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The map label for this gene is serA [H]

Identifier: 91789568

GI number: 91789568

Start: 3930279

End: 3931322

Strand: Reverse

Name: serA [H]

Synonym: Bpro_3722

Alternate gene names: 91789568

Gene position: 3931322-3930279 (Counterclockwise)

Preceding gene: 91789570

Following gene: 91789562

Centisome position: 75.6

GC content: 64.08

Gene sequence:

>1044_bases
GTGCGCAAACCACGCAATGAACAGGATCTGCAGGAAAAGGACAAAAAGGACAACTGGGTGGACATCTTACTTCTTGACGC
ATTGGTGCCGGAGGCCGTGACCTGGCTTCAAACCCGGCACAGCGTGGAATACCGTCCCGAACTGGCTGACGATCCCATCG
CCCTGCGCAAGGTGGCTTATAAAACCAGGGGCATTGTCTTTCCCAGGCAAACCGTCGTGACCCGGGGGTTTCTGGATTTC
CTGCCCAAGCTCAGGGCCGTTGGCCGCCTTCATGTTGGCACGGACAACATCGACATGGAAGCCTGCAAGGAGCGGGACAT
CAAGGTCGTACACGCCAACAGCGCCAATGTGCGCTCCAACGCCGAGTATTTGCTGAGCAGCCTGCTGCTGCTCTGCCGCC
GCGGTCTGGTGTCGGCCCTGATGGGCCACAAGCACCCCAGCGGCCAGATCGGGCGCGAGCTGCATGGCAGCACCGTCGGC
ATTCTGGGCCTGGCGCCGGCTGCGCATACGCTGGCCGGCATGCTGAGCGGCCTCGGCGTTCGCCTGATCGGCTACGACCC
GGCGGTGCACCATACCGCGCCCGTCTGGGAGCGTCTGGGCATTCAGCCCGTCTCCCTGCAAGAACTGGTGAGTCAGGCCG
ATGCGGTGTCGGTGCAGATGGTCTATGCCACGCGTTACAGGGGTTTCGTCAATGACAAATTGCTGTCCGCCTGCCGGCGA
GAGCAACTGTGGGTGGGCATCAGCCGCAGCGATCTGTTTGAGGAGGCGGCGCTGGCCGAAGCGCTGAGCGATGGCCGCAT
CGAGGCCTGCATTCTGGATGGCGTCGAGCCCGGCTTTGTGGGCGACACCTCGCCGCTCAAGGGCCTGAAGAATCTGTTTG
TCACCCCGCGCCTGGGGGCGTACACGCGGGAGGCGCGCTTGCGTGCGAGCTGGTACGTGGCGCACCGCATGCATGAAGCC
ATCGGGTCGCCACAGAGCGGGCTGGATTCGCTGCCCGCCGCGGCCTCACCGTCGCAGTGGCCCGAACCGGACCTCACGGT
GTAG

Upstream 100 bases:

>100_bases
TTGTTCAAGGTGAATTTTGGCATCGACTTTGATAGGTGAAAAAACTCAAGTGTTGCGGCTCAGGTAAAGCGCACGACGTC
GGACGACATCCCGAGTCGGC

Downstream 100 bases:

>100_bases
GCGGTTGACCCGCGACCCGGCGCCGGCACAGCGGCTCCGGCCTGCATGTGCGCTTATGCCAGACGTGCCAGCTGGTCCCT
GATTTTTTCCAGCGTCGCCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRKPRNEQDLQEKDKKDNWVDILLLDALVPEAVTWLQTRHSVEYRPELADDPIALRKVAYKTRGIVFPRQTVVTRGFLDF
LPKLRAVGRLHVGTDNIDMEACKERDIKVVHANSANVRSNAEYLLSSLLLLCRRGLVSALMGHKHPSGQIGRELHGSTVG
ILGLAPAAHTLAGMLSGLGVRLIGYDPAVHHTAPVWERLGIQPVSLQELVSQADAVSVQMVYATRYRGFVNDKLLSACRR
EQLWVGISRSDLFEEAALAEALSDGRIEACILDGVEPGFVGDTSPLKGLKNLFVTPRLGAYTREARLRASWYVAHRMHEA
IGSPQSGLDSLPAAASPSQWPEPDLTV

Sequences:

>Translated_347_residues
MRKPRNEQDLQEKDKKDNWVDILLLDALVPEAVTWLQTRHSVEYRPELADDPIALRKVAYKTRGIVFPRQTVVTRGFLDF
LPKLRAVGRLHVGTDNIDMEACKERDIKVVHANSANVRSNAEYLLSSLLLLCRRGLVSALMGHKHPSGQIGRELHGSTVG
ILGLAPAAHTLAGMLSGLGVRLIGYDPAVHHTAPVWERLGIQPVSLQELVSQADAVSVQMVYATRYRGFVNDKLLSACRR
EQLWVGISRSDLFEEAALAEALSDGRIEACILDGVEPGFVGDTSPLKGLKNLFVTPRLGAYTREARLRASWYVAHRMHEA
IGSPQSGLDSLPAAASPSQWPEPDLTV
>Mature_347_residues
MRKPRNEQDLQEKDKKDNWVDILLLDALVPEAVTWLQTRHSVEYRPELADDPIALRKVAYKTRGIVFPRQTVVTRGFLDF
LPKLRAVGRLHVGTDNIDMEACKERDIKVVHANSANVRSNAEYLLSSLLLLCRRGLVSALMGHKHPSGQIGRELHGSTVG
ILGLAPAAHTLAGMLSGLGVRLIGYDPAVHHTAPVWERLGIQPVSLQELVSQADAVSVQMVYATRYRGFVNDKLLSACRR
EQLWVGISRSDLFEEAALAEALSDGRIEACILDGVEPGFVGDTSPLKGLKNLFVTPRLGAYTREARLRASWYVAHRMHEA
IGSPQSGLDSLPAAASPSQWPEPDLTV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=286, Percent_Identity=28.6713286713287, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI145580578, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557499, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI145580575, Length=321, Percent_Identity=28.9719626168224, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI61743967, Length=278, Percent_Identity=30.5755395683453, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4557497, Length=278, Percent_Identity=30.5755395683453, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=28.1632653061224, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI87082289, Length=295, Percent_Identity=23.728813559322, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789279, Length=315, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787645, Length=187, Percent_Identity=26.2032085561497, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=29.8755186721992, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25147481, Length=244, Percent_Identity=29.0983606557377, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=346, Percent_Identity=23.4104046242775, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=22.3926380368098, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=248, Percent_Identity=28.2258064516129, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574286, Length=235, Percent_Identity=23.8297872340426, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=28.0575539568345, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=28.0575539568345, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=28.0575539568345, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=28.0575539568345, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=28.0575539568345, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=22.7272727272727, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=22.7272727272727, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552429, Length=242, Percent_Identity=22.7272727272727, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=22.7272727272727, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=22.7272727272727, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 38254; Mature: 38254

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPRNEQDLQEKDKKDNWVDILLLDALVPEAVTWLQTRHSVEYRPELADDPIALRKVAY
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
KTRGIVFPRQTVVTRGFLDFLPKLRAVGRLHVGTDNIDMEACKERDIKVVHANSANVRSN
HHCCCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHCCCEEEEECCCCCCCCC
AEYLLSSLLLLCRRGLVSALMGHKHPSGQIGRELHGSTVGILGLAPAAHTLAGMLSGLGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCE
RLIGYDPAVHHTAPVWERLGIQPVSLQELVSQADAVSVQMVYATRYRGFVNDKLLSACRR
EEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHEEEEEHHHHHCCHHHHHHHHHHHH
EQLWVGISRSDLFEEAALAEALSDGRIEACILDGVEPGFVGDTSPLKGLKNLFVTPRLGA
HHHEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCC
YTREARLRASWYVAHRMHEAIGSPQSGLDSLPAAASPSQWPEPDLTV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKPRNEQDLQEKDKKDNWVDILLLDALVPEAVTWLQTRHSVEYRPELADDPIALRKVAY
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
KTRGIVFPRQTVVTRGFLDFLPKLRAVGRLHVGTDNIDMEACKERDIKVVHANSANVRSN
HHCCCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHCCCEEEEECCCCCCCCC
AEYLLSSLLLLCRRGLVSALMGHKHPSGQIGRELHGSTVGILGLAPAAHTLAGMLSGLGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCE
RLIGYDPAVHHTAPVWERLGIQPVSLQELVSQADAVSVQMVYATRYRGFVNDKLLSACRR
EEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHEEEEEHHHHHCCHHHHHHHHHHHH
EQLWVGISRSDLFEEAALAEALSDGRIEACILDGVEPGFVGDTSPLKGLKNLFVTPRLGA
HHHEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCC
YTREARLRASWYVAHRMHEAIGSPQSGLDSLPAAASPSQWPEPDLTV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]