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The map label for this gene is nhaA [H]

Identifier: 91789506

GI number: 91789506

Start: 3854308

End: 3855393

Strand: Reverse

Name: nhaA [H]

Synonym: Bpro_3656

Alternate gene names: 91789506

Gene position: 3855393-3854308 (Counterclockwise)

Preceding gene: 91789507

Following gene: 91789503

Centisome position: 74.14

GC content: 62.34

Gene sequence:

>1086_bases
ATGAACGAATCCAACCGCCCCGACAATCCGAACGACACCTCTCCTGATCTCCTGCGGGAGTCGGATTTCAGGCCGAACCA
GCCGGAGTCCCGTCCTTATCCGGAAGATCGTGCTCCTGAAACGGGAGCGAAAAAATCCCTTCAAACCGACCCGTCCCTGG
CTCCCGGCTGGGAGCGTGCAACGCTGGAGAAGCTGGCGTTTGCATCGCTCAATGAGCAAAAAGCTGCCCGCCGCTGGAAA
GCCTTTGTGCGCCTGGCCTGGCTGGCGTTTTTCATCGCGCTGGTGTGGATGCTCCTGCACCGCGGTACCCCCGCCACCGA
TGCGGCCGCGCCGCACACGGCCGTGGTGGAGATCAAGGGTGAAATCGCCGCCGGCGCCGACGCCAGTGCCGAGTTTGTCA
ATGCGGCGCTGCGTGCCGCGTTTGAAGACGATGGCGCCAAGGCCGTGGTGCTGCTGATCAACTCCCCCGGGGGCAGCCCG
GTGCAGGCCGGCATGATGAATGACGAAATCCTGCGCCTCAAGATCAAGCACAAGAAGCCGGTTTATGCCGTGGTGGAAGA
AAGCTGCGCATCGGCAGCCTATTACATCGCGGTGGCAGCCGACAAGATTTACGTCGACAAGGCCAGCATTGTCGGCAGCA
TCGGCGTGTTGATGGACGGCTTTGGCTTTACCGGCCTGATGGACAAGCTGGGCGTGGAACGCCGGCTGCTGACCGCTGGC
GAGAACAAGGGCTTTCTGGACCCCTTCAGCCCGCAGAGCGACAAGCAGCGCGTGTATGCGCAGGCCATGCTGGACCAGAT
CCACCAGCAGTTCATCACGGTGGTGAAAGCCGGCCGCGGCAAGCGCCTCAAGGAGATGCCAGAGATGTTCAGCGGCCTGT
TCTGGAGCGGCCAGCAGGCGGTGGAGCTGGGTTTGGCTGACCAGCTGGGCGGCCTGGAGTATGTAGCCCGCGAGGTGGTC
AAGGCCGAGGAAATCATCGATTACACGCGCCGCGAGAATGTGGCCGAGCGCCTGGCCAAGAAGTTTGGCGCGGCCATGGG
TGAAGGTGCCATCAGGGCTTTCAAGGCCATTCCGGCGATTCGTTAA

Upstream 100 bases:

>100_bases
GATCAAAATCACGCTTTCGGAAAATGACGGGGTTGTTTATTGGCATTCCGCTTACAACCTCAGACCGGTACAGTTCTAAT
ACTTCTCTAAACTAGCGACC

Downstream 100 bases:

>100_bases
GCGTCTTCTCAAAGCGCGAAACGCCAAAAAAGCCGCAGCAACACAAAACCAAAAAGGCCCGCAATAGCGGGCTTTTTTCA
TCGGGTTGCCCCCTGATGCG

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNESNRPDNPNDTSPDLLRESDFRPNQPESRPYPEDRAPETGAKKSLQTDPSLAPGWERATLEKLAFASLNEQKAARRWK
AFVRLAWLAFFIALVWMLLHRGTPATDAAAPHTAVVEIKGEIAAGADASAEFVNAALRAAFEDDGAKAVVLLINSPGGSP
VQAGMMNDEILRLKIKHKKPVYAVVEESCASAAYYIAVAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGVERRLLTAG
ENKGFLDPFSPQSDKQRVYAQAMLDQIHQQFITVVKAGRGKRLKEMPEMFSGLFWSGQQAVELGLADQLGGLEYVAREVV
KAEEIIDYTRRENVAERLAKKFGAAMGEGAIRAFKAIPAIR

