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The map label for this gene is lysR [H]

Identifier: 91790216

GI number: 91790216

Start: 4623068

End: 4623979

Strand: Direct

Name: lysR [H]

Synonym: Bpro_4381

Alternate gene names: 91790216

Gene position: 4623068-4623979 (Clockwise)

Preceding gene: 91790204

Following gene: 91790221

Centisome position: 88.9

GC content: 64.69

Gene sequence:

>912_bases
TTGCGCCTCAGACAACTCGAAGCCTTCCGCGCCGTCATGCTGTGCCAGACCGTCACCCGCGCGGCCGACATGCTGTTCAT
TTCGCAGCCGGCCGTCACGCGCCTGCTCGCCGACCTGGAAGAAAGCGCGGGTTTCCCGCTCTTCGAACGCTCGCGCGGGC
GCCTGCATCCGACGGCCGAAGCGCAGCTGCTGTACGAGGAGGTCAACCGCTCACTGATCGGCGTCGAGCGCATTGCGCGT
ATGGCCCACGCCATCAAGACGCAGCAGCGCGGGGCGCTGCATGTGGCCGCGCCGCCGTCGATTGCGCTATCCTTCATGCC
GCGTGCAATCGGGCATTTCCTGAAGGAGCATGGCGAGATCAAGATCATGCTGGGGGTGTACGACTCGCGCACCATCGTGG
ACATGGTGATCGGCCAGCGCTGCGACGTGGGCATCGTCAACCTTTCCATCAGCAACACCGGCACGCACGGAGACAGCCTG
CTGTCGGCCGCGCATGTGTGCGCTGTGCCCGTCGGCCATCGCCTGGCCGGCCGCGAGGTGGTGGTGCCGGCCGACATCGA
AGGCGAACTCTTTCTTTCGCACCCGAGCTACCTCGGCACACGGCTGGTGATCGACGCCATGTTCGCGGCCCACGGCGTTA
AATACAAACCGGCGCAGGTGGAGGTCCAGGTCTCGGCCGCGCTGTGTTCGCTGGTGGCGGCAGGCCAGGGCATCTCGCTG
GTCGATGCAATCACGGCCATGGAATACAAGGGCAGTGACTTGCGCTTCATCCCCTTCGAGCCGTCGGTGCCGCTGGAGTT
TTCGGTGCTGACACCCTTGCAGCGCACCCCGACCAAGCTGGTCGAGCCCTTCATTGCGCATGTGCGCAAGTTCGCCATAG
CCGAACTGGATCCCCGGTTTCTGATGAAGTAG

Upstream 100 bases:

>100_bases
ACACTGACGAATTCAATGTTAGGTGGCAGTTTGATGTAAAACAAATACAATTATTTTTTTAGCCCATAACATTGTGTTAT
GGTTTTACCGGGGTTTTCCC

Downstream 100 bases:

>100_bases
GCTCGTGCCTCGGACAGCCCGAGCCTGACCTGGTGGCCAGCGCGTGAGTCGTCCACTGCATATCCGCCCAGATGCCGTAG
CGTCGTCATCCGGTAGGTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRLRQLEAFRAVMLCQTVTRAADMLFISQPAVTRLLADLEESAGFPLFERSRGRLHPTAEAQLLYEEVNRSLIGVERIAR
MAHAIKTQQRGALHVAAPPSIALSFMPRAIGHFLKEHGEIKIMLGVYDSRTIVDMVIGQRCDVGIVNLSISNTGTHGDSL
LSAAHVCAVPVGHRLAGREVVVPADIEGELFLSHPSYLGTRLVIDAMFAAHGVKYKPAQVEVQVSAALCSLVAAGQGISL
VDAITAMEYKGSDLRFIPFEPSVPLEFSVLTPLQRTPTKLVEPFIAHVRKFAIAELDPRFLMK

Sequences:

>Translated_303_residues
MRLRQLEAFRAVMLCQTVTRAADMLFISQPAVTRLLADLEESAGFPLFERSRGRLHPTAEAQLLYEEVNRSLIGVERIAR
MAHAIKTQQRGALHVAAPPSIALSFMPRAIGHFLKEHGEIKIMLGVYDSRTIVDMVIGQRCDVGIVNLSISNTGTHGDSL
LSAAHVCAVPVGHRLAGREVVVPADIEGELFLSHPSYLGTRLVIDAMFAAHGVKYKPAQVEVQVSAALCSLVAAGQGISL
VDAITAMEYKGSDLRFIPFEPSVPLEFSVLTPLQRTPTKLVEPFIAHVRKFAIAELDPRFLMK
>Mature_303_residues
MRLRQLEAFRAVMLCQTVTRAADMLFISQPAVTRLLADLEESAGFPLFERSRGRLHPTAEAQLLYEEVNRSLIGVERIAR
MAHAIKTQQRGALHVAAPPSIALSFMPRAIGHFLKEHGEIKIMLGVYDSRTIVDMVIGQRCDVGIVNLSISNTGTHGDSL
LSAAHVCAVPVGHRLAGREVVVPADIEGELFLSHPSYLGTRLVIDAMFAAHGVKYKPAQVEVQVSAALCSLVAAGQGISL
VDAITAMEYKGSDLRFIPFEPSVPLEFSVLTPLQRTPTKLVEPFIAHVRKFAIAELDPRFLMK

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=289, Percent_Identity=36.6782006920415, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=26.1410788381743, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI157672245, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=237, Percent_Identity=28.2700421940928, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081904, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788887, Length=266, Percent_Identity=25.187969924812, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788748, Length=293, Percent_Identity=25.5972696245734, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33153; Mature: 33153

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRQLEAFRAVMLCQTVTRAADMLFISQPAVTRLLADLEESAGFPLFERSRGRLHPTAE
CCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHH
AQLLYEEVNRSLIGVERIARMAHAIKTQQRGALHVAAPPSIALSFMPRAIGHFLKEHGEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCE
KIMLGVYDSRTIVDMVIGQRCDVGIVNLSISNTGTHGDSLLSAAHVCAVPVGHRLAGREV
EEEEEECCCCHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEE
VVPADIEGELFLSHPSYLGTRLVIDAMFAAHGVKYKPAQVEVQVSAALCSLVAAGQGISL
EEECCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCHH
VDAITAMEYKGSDLRFIPFEPSVPLEFSVLTPLQRTPTKLVEPFIAHVRKFAIAELDPRF
HHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
LMK
HCC
>Mature Secondary Structure
MRLRQLEAFRAVMLCQTVTRAADMLFISQPAVTRLLADLEESAGFPLFERSRGRLHPTAE
CCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHH
AQLLYEEVNRSLIGVERIARMAHAIKTQQRGALHVAAPPSIALSFMPRAIGHFLKEHGEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCE
KIMLGVYDSRTIVDMVIGQRCDVGIVNLSISNTGTHGDSLLSAAHVCAVPVGHRLAGREV
EEEEEECCCCHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEE
VVPADIEGELFLSHPSYLGTRLVIDAMFAAHGVKYKPAQVEVQVSAALCSLVAAGQGISL
EEECCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCHH
VDAITAMEYKGSDLRFIPFEPSVPLEFSVLTPLQRTPTKLVEPFIAHVRKFAIAELDPRF
HHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
LMK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]