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The map label for this gene is mutL [H]

Identifier: 91781911

GI number: 91781911

Start: 593976

End: 596042

Strand: Reverse

Name: mutL [H]

Synonym: Bxe_A3934

Alternate gene names: 91781911

Gene position: 596042-593976 (Counterclockwise)

Preceding gene: 91781913

Following gene: 91781910

Centisome position: 12.17

GC content: 67.59

Gene sequence:

>2067_bases
ATGTCCGAATTCTCCGAAACGCCTGCCGGCCTCGACACCGCAGCCGCGCCCGCGGTTTCCGCCGCCACGCCCGCGCCGCG
CCCGTTGCGCGCGATCCAGCCCCTTCCCGATCAGTTGATCAGTCAGATTGCCGCCGGCGAAGTGGTCGAGCGGCCCGCTT
CGGTCGTCAAGGAGCTGCTGGAAAATGCACTCGACGCGGGCGCGCAGTCGCTGCGCATCCTGCTCGACGAAGGCGGCGTC
AAACGCATCTCGATCACCGACGACGGCTGCGGCATCCCCGAGAACGAACTCGCGCTGGCGCTGATGCGTCACGCCACCAG
CAAAATCCGCTCGCTCGCCGAACTGGAAGCGGTCGCTACGCTGGGGTTCCGCGGCGAGGCGCTGGCCTCGATCGCCTCGG
TCGCGCAGATGACCATCACGAGCCGCACGGCCGACGCGGCGCACGCGGTGCGCGTGGATGCGCAAACCGGCGTGCTGAGT
CCCGCGGCCGGCACCCAGGGCACCACGATCGAAGTCCGCGAGTTGTACTTCAATACGCCGGCGCGCCGTAAATTTCTGAA
GAGCGAGCAGACCGAACTCGGCCATTGTCTCGAACAGATCCGCCGCGCCGCGCTGGCGCGGCCGGATGTCGCGATTTCGG
TGCTGCATAACGGCAAGGCGGTCGAACACTGGAACGCCAGCGAGCCGCCCGTGCGGGTCGCGAAGATTCTCGGCGACACG
TTTGCCACCGCTCATCTGCCGCTCGACGAATCCGCCGGACCGCTTGCGGTCTACGGTTGCGCGGGTCTGCCGACCGCGAG
CCGCGGGCGTGCCGATCAGCAGTATTTCTTCGTCAACGGCCGCTTCGTGCGCGACAAGCTGCTCACGCACGCCGTGCGCG
CCGCTTATGAAGACGTGCTGCATGGCGAGCGCTATCCGTCCTACGTGCTGTTCCTCGACCTGCCGCCTGAAGCGGTCGAT
GTGAACGTGCATCCGTCGAAAATCGAGGTGCGCTTCCGCGATTCGCGCTCGATTCACCAGTTCGTCTTCCACGCCGTGCA
GCGCGCGCTGGCGCGGCATGCGGGCGCATCGCCGGAAACGACGGCGGGCGGGCATGCGGCGCATCTGGCGCCTTCCGTTA
GCGGGCCGGCTTCGTTTGGCGCGACGCCACTGGGCGGCGCGGGCGTCGGCGGCGTCGGCTTCGGTGCTGGCAACGGCGCT
GGCGGCATCGGTGGCGGCTTGGGTGGCGCATCGGGCGGCGGCTTCGGATCGTCGTCGCAGCAGCCCGGCAATACCTGGAT
GCGCCAGGCGCGCATGACGCAAGGCACGCTGCCGGTTGCCCAACCGCTCGCGTTTTACGACGCGCTCTTCGGCCGCAAAG
ATACGAACGCGGGCACGGCGGAAGGCGCCACGCTTTTCGAGGCGCGCGATTCGGCCGCCGAAGCACCGTCACCGTACAAC
GCGTCCGCGCCGTACCCGGCGCCCGCTTTCCATGCCGCCGACGAGCAACCGCTCGGCTTCGCGCTCGGCCAGATCCACGG
CATCTATGTGCTGGCCCAGAACGCGCACGGTCTGGTGATCGTCGACATGCACGCCGCGCACGAGCGCATTCTGTACGAGC
AGTTCAAGAACGCGCTGGCCGATCGCACGATCGCCGTGCAACCGCTGCTGATCCCGCAGTCCATGCAGGCCGATCCGGTC
GAAATCGGTACGGTGGAAGAAGAGCGCGACACACTCGACGCACTCGGCTTCGATCTCGCCGTGCTGTCGCCGACCACACT
CGCCATCCGCGCCGTACCGGCGCTGCTGAAAGACGCCGATCTGCAGGCGCTGGCGCGCGCGGTCCTCTCCGACCTGCATG
CATTCGGCGGCTCGCGCGTACTGACCGAACGTCAGCACGAACTGCTCGGCACGCTCGCCTGCCATCACGCGGTGCGCGCG
AACCGGCGTCTGACGCTCGACGAAATGAACGCGCTGCTGCGTCAGATGGAAGCCACCGAGCGCGCCGATCAATGCAATCA
CGGACGTCCCACGTGGTATCAGTTGACGCTGTCCGATCTCGATCGGCTGTTCATGCGTGGTCAGTGA

Upstream 100 bases:

>100_bases
CATGATACAGAAAGTGCCCGGCGGCATTTAAAAATCTCCCGCGCCACGGTGCGCTTGCGCGCGCCGCGAGCTTGCCGCGC
CGAATCGCTATAATTTCGCC

Downstream 100 bases:

>100_bases
CGTGACGCTGCTGCAACCGCCGCTGCAACGCACGCCCGCCTGCCCATGACTTCACGCACGCCTACCACCGTCCCGTGTCT
GCTCGGCCCGACTGCATCCG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MSEFSETPAGLDTAAAPAVSAATPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGAQSLRILLDEGGV
KRISITDDGCGIPENELALALMRHATSKIRSLAELEAVATLGFRGEALASIASVAQMTITSRTADAAHAVRVDAQTGVLS
PAAGTQGTTIEVRELYFNTPARRKFLKSEQTELGHCLEQIRRAALARPDVAISVLHNGKAVEHWNASEPPVRVAKILGDT
FATAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGERYPSYVLFLDLPPEAVD
VNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPSVSGPASFGATPLGGAGVGGVGFGAGNGA
GGIGGGLGGASGGGFGSSSQQPGNTWMRQARMTQGTLPVAQPLAFYDALFGRKDTNAGTAEGATLFEARDSAAEAPSPYN
ASAPYPAPAFHAADEQPLGFALGQIHGIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTIAVQPLLIPQSMQADPV
EIGTVEEERDTLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLSDLHAFGGSRVLTERQHELLGTLACHHAVRA
NRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLSDLDRLFMRGQ

Sequences:

>Translated_688_residues
MSEFSETPAGLDTAAAPAVSAATPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGAQSLRILLDEGGV
KRISITDDGCGIPENELALALMRHATSKIRSLAELEAVATLGFRGEALASIASVAQMTITSRTADAAHAVRVDAQTGVLS
PAAGTQGTTIEVRELYFNTPARRKFLKSEQTELGHCLEQIRRAALARPDVAISVLHNGKAVEHWNASEPPVRVAKILGDT
FATAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGERYPSYVLFLDLPPEAVD
VNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPSVSGPASFGATPLGGAGVGGVGFGAGNGA
GGIGGGLGGASGGGFGSSSQQPGNTWMRQARMTQGTLPVAQPLAFYDALFGRKDTNAGTAEGATLFEARDSAAEAPSPYN
ASAPYPAPAFHAADEQPLGFALGQIHGIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTIAVQPLLIPQSMQADPV
EIGTVEEERDTLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLSDLHAFGGSRVLTERQHELLGTLACHHAVRA
NRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLSDLDRLFMRGQ
>Mature_687_residues
SEFSETPAGLDTAAAPAVSAATPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENALDAGAQSLRILLDEGGVK
RISITDDGCGIPENELALALMRHATSKIRSLAELEAVATLGFRGEALASIASVAQMTITSRTADAAHAVRVDAQTGVLSP
AAGTQGTTIEVRELYFNTPARRKFLKSEQTELGHCLEQIRRAALARPDVAISVLHNGKAVEHWNASEPPVRVAKILGDTF
ATAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGERYPSYVLFLDLPPEAVDV
NVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPSVSGPASFGATPLGGAGVGGVGFGAGNGAG
GIGGGLGGASGGGFGSSSQQPGNTWMRQARMTQGTLPVAQPLAFYDALFGRKDTNAGTAEGATLFEARDSAAEAPSPYNA
SAPYPAPAFHAADEQPLGFALGQIHGIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTIAVQPLLIPQSMQADPVE
IGTVEEERDTLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLSDLHAFGGSRVLTERQHELLGTLACHHAVRAN
RRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLSDLDRLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=36.0606060606061, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI189458898, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI4505911, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=26.5129682997118, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=26.5129682997118, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI189458896, Length=338, Percent_Identity=28.9940828402367, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=33.1914893617021, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=24.6666666666667, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=51.0574018126888, Blast_Score=311, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.6875, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=409, Percent_Identity=23.4718826405868, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=314, Percent_Identity=34.7133757961783, Blast_Score=177, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=26.5927977839335, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=707, Percent_Identity=20.0848656294201, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=449, Percent_Identity=23.162583518931, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=34.5161290322581, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17136970, Length=382, Percent_Identity=26.9633507853403, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 72856; Mature: 72725

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFSETPAGLDTAAAPAVSAATPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELL
CCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ENALDAGAQSLRILLDEGGVKRISITDDGCGIPENELALALMRHATSKIRSLAELEAVAT
HHHHHCCHHHEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFRGEALASIASVAQMTITSRTADAAHAVRVDAQTGVLSPAAGTQGTTIEVRELYFNTP
CCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCCCCCCEEEEHHHHHCCH
ARRKFLKSEQTELGHCLEQIRRAALARPDVAISVLHNGKAVEHWNASEPPVRVAKILGDT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCCHHHHHHHHHHH
FATAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVL
HHEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
HGERYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPET
CCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
TAGGHAAHLAPSVSGPASFGATPLGGAGVGGVGFGAGNGAGGIGGGLGGASGGGFGSSSQ
CCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPGNTWMRQARMTQGTLPVAQPLAFYDALFGRKDTNAGTAEGATLFEARDSAAEAPSPYN
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCC
ASAPYPAPAFHAADEQPLGFALGQIHGIYVLAQNAHGLVIVDMHAAHERILYEQFKNALA
CCCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHH
DRTIAVQPLLIPQSMQADPVEIGTVEEERDTLDALGFDLAVLSPTTLAIRAVPALLKDAD
CCEEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCC
LQALARAVLSDLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RADQCNHGRPTWYQLTLSDLDRLFMRGQ
HHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
SEFSETPAGLDTAAAPAVSAATPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELL
CCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ENALDAGAQSLRILLDEGGVKRISITDDGCGIPENELALALMRHATSKIRSLAELEAVAT
HHHHHCCHHHEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFRGEALASIASVAQMTITSRTADAAHAVRVDAQTGVLSPAAGTQGTTIEVRELYFNTP
CCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCCCCCCEEEEHHHHHCCH
ARRKFLKSEQTELGHCLEQIRRAALARPDVAISVLHNGKAVEHWNASEPPVRVAKILGDT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCCHHHHHHHHHHH
FATAHLPLDESAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVL
HHEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
HGERYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPET
CCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
TAGGHAAHLAPSVSGPASFGATPLGGAGVGGVGFGAGNGAGGIGGGLGGASGGGFGSSSQ
CCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPGNTWMRQARMTQGTLPVAQPLAFYDALFGRKDTNAGTAEGATLFEARDSAAEAPSPYN
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCC
ASAPYPAPAFHAADEQPLGFALGQIHGIYVLAQNAHGLVIVDMHAAHERILYEQFKNALA
CCCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHH
DRTIAVQPLLIPQSMQADPVEIGTVEEERDTLDALGFDLAVLSPTTLAIRAVPALLKDAD
CCEEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCC
LQALARAVLSDLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RADQCNHGRPTWYQLTLSDLDRLFMRGQ
HHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]