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The map label for this gene is uvrY [H]

Identifier: 91790134

GI number: 91790134

Start: 4530872

End: 4531516

Strand: Reverse

Name: uvrY [H]

Synonym: Bpro_4296

Alternate gene names: 91790134

Gene position: 4531516-4530872 (Counterclockwise)

Preceding gene: 91790135

Following gene: 91790133

Centisome position: 87.14

GC content: 64.5

Gene sequence:

>645_bases
TTGATCAGGATCGTCATTGTGGATGACCACGCCATTGTGCGGGAAGGTCTCAAACGCATCATTTCCTCGGCCGACGACAT
GGAGGTGGCGGGCGAAGCCGCCAATGGCGCCGAGGCCATGCAGCGCGTGCGCGAACTGGCCTTCGACGTACTGATGCTGG
ACCTGTCCATGCCGGGGCGCAGCGGCATGGAGTTGATCAAGCTGGTCCGTGCTGAGAAGCCCAAGCTGCGCATCCTGGTG
CTGAGCATGCACCAGGAGCTGCAGTACGCCGTGCGCGCCATCAAGTCCGGCGCCAGTGGCTACCTGACCAAGGAGAGCGC
GCCGGCGCAGCTGGAGCAGGCCATCCGCAAGATCGCCGCCGGCGGTGCTTTCATCAGTGCCGAAGTCGCCGAGCAGCTGG
CCCTGGGTGCCATGCCGGGCAGCGAGGTCGCCGCGCACGGAAGCCTGTCGGACCGTGAATTCGAAGTGTTCCGCCTGCTG
GTCGCGGGGGTGTCGGTGACCGAGATTGCGGGTCGGCTCAACCTGTCGGTCAAGACCGTCAGCACGCACAAGGCCAACCT
GATGCACAAGATGGGCCTGCATAACCAAAGCGAGTTGATCCGCTACGCGATGCGGCACGGCCTGACCGACCAGTTCGAGC
CCTAG

Upstream 100 bases:

>100_bases
GCGCACAGTTGCTCAAGGGGGCGGTCACCATTGACAGCCAGCCGGGGCAGGGAACCCGTATTGATGTGCGGATCCCGATA
CGGGAAGTGGGAGCTGCGGA

Downstream 100 bases:

>100_bases
CCCGCTCGGAAAATTCCTAGGCGCACTGAGGCGCCGGCCGAGGCGATTTTAGGGACGCGCCGAGGGGCATTTTCCACCGG
CGCCGATGGTCTGGCATTCG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIRIVIVDDHAIVREGLKRIISSADDMEVAGEAANGAEAMQRVRELAFDVLMLDLSMPGRSGMELIKLVRAEKPKLRILV
LSMHQELQYAVRAIKSGASGYLTKESAPAQLEQAIRKIAAGGAFISAEVAEQLALGAMPGSEVAAHGSLSDREFEVFRLL
VAGVSVTEIAGRLNLSVKTVSTHKANLMHKMGLHNQSELIRYAMRHGLTDQFEP

Sequences:

>Translated_214_residues
MIRIVIVDDHAIVREGLKRIISSADDMEVAGEAANGAEAMQRVRELAFDVLMLDLSMPGRSGMELIKLVRAEKPKLRILV
LSMHQELQYAVRAIKSGASGYLTKESAPAQLEQAIRKIAAGGAFISAEVAEQLALGAMPGSEVAAHGSLSDREFEVFRLL
VAGVSVTEIAGRLNLSVKTVSTHKANLMHKMGLHNQSELIRYAMRHGLTDQFEP
>Mature_214_residues
MIRIVIVDDHAIVREGLKRIISSADDMEVAGEAANGAEAMQRVRELAFDVLMLDLSMPGRSGMELIKLVRAEKPKLRILV
LSMHQELQYAVRAIKSGASGYLTKESAPAQLEQAIRKIAAGGAFISAEVAEQLALGAMPGSEVAAHGSLSDREFEVFRLL
VAGVSVTEIAGRLNLSVKTVSTHKANLMHKMGLHNQSELIRYAMRHGLTDQFEP

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=35.5450236966825, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=35.6435643564356, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=30.622009569378, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788521, Length=195, Percent_Identity=33.8461538461538, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788546, Length=208, Percent_Identity=32.2115384615385, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=35.1648351648352, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788712, Length=204, Percent_Identity=26.4705882352941, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082052, Length=228, Percent_Identity=27.6315789473684, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=32.1428571428571, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23270; Mature: 23270

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIVIVDDHAIVREGLKRIISSADDMEVAGEAANGAEAMQRVRELAFDVLMLDLSMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
SGMELIKLVRAEKPKLRILVLSMHQELQYAVRAIKSGASGYLTKESAPAQLEQAIRKIAA
CHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GGAFISAEVAEQLALGAMPGSEVAAHGSLSDREFEVFRLLVAGVSVTEIAGRLNLSVKTV
CCCHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCEEEEEE
STHKANLMHKMGLHNQSELIRYAMRHGLTDQFEP
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIRIVIVDDHAIVREGLKRIISSADDMEVAGEAANGAEAMQRVRELAFDVLMLDLSMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
SGMELIKLVRAEKPKLRILVLSMHQELQYAVRAIKSGASGYLTKESAPAQLEQAIRKIAA
CHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GGAFISAEVAEQLALGAMPGSEVAAHGSLSDREFEVFRLLVAGVSVTEIAGRLNLSVKTV
CCCHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCEEEEEE
STHKANLMHKMGLHNQSELIRYAMRHGLTDQFEP
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]