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The map label for this gene is lysR [H]

Identifier: 91790221

GI number: 91790221

Start: 4629483

End: 4630361

Strand: Direct

Name: lysR [H]

Synonym: Bpro_4387

Alternate gene names: 91790221

Gene position: 4629483-4630361 (Clockwise)

Preceding gene: 91790216

Following gene: 91790229

Centisome position: 89.02

GC content: 55.52

Gene sequence:

>879_bases
ATGAACTTCAAGCAGATAGAAACATTTCGGGCCGTCATGCTTACGGGATCAATGACCGTAGCGGCGCAGCAACTTCATAC
CTCTCAGCCGAACGTCAGCCGCGGCATCGGCAAACTCGAGGCGGAGATCGGCTTCGAGCTCTTTGATCGCCTCGCAGGGC
GCCTGGTGGCAACCAAAGGCGGGGAGGCACTCTTCAAGGAAGTGGAGCGCGCGTTCGTTGGACTGGACAGTCTCACCGAA
TCAGCGCGCGCTATTCGGGAGTTGGGGGTGGGAACCCTCCGCGTTGCCGCAGCTGCCTCGATCTCTATGAGTGTCCTTCC
TCTGGCTATTCGCATGTTCAGCGAAAAATATCCATTGATCCGGATCGTTGTGGACACCAGCGAGTCATCCATCGTTGCTA
ACTGGATAGCCACTCAGCATTGCGACATTGGGTTCGTGTCCTATATTTCCGACAAGCCAGGTGTCGTGGCATCAGTGATC
CACACCGAGAATGCAGTTTGCGTCATGCCATCCCGTCACCCGCTTGCAAGGAAAAGGCGTCTTGTACCGCAAGACCTGAA
TGGTGAGCGGTTCATATCGCTCCCGAGCGGAAGCTCCTCTCGATGTGCGGTCGATGCTGCGTTTCCCGAGGAAGGTCGAA
TCATGGTGCTCGAAACCACTTACGCAGCGACAATATGCAGGATGGTCAGCGAGGGACTCGGCTTGAGTCTTTTGAATCCT
ATCGTTAGTCGCACAATGAAGCTTCCCGGGATCGTCGCCATCCCCTTCAAGCCGGACGTGCCTTTCAAGAGCTACATGCT
CAGGGCCCAGCTGGCACCGCGTGACACACACGTAAACTTCTTTGTTTCCTGCATGCGGACAGCCTTTAAGTCATTTTGA

Upstream 100 bases:

>100_bases
GCAAGTATCAAGAGAGAGCGTCATGGCGTCAAATGACAGTTTTCAAGTACTCAATACGCATTTGATATGACTCACATCGA
AAGAAGTACTATTAGCACCT

Downstream 100 bases:

>100_bases
TGGCGCTGGTCCACATGGACATCATTGAGTGCTGACCACGCTACAGGTTTGTCTGCAGACAGACTGACCCCTGACCCTTG
AGGATGCCCTTTCTCACTGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNFKQIETFRAVMLTGSMTVAAQQLHTSQPNVSRGIGKLEAEIGFELFDRLAGRLVATKGGEALFKEVERAFVGLDSLTE
SARAIRELGVGTLRVAAAASISMSVLPLAIRMFSEKYPLIRIVVDTSESSIVANWIATQHCDIGFVSYISDKPGVVASVI
HTENAVCVMPSRHPLARKRRLVPQDLNGERFISLPSGSSSRCAVDAAFPEEGRIMVLETTYAATICRMVSEGLGLSLLNP
IVSRTMKLPGIVAIPFKPDVPFKSYMLRAQLAPRDTHVNFFVSCMRTAFKSF

Sequences:

>Translated_292_residues
MNFKQIETFRAVMLTGSMTVAAQQLHTSQPNVSRGIGKLEAEIGFELFDRLAGRLVATKGGEALFKEVERAFVGLDSLTE
SARAIRELGVGTLRVAAAASISMSVLPLAIRMFSEKYPLIRIVVDTSESSIVANWIATQHCDIGFVSYISDKPGVVASVI
HTENAVCVMPSRHPLARKRRLVPQDLNGERFISLPSGSSSRCAVDAAFPEEGRIMVLETTYAATICRMVSEGLGLSLLNP
IVSRTMKLPGIVAIPFKPDVPFKSYMLRAQLAPRDTHVNFFVSCMRTAFKSF
>Mature_292_residues
MNFKQIETFRAVMLTGSMTVAAQQLHTSQPNVSRGIGKLEAEIGFELFDRLAGRLVATKGGEALFKEVERAFVGLDSLTE
SARAIRELGVGTLRVAAAASISMSVLPLAIRMFSEKYPLIRIVVDTSESSIVANWIATQHCDIGFVSYISDKPGVVASVI
HTENAVCVMPSRHPLARKRRLVPQDLNGERFISLPSGSSSRCAVDAAFPEEGRIMVLETTYAATICRMVSEGLGLSLLNP
IVSRTMKLPGIVAIPFKPDVPFKSYMLRAQLAPRDTHVNFFVSCMRTAFKSF

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=283, Percent_Identity=37.4558303886926, Blast_Score=193, Evalue=9e-51,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=29.2181069958848, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788481, Length=243, Percent_Identity=28.8065843621399, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI157672245, Length=260, Percent_Identity=25.7692307692308, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=24.1803278688525, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=29.9595141700405, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787530, Length=243, Percent_Identity=23.4567901234568, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790399, Length=266, Percent_Identity=23.3082706766917, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788887, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367136, Length=269, Percent_Identity=21.9330855018587, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790262, Length=195, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=298, Percent_Identity=22.8187919463087, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=217, Percent_Identity=25.8064516129032, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31912; Mature: 31912

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKQIETFRAVMLTGSMTVAAQQLHTSQPNVSRGIGKLEAEIGFELFDRLAGRLVATKG
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCC
GEALFKEVERAFVGLDSLTESARAIRELGVGTLRVAAAASISMSVLPLAIRMFSEKYPLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
RIVVDTSESSIVANWIATQHCDIGFVSYISDKPGVVASVIHTENAVCVMPSRHPLARKRR
EEEEECCCCCEEEHHHHHCCCCCCHHHHHCCCCCCEEEEEECCCEEEEECCCCCHHHHHC
LVPQDLNGERFISLPSGSSSRCAVDAAFPEEGRIMVLETTYAATICRMVSEGLGLSLLNP
CCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHH
IVSRTMKLPGIVAIPFKPDVPFKSYMLRAQLAPRDTHVNFFVSCMRTAFKSF
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFKQIETFRAVMLTGSMTVAAQQLHTSQPNVSRGIGKLEAEIGFELFDRLAGRLVATKG
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCC
GEALFKEVERAFVGLDSLTESARAIRELGVGTLRVAAAASISMSVLPLAIRMFSEKYPLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
RIVVDTSESSIVANWIATQHCDIGFVSYISDKPGVVASVIHTENAVCVMPSRHPLARKRR
EEEEECCCCCEEEHHHHHCCCCCCHHHHHCCCCCCEEEEEECCCEEEEECCCCCHHHHHC
LVPQDLNGERFISLPSGSSSRCAVDAAFPEEGRIMVLETTYAATICRMVSEGLGLSLLNP
CCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHH
IVSRTMKLPGIVAIPFKPDVPFKSYMLRAQLAPRDTHVNFFVSCMRTAFKSF
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]