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The map label for this gene is fadJ [H]

Identifier: 91788876

GI number: 91788876

Start: 3177172

End: 3179331

Strand: Direct

Name: fadJ [H]

Synonym: Bpro_3016

Alternate gene names: 91788876

Gene position: 3177172-3179331 (Clockwise)

Preceding gene: 91788875

Following gene: 91788879

Centisome position: 61.1

GC content: 64.91

Gene sequence:

>2160_bases
ATGAAAACCATCCAGTACGCACTGACCGAAGAGTCTTTTGGCCGGGTGGCCACCATTACCTTTGACGAGCCCGGCTCGCC
CGTCAACACCATGTGCCGGCAATGGCAGGACGACCTGAGCGAAGTCACCGCCCAGGTGCTCAAGGACAGGGAAGCCATCC
AGGGCGTGATCCTGGCCTCTGCCAAGAGCACGTTTTTTGCCGGCGCCGACCTGAAGGCCGCGATGCGACTGACGGCCGCC
GATGCGTCCCAGGTGTACGCCGAGATCGAACGGGTGAAGAAAAACTTCCGCACGCTGGAGACCCTGGGCAAGCCGGTGGT
GAGCTGCCTCAACGGCGCGGCCCTGGGCGGCGGCTGGGAACTGGCGCTCGTGGGCCACTACCGTGTGGCGGTGGATGACA
GCAAGGTACGGTTTGGCCTGCCCGAAGTCACGCTGGGCCTGCTGCCGGGCGCCAGCGGCGTGACCAAGATGACGCGCCAC
CTGGGCCTGATGGCAGCGCAGCCCTATCTGGTGGAAGGCAAGACCTTTGGCCCGCGTGAAGCGCTGGCGCTGAGCCTGGT
GCATGCGCTGGTGCCCGATGCCGCTGCACTCCGCGCCCAGGCGCTCGCCTGGATAGCCGCCAACCCCAGGGCGCAGCACC
CCTGGGACGCCAGGGACTACGAGATCCCCGGCGGAACCCCTGCCAGCCCCGAGGTTGCCGCAGCGCTGAGCGTGGCGCCC
GCCATGCTGAAGAAAAAGACGCGCGGACTCTACCCGGCCCCGGAAGCCATCCTGGCCTGCATGGTCGAAGGTGCGCTGGT
AGACCTGGAAACCGCCTTGCGCATTGAGAGCCGCTACCTGGCCAGGCTCATGACCGGCCCCAACGCCAGGGCCATGATCA
ACACCTTTTTCTTCAACATGAACGCGATCAAAAGCGGGCAGTCGCGGCCGTCCAGCGTGCCGCACGCCACGCCCCTCAAG
GTCGGTGTACTGGGCGCCGGCATGATGGGCGCGGGCATTGCGTACGCGCAGGCCAGCCGGGGCTTGGCCACCGTGCTCAA
GGACGTGAGCCTGGACAAGGCCGAGGCCGGCAAGGCCTACAGCGCCAGGCTCACGCAGCCGCAGGTCGAGAAGGGCCACA
TGACCCCGGCGAACCAGGCAGCCCTGCTCTCACGCATCACGGCAACTGACCAGCTGGCGGATCTGGCGGGCTGCGACCTC
ATCATCGAGGCGGTATTCGAACAACGCGACCTGAAGGCCAAAGTGACTCAGGAGGCCGAACCGCTGCTGGCGGCGGGCGG
TTTTTTCGCGTCCAACACGTCCACCCTGCCCATCTCCGGCCTGGCAGTGGCCAGCAGCCGCCCCGAGAAATTCATTGGCA
TCCACTTCTTCAGCCCGGTGGACAAGATGAAGCTGGTCGAGATCATTCGCGGCCGGCAGACCGATGACGAAACCGTGGCG
CGCGCCTTCGACTACGTGCAGGCGCTGGGCAAGATTCCCATCGTGGTCAACGACTCGCGCGGCTTTTACACCAGCCGCAC
TTTCGCCGCCTTCGTGATGGAAGGCGCGGCCATGCTGGGCGAAGGCATTCCGGCCGCGGTGATTGAAAACGCCGGGATGC
AGGCCGGCATGCCGGTCGGCCCGCTGGCAGTGCTGGACGAAACCGCCCTGTCGCTGAGCGTGCATGTGCTGGACCAGACG
CGCGCCGACTTCGCCGCCGAAGGCAAAACCTATATCGCAACACCGGGCGAATTGCTGGTGGAACGCATGGTCAAGGAATT
CCAGCGAAATGGCCGGGCCGAAGGGGGCGGTTTTTATGACTACCCCGCTGAAAAGGGGGCGAAGAAAATGCTGTGGCCAC
ACCTCAAGGCACTGTTTGAAAAGTCCGGAACACCCTGGGACATAACCGGGATCAAGGACCGCCTGCTCTACCGCCAGGCC
GTGGAAGCAGCGCGCTGCCTCAGCGAAGGCGTGCTGACCACCGTCGCAGAAGCCAATATCGGCTCCATCTTCGGCATCGG
GTTTCCGGCCTGGACCGGCGGCACCCTGCAGTTCATTTACGGCATGGGCCTGGACGACTTTATCCGGCGCTGCGATGAAC
TGGCGGCAAAATTCGGCCCGGGCTTTATGCTGACCAACACGGTCAGAAGTGCCCTGCGCAAGCACCAGCCCGTCTACTGA

Upstream 100 bases:

>100_bases
CGCTGGTCGACGAGCTGCACCGGCGCCAGCTGCGCTATGGCCTGGCCACGCTGTGCGTGGGCGGCGGCATGGGCATTGCG
ACGATTGTGGAGAGAGTCTG

Downstream 100 bases:

>100_bases
AGCTCGAACCGATTTCTTTCAACCAAGCTCACCATCTCATGCAACGACTCCAGAACAAGATAAGCGTCATCACCGGCGCG
TGTGATGAACGAGATGGAAG

Product: short chain enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MKTIQYALTEESFGRVATITFDEPGSPVNTMCRQWQDDLSEVTAQVLKDREAIQGVILASAKSTFFAGADLKAAMRLTAA
DASQVYAEIERVKKNFRTLETLGKPVVSCLNGAALGGGWELALVGHYRVAVDDSKVRFGLPEVTLGLLPGASGVTKMTRH
LGLMAAQPYLVEGKTFGPREALALSLVHALVPDAAALRAQALAWIAANPRAQHPWDARDYEIPGGTPASPEVAAALSVAP
AMLKKKTRGLYPAPEAILACMVEGALVDLETALRIESRYLARLMTGPNARAMINTFFFNMNAIKSGQSRPSSVPHATPLK
VGVLGAGMMGAGIAYAQASRGLATVLKDVSLDKAEAGKAYSARLTQPQVEKGHMTPANQAALLSRITATDQLADLAGCDL
IIEAVFEQRDLKAKVTQEAEPLLAAGGFFASNTSTLPISGLAVASSRPEKFIGIHFFSPVDKMKLVEIIRGRQTDDETVA
RAFDYVQALGKIPIVVNDSRGFYTSRTFAAFVMEGAAMLGEGIPAAVIENAGMQAGMPVGPLAVLDETALSLSVHVLDQT
RADFAAEGKTYIATPGELLVERMVKEFQRNGRAEGGGFYDYPAEKGAKKMLWPHLKALFEKSGTPWDITGIKDRLLYRQA
VEAARCLSEGVLTTVAEANIGSIFGIGFPAWTGGTLQFIYGMGLDDFIRRCDELAAKFGPGFMLTNTVRSALRKHQPVY

Sequences:

>Translated_719_residues
MKTIQYALTEESFGRVATITFDEPGSPVNTMCRQWQDDLSEVTAQVLKDREAIQGVILASAKSTFFAGADLKAAMRLTAA
DASQVYAEIERVKKNFRTLETLGKPVVSCLNGAALGGGWELALVGHYRVAVDDSKVRFGLPEVTLGLLPGASGVTKMTRH
LGLMAAQPYLVEGKTFGPREALALSLVHALVPDAAALRAQALAWIAANPRAQHPWDARDYEIPGGTPASPEVAAALSVAP
AMLKKKTRGLYPAPEAILACMVEGALVDLETALRIESRYLARLMTGPNARAMINTFFFNMNAIKSGQSRPSSVPHATPLK
VGVLGAGMMGAGIAYAQASRGLATVLKDVSLDKAEAGKAYSARLTQPQVEKGHMTPANQAALLSRITATDQLADLAGCDL
IIEAVFEQRDLKAKVTQEAEPLLAAGGFFASNTSTLPISGLAVASSRPEKFIGIHFFSPVDKMKLVEIIRGRQTDDETVA
RAFDYVQALGKIPIVVNDSRGFYTSRTFAAFVMEGAAMLGEGIPAAVIENAGMQAGMPVGPLAVLDETALSLSVHVLDQT
RADFAAEGKTYIATPGELLVERMVKEFQRNGRAEGGGFYDYPAEKGAKKMLWPHLKALFEKSGTPWDITGIKDRLLYRQA
VEAARCLSEGVLTTVAEANIGSIFGIGFPAWTGGTLQFIYGMGLDDFIRRCDELAAKFGPGFMLTNTVRSALRKHQPVY
>Mature_719_residues
MKTIQYALTEESFGRVATITFDEPGSPVNTMCRQWQDDLSEVTAQVLKDREAIQGVILASAKSTFFAGADLKAAMRLTAA
DASQVYAEIERVKKNFRTLETLGKPVVSCLNGAALGGGWELALVGHYRVAVDDSKVRFGLPEVTLGLLPGASGVTKMTRH
LGLMAAQPYLVEGKTFGPREALALSLVHALVPDAAALRAQALAWIAANPRAQHPWDARDYEIPGGTPASPEVAAALSVAP
AMLKKKTRGLYPAPEAILACMVEGALVDLETALRIESRYLARLMTGPNARAMINTFFFNMNAIKSGQSRPSSVPHATPLK
VGVLGAGMMGAGIAYAQASRGLATVLKDVSLDKAEAGKAYSARLTQPQVEKGHMTPANQAALLSRITATDQLADLAGCDL
IIEAVFEQRDLKAKVTQEAEPLLAAGGFFASNTSTLPISGLAVASSRPEKFIGIHFFSPVDKMKLVEIIRGRQTDDETVA
RAFDYVQALGKIPIVVNDSRGFYTSRTFAAFVMEGAAMLGEGIPAAVIENAGMQAGMPVGPLAVLDETALSLSVHVLDQT
RADFAAEGKTYIATPGELLVERMVKEFQRNGRAEGGGFYDYPAEKGAKKMLWPHLKALFEKSGTPWDITGIKDRLLYRQA
VEAARCLSEGVLTTVAEANIGSIFGIGFPAWTGGTLQFIYGMGLDDFIRRCDELAAKFGPGFMLTNTVRSALRKHQPVY

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=715, Percent_Identity=31.6083916083916, Blast_Score=327, Evalue=4e-89,
Organism=Homo sapiens, GI68989263, Length=701, Percent_Identity=27.9600570613409, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI261878539, Length=601, Percent_Identity=28.1198003327787, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=31.8339100346021, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=30.0653594771242, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI194097323, Length=192, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1788682, Length=693, Percent_Identity=33.4776334776335, Blast_Score=315, Evalue=6e-87,
Organism=Escherichia coli, GI1790281, Length=721, Percent_Identity=31.3453536754508, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI1787661, Length=290, Percent_Identity=30, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI221142681, Length=181, Percent_Identity=30.939226519337, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1787659, Length=94, Percent_Identity=38.2978723404255, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=737, Percent_Identity=29.9864314789688, Blast_Score=281, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17508953, Length=743, Percent_Identity=31.4939434724092, Blast_Score=281, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17508951, Length=743, Percent_Identity=31.4939434724092, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25144276, Length=649, Percent_Identity=31.8952234206472, Blast_Score=238, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71985923, Length=389, Percent_Identity=27.7634961439589, Blast_Score=145, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=380, Percent_Identity=25.7894736842105, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=33.7931034482759, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=31.1643835616438, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17563036, Length=310, Percent_Identity=29.0322580645161, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=178, Percent_Identity=34.2696629213483, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=176, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=178, Percent_Identity=28.6516853932584, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583077, Length=738, Percent_Identity=29.2682926829268, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24583079, Length=738, Percent_Identity=29.2682926829268, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI19921000, Length=738, Percent_Identity=29.2682926829268, Blast_Score=259, Evalue=6e-69,
Organism=Drosophila melanogaster, GI20129971, Length=183, Percent_Identity=32.7868852459016, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653477, Length=183, Percent_Identity=32.7868852459016, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653139, Length=193, Percent_Identity=31.0880829015544, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 77001; Mature: 77001

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIQYALTEESFGRVATITFDEPGSPVNTMCRQWQDDLSEVTAQVLKDREAIQGVILAS
CCCEEEECCHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
AKSTFFAGADLKAAMRLTAADASQVYAEIERVKKNFRTLETLGKPVVSCLNGAALGGGWE
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LALVGHYRVAVDDSKVRFGLPEVTLGLLPGASGVTKMTRHLGLMAAQPYLVEGKTFGPRE
EEEEEEEEEEEECCCEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHH
ALALSLVHALVPDAAALRAQALAWIAANPRAQHPWDARDYEIPGGTPASPEVAAALSVAP
HHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHH
AMLKKKTRGLYPAPEAILACMVEGALVDLETALRIESRYLARLMTGPNARAMINTFFFNM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEH
NAIKSGQSRPSSVPHATPLKVGVLGAGMMGAGIAYAQASRGLATVLKDVSLDKAEAGKAY
HHHHCCCCCCCCCCCCCCCEEEEECCCHHHCCHHHHHHHCCHHHHHHHCCCCHHHCCCCC
SARLTQPQVEKGHMTPANQAALLSRITATDQLADLAGCDLIIEAVFEQRDLKAKVTQEAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
PLLAAGGFFASNTSTLPISGLAVASSRPEKFIGIHFFSPVDKMKLVEIIRGRQTDDETVA
CHHEECCEEECCCCCCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHH
RAFDYVQALGKIPIVVNDSRGFYTSRTFAAFVMEGAAMLGEGIPAAVIENAGMQAGMPVG
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCC
PLAVLDETALSLSVHVLDQTRADFAAEGKTYIATPGELLVERMVKEFQRNGRAEGGGFYD
CHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
YPAEKGAKKMLWPHLKALFEKSGTPWDITGIKDRLLYRQAVEAARCLSEGVLTTVAEANI
CCHHCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSIFGIGFPAWTGGTLQFIYGMGLDDFIRRCDELAAKFGPGFMLTNTVRSALRKHQPVY
CCEEECCCCCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTIQYALTEESFGRVATITFDEPGSPVNTMCRQWQDDLSEVTAQVLKDREAIQGVILAS
CCCEEEECCHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
AKSTFFAGADLKAAMRLTAADASQVYAEIERVKKNFRTLETLGKPVVSCLNGAALGGGWE
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LALVGHYRVAVDDSKVRFGLPEVTLGLLPGASGVTKMTRHLGLMAAQPYLVEGKTFGPRE
EEEEEEEEEEEECCCEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHH
ALALSLVHALVPDAAALRAQALAWIAANPRAQHPWDARDYEIPGGTPASPEVAAALSVAP
HHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHH
AMLKKKTRGLYPAPEAILACMVEGALVDLETALRIESRYLARLMTGPNARAMINTFFFNM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEH
NAIKSGQSRPSSVPHATPLKVGVLGAGMMGAGIAYAQASRGLATVLKDVSLDKAEAGKAY
HHHHCCCCCCCCCCCCCCCEEEEECCCHHHCCHHHHHHHCCHHHHHHHCCCCHHHCCCCC
SARLTQPQVEKGHMTPANQAALLSRITATDQLADLAGCDLIIEAVFEQRDLKAKVTQEAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
PLLAAGGFFASNTSTLPISGLAVASSRPEKFIGIHFFSPVDKMKLVEIIRGRQTDDETVA
CHHEECCEEECCCCCCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCHHHHH
RAFDYVQALGKIPIVVNDSRGFYTSRTFAAFVMEGAAMLGEGIPAAVIENAGMQAGMPVG
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCC
PLAVLDETALSLSVHVLDQTRADFAAEGKTYIATPGELLVERMVKEFQRNGRAEGGGFYD
CHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
YPAEKGAKKMLWPHLKALFEKSGTPWDITGIKDRLLYRQAVEAARCLSEGVLTTVAEANI
CCHHCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSIFGIGFPAWTGGTLQFIYGMGLDDFIRRCDELAAKFGPGFMLTNTVRSALRKHQPVY
CCEEECCCCCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA