Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 91789655

GI number: 91789655

Start: 4000253

End: 4001182

Strand: Direct

Name: gyaR [H]

Synonym: Bpro_3811

Alternate gene names: 91789655

Gene position: 4000253-4001182 (Clockwise)

Preceding gene: 91789654

Following gene: 91789657

Centisome position: 76.92

GC content: 63.44

Gene sequence:

>930_bases
ATGCAGGCTATCGTCAAAATTGGGACCTTTGCCGGAGAGCTTCAGCAGACCATTGACCGGGAATTCCAATGCCATGGGCC
TGAGGATATTGCGCGGGATGATGGGTTGCGCCAGTCCATCCGCGGACTGATCACCCGGAGCAACTACCAGGTGCCCTTGG
CGCTGCTGGAGTTGCTCCCGGCCCTGCAGGTCATCTCAACCTGCGGCGTAGGCTACGACGGCATCCCCGTGGCGTATGCC
CAGGCAAGAGGGATCGCCGTCACCCACACGCCGGGCGTGCTGGATGACGCCGTCTGCGAATTGGGCGTGGGCCTGCTGCT
GGGACTGCTGCGCGACATCCCCGCTTCAGACCGCTTTGTGCGTGACGGGCGATGGTCAGACAGTGCTTATCCGCTCACCA
CCAGCCTGGCCGGAAAGGCCGTTGGCATCGTCGGCCTGGGCCGCATTGGCCGGGGCATCGCGGCAAGGTTGCAGCCATTC
GGTGTAGCACTGGCTTATTCCGGGTCCCCAAAAATCGACGTTCCGTATCGCCATGTCCAGAGCGTGCTGGCACTGGCCGG
CGAATGCAGCATTCTCATCGTCTGCTGCAAGGGTGGAAGCGAGACCCGGCATCTGGTCAATGCGGAGATTCTGCAAGCCC
TTGGACCGGCTGGCTACCTCGTCAACATCGCGCGCGGCAGCGTCGTCGACGAAGAGGCATTGGTCCATGCATTGACGACG
GGTGGCATTCGCGCTGCGGCACTGGATGTGTTCGAGGACGAACCGCTGCGCAATTCTGCGCTGACGTCGCTTCCCAATGT
GCTTTTGTCGCCCCACGCCGGATCGGCCACCCGGGAAGCACGGACGGCCATGTTGCGTCTGACGCTGGACAACCTCCATG
CCGTCCTGAACGGGCAGCCAGCGCTGTCGCCCACGCCCCGCATCGGCTAG

Upstream 100 bases:

>100_bases
CGCAGGCTGTTCCTGCAGACCGTCACGCAAGCCGACAAGGGCGTCGATTTTGACTTTCTGAGGGCCGCAAAGATCACCGG
AAAAACGCCTCGATCCTGAC

Downstream 100 bases:

>100_bases
CCCGCGTCAGCGATTTGTTTCTTCCGGCGGCTGCTTGCTGCCGGCTTGATGGTCTGCTTGATGGTCTGGGTGGGGGCCTG
CTGTGGGACCGGCCTGGCAA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MQAIVKIGTFAGELQQTIDREFQCHGPEDIARDDGLRQSIRGLITRSNYQVPLALLELLPALQVISTCGVGYDGIPVAYA
QARGIAVTHTPGVLDDAVCELGVGLLLGLLRDIPASDRFVRDGRWSDSAYPLTTSLAGKAVGIVGLGRIGRGIAARLQPF
GVALAYSGSPKIDVPYRHVQSVLALAGECSILIVCCKGGSETRHLVNAEILQALGPAGYLVNIARGSVVDEEALVHALTT
GGIRAAALDVFEDEPLRNSALTSLPNVLLSPHAGSATREARTAMLRLTLDNLHAVLNGQPALSPTPRIG

Sequences:

>Translated_309_residues
MQAIVKIGTFAGELQQTIDREFQCHGPEDIARDDGLRQSIRGLITRSNYQVPLALLELLPALQVISTCGVGYDGIPVAYA
QARGIAVTHTPGVLDDAVCELGVGLLLGLLRDIPASDRFVRDGRWSDSAYPLTTSLAGKAVGIVGLGRIGRGIAARLQPF
GVALAYSGSPKIDVPYRHVQSVLALAGECSILIVCCKGGSETRHLVNAEILQALGPAGYLVNIARGSVVDEEALVHALTT
GGIRAAALDVFEDEPLRNSALTSLPNVLLSPHAGSATREARTAMLRLTLDNLHAVLNGQPALSPTPRIG
>Mature_309_residues
MQAIVKIGTFAGELQQTIDREFQCHGPEDIARDDGLRQSIRGLITRSNYQVPLALLELLPALQVISTCGVGYDGIPVAYA
QARGIAVTHTPGVLDDAVCELGVGLLLGLLRDIPASDRFVRDGRWSDSAYPLTTSLAGKAVGIVGLGRIGRGIAARLQPF
GVALAYSGSPKIDVPYRHVQSVLALAGECSILIVCCKGGSETRHLVNAEILQALGPAGYLVNIARGSVVDEEALVHALTT
GGIRAAALDVFEDEPLRNSALTSLPNVLLSPHAGSATREARTAMLRLTLDNLHAVLNGQPALSPTPRIG

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=39.9193548387097, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=35.7429718875502, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI61743967, Length=242, Percent_Identity=30.1652892561983, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4557497, Length=242, Percent_Identity=30.1652892561983, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=28.7937743190661, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=28.7937743190661, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=28.7937743190661, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI87082289, Length=303, Percent_Identity=34.6534653465347, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789279, Length=262, Percent_Identity=30.1526717557252, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787645, Length=266, Percent_Identity=25.187969924812, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081824, Length=145, Percent_Identity=33.1034482758621, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=28.7162162162162, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=260, Percent_Identity=27.3076923076923, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=308, Percent_Identity=33.4415584415584, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=284, Percent_Identity=26.7605633802817, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=254, Percent_Identity=27.9527559055118, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=175, Percent_Identity=30.8571428571429, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571528, Length=248, Percent_Identity=41.1290322580645, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=32.6771653543307, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=32.2709163346614, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=31.1284046692607, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=31.1284046692607, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=31.1284046692607, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=31.1284046692607, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=31.1284046692607, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19921140, Length=231, Percent_Identity=31.1688311688312, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=31.8367346938775, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=31.8367346938775, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=31.8367346938775, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=31.8367346938775, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=31.8367346938775, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32501; Mature: 32501

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIVKIGTFAGELQQTIDREFQCHGPEDIARDDGLRQSIRGLITRSNYQVPLALLELLP
CCCEEEHHHHHHHHHHHHCCCEECCCCHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHH
ALQVISTCGVGYDGIPVAYAQARGIAVTHTPGVLDDAVCELGVGLLLGLLRDIPASDRFV
HHHHHHHCCCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
RDGRWSDSAYPLTTSLAGKAVGIVGLGRIGRGIAARLQPFGVALAYSGSPKIDVPYRHVQ
CCCCCCCCCCCEEHHHCCCCEEEEEHHHHCHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
SVLALAGECSILIVCCKGGSETRHLVNAEILQALGPAGYLVNIARGSVVDEEALVHALTT
HHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHC
GGIRAAALDVFEDEPLRNSALTSLPNVLLSPHAGSATREARTAMLRLTLDNLHAVLNGQP
CCHHHHHHHHHCCCCCCHHHHHHCCHHHCCCCCCCHHHHHHHHHHEEEHHHHHHHHCCCC
ALSPTPRIG
CCCCCCCCC
>Mature Secondary Structure
MQAIVKIGTFAGELQQTIDREFQCHGPEDIARDDGLRQSIRGLITRSNYQVPLALLELLP
CCCEEEHHHHHHHHHHHHCCCEECCCCHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHH
ALQVISTCGVGYDGIPVAYAQARGIAVTHTPGVLDDAVCELGVGLLLGLLRDIPASDRFV
HHHHHHHCCCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
RDGRWSDSAYPLTTSLAGKAVGIVGLGRIGRGIAARLQPFGVALAYSGSPKIDVPYRHVQ
CCCCCCCCCCCEEHHHCCCCEEEEEHHHHCHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
SVLALAGECSILIVCCKGGSETRHLVNAEILQALGPAGYLVNIARGSVVDEEALVHALTT
HHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHC
GGIRAAALDVFEDEPLRNSALTSLPNVLLSPHAGSATREARTAMLRLTLDNLHAVLNGQP
CCHHHHHHHHHCCCCCCHHHHHHCCHHHCCCCCCCHHHHHHHHHHEEEHHHHHHHHCCCC
ALSPTPRIG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA