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The map label for this gene is ywrD [H]

Identifier: 91789720

GI number: 91789720

Start: 4069259

End: 4070917

Strand: Reverse

Name: ywrD [H]

Synonym: Bpro_3878

Alternate gene names: 91789720

Gene position: 4070917-4069259 (Counterclockwise)

Preceding gene: 91789721

Following gene: 91789719

Centisome position: 78.28

GC content: 63.59

Gene sequence:

>1659_bases
GTGCCAGACATTGCCACCATCCTGTTTCAAACCCTTGATAATCCCGTGATGGACTTCAACTTCAGCAACCCCTACACCTC
GACCCGTATTCCCCTGTTTGCGCGCAATGTGGTTTCCACGTCCCATCCGCTGGGCGCGCAGGCCGGCCTGCGCATGCTGC
TCAAGGGGGGCAATGCGGTGGATGCAGCCATTGCGGCCGCCGCCGCCATGGCCATCGTGGAGCCGGTCAGCAATGGTCTG
GGGAGCGATTCTTTCTGCATCCTGTGGGACGGCAAGGACATGCATGGCCTGAACGCCTCGGGCCGCGCGCCGCAGAGCTG
GACGCCCGAGTACTTCAAGCGCAAATACGGTGACAGCGCCACCACGCCACCCAAGCGCGGGATGGATTCAGTCAGCGTGC
CCGGCGCCGTGGCGAGCTGGGTTGCCCTGAGTGAGCGTTTTGGTAAGCTGCCGTTCGCCGACCTGATGGAGCCTGCCATT
GAAATCGCCGAGCGCGGCTATCTTCTGTCGCCGGTGGTGCAGCAGAAGTGGGCGGCCGCTACGGCCGAGTTGCAGTCGCA
GCCCGGTTTTGCCGGTGCCTTCCTGCCCTGGGGCCGGGCGCCCAAGGTGGGCGAGCTGTTCCAGTTCAAGGCGGCGGCCA
AAGCCCTGCGGGCCATCGCCCAGACCCGGGGCGCCGCGTATTACGGCGGCGAGATCGCCCACGCCATTGAAAAATTCTCC
GCGCAAAACGGGGGCAGCATCACGGCGAAAGATTTTGAAGCCTACCAGCCTGAATGGATCCAGCCCATCACCAAGGACTA
CCGCGGCTACACCCTGCACGAGATTCCCCCCAACGGGCAAGGCATTGCGGCCCTGATTGCGCTGGGCATCCTGGACAAGT
TCGACGTCGCCGGCCTGCCCGTCGATGGTGTGGATTCGCAGCATCTGCAGATTGAAGCCATGAAGCTGGCATTTGCCGAC
GTGTACCGGTATGTGGCCGAGCCGTCGTCAATGGAGGTGACGGCCGCGCAAATGCTCGATGACGCCTACCTGGCATCCCG
TGCCAAACTCATCGACATGAAAAAGGCACAGGACTTTGGCGCTGGCAATCCGGTCAAGGGCGGCACGATTTACCTCACCG
CCGCCGACGAAGACGGCATGATGGTGAGCTTCATCCAGAGCAACTACATGGGCTTTGGCTCGGGCTGTGTCGAGCCTGAA
TTTGGCATCAGCCTGCAAAACCGCGGCCATGGCTTCAGCGTGCAGGCCGGCGTCAACCAGGTTGCACCCGGCAAGCGGCC
CTTTCACACCATCATCCCGGCCTTCCTCAGCAAGGACGGCCAGCCCGTGATGAGCTTCGGCGTGATGGGCGCCAACATGC
AGCCGCAGGGCCACCTGCAGACACTGGTGCGCATGCTGGACTATAGGCAGAGCCCGCAGGTGGCCTGCGATGCACCGCGC
TGGCGCTACAACGAGGGCCTTGAAATCAACGTCGAAGCCGCGATGAACCCAGCGACCGTCCAGGGGCTGGCCGGGCGCGG
CCACCGCATGGAGGTCATCAACGACTCCTACCAGGACTTCGGCGCCGGCCAGTTCATCTGGCGCGCCGGCAACCCCAAAG
TGGAAGGCTATGTGTCGGCGAGCGACGCCCGTCGCGATGGCCAGGCCGTGGGTTTCTAA

Upstream 100 bases:

>100_bases
TGCCGCCTCCGGGCGCTTTTTTTTTTCAGACTGATGATTCACTGTCTCGGCAACTTCGCACGCCTATCCCTGAAGGCACT
CTTTCGTGGGCACGTGAGGT

Downstream 100 bases:

>100_bases
AAGCGCATCTTGAGCGATATTTCAGAGTCAACAGCGCCTGCAAGCCAGGAAGCACAAGAACATAAAGCTGCAAAAAACAT
AGCATCCGGCCTGTTGCTCG

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MPDIATILFQTLDNPVMDFNFSNPYTSTRIPLFARNVVSTSHPLGAQAGLRMLLKGGNAVDAAIAAAAAMAIVEPVSNGL
GSDSFCILWDGKDMHGLNASGRAPQSWTPEYFKRKYGDSATTPPKRGMDSVSVPGAVASWVALSERFGKLPFADLMEPAI
EIAERGYLLSPVVQQKWAAATAELQSQPGFAGAFLPWGRAPKVGELFQFKAAAKALRAIAQTRGAAYYGGEIAHAIEKFS
AQNGGSITAKDFEAYQPEWIQPITKDYRGYTLHEIPPNGQGIAALIALGILDKFDVAGLPVDGVDSQHLQIEAMKLAFAD
VYRYVAEPSSMEVTAAQMLDDAYLASRAKLIDMKKAQDFGAGNPVKGGTIYLTAADEDGMMVSFIQSNYMGFGSGCVEPE
FGISLQNRGHGFSVQAGVNQVAPGKRPFHTIIPAFLSKDGQPVMSFGVMGANMQPQGHLQTLVRMLDYRQSPQVACDAPR
WRYNEGLEINVEAAMNPATVQGLAGRGHRMEVINDSYQDFGAGQFIWRAGNPKVEGYVSASDARRDGQAVGF

Sequences:

>Translated_552_residues
MPDIATILFQTLDNPVMDFNFSNPYTSTRIPLFARNVVSTSHPLGAQAGLRMLLKGGNAVDAAIAAAAAMAIVEPVSNGL
GSDSFCILWDGKDMHGLNASGRAPQSWTPEYFKRKYGDSATTPPKRGMDSVSVPGAVASWVALSERFGKLPFADLMEPAI
EIAERGYLLSPVVQQKWAAATAELQSQPGFAGAFLPWGRAPKVGELFQFKAAAKALRAIAQTRGAAYYGGEIAHAIEKFS
AQNGGSITAKDFEAYQPEWIQPITKDYRGYTLHEIPPNGQGIAALIALGILDKFDVAGLPVDGVDSQHLQIEAMKLAFAD
VYRYVAEPSSMEVTAAQMLDDAYLASRAKLIDMKKAQDFGAGNPVKGGTIYLTAADEDGMMVSFIQSNYMGFGSGCVEPE
FGISLQNRGHGFSVQAGVNQVAPGKRPFHTIIPAFLSKDGQPVMSFGVMGANMQPQGHLQTLVRMLDYRQSPQVACDAPR
WRYNEGLEINVEAAMNPATVQGLAGRGHRMEVINDSYQDFGAGQFIWRAGNPKVEGYVSASDARRDGQAVGF
>Mature_551_residues
PDIATILFQTLDNPVMDFNFSNPYTSTRIPLFARNVVSTSHPLGAQAGLRMLLKGGNAVDAAIAAAAAMAIVEPVSNGLG
SDSFCILWDGKDMHGLNASGRAPQSWTPEYFKRKYGDSATTPPKRGMDSVSVPGAVASWVALSERFGKLPFADLMEPAIE
IAERGYLLSPVVQQKWAAATAELQSQPGFAGAFLPWGRAPKVGELFQFKAAAKALRAIAQTRGAAYYGGEIAHAIEKFSA
QNGGSITAKDFEAYQPEWIQPITKDYRGYTLHEIPPNGQGIAALIALGILDKFDVAGLPVDGVDSQHLQIEAMKLAFADV
YRYVAEPSSMEVTAAQMLDDAYLASRAKLIDMKKAQDFGAGNPVKGGTIYLTAADEDGMMVSFIQSNYMGFGSGCVEPEF
GISLQNRGHGFSVQAGVNQVAPGKRPFHTIIPAFLSKDGQPVMSFGVMGANMQPQGHLQTLVRMLDYRQSPQVACDAPRW
RYNEGLEINVEAAMNPATVQGLAGRGHRMEVINDSYQDFGAGQFIWRAGNPKVEGYVSASDARRDGQAVGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=552, Percent_Identity=24.6376811594203, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI73915090, Length=552, Percent_Identity=24.6376811594203, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI73915096, Length=552, Percent_Identity=24.6376811594203, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI73915094, Length=552, Percent_Identity=24.6376811594203, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI109148539, Length=572, Percent_Identity=26.2237762237762, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI113429324, Length=540, Percent_Identity=24.2592592592593, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI113429326, Length=541, Percent_Identity=24.2144177449168, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI153266901, Length=549, Percent_Identity=22.7686703096539, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI153266885, Length=548, Percent_Identity=22.8102189781022, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI153266907, Length=545, Percent_Identity=21.8348623853211, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1789856, Length=497, Percent_Identity=28.169014084507, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17506189, Length=527, Percent_Identity=24.0986717267552, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17542894, Length=477, Percent_Identity=25.9958071278826, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI212646519, Length=494, Percent_Identity=23.4817813765182, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI72000294, Length=494, Percent_Identity=23.2793522267206, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193208245, Length=489, Percent_Identity=23.3128834355828, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193208247, Length=489, Percent_Identity=23.3128834355828, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24642670, Length=568, Percent_Identity=26.056338028169, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642666, Length=568, Percent_Identity=26.056338028169, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077878, Length=568, Percent_Identity=26.056338028169, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551474, Length=568, Percent_Identity=26.056338028169, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077880, Length=568, Percent_Identity=26.056338028169, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18859893, Length=496, Percent_Identity=24.7983870967742, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859741, Length=509, Percent_Identity=25.147347740668, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI161077496, Length=502, Percent_Identity=23.5059760956175, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59379; Mature: 59248

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIATILFQTLDNPVMDFNFSNPYTSTRIPLFARNVVSTSHPLGAQAGLRMLLKGGNAV
CCHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCHH
DAAIAAAAAMAIVEPVSNGLGSDSFCILWDGKDMHGLNASGRAPQSWTPEYFKRKYGDSA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
TTPPKRGMDSVSVPGAVASWVALSERFGKLPFADLMEPAIEIAERGYLLSPVVQQKWAAA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECHHHHHHHHHH
TAELQSQPGFAGAFLPWGRAPKVGELFQFKAAAKALRAIAQTRGAAYYGGEIAHAIEKFS
HHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHH
AQNGGSITAKDFEAYQPEWIQPITKDYRGYTLHEIPPNGQGIAALIALGILDKFDVAGLP
CCCCCEEEECCHHCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
VDGVDSQHLQIEAMKLAFADVYRYVAEPSSMEVTAAQMLDDAYLASRAKLIDMKKAQDFG
CCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGNPVKGGTIYLTAADEDGMMVSFIQSNYMGFGSGCVEPEFGISLQNRGHGFSVQAGVNQ
CCCCCCCCEEEEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCC
VAPGKRPFHTIIPAFLSKDGQPVMSFGVMGANMQPQGHLQTLVRMLDYRQSPQVACDAPR
CCCCCCCHHHHHHHHHCCCCCHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCCC
WRYNEGLEINVEAAMNPATVQGLAGRGHRMEVINDSYQDFGAGQFIWRAGNPKVEGYVSA
CCCCCCCEEEEEECCCCHHHHHHCCCCCEEEECCCCHHHCCCCEEEEECCCCCEEEEEEC
SDARRDGQAVGF
CCCCCCCCCCCC
>Mature Secondary Structure 
PDIATILFQTLDNPVMDFNFSNPYTSTRIPLFARNVVSTSHPLGAQAGLRMLLKGGNAV
CHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCHH
DAAIAAAAAMAIVEPVSNGLGSDSFCILWDGKDMHGLNASGRAPQSWTPEYFKRKYGDSA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
TTPPKRGMDSVSVPGAVASWVALSERFGKLPFADLMEPAIEIAERGYLLSPVVQQKWAAA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECHHHHHHHHHH
TAELQSQPGFAGAFLPWGRAPKVGELFQFKAAAKALRAIAQTRGAAYYGGEIAHAIEKFS
HHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHH
AQNGGSITAKDFEAYQPEWIQPITKDYRGYTLHEIPPNGQGIAALIALGILDKFDVAGLP
CCCCCEEEECCHHCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
VDGVDSQHLQIEAMKLAFADVYRYVAEPSSMEVTAAQMLDDAYLASRAKLIDMKKAQDFG
CCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGNPVKGGTIYLTAADEDGMMVSFIQSNYMGFGSGCVEPEFGISLQNRGHGFSVQAGVNQ
CCCCCCCCEEEEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCC
VAPGKRPFHTIIPAFLSKDGQPVMSFGVMGANMQPQGHLQTLVRMLDYRQSPQVACDAPR
CCCCCCCHHHHHHHHHCCCCCHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCCC
WRYNEGLEINVEAAMNPATVQGLAGRGHRMEVINDSYQDFGAGQFIWRAGNPKVEGYVSA
CCCCCCCEEEEEECCCCHHHHHHCCCCCEEEECCCCHHHCCCCEEEEECCCCCEEEEEEC
SDARRDGQAVGF
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]