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The map label for this gene is ascD [H]

Identifier: 91789635

GI number: 91789635

Start: 3976427

End: 3977467

Strand: Direct

Name: ascD [H]

Synonym: Bpro_3790

Alternate gene names: 91789635

Gene position: 3976427-3977467 (Clockwise)

Preceding gene: 91789633

Following gene: 91789636

Centisome position: 76.47

GC content: 61.96

Gene sequence:

>1041_bases
ATGAGTTTCAACGTGAGCGTTCAGCCCAGCGGGCGGGTCTTTACCGCCGAGGCCGATGAGGCCCTGCTGGCTGCAGCGAT
TCGGCAGGGAATCGGTCTGCCCTACGGTTGCAAGGACGGCGCGTGCGGCTCCTGCAAATGCAAAAAGCTGGAAGGCACGG
TGACCCACGGCCCGCATCAGTTGAAAGCCTTGTCGCTCGAGGAAGCAGCCAGTGGCTTTATCCTGACCTGCTGCGCCACG
GCCCACTCCGATATCGTCATCGAGTCACGCCACGTCACCGACGAAAGCGCCTTTCCGGTCAAGAAGATGCCGGTGCGCAT
CAACAGCCTGGCCAAGGCCTCGCACGACGTGATGGTGGTGCGCCTGCAGCTGCCGGCCAGCGACGTCTTCAAATACCACG
CCGGCCAGTATGTGGAATTCCTGCTGCGCGATGGCGACCGCCGCGCCTACTCGGTGGGCAACGCGCCGCATACCCAGGCG
GAAAACCCCGGCCTGGAACTGCATATCCGCTACATGCCCGGCGGCAAGTTCACCGAGCATGTGTTTGGCCCCATGAAGGA
AAAGGAAATCCTGCGCATCGAAGGTCCCTTCGGCAGTTTTTACCTGCGCGAAGACAGCACCAAACCCATGGTGCTGCTGG
CTTCGGGCACCGGCTTTGCACCCATCAAGGCCATCATCGAACACATGCAGTTCAAGGGCATCACGCGCCCCGCCGTGCTG
TACTGGGGCGGCCGCCGCCCTGTCGACCTGTACATGAATGACTGGGTGCTCGGCAAGGTGGCCGAGATGCCGAATCTTCG
CTACGTGCCGGTGGTGTCCGATGCCCTCGCAGAAGATGCCTGGACGGGCCGTACCGGCTTCGTGCACAAGGCCGTGCTTG
AAGATTTCCCCGATCTCTCGGGTCATCAGGTCTACGCCTGTGGCGCACCGATTGTGGTGGACTCCGCGCAGGCCGATTAC
GCGGCAGCGGGCTTGCCTGCCGATGAGTTTTATGCGGACTCGTTCGTGACGGAAAAGGAAAAGGCACAAGCCGTGGTGTA
A

Upstream 100 bases:

>100_bases
AAAAGGCAGGGCGCCAAGGGGATTCAGGTTTGAGGGCAAAATTGGGGGTTGGCTGGAAAACCAGCCAGGTCAGACAACAG
AAACCGCAAGGATACCCAAT

Downstream 100 bases:

>100_bases
CGCGCAGGCGCACGCATGTGAGCAAACGGGACTCGGGCGCGGACTCATGGGCAGCCAGCCGGCTGTCAGGGTATGCCATA
GAGGCCACCTGCCAGGATTC

Product: CDP-6-deoxy-delta-3,4-glucoseen reductase

Products: NAD(P); FMNH2; 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: CDP-6-deoxy-delta-3,4-glucoseen reductase; E3 [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSFNVSVQPSGRVFTAEADEALLAAAIRQGIGLPYGCKDGACGSCKCKKLEGTVTHGPHQLKALSLEEAASGFILTCCAT
AHSDIVIESRHVTDESAFPVKKMPVRINSLAKASHDVMVVRLQLPASDVFKYHAGQYVEFLLRDGDRRAYSVGNAPHTQA
ENPGLELHIRYMPGGKFTEHVFGPMKEKEILRIEGPFGSFYLREDSTKPMVLLASGTGFAPIKAIIEHMQFKGITRPAVL
YWGGRRPVDLYMNDWVLGKVAEMPNLRYVPVVSDALAEDAWTGRTGFVHKAVLEDFPDLSGHQVYACGAPIVVDSAQADY
AAAGLPADEFYADSFVTEKEKAQAVV

Sequences:

>Translated_346_residues
MSFNVSVQPSGRVFTAEADEALLAAAIRQGIGLPYGCKDGACGSCKCKKLEGTVTHGPHQLKALSLEEAASGFILTCCAT
AHSDIVIESRHVTDESAFPVKKMPVRINSLAKASHDVMVVRLQLPASDVFKYHAGQYVEFLLRDGDRRAYSVGNAPHTQA
ENPGLELHIRYMPGGKFTEHVFGPMKEKEILRIEGPFGSFYLREDSTKPMVLLASGTGFAPIKAIIEHMQFKGITRPAVL
YWGGRRPVDLYMNDWVLGKVAEMPNLRYVPVVSDALAEDAWTGRTGFVHKAVLEDFPDLSGHQVYACGAPIVVDSAQADY
AAAGLPADEFYADSFVTEKEKAQAVV
>Mature_345_residues
SFNVSVQPSGRVFTAEADEALLAAAIRQGIGLPYGCKDGACGSCKCKKLEGTVTHGPHQLKALSLEEAASGFILTCCATA
HSDIVIESRHVTDESAFPVKKMPVRINSLAKASHDVMVVRLQLPASDVFKYHAGQYVEFLLRDGDRRAYSVGNAPHTQAE
NPGLELHIRYMPGGKFTEHVFGPMKEKEILRIEGPFGSFYLREDSTKPMVLLASGTGFAPIKAIIEHMQFKGITRPAVLY
WGGRRPVDLYMNDWVLGKVAEMPNLRYVPVVSDALAEDAWTGRTGFVHKAVLEDFPDLSGHQVYACGAPIVVDSAQADYA
AAGLPADEFYADSFVTEKEKAQAVV

Specific function: Participates in the conversion of CDP-6-deoxy-D-glycero- L-threo-4-hexulose to 3,6-dideoxy-D-glycero-D-glycero-4-hexulose together with CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) in two consecutive steps. The detailed mechanism of E3 is not

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI2367314, Length=190, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787658, Length=90, Percent_Identity=42.2222222222222, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.5.1.29 [C]

Molecular weight: Translated: 37675; Mature: 37544

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNVSVQPSGRVFTAEADEALLAAAIRQGIGLPYGCKDGACGSCKCKKLEGTVTHGPHQ
CCEEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCHH
LKALSLEEAASGFILTCCATAHSDIVIESRHVTDESAFPVKKMPVRINSLAKASHDVMVV
EEEEEHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHCCEEHHHHHCCCCCEEEE
RLQLPASDVFKYHAGQYVEFLLRDGDRRAYSVGNAPHTQAENPGLELHIRYMPGGKFTEH
EEECCHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHH
VFGPMKEKEILRIEGPFGSFYLREDSTKPMVLLASGTGFAPIKAIIEHMQFKGITRPAVL
HCCCCCCCEEEEEECCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEE
YWGGRRPVDLYMNDWVLGKVAEMPNLRYVPVVSDALAEDAWTGRTGFVHKAVLEDFPDLS
EECCCCCEEEEECCEEEEHHHCCCCCEEEEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
GHQVYACGAPIVVDSAQADYAAAGLPADEFYADSFVTEKEKAQAVV
CCEEEECCCCEEEECCCCCHHHCCCCHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure 
SFNVSVQPSGRVFTAEADEALLAAAIRQGIGLPYGCKDGACGSCKCKKLEGTVTHGPHQ
CEEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCHH
LKALSLEEAASGFILTCCATAHSDIVIESRHVTDESAFPVKKMPVRINSLAKASHDVMVV
EEEEEHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHCCEEHHHHHCCCCCEEEE
RLQLPASDVFKYHAGQYVEFLLRDGDRRAYSVGNAPHTQAENPGLELHIRYMPGGKFTEH
EEECCHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCHHH
VFGPMKEKEILRIEGPFGSFYLREDSTKPMVLLASGTGFAPIKAIIEHMQFKGITRPAVL
HCCCCCCCEEEEEECCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEE
YWGGRRPVDLYMNDWVLGKVAEMPNLRYVPVVSDALAEDAWTGRTGFVHKAVLEDFPDLS
EECCCCCEEEEECCEEEEHHHCCCCCEEEEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
GHQVYACGAPIVVDSAQADYAAAGLPADEFYADSFVTEKEKAQAVV
CCEEEECCCCEEEECCCCCHHHCCCCHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD(P)H2; FMN [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; FMN; 2 2-octaprenylphenol; O2 [C]

Specific reaction: NAD(P)H2 + FMN = NAD(P) + FMNH2 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10931327; 11586360; 12142430 [H]