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The map label for this gene is degP [H]

Identifier: 91789523

GI number: 91789523

Start: 3887277

End: 3888788

Strand: Direct

Name: degP [H]

Synonym: Bpro_3676

Alternate gene names: 91789523

Gene position: 3887277-3888788 (Clockwise)

Preceding gene: 91789522

Following gene: 91789524

Centisome position: 74.75

GC content: 65.54

Gene sequence:

>1512_bases
ATGACATCTGCAGCATTGAAAAATACCCGACTGGTCGTTGCCCTGCTGGCCGCTGGCGCCATGGGTGGCGCCAGCGTCAG
CGCACTGAACGCCCTGCATGGCAGCGCCGTTGCCGCCCCTACATCCGCAGCCGTTGCCACTACCGGCAGCGTGGCCAGCA
CGCCCGTGGCGCTACCCGACTTTTCCCGCATCACCGAGCGCCACGGCCCGGCAGTCGTCAACATCAGCGTCACCGGCACC
ACCAAGGTGTCCAGCGGATCACCGCTGGCTCAGGGCGATGGCGATGATGACGACGATGCTCTGGCCGGTGATCCATTTTT
CGAGTTCTTCCGCCGCTTCCAGCAAGGGCAGGGCCGACAGGGCCGCGGCGGCCAGCAGGAGGTCCCCACCCGGGGCCAGG
GCTCCGGCTTCATCGTGAGCAGCGACGGCATCATCCTGACCAATGCACACGTGGTGCGCGATGCCCGCGAAGTCACGGTC
AAGCTGACCGACCGGCGCGAATTCCGCGCCAAGGTGCTGGGCGCTGATCCGAGGACCGACGTCGCCGTGCTGCGGATTGC
GGCCAGCAACCTGCCGGTCGTGACCCTGGGCAAAACCAGCGAACTGAAGGTCGGCGAGTGGGTGCTGGCGATTGGCTCGC
CCTTTGGTTTCGAAAACACCGTGACGGCCGGCGTCGTCAGCGCCAAGGGCCGGTCCCTGCCCGACGACAGCACCGTGCCT
TTCATCCAGACCGACGTCGCCATCAACCCCGGCAACTCGGGCGGCCCGCTGTTTAATGCCCGCGGCGAGGTGGTCGGCAT
CAATTCGCAGATCTACTCCCGCAGCGGCGGCTATCAAGGTGTGTCGTTTGCGATTCCGATTGATATAGCGGCCAGAATCC
AGAAGCAGATCGTGGCAAACGGCAAGGTGGAGCATGCGCGTCTAGGCGTCGCGGTGCAGGAAGTGAATCAGACCTTTGCC
GACTCGTTCAAACTCGACAAACCGGAAGGCGCCCTGGTGTCCACGGTTGAAAAAGGCAGCCCGGCCGAGAAGGCGGGCCT
GCAGTCGGGCGACGTGGTTCGCAAGGTCAATGGCCAACCCATCGTCTCCTCGGGCGACCTGGCGGCCCTCATTGGCCTGG
CCGCCCCTGGCGACACGGTCAAGCTGGACGTCTGGCGTCAAGGTTCGGCCAAGGAAATCACCGCACGCCTTGCCAGTGCA
GACGAGAAGTCGGCCCAGGCGGCCGGCAAGAAAGACTCGCCCAGCCAGGGCAAGCTGGGCCTGGCCCTGCGCCCGCTTCA
GCCCGACGAAAGGCAGGAGGCGGGCCTGGACAGCGGCCTGGTGGTGCAGCAAGCCAGTGGTCCGGCGGCGCTGGCCGGCG
TGCAGGCTGGCGACGTACTGATCGCCATCAATGGCACACCGGTCAGGAATGTCGAGCAGGTGCGCAGCGTGGTCGCCAAA
GCGGACAAATCGGTGGCGCTGCTCATCCAGCGTGGCGACAGCAAGATTTTTGTGCCGGTGAACCTGGGCTGA

Upstream 100 bases:

>100_bases
TAAGCCTCGTCTAAGGCTGGCTCCCCATAGTTAGTCCTGTGGGCACCGATGCGTGTCCGATGTGTGTTCGATGTATATCT
CCAACCCAAGGAAGCCAACC

Downstream 100 bases:

>100_bases
GGTGAGCCGAAAATAAGGGGGGCAGGTTGGGCCGCAAAAGGCTGCTGCCCACCGAACCCGACACACTGGAAGAAACCATG
GAGACAAGCCATGTCACAAG

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTSAALKNTRLVVALLAAGAMGGASVSALNALHGSAVAAPTSAAVATTGSVASTPVALPDFSRITERHGPAVVNISVTGT
TKVSSGSPLAQGDGDDDDDALAGDPFFEFFRRFQQGQGRQGRGGQQEVPTRGQGSGFIVSSDGIILTNAHVVRDAREVTV
KLTDRREFRAKVLGADPRTDVAVLRIAASNLPVVTLGKTSELKVGEWVLAIGSPFGFENTVTAGVVSAKGRSLPDDSTVP
FIQTDVAINPGNSGGPLFNARGEVVGINSQIYSRSGGYQGVSFAIPIDIAARIQKQIVANGKVEHARLGVAVQEVNQTFA
DSFKLDKPEGALVSTVEKGSPAEKAGLQSGDVVRKVNGQPIVSSGDLAALIGLAAPGDTVKLDVWRQGSAKEITARLASA
DEKSAQAAGKKDSPSQGKLGLALRPLQPDERQEAGLDSGLVVQQASGPAALAGVQAGDVLIAINGTPVRNVEQVRSVVAK
ADKSVALLIQRGDSKIFVPVNLG

Sequences:

>Translated_503_residues
MTSAALKNTRLVVALLAAGAMGGASVSALNALHGSAVAAPTSAAVATTGSVASTPVALPDFSRITERHGPAVVNISVTGT
TKVSSGSPLAQGDGDDDDDALAGDPFFEFFRRFQQGQGRQGRGGQQEVPTRGQGSGFIVSSDGIILTNAHVVRDAREVTV
KLTDRREFRAKVLGADPRTDVAVLRIAASNLPVVTLGKTSELKVGEWVLAIGSPFGFENTVTAGVVSAKGRSLPDDSTVP
FIQTDVAINPGNSGGPLFNARGEVVGINSQIYSRSGGYQGVSFAIPIDIAARIQKQIVANGKVEHARLGVAVQEVNQTFA
DSFKLDKPEGALVSTVEKGSPAEKAGLQSGDVVRKVNGQPIVSSGDLAALIGLAAPGDTVKLDVWRQGSAKEITARLASA
DEKSAQAAGKKDSPSQGKLGLALRPLQPDERQEAGLDSGLVVQQASGPAALAGVQAGDVLIAINGTPVRNVEQVRSVVAK
ADKSVALLIQRGDSKIFVPVNLG
>Mature_502_residues
TSAALKNTRLVVALLAAGAMGGASVSALNALHGSAVAAPTSAAVATTGSVASTPVALPDFSRITERHGPAVVNISVTGTT
KVSSGSPLAQGDGDDDDDALAGDPFFEFFRRFQQGQGRQGRGGQQEVPTRGQGSGFIVSSDGIILTNAHVVRDAREVTVK
LTDRREFRAKVLGADPRTDVAVLRIAASNLPVVTLGKTSELKVGEWVLAIGSPFGFENTVTAGVVSAKGRSLPDDSTVPF
IQTDVAINPGNSGGPLFNARGEVVGINSQIYSRSGGYQGVSFAIPIDIAARIQKQIVANGKVEHARLGVAVQEVNQTFAD
SFKLDKPEGALVSTVEKGSPAEKAGLQSGDVVRKVNGQPIVSSGDLAALIGLAAPGDTVKLDVWRQGSAKEITARLASAD
EKSAQAAGKKDSPSQGKLGLALRPLQPDERQEAGLDSGLVVQQASGPAALAGVQAGDVLIAINGTPVRNVEQVRSVVAKA
DKSVALLIQRGDSKIFVPVNLG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=38.9473684210526, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI24308541, Length=260, Percent_Identity=38.4615384615385, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI22129776, Length=264, Percent_Identity=37.8787878787879, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI7019477, Length=259, Percent_Identity=38.996138996139, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1786356, Length=471, Percent_Identity=37.1549893842887, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789629, Length=481, Percent_Identity=34.5114345114345, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1789630, Length=267, Percent_Identity=34.8314606741573, Blast_Score=161, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24646839, Length=260, Percent_Identity=39.2307692307692, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51648; Mature: 51517

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAALKNTRLVVALLAAGAMGGASVSALNALHGSAVAAPTSAAVATTGSVASTPVALPD
CCCCHHCCCCEEEEEEHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCC
FSRITERHGPAVVNISVTGTTKVSSGSPLAQGDGDDDDDALAGDPFFEFFRRFQQGQGRQ
HHHHHHHCCCEEEEEEEECCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GRGGQQEVPTRGQGSGFIVSSDGIILTNAHVVRDAREVTVKLTDRREFRAKVLGADPRTD
CCCCCCCCCCCCCCCEEEEECCCEEEECHHHHHCCEEEEEEEECCCCCHHHEECCCCCCC
VAVLRIAASNLPVVTLGKTSELKVGEWVLAIGSPFGFENTVTAGVVSAKGRSLPDDSTVP
EEEEEEECCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCC
FIQTDVAINPGNSGGPLFNARGEVVGINSQIYSRSGGYQGVSFAIPIDIAARIQKQIVAN
EEEEEEEECCCCCCCCEEECCCCEEEECHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHC
GKVEHARLGVAVQEVNQTFADSFKLDKPEGALVSTVEKGSPAEKAGLQSGDVVRKVNGQP
CCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHCCCCCCEEEECCCCE
IVSSGDLAALIGLAAPGDTVKLDVWRQGSAKEITARLASADEKSAQAAGKKDSPSQGKLG
EECCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
LALRPLQPDERQEAGLDSGLVVQQASGPAALAGVQAGDVLIAINGTPVRNVEQVRSVVAK
EEEECCCCCCHHHCCCCCCEEEEECCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHH
ADKSVALLIQRGDSKIFVPVNLG
CCCCEEEEEEECCCEEEEEEECC
>Mature Secondary Structure 
TSAALKNTRLVVALLAAGAMGGASVSALNALHGSAVAAPTSAAVATTGSVASTPVALPD
CCCHHCCCCEEEEEEHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCC
FSRITERHGPAVVNISVTGTTKVSSGSPLAQGDGDDDDDALAGDPFFEFFRRFQQGQGRQ
HHHHHHHCCCEEEEEEEECCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GRGGQQEVPTRGQGSGFIVSSDGIILTNAHVVRDAREVTVKLTDRREFRAKVLGADPRTD
CCCCCCCCCCCCCCCEEEEECCCEEEECHHHHHCCEEEEEEEECCCCCHHHEECCCCCCC
VAVLRIAASNLPVVTLGKTSELKVGEWVLAIGSPFGFENTVTAGVVSAKGRSLPDDSTVP
EEEEEEECCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCC
FIQTDVAINPGNSGGPLFNARGEVVGINSQIYSRSGGYQGVSFAIPIDIAARIQKQIVAN
EEEEEEEECCCCCCCCEEECCCCEEEECHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHC
GKVEHARLGVAVQEVNQTFADSFKLDKPEGALVSTVEKGSPAEKAGLQSGDVVRKVNGQP
CCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHCCCCCCEEEECCCCE
IVSSGDLAALIGLAAPGDTVKLDVWRQGSAKEITARLASADEKSAQAAGKKDSPSQGKLG
EECCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
LALRPLQPDERQEAGLDSGLVVQQASGPAALAGVQAGDVLIAINGTPVRNVEQVRSVVAK
EEEECCCCCCHHHCCCCCCEEEEECCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHH
ADKSVALLIQRGDSKIFVPVNLG
CCCCEEEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]