Sequences:

>Translated_361_residues
MNESNRPDNPNDTSPDLLRESDFRPNQPESRPYPEDRAPETGAKKSLQTDPSLAPGWERATLEKLAFASLNEQKAARRWK
AFVRLAWLAFFIALVWMLLHRGTPATDAAAPHTAVVEIKGEIAAGADASAEFVNAALRAAFEDDGAKAVVLLINSPGGSP
VQAGMMNDEILRLKIKHKKPVYAVVEESCASAAYYIAVAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGVERRLLTAG
ENKGFLDPFSPQSDKQRVYAQAMLDQIHQQFITVVKAGRGKRLKEMPEMFSGLFWSGQQAVELGLADQLGGLEYVAREVV
KAEEIIDYTRRENVAERLAKKFGAAMGEGAIRAFKAIPAIR
>Mature_361_residues
MNESNRPDNPNDTSPDLLRESDFRPNQPESRPYPEDRAPETGAKKSLQTDPSLAPGWERATLEKLAFASLNEQKAARRWK
AFVRLAWLAFFIALVWMLLHRGTPATDAAAPHTAVVEIKGEIAAGADASAEFVNAALRAAFEDDGAKAVVLLINSPGGSP
VQAGMMNDEILRLKIKHKKPVYAVVEESCASAAYYIAVAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGVERRLLTAG
ENKGFLDPFSPQSDKQRVYAQAMLDQIHQQFITVVKAGRGKRLKEMPEMFSGLFWSGQQAVELGLADQLGGLEYVAREVV
KAEEIIDYTRRENVAERLAKKFGAAMGEGAIRAFKAIPAIR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=253, Percent_Identity=30.8300395256917, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788064, Length=218, Percent_Identity=27.9816513761468, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 39466; Mature: 39466

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESNRPDNPNDTSPDLLRESDFRPNQPESRPYPEDRAPETGAKKSLQTDPSLAPGWERA
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
TLEKLAFASLNEQKAARRWKAFVRLAWLAFFIALVWMLLHRGTPATDAAAPHTAVVEIKG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEC
EIAAGADASAEFVNAALRAAFEDDGAKAVVLLINSPGGSPVQAGMMNDEILRLKIKHKKP
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEECCCCCCCEEEEEECCCCC
VYAVVEESCASAAYYIAVAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGVERRLLTAG
HHHHHHHHHHHHEEEEEEEECCCEEEHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHCC
ENKGFLDPFSPQSDKQRVYAQAMLDQIHQQFITVVKAGRGKRLKEMPEMFSGLFWSGQQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHH
VELGLADQLGGLEYVAREVVKAEEIIDYTRRENVAERLAKKFGAAMGEGAIRAFKAIPAI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
R
C
>Mature Secondary Structure
MNESNRPDNPNDTSPDLLRESDFRPNQPESRPYPEDRAPETGAKKSLQTDPSLAPGWERA
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
TLEKLAFASLNEQKAARRWKAFVRLAWLAFFIALVWMLLHRGTPATDAAAPHTAVVEIKG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEC
EIAAGADASAEFVNAALRAAFEDDGAKAVVLLINSPGGSPVQAGMMNDEILRLKIKHKKP
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEECCCCCCCEEEEEECCCCC
VYAVVEESCASAAYYIAVAADKIYVDKASIVGSIGVLMDGFGFTGLMDKLGVERRLLTAG
HHHHHHHHHHHHEEEEEEEECCCEEEHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHCC
ENKGFLDPFSPQSDKQRVYAQAMLDQIHQQFITVVKAGRGKRLKEMPEMFSGLFWSGQQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHH
VELGLADQLGGLEYVAREVVKAEEIIDYTRRENVAERLAKKFGAAMGEGAIRAFKAIPAI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA