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The map label for this gene is cbbA [H]

Identifier: 91790459

GI number: 91790459

Start: 4910494

End: 4911558

Strand: Reverse

Name: cbbA [H]

Synonym: Bpro_4630

Alternate gene names: 91790459

Gene position: 4911558-4910494 (Counterclockwise)

Preceding gene: 91790460

Following gene: 91790458

Centisome position: 94.45

GC content: 62.63

Gene sequence:

>1065_bases
ATGGCACTCGTTTCGATGCGCGAGCTGCTGGACCATGCGGCAGTCAACACGTATGGCATTCCGGCTTTCAACGTCAACAA
CCTTGAGCAGGTCACCGCCATCATGCAGGCGGCGGACGAAGTCAACGCCCCGGTGATCATGCAGGCCAGCGCCGGTGCGC
GCAAGTATGCCGGCGAAGGTTTCCTGAAGCACCTGATCCAGGCCGCTGTCGAGAGTTTTCCGCACATCCCCGTGGTGATG
CACCAGGACCATGGCCAGAGCCCCGATGTGTGCCTGGGCGCCATCAAGCTGGGCTTCAGCTCGGTCATGATGGACGGCTC
GCTGATGGCCGACGGCAAGACCATTGCCGACTACGACTACAACATCGATGTCACCCGCAAGGTGGTTGAAATGGCCCATG
CGACCGGCGTCTCGGTCGAGGGCGAGCTCGGTTGCCTGGGCAGCCTGGAAACCATGCAGGGCGACAAGGAAGATGGCCAT
GGCACCGATGCCGTCATGACGCACGACCAGCTGCTGACCGACCCCGAGCAGGCGGCCGATTTCGTCAAGCGCACCCAGCT
GGATGCGCTGGCCATTGCCATCGGCACCAGTCACGGCGCCTACAAGTTCACGCGCAAGCCCACCGGTGACATCCTGGCCA
TCGAGCGCATCAAGGAAATCCACCGCCGCATCCCCAACACCCACCTGGTGATGCACGGCTCGTCCAGCGTGCCGCAGGAC
CTGCTGGCCATCATCCGCAACTACGGCGGCGACATGAAGGAAACCTACGGCGTGCCCGTGGAAGAAATCCAGAAGGCCAT
CAAGTTCGGCGTGCGCAAGATCAACATCGACACCGACATCCGCCTGGCGATGACAGCTGCCACGCGCAAATTCATGGCCG
AGAACCCCAGCAAATTCGACCCGCGCGAATGGCTCAAGCCGGCCACCGCCGCCGCCAAGGCCATCTGCAAGCAGCGTTAC
ATCGAGTTCGGCTGCGAGGGCCAGGCCAGCAAGATCAAGGGCGAGAGCCTGTCGGTCGTGGCGGCCAAATACGCCAAGGG
CGAACTGGCCCAGGTCGTGCATTAA

Upstream 100 bases:

>100_bases
TTACTTCGCGGTTACAGCCCCTGAACACAGCGCCTGCGCTGTCTGGCGGCCGCAGGACCCACCGTTTTTTACAGTGTTTT
AACTTTCTGGGGATTCGAAC

Downstream 100 bases:

>100_bases
GGCAACTGTCGCTGCCTGTTTTCGCCCCTTTTCCGTCTTTTTCCGCTTTCCCGCCTTCTCCGGATTGGCGATAATTCAAA
GCCCGTGCATGCCTTGAGCC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MALVSMRELLDHAAVNTYGIPAFNVNNLEQVTAIMQAADEVNAPVIMQASAGARKYAGEGFLKHLIQAAVESFPHIPVVM
HQDHGQSPDVCLGAIKLGFSSVMMDGSLMADGKTIADYDYNIDVTRKVVEMAHATGVSVEGELGCLGSLETMQGDKEDGH
GTDAVMTHDQLLTDPEQAADFVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHRRIPNTHLVMHGSSSVPQD
LLAIIRNYGGDMKETYGVPVEEIQKAIKFGVRKINIDTDIRLAMTAATRKFMAENPSKFDPREWLKPATAAAKAICKQRY
IEFGCEGQASKIKGESLSVVAAKYAKGELAQVVH

Sequences:

>Translated_354_residues
MALVSMRELLDHAAVNTYGIPAFNVNNLEQVTAIMQAADEVNAPVIMQASAGARKYAGEGFLKHLIQAAVESFPHIPVVM
HQDHGQSPDVCLGAIKLGFSSVMMDGSLMADGKTIADYDYNIDVTRKVVEMAHATGVSVEGELGCLGSLETMQGDKEDGH
GTDAVMTHDQLLTDPEQAADFVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHRRIPNTHLVMHGSSSVPQD
LLAIIRNYGGDMKETYGVPVEEIQKAIKFGVRKINIDTDIRLAMTAATRKFMAENPSKFDPREWLKPATAAAKAICKQRY
IEFGCEGQASKIKGESLSVVAAKYAKGELAQVVH
>Mature_353_residues
ALVSMRELLDHAAVNTYGIPAFNVNNLEQVTAIMQAADEVNAPVIMQASAGARKYAGEGFLKHLIQAAVESFPHIPVVMH
QDHGQSPDVCLGAIKLGFSSVMMDGSLMADGKTIADYDYNIDVTRKVVEMAHATGVSVEGELGCLGSLETMQGDKEDGHG
TDAVMTHDQLLTDPEQAADFVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHRRIPNTHLVMHGSSSVPQDL
LAIIRNYGGDMKETYGVPVEEIQKAIKFGVRKINIDTDIRLAMTAATRKFMAENPSKFDPREWLKPATAAAKAICKQRYI
EFGCEGQASKIKGESLSVVAAKYAKGELAQVVH

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=32.5227963525836, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1789526, Length=319, Percent_Identity=31.0344827586207, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788072, Length=341, Percent_Identity=29.6187683284457, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789293, Length=370, Percent_Identity=24.3243243243243, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38418; Mature: 38286

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVSMRELLDHAAVNTYGIPAFNVNNLEQVTAIMQAADEVNAPVIMQASAGARKYAGEG
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCH
FLKHLIQAAVESFPHIPVVMHQDHGQSPDVCLGAIKLGFSSVMMDGSLMADGKTIADYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCC
NIDVTRKVVEMAHATGVSVEGELGCLGSLETMQGDKEDGHGTDAVMTHDQLLTDPEQAAD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEECHHHHCCHHHHHH
FVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHRRIPNTHLVMHGSSSVPQD
HHHHHHHHHEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAIIRNYGGDMKETYGVPVEEIQKAIKFGVRKINIDTDIRLAMTAATRKFMAENPSKFD
HHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCEEEHHHHHHHHHHHCCCCCCC
PREWLKPATAAAKAICKQRYIEFGCEGQASKIKGESLSVVAAKYAKGELAQVVH
HHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
ALVSMRELLDHAAVNTYGIPAFNVNNLEQVTAIMQAADEVNAPVIMQASAGARKYAGEG
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCH
FLKHLIQAAVESFPHIPVVMHQDHGQSPDVCLGAIKLGFSSVMMDGSLMADGKTIADYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCC
NIDVTRKVVEMAHATGVSVEGELGCLGSLETMQGDKEDGHGTDAVMTHDQLLTDPEQAAD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEECHHHHCCHHHHHH
FVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHRRIPNTHLVMHGSSSVPQD
HHHHHHHHHEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAIIRNYGGDMKETYGVPVEEIQKAIKFGVRKINIDTDIRLAMTAATRKFMAENPSKFD
HHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCEEEHHHHHHHHHHHCCCCCCC
PREWLKPATAAAKAICKQRYIEFGCEGQASKIKGESLSVVAAKYAKGELAQVVH
HHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]