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The map label for this gene is ilvB [H]

Identifier: 91789534

GI number: 91789534

Start: 3899226

End: 3900896

Strand: Reverse

Name: ilvB [H]

Synonym: Bpro_3687

Alternate gene names: 91789534

Gene position: 3900896-3899226 (Counterclockwise)

Preceding gene: 91789535

Following gene: 91789533

Centisome position: 75.01

GC content: 68.52

Gene sequence:

>1671_bases
ATGCCTGACAACAACCAAATCACGGTCGGCGCCGCCATTGCCGCATTCCTCGAGGAGTGCGGTGTCAAGGCTGCCTTCGG
CGTCATTTCCATCCACAACATGCCCATCCTGGATGCCTTCAACGAGCGCGGCAAAATCCGTTTCGTGATGGCGCGCGGCG
AGGCCGGCGGCACCAACATGGCCGACGCGTATGCCCGCACCACGGGCGGCCTGGGCGTGTGCCTGACCAGCACCGGCACC
GCCGCCGGCAACGCCGCCGGCGCCATGGTGGAAGCGCTCACCGCCGGCACGCCGCTGCTGCACCTGACGGGCCAGATCGA
AACGCCTTACCTCGACCAGAGCCTGTCCTACATCCACGAAGCGCCCGACCAGCTCACCATGCTGCAGGCCGTGTCCAAGG
CGGCCTTTCGCGTGCGCAGTGTCGAGACCGCGCTCAGCACCATCAAGCTGGCTGTGCAGACCGCGCTGACGGCGCCGACC
GGCCCGGTCAGCGTGGAGATACCGATCGACATCCAGGCGGCGCTGATGCCCCTGCCGGCCGACCTCAAGCCGCTGCCCGT
GGTGGCGCACCAGCCGTCCGCCCATGCGCTGGACGAACTCGCCGACCGCCTGGCCAAGGCCCGCCGCCCGCTGCTGTGGC
TGGGCGGTGGAGCCCGCCATGCGGGCGCGGCGGTGGCCCGCCTCATGGCCATGGGCCTGGGCGTGGTCAGCAGCACCCAG
GGCCGCGGCATCGTGCCCGAGGACGACGTCCGGTCGCTGGGCGCCTACAACCTGCACAAACCGGTGGAAAACTTCTACCA
GACCTGCGATGCCATGGTGGTCGTGGGCTCGCGCCTGCGCGGCAACGAGACGCTGAAGTACGAACTCAAACTGCCGCGCC
CGCTCTACCGCGTGGACGCCGACCCCGCCGCCGAAGGCCGCTGCTACGCCACGGACTATTTCGTGCACGGCGACTCCGAA
CTCGTGCTGCAGGGGCTGGCCGACCGTCTCGAAGGCCGCCTGTCGATTGACCCGGCCTTCATGGCCGACCTGCGTGCCGC
GCGTGCCGCGGCCGAGAAAAGCCTGCTCGACGGCCTCGGCCCCTACACGGAACTGGTGAGCCAGCTGCAGCAGGCCGCCG
GCCGAAACTTCAACTGGGTGCGTGACGTCACGGTGTCCAACAGCACCTGGGGCAACCGCCAGCTGCACATCTTCGATCCG
CGTGCCGGCGTGCATGCGCTGGGCGGCGGCATCGGGCAGGGCCTGGCCATGGGCGTGGGCGCCGCCGTGGGTTCTGCCGT
CACCGGTTCGGGCCGCAAAACCTTTTGCCTGTCGGGCGATGGCGGCTTCATCCTGAATCTGGGCGAACTGGCCACGGCCG
TGCAGGAGAAGGCCGGCGTGGTGTACGTGCTGATGAACGACAAGCGCTATGGCGTGATCCAGAACATCCAGGACGCCCAG
TACGGTGGCCGCCGATGCTATGTCGACCTGCACACGCCGGACTACGCGCAACTGTGTGCCTCGTTGCAGCTGGGCCACAC
GCGCGTGAGCCGGCTCGCCGACCTGCCCGCCGGCCTGGACAAGGCGCTGGCTGCCAGCGGTCCCTTTATCCTGGAGATCG
ACATGCTCTCCATCGGCAGCTTCAAAACTGCTTTTGCCGGCCCGCCGACCAAAGTCGTGGTCGCGGCCTGA

Upstream 100 bases:

>100_bases
CTGCCGCAAGAGGCCGCCCGCGCCATTTTCTTTTTAGCCACCCCGCTGTCGTCGTACACGACCGGCAGCCACATCGATGT
TTCCGGAGGTCTTTCCCATC

Downstream 100 bases:

>100_bases
AGCGTGATGCCATGCTGAAAATTGCCATGATTGGTTGCGGCGCGATTGGCGCCAGCGTGCTGGAGTTGCTGCATGGCGAC
TCCGACGTGGTGGTGGACCG

Product: hypothetical protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MPDNNQITVGAAIAAFLEECGVKAAFGVISIHNMPILDAFNERGKIRFVMARGEAGGTNMADAYARTTGGLGVCLTSTGT
AAGNAAGAMVEALTAGTPLLHLTGQIETPYLDQSLSYIHEAPDQLTMLQAVSKAAFRVRSVETALSTIKLAVQTALTAPT
GPVSVEIPIDIQAALMPLPADLKPLPVVAHQPSAHALDELADRLAKARRPLLWLGGGARHAGAAVARLMAMGLGVVSSTQ
GRGIVPEDDVRSLGAYNLHKPVENFYQTCDAMVVVGSRLRGNETLKYELKLPRPLYRVDADPAAEGRCYATDYFVHGDSE
LVLQGLADRLEGRLSIDPAFMADLRAARAAAEKSLLDGLGPYTELVSQLQQAAGRNFNWVRDVTVSNSTWGNRQLHIFDP
RAGVHALGGGIGQGLAMGVGAAVGSAVTGSGRKTFCLSGDGGFILNLGELATAVQEKAGVVYVLMNDKRYGVIQNIQDAQ
YGGRRCYVDLHTPDYAQLCASLQLGHTRVSRLADLPAGLDKALAASGPFILEIDMLSIGSFKTAFAGPPTKVVVAA

Sequences:

>Translated_556_residues
MPDNNQITVGAAIAAFLEECGVKAAFGVISIHNMPILDAFNERGKIRFVMARGEAGGTNMADAYARTTGGLGVCLTSTGT
AAGNAAGAMVEALTAGTPLLHLTGQIETPYLDQSLSYIHEAPDQLTMLQAVSKAAFRVRSVETALSTIKLAVQTALTAPT
GPVSVEIPIDIQAALMPLPADLKPLPVVAHQPSAHALDELADRLAKARRPLLWLGGGARHAGAAVARLMAMGLGVVSSTQ
GRGIVPEDDVRSLGAYNLHKPVENFYQTCDAMVVVGSRLRGNETLKYELKLPRPLYRVDADPAAEGRCYATDYFVHGDSE
LVLQGLADRLEGRLSIDPAFMADLRAARAAAEKSLLDGLGPYTELVSQLQQAAGRNFNWVRDVTVSNSTWGNRQLHIFDP
RAGVHALGGGIGQGLAMGVGAAVGSAVTGSGRKTFCLSGDGGFILNLGELATAVQEKAGVVYVLMNDKRYGVIQNIQDAQ
YGGRRCYVDLHTPDYAQLCASLQLGHTRVSRLADLPAGLDKALAASGPFILEIDMLSIGSFKTAFAGPPTKVVVAA
>Mature_555_residues
PDNNQITVGAAIAAFLEECGVKAAFGVISIHNMPILDAFNERGKIRFVMARGEAGGTNMADAYARTTGGLGVCLTSTGTA
AGNAAGAMVEALTAGTPLLHLTGQIETPYLDQSLSYIHEAPDQLTMLQAVSKAAFRVRSVETALSTIKLAVQTALTAPTG
PVSVEIPIDIQAALMPLPADLKPLPVVAHQPSAHALDELADRLAKARRPLLWLGGGARHAGAAVARLMAMGLGVVSSTQG
RGIVPEDDVRSLGAYNLHKPVENFYQTCDAMVVVGSRLRGNETLKYELKLPRPLYRVDADPAAEGRCYATDYFVHGDSEL
VLQGLADRLEGRLSIDPAFMADLRAARAAAEKSLLDGLGPYTELVSQLQQAAGRNFNWVRDVTVSNSTWGNRQLHIFDPR
AGVHALGGGIGQGLAMGVGAAVGSAVTGSGRKTFCLSGDGGFILNLGELATAVQEKAGVVYVLMNDKRYGVIQNIQDAQY
GGRRCYVDLHTPDYAQLCASLQLGHTRVSRLADLPAGLDKALAASGPFILEIDMLSIGSFKTAFAGPPTKVVVAA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=538, Percent_Identity=24.3494423791822, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI93004078, Length=504, Percent_Identity=24.0079365079365, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1790104, Length=538, Percent_Identity=25.8364312267658, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786717, Length=561, Percent_Identity=25.8467023172906, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081685, Length=529, Percent_Identity=26.4650283553875, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787096, Length=547, Percent_Identity=24.4972577696526, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788716, Length=495, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323755, Length=565, Percent_Identity=24.7787610619469, Blast_Score=139, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 58493; Mature: 58362

