BacMap

Definition	Polaromonas sp. JS666 chromosome, complete genome.
Accession	NC_007948
Length	5,200,264

Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 91789535

GI number: 91789535

Start: 3900889

End: 3901686

Strand: Reverse

Name: fabG [C]

Synonym: Bpro_3688

Alternate gene names: 91789535

Gene position: 3901686-3900889 (Counterclockwise)

Preceding gene: 91789536

Following gene: 91789534

Centisome position: 75.03

GC content: 69.05

Gene sequence:

>798_bases
ATGAACCTGATTGACCTGAACCATACCGTGGCCGTGGTCACGGGCGGCTCGTCCGGCATCGGCCTGGCGACAGTCGAGCT
GTTGCTGCAAGGCGGCGCGGCCGTGGCCTTCTGCGGCCGCGACGAAAAACGCCTGCGTGACGCCGAGGCCGGGCTGCGCG
CCCGGTTCCCGGAGGCCCGCCTGTTTGCCGCCACCTGCAACGTGCTGGACGCTGCCGATGTGCAGCGATTCGCCGAGAGC
AGCGAACGCGCGCTGGGCGCCGCCTCCGTTCTGGTCAACAACGCCGGCCAGGGCCGTGTGTCCACCTTTGCCGATACCGA
AGACAGCGCCTGGACTGAAGAGCTGCACCTGAAGTTCTTCTCGGTCATCCATCCCACGCGGGCCTTCCTGCCGCAGCTGC
GGCGCCAGGCCGCGCCGGCCATCGTCTGCGTCAACTCCCTGCTGGCCGCCCAGCCCGAGCCCCATATGGTGGCCACCTCG
GCAGCCCGCGCCGGCATCAAGAACCTCGTGCGCTCCATGGCCACCGAGTTCGCCCCCATGGGGGTGCGCGTGAACGGCAT
CCTCGTGGGCCTGATCGAGTCCGGCCAATGGCGCCGCCGCTTCGAGGCGCGCGAGAACCGCGCGCTGGACTGGGCCGCCT
GGACCGGCGAGCTCGCCGCACGCAAACGCATTCCGCTGGGCCGCCTGGGGCTGCCGCAAGAGGCCGCCCGCGCCATTTTC
TTTTTAGCCACCCCGCTGTCGTCGTACACGACCGGCAGCCACATCGATGTTTCCGGAGGTCTTTCCCATCATGCCTGA

Upstream 100 bases:

>100_bases
GCCTGTCGGCCGACGAGTTGTCCCGCCTCCTGAATTACCAACCGCGCAGCGACAGCCTCAACACGGTCGTCGCCCTGCGC
CTGCGCTGAGTGCCTTCGCG

Downstream 100 bases:

>100_bases
CAACAACCAAATCACGGTCGGCGCCGCCATTGCCGCATTCCTCGAGGAGTGCGGTGTCAAGGCTGCCTTCGGCGTCATTT
CCATCCACAACATGCCCATC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MNLIDLNHTVAVVTGGSSGIGLATVELLLQGGAAVAFCGRDEKRLRDAEAGLRARFPEARLFAATCNVLDAADVQRFAES
SERALGAASVLVNNAGQGRVSTFADTEDSAWTEELHLKFFSVIHPTRAFLPQLRRQAAPAIVCVNSLLAAQPEPHMVATS
AARAGIKNLVRSMATEFAPMGVRVNGILVGLIESGQWRRRFEARENRALDWAAWTGELAARKRIPLGRLGLPQEAARAIF
FLATPLSSYTTGSHIDVSGGLSHHA

Sequences:

>Translated_265_residues
MNLIDLNHTVAVVTGGSSGIGLATVELLLQGGAAVAFCGRDEKRLRDAEAGLRARFPEARLFAATCNVLDAADVQRFAES
SERALGAASVLVNNAGQGRVSTFADTEDSAWTEELHLKFFSVIHPTRAFLPQLRRQAAPAIVCVNSLLAAQPEPHMVATS
AARAGIKNLVRSMATEFAPMGVRVNGILVGLIESGQWRRRFEARENRALDWAAWTGELAARKRIPLGRLGLPQEAARAIF
FLATPLSSYTTGSHIDVSGGLSHHA
>Mature_265_residues
MNLIDLNHTVAVVTGGSSGIGLATVELLLQGGAAVAFCGRDEKRLRDAEAGLRARFPEARLFAATCNVLDAADVQRFAES
SERALGAASVLVNNAGQGRVSTFADTEDSAWTEELHLKFFSVIHPTRAFLPQLRRQAAPAIVCVNSLLAAQPEPHMVATS
AARAGIKNLVRSMATEFAPMGVRVNGILVGLIESGQWRRRFEARENRALDWAAWTGELAARKRIPLGRLGLPQEAARAIF
FLATPLSSYTTGSHIDVSGGLSHHA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=29.811320754717, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=26.5625, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=28.968253968254, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI126723750, Length=259, Percent_Identity=24.3243243243243, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI10190704, Length=258, Percent_Identity=24.8062015503876, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI66933014, Length=238, Percent_Identity=26.0504201680672, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI59889578, Length=245, Percent_Identity=27.7551020408163, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=25.668449197861, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=27.7992277992278, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=258, Percent_Identity=25.5813953488372, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=29.4573643410853, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=26.0700389105058, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786812, Length=263, Percent_Identity=30.7984790874525, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=29.0697674418605, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=27.1317829457364, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=25.6, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=28.2442748091603, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=32.156862745098, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=26.8774703557312, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=30.3030303030303, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=31.6793893129771, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=31.6981132075472, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=257, Percent_Identity=27.2373540856031, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=30.0380228136882, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=31.4393939393939, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=255, Percent_Identity=29.0196078431373, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=28.0632411067194, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=30.5660377358491, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=28.4046692607004, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=28.8973384030418, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=29.5719844357977, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=271, Percent_Identity=29.8892988929889, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=28.2945736434109, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=28.5185185185185, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=29.4339622641509, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=29.2134831460674, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=28.5185185185185, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=27.7566539923954, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=276, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=200, Percent_Identity=26, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=27.8195488721804, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=264, Percent_Identity=24.6212121212121, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=264, Percent_Identity=22.3484848484848, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=26.5625, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=29.296875, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=29.4573643410853, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=32.4110671936759, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24639444, Length=264, Percent_Identity=29.9242424242424, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=29.3650793650794, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24644337, Length=259, Percent_Identity=30.1158301158301, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=29.2490118577075, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24643142, Length=267, Percent_Identity=29.5880149812734, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007238, Length=222, Percent_Identity=28.3783783783784, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007236, Length=258, Percent_Identity=27.1317829457364, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28377; Mature: 28377

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIDLNHTVAVVTGGSSGIGLATVELLLQGGAAVAFCGRDEKRLRDAEAGLRARFPEAR
CCEEECCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCHH
LFAATCNVLDAADVQRFAESSERALGAASVLVNNAGQGRVSTFADTEDSAWTEELHLKFF
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHH
SVIHPTRAFLPQLRRQAAPAIVCVNSLLAAQPEPHMVATSAARAGIKNLVRSMATEFAPM
HHHCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCC
GVRVNGILVGLIESGQWRRRFEARENRALDWAAWTGELAARKRIPLGRLGLPQEAARAIF
CEEEEEEEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHEEE
FLATPLSSYTTGSHIDVSGGLSHHA
EEECCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MNLIDLNHTVAVVTGGSSGIGLATVELLLQGGAAVAFCGRDEKRLRDAEAGLRARFPEAR
CCEEECCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCHH
LFAATCNVLDAADVQRFAESSERALGAASVLVNNAGQGRVSTFADTEDSAWTEELHLKFF
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHH
SVIHPTRAFLPQLRRQAAPAIVCVNSLLAAQPEPHMVATSAARAGIKNLVRSMATEFAPM
HHHCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCC
GVRVNGILVGLIESGQWRRRFEARENRALDWAAWTGELAARKRIPLGRLGLPQEAARAIF
CEEEEEEEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHEEE
FLATPLSSYTTGSHIDVSGGLSHHA
EEECCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]