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The map label for this gene is hemE

Identifier: 91790102

GI number: 91790102

Start: 4495404

End: 4496513

Strand: Direct

Name: hemE

Synonym: Bpro_4264

Alternate gene names: 91790102

Gene position: 4495404-4496513 (Clockwise)

Preceding gene: 91790100

Following gene: 91790103

Centisome position: 86.45

GC content: 66.49

Gene sequence:

>1110_bases
ATGTTTGCACCACTTCAAAACGACACCTTTCTGCGTGCCTGCCTGCGCCAGGCCACCGACTACACGCCCGTCTGGCTGAT
GCGCCAGGCCGGCCGCTATTTGCCCGAATACCGCGCCACTCGCGCCCGTGCCGGCAGTTTCATGGGGCTGGCCACCAACA
CCGATTACGCCACCGAGGTCACGCTGCAGCCGCTGGAGCGTTACCCGCTGGACGCCGCCATCCTGTTTTCCGACATCCTG
ACCGTGCCCGATGCCATGGGGCTGGGCCTGTCATTTGCGCTCGGCGAAGGCCCGCGCTTTGCCACCCCCGTGCGCGACGA
GGCGGCGGTAGCCCGGCTGGAGGTGCCTGACATGGGCAAGCTGCGCTATGTGTTCGACGCCGTCACCTCGATCCGCAAGG
CCCTCAACGGCCGGGTGCCGCTGATCGGGTTTTCCGGCAGCCCCTGGACGCTGGCCTGCTACATGGTCGAGGGAGCGGGC
TCGGACGACTACCGGCTCGTCAAGACCATGCTGTACCAGCGCCCCGACCTGATGCACAAAATGCTGGCCGTCAACGCCGA
TGCGGTGGCCGCCTACCTGAACGCGCAGATTGAGGCCGGCGCCCAGGCCGTGATGATTTTTGACAGCTGGGGCGGCGTGC
TGGCCGACGCGGCCTTCCAGACCTTCAGCCTGGCCTACACCGCGCGCGTGCTGGGCCAGCTCAAGCGCGAGCACGATGGC
GTGAAGATTCCCCGCCTGGTCTTCACCAAAGGCGGCGGGCAGTGGCTGCAAGCCATGGCGGCCCTCGACTGCGAGGTGCT
GGGCCTAGACTGGACCGTCAACCTCGCCCAGGCCCGCGCGCGGGTCGGCGAGAACGGGCCCCATGCCAAGGCCCTGCAAG
GCAACCTGGACCCGAACGTGCTGTTTGCCAGCCCGGCCCAAATCGAAACCGAAGTGGCTGCCGTGCTGGACAGCTTTGGT
CGACCCCATCTGGATAGCAGCCAGCCCGGACCGACCCATATTTTCAACCTCGGCCACGGCATCAGCCAGCACACGCCACC
GGAAAGCGTCGAAGTGCTGGTCAACGCAGTGCACACTCACTCTCGCAGCATGCGCGCCGTCCGGACTTGA

Upstream 100 bases:

>100_bases
CGGCACCATGGTAAAGCTGAATCGCGGCGCTGGATAGACGACGCCTGCCCCCCATGCTGCCTGCCGCACCGCCCCTGCCG
ACACCTGAGACAATCTGCTC

Downstream 100 bases:

>100_bases
TGCCGTCTGCCGAGGCCAGGAAACACCTGATTGAGCCGTCATTTCACCCATGACTAGCACAAAATCAGCGCCTCGCGCTC
GGACTTATGCACAAAATCCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MFAPLQNDTFLRACLRQATDYTPVWLMRQAGRYLPEYRATRARAGSFMGLATNTDYATEVTLQPLERYPLDAAILFSDIL
TVPDAMGLGLSFALGEGPRFATPVRDEAAVARLEVPDMGKLRYVFDAVTSIRKALNGRVPLIGFSGSPWTLACYMVEGAG
SDDYRLVKTMLYQRPDLMHKMLAVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADAAFQTFSLAYTARVLGQLKREHDG
VKIPRLVFTKGGGQWLQAMAALDCEVLGLDWTVNLAQARARVGENGPHAKALQGNLDPNVLFASPAQIETEVAAVLDSFG
RPHLDSSQPGPTHIFNLGHGISQHTPPESVEVLVNAVHTHSRSMRAVRT

Sequences:

>Translated_369_residues
MFAPLQNDTFLRACLRQATDYTPVWLMRQAGRYLPEYRATRARAGSFMGLATNTDYATEVTLQPLERYPLDAAILFSDIL
TVPDAMGLGLSFALGEGPRFATPVRDEAAVARLEVPDMGKLRYVFDAVTSIRKALNGRVPLIGFSGSPWTLACYMVEGAG
SDDYRLVKTMLYQRPDLMHKMLAVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADAAFQTFSLAYTARVLGQLKREHDG
VKIPRLVFTKGGGQWLQAMAALDCEVLGLDWTVNLAQARARVGENGPHAKALQGNLDPNVLFASPAQIETEVAAVLDSFG
RPHLDSSQPGPTHIFNLGHGISQHTPPESVEVLVNAVHTHSRSMRAVRT
>Mature_369_residues
MFAPLQNDTFLRACLRQATDYTPVWLMRQAGRYLPEYRATRARAGSFMGLATNTDYATEVTLQPLERYPLDAAILFSDIL
TVPDAMGLGLSFALGEGPRFATPVRDEAAVARLEVPDMGKLRYVFDAVTSIRKALNGRVPLIGFSGSPWTLACYMVEGAG
SDDYRLVKTMLYQRPDLMHKMLAVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADAAFQTFSLAYTARVLGQLKREHDG
VKIPRLVFTKGGGQWLQAMAALDCEVLGLDWTVNLAQARARVGENGPHAKALQGNLDPNVLFASPAQIETEVAAVLDSFG
RPHLDSSQPGPTHIFNLGHGISQHTPPESVEVLVNAVHTHSRSMRAVRT

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=369, Percent_Identity=47.6964769647696, Blast_Score=313, Evalue=1e-85,
Organism=Escherichia coli, GI2367337, Length=360, Percent_Identity=59.1666666666667, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320252, Length=366, Percent_Identity=36.3387978142077, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI19921920, Length=362, Percent_Identity=40.3314917127072, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI221330099, Length=362, Percent_Identity=40.3314917127072, Blast_Score=258, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_POLSJ (Q123Y6)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_551054.1
- ProteinModelPortal:   Q123Y6
- SMR:   Q123Y6
- STRING:   Q123Y6
- GeneID:   4013066
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_4264
- NMPDR:   fig|296591.1.peg.4337
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q123Y6
- ProtClustDB:   PRK00115
- BioCyc:   PSP296591:BPRO_4264-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 40186; Mature: 40186

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 78-78 BINDING 154-154 BINDING 209-209 BINDING 339-339

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAPLQNDTFLRACLRQATDYTPVWLMRQAGRYLPEYRATRARAGSFMGLATNTDYATEV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCEEEE
TLQPLERYPLDAAILFSDILTVPDAMGLGLSFALGEGPRFATPVRDEAAVARLEVPDMGK
EECHHHHCCCHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCCCCHHEEEECCCCCCH
LRYVFDAVTSIRKALNGRVPLIGFSGSPWTLACYMVEGAGSDDYRLVKTMLYQRPDLMHK
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
MLAVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADAAFQTFSLAYTARVLGQLKREHDG
HHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VKIPRLVFTKGGGQWLQAMAALDCEVLGLDWTVNLAQARARVGENGPHAKALQGNLDPNV
CCCCEEEEECCCHHHHHHHHHCCCEEEECCEEEHHHHHHHHHCCCCCCCHHEECCCCCCE
LFASPAQIETEVAAVLDSFGRPHLDSSQPGPTHIFNLGHGISQHTPPESVEVLVNAVHTH
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
SRSMRAVRT
HHHHHHHCC
>Mature Secondary Structure
MFAPLQNDTFLRACLRQATDYTPVWLMRQAGRYLPEYRATRARAGSFMGLATNTDYATEV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCEEEE
TLQPLERYPLDAAILFSDILTVPDAMGLGLSFALGEGPRFATPVRDEAAVARLEVPDMGK
EECHHHHCCCHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCCCCHHEEEECCCCCCH
LRYVFDAVTSIRKALNGRVPLIGFSGSPWTLACYMVEGAGSDDYRLVKTMLYQRPDLMHK
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
MLAVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADAAFQTFSLAYTARVLGQLKREHDG
HHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VKIPRLVFTKGGGQWLQAMAALDCEVLGLDWTVNLAQARARVGENGPHAKALQGNLDPNV
CCCCEEEEECCCHHHHHHHHHCCCEEEECCEEEHHHHHHHHHCCCCCCCHHEECCCCCCE
LFASPAQIETEVAAVLDSFGRPHLDSSQPGPTHIFNLGHGISQHTPPESVEVLVNAVHTH
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
SRSMRAVRT
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA