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The map label for this gene is lysR [H]

Identifier: 91790241

GI number: 91790241

Start: 4653741

End: 4654775

Strand: Direct

Name: lysR [H]

Synonym: Bpro_4408

Alternate gene names: 91790241

Gene position: 4653741-4654775 (Clockwise)

Preceding gene: 91790229

Following gene: 91790255

Centisome position: 89.49

GC content: 55.75

Gene sequence:

>1035_bases
GTGGCTACGTTATCCACCCATAACTTTTGGTTACTATTTGAGCCAGAACACGAAAAGGCAGTAGCTATGAAATTTCGACT
TATTGAGATCTTCAGGGCAATGATGGAATGCGGCACAGTTACAGCAGCAGCTCACTCGCTCAAGATCTCTCAGCCGGCGA
TGACAAAGCAACTCACCCAGCTGCAAAGCGAGCTTGACTTAGTACTCTTCGAACAGCGCGGTGGACGTCTGGTGCCGACA
GCAGAAGCGAGAGCCCTCATTGGTTCGATGGATCGGGCATGGCGCAGCGTCATCGAGTTGAAGGAAGTTGCCAGAGATGT
GCGCGACATGCGACGCGGCCGACTCACAGTAGTCGCTTCCCCGAGCTTCGCTCAGACGCTGATGGCCGATTTCGTCACTC
AGTTCTCTCGTGAATCGAGCAAGGTCACAATCGCGTTGCACGCGCAATCTTCACCTCGTGTGATTGACTGGACAGCTGAC
GGACAGGCAGATGTCGGAATATCAATGATCCTTGCGCCCCGTCCCGGCGTGCACGTGGAGCCGCTGGGAAGTCTTGTTGG
AGTTTGCGCGCTGCCAGTTGGCCACGCACTCGCTGCAAATAAGGTCATACGTGCGGAGGACCTCCATGGTCAGCGATTCA
TCTCATTAGCCGAGATTGATGATGCGCGCTCCCGGGTCGAAGCTGCATTCGATGGGCAAGCGATAGAACGCGATATCGCT
TTGACAACACCACAATCCGCAGTGGCATTAGCGCTTGTCACGCATGGCGCCGGCGTGGCGGTCATTGACGAGGCCACAGC
GACGATGGCTGACCTGACTCGGGTGGCCATCCGCCCATTCTTGCCTACGGTGAGCTTTGAAGTCTATATGTACCATCCCG
CGAATAGGGTGCCTTCACAGTTGCATGAGCGGTTTGTGCGAAAGTTTCGGACATGGTTTAAAGGCCGCCGTGCGATCGCG
AGAGCCACCATCACCACATCGTTGTCGCAAATATCTGCATCCCGCGCGGACTCGGCTCGTGCACGCGGCAAATAA

Upstream 100 bases:

>100_bases
ACGAAATCACGACGATCCATTCTTGCTCCTCAGTTGATCAGGCCCAAGCCCGTTATGCGACAAGTCTATGAACGAAGATT
CGGGGAAGTCCACGCCAAGC

Downstream 100 bases:

>100_bases
ATTTCGTGGATGCCAGATCGGCTGTGGTCATCAAGCGCACGCTCTGCGCAAGATAGTCTTCGGCTATGACGGAAAAACCA
ACGGTGAGCAGCATCACTAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MATLSTHNFWLLFEPEHEKAVAMKFRLIEIFRAMMECGTVTAAAHSLKISQPAMTKQLTQLQSELDLVLFEQRGGRLVPT
AEARALIGSMDRAWRSVIELKEVARDVRDMRRGRLTVVASPSFAQTLMADFVTQFSRESSKVTIALHAQSSPRVIDWTAD
GQADVGISMILAPRPGVHVEPLGSLVGVCALPVGHALAANKVIRAEDLHGQRFISLAEIDDARSRVEAAFDGQAIERDIA
LTTPQSAVALALVTHGAGVAVIDEATATMADLTRVAIRPFLPTVSFEVYMYHPANRVPSQLHERFVRKFRTWFKGRRAIA
RATITTSLSQISASRADSARARGK

