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The map label for this gene is hda [H]

Identifier: 91789418

GI number: 91789418

Start: 3763663

End: 3764349

Strand: Reverse

Name: hda [H]

Synonym: Bpro_3564

Alternate gene names: 91789418

Gene position: 3764349-3763663 (Counterclockwise)

Preceding gene: 91789419

Following gene: 91789417

Centisome position: 72.39

GC content: 64.05

Gene sequence:

>687_bases
ATGAAACAGATAGCGCTTGATATCGGGCTGGCCTCCGCCCCGTCGTTTGCCAATTTCTTTGGCGGACCGAACGAGGCGGC
GCTTAAGCACCTGGAGCTTTGGGCTGGCAACACCCTGCGTTCACCGGTGCCGACCTACCTGTGGGGCGAGCCGGCCAGCG
GCAAAACCCATTTGCTCCGGGCCGTCAGCGAGGCGCTGCGGGAGCAGGGCGCCCCGGTGGGCTGGATGGATGCGTTCGTG
CTCGAACCGCCGGAATTCAGCGAATCCTGGGCCGCCGTGATTCTGGACGACTGTCATCTTTACACGGCGGTGCAGCAGCA
GGCCGCGTTCAACTGGTTTGTCAATGCTCTTAATTCGGCCGATGGCCGACCGCGCTGGGTGCTGGCGGCCGGCTTGGTGC
CGCCCGCCGATCTGGCCTTGCGTGAGGACTTGCGCACGCGGCTGGGCTGGGGTCACGTGTTTGCCCTGCAGGCCCTGACC
GAAGCGGAGCGCCGTGCCGTGCTCAGGCGCGAAGCCGATGCGCGCGGTGTGTTTCTGGGCGATGACGCCATGGACTTCAT
GCTGACACGGTTTTCGCGCGACCTCGCAAGCCTCATGCAACTGCTGGACCAGCTCGACAGCTACGCCCTGCAAACCAAGC
GGGCCATCACGATCCCGCTGATCAAATCCATGCTGGAAAACGGATAA

Upstream 100 bases:

>100_bases
CTGGTGGGTATTCGTCGCCTCAAGGCCAGCTACATCGCCAGCAGGCTTTACACGGCCTGAGGGCTTCCATGGGCAGACGT
GAAACCGGCAGCGTGCAGGC

Downstream 100 bases:

>100_bases
GTACTCGGATAAGTATTGCTCTATACAACAAATATTAATTTGTTGTATAGTTCGGGCCATGCTCCTGCATGCTGAACTTC
CCCTTTCTGCCCAGACGGCT

Product: chromosomal replication initiator DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKQIALDIGLASAPSFANFFGGPNEAALKHLELWAGNTLRSPVPTYLWGEPASGKTHLLRAVSEALREQGAPVGWMDAFV
LEPPEFSESWAAVILDDCHLYTAVQQQAAFNWFVNALNSADGRPRWVLAAGLVPPADLALREDLRTRLGWGHVFALQALT
EAERRAVLRREADARGVFLGDDAMDFMLTRFSRDLASLMQLLDQLDSYALQTKRAITIPLIKSMLENG

Sequences:

>Translated_228_residues
MKQIALDIGLASAPSFANFFGGPNEAALKHLELWAGNTLRSPVPTYLWGEPASGKTHLLRAVSEALREQGAPVGWMDAFV
LEPPEFSESWAAVILDDCHLYTAVQQQAAFNWFVNALNSADGRPRWVLAAGLVPPADLALREDLRTRLGWGHVFALQALT
EAERRAVLRREADARGVFLGDDAMDFMLTRFSRDLASLMQLLDQLDSYALQTKRAITIPLIKSMLENG
>Mature_228_residues
MKQIALDIGLASAPSFANFFGGPNEAALKHLELWAGNTLRSPVPTYLWGEPASGKTHLLRAVSEALREQGAPVGWMDAFV
LEPPEFSESWAAVILDDCHLYTAVQQQAAFNWFVNALNSADGRPRWVLAAGLVPPADLALREDLRTRLGWGHVFALQALT
EAERRAVLRREADARGVFLGDDAMDFMLTRFSRDLASLMQLLDQLDSYALQTKRAITIPLIKSMLENG

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=234, Percent_Identity=31.6239316239316, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367267, Length=231, Percent_Identity=26.8398268398268, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 25175; Mature: 25175

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIALDIGLASAPSFANFFGGPNEAALKHLELWAGNTLRSPVPTYLWGEPASGKTHLLR
CCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHH
AVSEALREQGAPVGWMDAFVLEPPEFSESWAAVILDDCHLYTAVQQQAAFNWFVNALNSA
HHHHHHHHCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DGRPRWVLAAGLVPPADLALREDLRTRLGWGHVFALQALTEAERRAVLRREADARGVFLG
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
DDAMDFMLTRFSRDLASLMQLLDQLDSYALQTKRAITIPLIKSMLENG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHCCC
>Mature Secondary Structure
MKQIALDIGLASAPSFANFFGGPNEAALKHLELWAGNTLRSPVPTYLWGEPASGKTHLLR
CCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHH
AVSEALREQGAPVGWMDAFVLEPPEFSESWAAVILDDCHLYTAVQQQAAFNWFVNALNSA
HHHHHHHHCCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DGRPRWVLAAGLVPPADLALREDLRTRLGWGHVFALQALTEAERRAVLRREADARGVFLG
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
DDAMDFMLTRFSRDLASLMQLLDQLDSYALQTKRAITIPLIKSMLENG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA