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The map label for this gene is degS [H]

Identifier: 91790135

GI number: 91790135

Start: 4531513

End: 4532556

Strand: Reverse

Name: degS [H]

Synonym: Bpro_4297

Alternate gene names: 91790135

Gene position: 4532556-4531513 (Counterclockwise)

Preceding gene: 91790137

Following gene: 91790134

Centisome position: 87.16

GC content: 65.71

Gene sequence:

>1044_bases
ATGGACGCCACCGCCGCCCGGCTGGCGGGCCTGCTCGACTCGGCCATGGACGCCATCATTACGGTGGACGAAGAACAGCG
CATCGTGCTGTACAACCGTGCGGCTGAGAGAATCTTCGGCTGGCCGAGCGCACAGGCGATGGGGGAACACCTGGAAAAGC
TGATGCCGGAGCGCTTTCGCACCAGCCATGCCGGGCATATCCGCCGTTTTACCGCCACGGGCATCACGTCGAGGCGCATG
GGCGACGGCACCGTGCTTTACGGGCAGCGCGCCAACGGTGAAGAATTCCCGATGGAGGCCTCCATCTCCCAACTGGACAC
GGCGGACGGCAAGCTGTTCACCGTGATCCTGCGCGATGTCAGCGAACGGGTGCGCGCCCAGGAAGAACTGAGCGCCTTCG
CCGCTGCGGCCCACACCATTCGCGAAGGCGAGAAGACCCGCATTGCGCGGGAACTGCACGACGAGCTGGCCCAGTCGCTC
ACAGCCCTCAAGATGGACGCGATCTGGGTGCGCGACCAGCTGCCAGAGGGAGCGCAGGCGGCCGCAGCCAAGCTCGGTGA
CATGCTGGCTATGCTGGACACCACGGTCGCCGCCACCCGCCGCATCGCCTCGGACCTGCGCCCGCTGTTGCTGGACGACC
TGGGCCTGGGGCCGGCTATCGAATGGCTGGCTCAAAATTTCAGCCAGCGCTCCGGCGTGGCCTGCACGCTCTCGGTGGAT
GACGAGGTGGAACTGCACGAGCCTTATGCCACCGCGGTGTTCCGCATCGTGCAGGAGTCGCTGGCCAATGTGGCCAAGCA
TGCCGAAGCCTCGCGTGTCGAAGTAAAAATCGAGCGGACGGTGGAGGCGGTCACCCTGCGTGTCGCCGATAACGGCCGGG
GTTTTTCGCTGGCCGCACCGCGCAACCCCAACTCCCTGGGACTTCTGGGCTTGCGCGAGCGCGCACAGTTGCTCAAGGGG
GCGGTCACCATTGACAGCCAGCCGGGGCAGGGAACCCGTATTGATGTGCGGATCCCGATACGGGAAGTGGGAGCTGCGGA
TTGA

Upstream 100 bases:

>100_bases
GGTCGGTGACGCCACCGTGTCCCTGCCGTCGGTGGCCGCCGCGCCCGAGTTGGCCCGTGCCGGCGGCGGAGCTGTCCAGC
GTCCCGCAGGTGCAAGTGCA

Downstream 100 bases:

>100_bases
TCAGGATCGTCATTGTGGATGACCACGCCATTGTGCGGGAAGGTCTCAAACGCATCATTTCCTCGGCCGACGACATGGAG
GTGGCGGGCGAAGCCGCCAA

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDATAARLAGLLDSAMDAIITVDEEQRIVLYNRAAERIFGWPSAQAMGEHLEKLMPERFRTSHAGHIRRFTATGITSRRM
GDGTVLYGQRANGEEFPMEASISQLDTADGKLFTVILRDVSERVRAQEELSAFAAAAHTIREGEKTRIARELHDELAQSL
TALKMDAIWVRDQLPEGAQAAAAKLGDMLAMLDTTVAATRRIASDLRPLLLDDLGLGPAIEWLAQNFSQRSGVACTLSVD
DEVELHEPYATAVFRIVQESLANVAKHAEASRVEVKIERTVEAVTLRVADNGRGFSLAAPRNPNSLGLLGLRERAQLLKG
AVTIDSQPGQGTRIDVRIPIREVGAAD

Sequences:

>Translated_347_residues
MDATAARLAGLLDSAMDAIITVDEEQRIVLYNRAAERIFGWPSAQAMGEHLEKLMPERFRTSHAGHIRRFTATGITSRRM
GDGTVLYGQRANGEEFPMEASISQLDTADGKLFTVILRDVSERVRAQEELSAFAAAAHTIREGEKTRIARELHDELAQSL
TALKMDAIWVRDQLPEGAQAAAAKLGDMLAMLDTTVAATRRIASDLRPLLLDDLGLGPAIEWLAQNFSQRSGVACTLSVD
DEVELHEPYATAVFRIVQESLANVAKHAEASRVEVKIERTVEAVTLRVADNGRGFSLAAPRNPNSLGLLGLRERAQLLKG
AVTIDSQPGQGTRIDVRIPIREVGAAD
>Mature_347_residues
MDATAARLAGLLDSAMDAIITVDEEQRIVLYNRAAERIFGWPSAQAMGEHLEKLMPERFRTSHAGHIRRFTATGITSRRM
GDGTVLYGQRANGEEFPMEASISQLDTADGKLFTVILRDVSERVRAQEELSAFAAAAHTIREGEKTRIARELHDELAQSL
TALKMDAIWVRDQLPEGAQAAAAKLGDMLAMLDTTVAATRRIASDLRPLLLDDLGLGPAIEWLAQNFSQRSGVACTLSVD
DEVELHEPYATAVFRIVQESLANVAKHAEASRVEVKIERTVEAVTLRVADNGRGFSLAAPRNPNSLGLLGLRERAQLLKG
AVTIDSQPGQGTRIDVRIPIREVGAAD

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=197, Percent_Identity=32.48730964467, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788812, Length=201, Percent_Identity=29.3532338308458, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082311, Length=233, Percent_Identity=33.4763948497854, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37825; Mature: 37825

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATAARLAGLLDSAMDAIITVDEEQRIVLYNRAAERIFGWPSAQAMGEHLEKLMPERFR
CCCHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TSHAGHIRRFTATGITSRRMGDGTVLYGQRANGEEFPMEASISQLDTADGKLFTVILRDV
CCCCCHHEEEEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
SERVRAQEELSAFAAAAHTIREGEKTRIARELHDELAQSLTALKMDAIWVRDQLPEGAQA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCHHH
AAAKLGDMLAMLDTTVAATRRIASDLRPLLLDDLGLGPAIEWLAQNFSQRSGVACTLSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECC
DEVELHEPYATAVFRIVQESLANVAKHAEASRVEVKIERTVEAVTLRVADNGRGFSLAAP
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEEEEEEEEEECCCCCEEEECC
RNPNSLGLLGLRERAQLLKGAVTIDSQPGQGTRIDVRIPIREVGAAD
CCCCCCCEECHHHHHHHHHCCEEECCCCCCCCEEEEEECHHHCCCCC
>Mature Secondary Structure
MDATAARLAGLLDSAMDAIITVDEEQRIVLYNRAAERIFGWPSAQAMGEHLEKLMPERFR
CCCHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TSHAGHIRRFTATGITSRRMGDGTVLYGQRANGEEFPMEASISQLDTADGKLFTVILRDV
CCCCCHHEEEEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
SERVRAQEELSAFAAAAHTIREGEKTRIARELHDELAQSLTALKMDAIWVRDQLPEGAQA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCHHH
AAAKLGDMLAMLDTTVAATRRIASDLRPLLLDDLGLGPAIEWLAQNFSQRSGVACTLSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECC
DEVELHEPYATAVFRIVQESLANVAKHAEASRVEVKIERTVEAVTLRVADNGRGFSLAAP
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEEEEEEEEEECCCCCEEEECC
RNPNSLGLLGLRERAQLLKGAVTIDSQPGQGTRIDVRIPIREVGAAD
CCCCCCCEECHHHHHHHHHCCEEECCCCCCCCEEEEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]