILWAISFMNLIDLYFLSNWLPTVMRDAGYSPSTAVLVGTVLQTGGVVGTLLLGWFI
ERFGFVRVLFVCFAGAALAVSTIGTVAHMLPWLLIVVFAGGFCVVGGQPAVNALAGHFYPTALRSTGIGWSLGIGRIGSV
IGPLIGGQLIALNWSNASLFHAAAVPVLCSALLVIGLAAATRQRGRPSEPRTA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=470, Percent_Identity=25.1063829787234, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI166064021, Length=365, Percent_Identity=25.2054794520548, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI8923870, Length=379, Percent_Identity=27.9683377308707, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI7662270, Length=238, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI216548223, Length=343, Percent_Identity=24.198250728863, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI213021148, Length=447, Percent_Identity=23.0425055928412, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081723, Length=424, Percent_Identity=33.9622641509434, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082231, Length=454, Percent_Identity=25.7709251101322, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082404, Length=422, Percent_Identity=22.9857819905213, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786229, Length=368, Percent_Identity=22.8260869565217, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788068, Length=438, Percent_Identity=23.972602739726, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32564663, Length=403, Percent_Identity=24.0694789081886, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980582, Length=342, Percent_Identity=23.3918128654971, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922874, Length=404, Percent_Identity=25.4950495049505, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24640198, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640196, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640200, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161077756, Length=454, Percent_Identity=22.4669603524229, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922616, Length=371, Percent_Identity=23.7196765498652, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573099, Length=266, Percent_Identity=24.0601503759398, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28573101, Length=265, Percent_Identity=24.9056603773585, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47771; Mature: 47639

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKPAAAATNVIEVERVLAETHHPAFQLMLLVLCGLCLVIDGFDAQAMGYVAPSVIGEW
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
HVSKAALGPVFSASLFGMLLGALGLSVLADRVGRRPVLIGSTFFFALAMLTTPFVTTIPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHHHHH
LIALRFVTGLGLGCIMPNAMALVGEFSTPVHRVKRMMLVSCGFTLGAALGGFISAALIPA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
YGWRSVFWVGGAAPLLLALAMLVALPESLQFLVLKGHNERALRWLAKFNPMLPIDANTRL
CCCCHHEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEE
VVREKGNDGAPVAELFRAGRGPVTLILWAISFMNLIDLYFLSNWLPTVMRDAGYSPSTAV
EEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LVGTVLQTGGVVGTLLLGWFIERFGFVRVLFVCFAGAALAVSTIGTVAHMLPWLLIVVFA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFCVVGGQPAVNALAGHFYPTALRSTGIGWSLGIGRIGSVIGPLIGGQLIALNWSNASL
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHH
FHAAAVPVLCSALLVIGLAAATRQRGRPSEPRTA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SAKPAAAATNVIEVERVLAETHHPAFQLMLLVLCGLCLVIDGFDAQAMGYVAPSVIGEW
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
HVSKAALGPVFSASLFGMLLGALGLSVLADRVGRRPVLIGSTFFFALAMLTTPFVTTIPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHHHHH
LIALRFVTGLGLGCIMPNAMALVGEFSTPVHRVKRMMLVSCGFTLGAALGGFISAALIPA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
YGWRSVFWVGGAAPLLLALAMLVALPESLQFLVLKGHNERALRWLAKFNPMLPIDANTRL
CCCCHHEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEE
VVREKGNDGAPVAELFRAGRGPVTLILWAISFMNLIDLYFLSNWLPTVMRDAGYSPSTAV
EEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LVGTVLQTGGVVGTLLLGWFIERFGFVRVLFVCFAGAALAVSTIGTVAHMLPWLLIVVFA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFCVVGGQPAVNALAGHFYPTALRSTGIGWSLGIGRIGSVIGPLIGGQLIALNWSNASL
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHH
FHAAAVPVLCSALLVIGLAAATRQRGRPSEPRTA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]