Sequences:

>Translated_344_residues
MATLSTHNFWLLFEPEHEKAVAMKFRLIEIFRAMMECGTVTAAAHSLKISQPAMTKQLTQLQSELDLVLFEQRGGRLVPT
AEARALIGSMDRAWRSVIELKEVARDVRDMRRGRLTVVASPSFAQTLMADFVTQFSRESSKVTIALHAQSSPRVIDWTAD
GQADVGISMILAPRPGVHVEPLGSLVGVCALPVGHALAANKVIRAEDLHGQRFISLAEIDDARSRVEAAFDGQAIERDIA
LTTPQSAVALALVTHGAGVAVIDEATATMADLTRVAIRPFLPTVSFEVYMYHPANRVPSQLHERFVRKFRTWFKGRRAIA
RATITTSLSQISASRADSARARGK
>Mature_343_residues
ATLSTHNFWLLFEPEHEKAVAMKFRLIEIFRAMMECGTVTAAAHSLKISQPAMTKQLTQLQSELDLVLFEQRGGRLVPTA
EARALIGSMDRAWRSVIELKEVARDVRDMRRGRLTVVASPSFAQTLMADFVTQFSRESSKVTIALHAQSSPRVIDWTADG
QADVGISMILAPRPGVHVEPLGSLVGVCALPVGHALAANKVIRAEDLHGQRFISLAEIDDARSRVEAAFDGQAIERDIAL
TTPQSAVALALVTHGAGVAVIDEATATMADLTRVAIRPFLPTVSFEVYMYHPANRVPSQLHERFVRKFRTWFKGRRAIAR
ATITTSLSQISASRADSARARGK

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=284, Percent_Identity=31.3380281690141, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI157672245, Length=267, Percent_Identity=26.5917602996255, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=22.4066390041494, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 37763; Mature: 37632

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLSTHNFWLLFEPEHEKAVAMKFRLIEIFRAMMECGTVTAAAHSLKISQPAMTKQLTQ
CCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCHHHHHHHHH
LQSELDLVLFEQRGGRLVPTAEARALIGSMDRAWRSVIELKEVARDVRDMRRGRLTVVAS
HHHHHCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PSFAQTLMADFVTQFSRESSKVTIALHAQSSPRVIDWTADGQADVGISMILAPRPGVHVE
CHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCC
PLGSLVGVCALPVGHALAANKVIRAEDLHGQRFISLAEIDDARSRVEAAFDGQAIERDIA
HHHHHHHHHHHHHHHHHHHCCEEEHHCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHCCEE
LTTPQSAVALALVTHGAGVAVIDEATATMADLTRVAIRPFLPTVSFEVYMYHPANRVPSQ
EECCCHHHEEEEEECCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHH
LHERFVRKFRTWFKGRRAIARATITTSLSQISASRADSARARGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATLSTHNFWLLFEPEHEKAVAMKFRLIEIFRAMMECGTVTAAAHSLKISQPAMTKQLTQ
CEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCHHHHHHHHH
LQSELDLVLFEQRGGRLVPTAEARALIGSMDRAWRSVIELKEVARDVRDMRRGRLTVVAS
HHHHHCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PSFAQTLMADFVTQFSRESSKVTIALHAQSSPRVIDWTADGQADVGISMILAPRPGVHVE
CHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCC
PLGSLVGVCALPVGHALAANKVIRAEDLHGQRFISLAEIDDARSRVEAAFDGQAIERDIA
HHHHHHHHHHHHHHHHHHHCCEEEHHCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHCCEE
LTTPQSAVALALVTHGAGVAVIDEATATMADLTRVAIRPFLPTVSFEVYMYHPANRVPSQ
EECCCHHHEEEEEECCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHH
LHERFVRKFRTWFKGRRAIARATITTSLSQISASRADSARARGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]