Click here to switch to the map view.

The map label for this gene is yngG [H]

Identifier: 91789877

GI number: 91789877

Start: 4238394

End: 4239335

Strand: Direct

Name: yngG [H]

Synonym: Bpro_4037

Alternate gene names: 91789877

Gene position: 4238394-4239335 (Clockwise)

Preceding gene: 91789876

Following gene: 91789878

Centisome position: 81.5

GC content: 65.5

Gene sequence:

>942_bases
ATGACAACACGGATCTTCTTCAATGAAGTCGCCACGCGCGACGGCTTCCAGATCGAGCCGACCTTCATCCCGACCGATAC
CAAGGTGGCGCTGGTCGATGCCCTGAGTGAATGCGGCTACGCCAAGATCGAGGTCACTTCGTTCACCTCGCCCAAGGCGA
TCCCGATGCTGCGCGACGCCGAAGAAGTCATGGGCCGCATCCGCCGCGTGCCGGGCGTAGAGTACACGGTGCTGGTGCCC
AACCTGCGCGGGGCCGAGCGTGCGCTGGAGTCACGGGCCGATGAGCTTAACCTGGTCATGTCGACCTCCGAGACGCACAA
CCTGGCCAACCTGCGCATGCCGATGGCGCGCAGTTTTGCGGCGCTGTCGGACGTGATTGCGCATGTCGATGGCCGCACCC
CCATCAACGTCTCGCTGTCCTGCTGCTTTGGCTGCCCGATGGAAGGGGATGTGCCGCAGGAGAGGGTACTGGACTGGGCT
GCGCGCTTTGCCGACCTGGGCGTGCGCGGCATCACGATTTGCGACACCACCGGCATGGCGCACCCCGCGCAGGTCAGCCG
CATGGTGGAGGCCTTGCAAGAACGTTTTGAGCAGTTGCAACTCACCCTGCACTTCCACAACACGCGCGGCATGGGTCTGG
CCAATGTGCTGGCCGCGGTACAAGGCGGCATCACCCGCTTCGACGGCTCACTCGGCGGCCTGGGCGGCTGCCCCTACGCG
CCCGGCGCCAGCGGCAACATCAGCAGCGAAGATGCCATCCACATGCTGGCCGCCATGGGCTACGACACCGGCATCGATTT
GCCCAGATTGCTGGCAGTGGCGCGGCAGATGCCGCAGATCGTCGGCCACGAGGTACCGGGCCAGGTGGCCAAGGCGGGGC
GCATTGAAGACCTGCATCCGGCGCCGGAATTTGTGGCGGCCCTGCGGGAGCAGTTCGCGTGA

Upstream 100 bases:

>100_bases
ACACCGACGCCGTGCTGCATGAACTCGGCCTCACGCCTGAACAGATTCAGGGCCTCAAGGACAAAGGTATCGTTTCATGC
ACTGCTACAGGAGCCCAATC

Downstream 100 bases:

>100_bases
CCGATCATCTGGATCATCTGGTACTGACCACGTCCAACGAAACCGCCTGCGTCGATTTTTATACCCGGGTGCTGGGCATG
ACGCTGGAAAGTTTTGTGGG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTTRIFFNEVATRDGFQIEPTFIPTDTKVALVDALSECGYAKIEVTSFTSPKAIPMLRDAEEVMGRIRRVPGVEYTVLVP
NLRGAERALESRADELNLVMSTSETHNLANLRMPMARSFAALSDVIAHVDGRTPINVSLSCCFGCPMEGDVPQERVLDWA
ARFADLGVRGITICDTTGMAHPAQVSRMVEALQERFEQLQLTLHFHNTRGMGLANVLAAVQGGITRFDGSLGGLGGCPYA
PGASGNISSEDAIHMLAAMGYDTGIDLPRLLAVARQMPQIVGHEVPGQVAKAGRIEDLHPAPEFVAALREQFA

Sequences:

>Translated_313_residues
MTTRIFFNEVATRDGFQIEPTFIPTDTKVALVDALSECGYAKIEVTSFTSPKAIPMLRDAEEVMGRIRRVPGVEYTVLVP
NLRGAERALESRADELNLVMSTSETHNLANLRMPMARSFAALSDVIAHVDGRTPINVSLSCCFGCPMEGDVPQERVLDWA
ARFADLGVRGITICDTTGMAHPAQVSRMVEALQERFEQLQLTLHFHNTRGMGLANVLAAVQGGITRFDGSLGGLGGCPYA
PGASGNISSEDAIHMLAAMGYDTGIDLPRLLAVARQMPQIVGHEVPGQVAKAGRIEDLHPAPEFVAALREQFA
>Mature_312_residues
TTRIFFNEVATRDGFQIEPTFIPTDTKVALVDALSECGYAKIEVTSFTSPKAIPMLRDAEEVMGRIRRVPGVEYTVLVPN
LRGAERALESRADELNLVMSTSETHNLANLRMPMARSFAALSDVIAHVDGRTPINVSLSCCFGCPMEGDVPQERVLDWAA
RFADLGVRGITICDTTGMAHPAQVSRMVEALQERFEQLQLTLHFHNTRGMGLANVLAAVQGGITRFDGSLGGLGGCPYAP
GASGNISSEDAIHMLAAMGYDTGIDLPRLLAVARQMPQIVGHEVPGQVAKAGRIEDLHPAPEFVAALREQFA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=287, Percent_Identity=36.5853658536585, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI109150427, Length=287, Percent_Identity=36.5853658536585, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI62198232, Length=290, Percent_Identity=36.551724137931, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI260654708, Length=131, Percent_Identity=38.1679389312977, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17510563, Length=286, Percent_Identity=36.3636363636364, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24582381, Length=287, Percent_Identity=36.5853658536585, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33818; Mature: 33687

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIFFNEVATRDGFQIEPTFIPTDTKVALVDALSECGYAKIEVTSFTSPKAIPMLRDA
CCCEEEEHHHHCCCCCEECCEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHH
EEVMGRIRRVPGVEYTVLVPNLRGAERALESRADELNLVMSTSETHNLANLRMPMARSFA
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCHHHEEEEEECCCCCCHHHHCCHHHHHHH
ALSDVIAHVDGRTPINVSLSCCFGCPMEGDVPQERVLDWAARFADLGVRGITICDTTGMA
HHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCC
HPAQVSRMVEALQERFEQLQLTLHFHNTRGMGLANVLAAVQGGITRFDGSLGGLGGCPYA
CHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCC
PGASGNISSEDAIHMLAAMGYDTGIDLPRLLAVARQMPQIVGHEVPGQVAKAGRIEDLHP
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCC
APEFVAALREQFA
CHHHHHHHHHHCC
>Mature Secondary Structure 
TTRIFFNEVATRDGFQIEPTFIPTDTKVALVDALSECGYAKIEVTSFTSPKAIPMLRDA
CCEEEEHHHHCCCCCEECCEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHH
EEVMGRIRRVPGVEYTVLVPNLRGAERALESRADELNLVMSTSETHNLANLRMPMARSFA
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCHHHEEEEEECCCCCCHHHHCCHHHHHHH
ALSDVIAHVDGRTPINVSLSCCFGCPMEGDVPQERVLDWAARFADLGVRGITICDTTGMA
HHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCC
HPAQVSRMVEALQERFEQLQLTLHFHNTRGMGLANVLAAVQGGITRFDGSLGGLGGCPYA
CHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCC
PGASGNISSEDAIHMLAAMGYDTGIDLPRLLAVARQMPQIVGHEVPGQVAKAGRIEDLHP
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCC
APEFVAALREQFA
CHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]