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDNNQITVGAAIAAFLEECGVKAAFGVISIHNMPILDAFNERGKIRFVMARGEAGGTNM
CCCCCEEEHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCCCH
ADAYARTTGGLGVCLTSTGTAAGNAAGAMVEALTAGTPLLHLTGQIETPYLDQSLSYIHE
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
APDQLTMLQAVSKAAFRVRSVETALSTIKLAVQTALTAPTGPVSVEIPIDIQAALMPLPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCC
DLKPLPVVAHQPSAHALDELADRLAKARRPLLWLGGGARHAGAAVARLMAMGLGVVSSTQ
CCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCEECCC
GRGIVPEDDVRSLGAYNLHKPVENFYQTCDAMVVVGSRLRGNETLKYELKLPRPLYRVDA
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCEEECC
DPAAEGRCYATDYFVHGDSELVLQGLADRLEGRLSIDPAFMADLRAARAAAEKSLLDGLG
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PYTELVSQLQQAAGRNFNWVRDVTVSNSTWGNRQLHIFDPRAGVHALGGGIGQGLAMGVG
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHCCCHHHHHHHHHH
AAVGSAVTGSGRKTFCLSGDGGFILNLGELATAVQEKAGVVYVLMNDKRYGVIQNIQDAQ
HHHCCCEECCCCEEEEEECCCCEEEEHHHHHHHHHHHCCEEEEEECCCCCCHHCCCCHHC
YGGRRCYVDLHTPDYAQLCASLQLGHTRVSRLADLPAGLDKALAASGPFILEIDMLSIGS
CCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCCEEEEEEEEECCC
FKTAFAGPPTKVVVAA
CCHHCCCCCCEEEEEC
>Mature Secondary Structure 
PDNNQITVGAAIAAFLEECGVKAAFGVISIHNMPILDAFNERGKIRFVMARGEAGGTNM
CCCCEEEHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCCCH
ADAYARTTGGLGVCLTSTGTAAGNAAGAMVEALTAGTPLLHLTGQIETPYLDQSLSYIHE
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
APDQLTMLQAVSKAAFRVRSVETALSTIKLAVQTALTAPTGPVSVEIPIDIQAALMPLPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCC
DLKPLPVVAHQPSAHALDELADRLAKARRPLLWLGGGARHAGAAVARLMAMGLGVVSSTQ
CCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCEECCC
GRGIVPEDDVRSLGAYNLHKPVENFYQTCDAMVVVGSRLRGNETLKYELKLPRPLYRVDA
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCEEECC
DPAAEGRCYATDYFVHGDSELVLQGLADRLEGRLSIDPAFMADLRAARAAAEKSLLDGLG
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PYTELVSQLQQAAGRNFNWVRDVTVSNSTWGNRQLHIFDPRAGVHALGGGIGQGLAMGVG
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHCCCHHHHHHHHHH
AAVGSAVTGSGRKTFCLSGDGGFILNLGELATAVQEKAGVVYVLMNDKRYGVIQNIQDAQ
HHHCCCEECCCCEEEEEECCCCEEEEHHHHHHHHHHHCCEEEEEECCCCCCHHCCCCHHC
YGGRRCYVDLHTPDYAQLCASLQLGHTRVSRLADLPAGLDKALAASGPFILEIDMLSIGS
CCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCCEEEEEEEEECCC
FKTAFAGPPTKVVVAA
CCHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]