Click here to switch to the map view.

The map label for this gene is fucA [C]

Identifier: 91789921

GI number: 91789921

Start: 4292474

End: 4293316

Strand: Reverse

Name: fucA [C]

Synonym: Bpro_4082

Alternate gene names: 91789921

Gene position: 4293316-4292474 (Counterclockwise)

Preceding gene: 91789923

Following gene: 91789919

Centisome position: 82.56

GC content: 61.8

Gene sequence:

>843_bases
ATGTCTGCAGTGCTTGAAGCGAGCCGCGATGTCCAGCTGGATGAAGCGCGAATTTCCATCTACCAACCGGAGCAGGCTGG
CCTGATTTATCCGTCAACCCCCCGGTTTTCAAATGCCGCCGAGGAGCGCCAGCACCTGAAAGAGCGGCTTGTCGCCGCGT
GCCGTGCGTTTGCCTTGCAGGGTTTCGATTACGGTTTTGCCGGGCACCTGACGGTACGTGACCCGGAGAACCCCGGCCTG
TACTGGACCAATCCCATGGCCGTGCATTTTTCCCAGGTCAAGGTGTCCAACCTGATTTTGGCCGATCACAGCGGCCAGGT
CGTTGAGGGCCGCCACGCGATCAATCGCGCCGGCTTTGTCCTGCATTCAGCCGTGCATGAGGCGCATCCGGATATCGTCG
CGATGTGCCACGCGCACACCGTCTACGGAACCGCTTTTGCCTCACTCGGCAAAAAGCTCGAGCCGATCAGCCAGGATGCG
GCAGCCTTCTTCGAAGACCATGTGGTCATTGGTGATGAGGCGGGCCAGGTGGCCGTGGAAGTCAAGGCAGGGCACAAGGT
GGCCCAGGCCTTCAAGGGTGTCAAGGCGGCCATCCACCAGAACCACGGGCTGCTCACGGCCAGCCGCCACAGCATCGAGG
CGGCCGCCTTCTGGTTCATCGCGCTGGAGCGCTGCTGCAAGCAACAGCTGATGATCGACGCAGCCGGCATTGCCCCGCGC
CTGGTGACGCCGGAGCGCGCCCGCTACAGCCGTGAACATGTGGGCAGCGAATACATCGGCTGGCTGCATTTCCAGCCGAT
CTGGGATCACCTGGTCAAAACCCAGCCGGACATGTTTGACTGA

Upstream 100 bases:

>100_bases
GGCCTTGGTTCGATGTGAAAACCGCAAGACGCCTTCCATGAGATTGATACAGAGACCAAAGACCAAAGACCTTAAGACCC
AAACTCAAAAGGAGCAAGAA

Downstream 100 bases:

>100_bases
TGACCGGTTGAATCCGGGCCAAAGGCAAAAGCGTGAAGTGCGCCTGCTGGAAGACCCGGGCATGTCCGGTGCCCAGTCAA
GCAGGATTGAAGGCTGCGGT

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSAVLEASRDVQLDEARISIYQPEQAGLIYPSTPRFSNAAEERQHLKERLVAACRAFALQGFDYGFAGHLTVRDPENPGL
YWTNPMAVHFSQVKVSNLILADHSGQVVEGRHAINRAGFVLHSAVHEAHPDIVAMCHAHTVYGTAFASLGKKLEPISQDA
AAFFEDHVVIGDEAGQVAVEVKAGHKVAQAFKGVKAAIHQNHGLLTASRHSIEAAAFWFIALERCCKQQLMIDAAGIAPR
LVTPERARYSREHVGSEYIGWLHFQPIWDHLVKTQPDMFD

Sequences:

>Translated_280_residues
MSAVLEASRDVQLDEARISIYQPEQAGLIYPSTPRFSNAAEERQHLKERLVAACRAFALQGFDYGFAGHLTVRDPENPGL
YWTNPMAVHFSQVKVSNLILADHSGQVVEGRHAINRAGFVLHSAVHEAHPDIVAMCHAHTVYGTAFASLGKKLEPISQDA
AAFFEDHVVIGDEAGQVAVEVKAGHKVAQAFKGVKAAIHQNHGLLTASRHSIEAAAFWFIALERCCKQQLMIDAAGIAPR
LVTPERARYSREHVGSEYIGWLHFQPIWDHLVKTQPDMFD
>Mature_279_residues
SAVLEASRDVQLDEARISIYQPEQAGLIYPSTPRFSNAAEERQHLKERLVAACRAFALQGFDYGFAGHLTVRDPENPGLY
WTNPMAVHFSQVKVSNLILADHSGQVVEGRHAINRAGFVLHSAVHEAHPDIVAMCHAHTVYGTAFASLGKKLEPISQDAA
AFFEDHVVIGDEAGQVAVEVKAGHKVAQAFKGVKAAIHQNHGLLTASRHSIEAAAFWFIALERCCKQQLMIDAAGIAPRL
VTPERARYSREHVGSEYIGWLHFQPIWDHLVKTQPDMFD

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=234, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI29826323, Length=234, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI29826321, Length=234, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI29826319, Length=234, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI89276787, Length=239, Percent_Identity=24.2677824267782, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI9257190, Length=228, Percent_Identity=24.5614035087719, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI297307160, Length=239, Percent_Identity=24.2677824267782, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115533216, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115533218, Length=192, Percent_Identity=27.6041666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363755, Length=214, Percent_Identity=27.5700934579439, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281363751, Length=214, Percent_Identity=27.5700934579439, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24655690, Length=214, Percent_Identity=27.5700934579439, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24655685, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281363763, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281363757, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136738, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281363761, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363759, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363753, Length=208, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 30945; Mature: 30814

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLEASRDVQLDEARISIYQPEQAGLIYPSTPRFSNAAEERQHLKERLVAACRAFALQ
CCCHHCCCCCCEEECCEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GFDYGFAGHLTVRDPENPGLYWTNPMAVHFSQVKVSNLILADHSGQVVEGRHAINRAGFV
CCCCCCEEEEEEECCCCCCEEECCCCEEEEEHEEEEEEEEECCCCCEECCHHHHHHHHHH
LHSAVHEAHPDIVAMCHAHTVYGTAFASLGKKLEPISQDAAAFFEDHVVIGDEAGQVAVE
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCEEEEE
VKAGHKVAQAFKGVKAAIHQNHGLLTASRHSIEAAAFWFIALERCCKQQLMIDAAGIAPR
EECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LVTPERARYSREHVGSEYIGWLHFQPIWDHLVKTQPDMFD
CCCCHHHHHHHHHCCCHHHEEEECCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAVLEASRDVQLDEARISIYQPEQAGLIYPSTPRFSNAAEERQHLKERLVAACRAFALQ
CCHHCCCCCCEEECCEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GFDYGFAGHLTVRDPENPGLYWTNPMAVHFSQVKVSNLILADHSGQVVEGRHAINRAGFV
CCCCCCEEEEEEECCCCCCEEECCCCEEEEEHEEEEEEEEECCCCCEECCHHHHHHHHHH
LHSAVHEAHPDIVAMCHAHTVYGTAFASLGKKLEPISQDAAAFFEDHVVIGDEAGQVAVE
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCEEEEE
VKAGHKVAQAFKGVKAAIHQNHGLLTASRHSIEAAAFWFIALERCCKQQLMIDAAGIAPR
EECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LVTPERARYSREHVGSEYIGWLHFQPIWDHLVKTQPDMFD
CCCCHHHHHHHHHCCCHHHEEEECCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]