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The map label for this gene is fadA [H]

Identifier: 91788875

GI number: 91788875

Start: 3175967

End: 3177172

Strand: Direct

Name: fadA [H]

Synonym: Bpro_3015

Alternate gene names: 91788875

Gene position: 3175967-3177172 (Clockwise)

Preceding gene: 91788872

Following gene: 91788876

Centisome position: 61.07

GC content: 65.51

Gene sequence:

>1206_bases
ATGACTGAAGCATTCATCTATGACGCCATACGCACGCCGCGTGGCAAAGGCAAAAAGGACGGCAGCCTGCATGAAGTCAA
GCCGGTGAACCTGCTGGCCGGCGTGCTGACCGAACTGCAGCGCCGCAATGGCTTTGACACCGCGGCGATAGACGACGTGG
TGATGGGCGTGGTCTCGCCGGTCGGCGAACAGGGTGCGGTCATTGCCAAGGTGGCGGCGCTCCGGGCTGGCTGGGATTTC
CGCGCTTCGGGGGTGCAGGTCAACCGCTTCTGCGCCTCGGGCCTGGAAGCGGTGAACCTGGCAGCGCAAAAGGTACGCTC
GGGCTGGGAAGACCTGGTGGTGGCCGGCGGCGTGGAGAGCATGAGCCGGGTGCCGATTGGCTCCGACGGCGGCGCCTGGG
CTCAGGACCCTGAAACCAACAGCGCGACCCTGTTTGTGCCGCAGGGCATAGGCGCCGACCTGATTGCAACGATCGAGGGT
TTCAGCCGTGCAGAGGTGGACGCCTTTGCCTTGCAAAGCCAGCAGCGCGCTGCCGCAGCGCGTTCGGCCGGCCATTTTTT
CAATTCCGTCGTGCCGGTGAAAGACCCGCTGGGCCAGATCATCCTGGGCGAAGATGAATTCATCAAGCCCCACACCACGC
TGGAGGGCCTGGCTCAGCTCAAGCCCGCGTTTGAGCAGCTGGGGGCGATGGGCTTTGACGCCGTGGCGCTGCAGCGCTAT
CCGCAGGTCGAGCGCATCCAGCATGTGCACCACGCAGGCAACTCTTCGGGCATTGTGGATGGTGCGGCGGCGGTGCTGAT
TGGCTCGGACGCGGCGGGCAGAACGCATGGCCTGCAGCCCCGCGCACGCATTGTGGCGGCGGCGCTGAGCGGCGCCGACC
CGACCATCATGCTGACCGGGCCCATGCCGGCCACGCGCAAGGTGCTGGCCAAAGCAGGCATGACGGTGGAGCAGATCGAC
CTCTTTGAAGTCAACGAAGCCTTTGCCGCCGTGGTGATGCGCTTCATGAAGGAGATGCAGGTGCCGCACGAAAAAATCAA
CGTGAACGGCGGCGCGATTGCCATGGGCCACCCGCTGGGCGCCACCGGCGCGATGATTCTGGGCACGCTGGTCGACGAGC
TGCACCGGCGCCAGCTGCGCTATGGCCTGGCCACGCTGTGCGTGGGCGGCGGCATGGGCATTGCGACGATTGTGGAGAGA
GTCTGA

Upstream 100 bases:

>100_bases
ATATCGTCAGGTTGTCGATCTCGCCTATTTCGTCCGATTTCGTCCAATTTCGTTTTATTTCGTCCTGCTGATCCATTCCC
TGCCCCTGAGGAAAGCTGCC

Downstream 100 bases:

>100_bases
TGAAAACCATCCAGTACGCACTGACCGAAGAGTCTTTTGGCCGGGTGGCCACCATTACCTTTGACGAGCCCGGCTCGCCC
GTCAACACCATGTGCCGGCA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTEAFIYDAIRTPRGKGKKDGSLHEVKPVNLLAGVLTELQRRNGFDTAAIDDVVMGVVSPVGEQGAVIAKVAALRAGWDF
RASGVQVNRFCASGLEAVNLAAQKVRSGWEDLVVAGGVESMSRVPIGSDGGAWAQDPETNSATLFVPQGIGADLIATIEG
FSRAEVDAFALQSQQRAAAARSAGHFFNSVVPVKDPLGQIILGEDEFIKPHTTLEGLAQLKPAFEQLGAMGFDAVALQRY
PQVERIQHVHHAGNSSGIVDGAAAVLIGSDAAGRTHGLQPRARIVAAALSGADPTIMLTGPMPATRKVLAKAGMTVEQID
LFEVNEAFAAVVMRFMKEMQVPHEKINVNGGAIAMGHPLGATGAMILGTLVDELHRRQLRYGLATLCVGGGMGIATIVER
V

Sequences:

>Translated_401_residues
MTEAFIYDAIRTPRGKGKKDGSLHEVKPVNLLAGVLTELQRRNGFDTAAIDDVVMGVVSPVGEQGAVIAKVAALRAGWDF
RASGVQVNRFCASGLEAVNLAAQKVRSGWEDLVVAGGVESMSRVPIGSDGGAWAQDPETNSATLFVPQGIGADLIATIEG
FSRAEVDAFALQSQQRAAAARSAGHFFNSVVPVKDPLGQIILGEDEFIKPHTTLEGLAQLKPAFEQLGAMGFDAVALQRY
PQVERIQHVHHAGNSSGIVDGAAAVLIGSDAAGRTHGLQPRARIVAAALSGADPTIMLTGPMPATRKVLAKAGMTVEQID
LFEVNEAFAAVVMRFMKEMQVPHEKINVNGGAIAMGHPLGATGAMILGTLVDELHRRQLRYGLATLCVGGGMGIATIVER
V
>Mature_400_residues
TEAFIYDAIRTPRGKGKKDGSLHEVKPVNLLAGVLTELQRRNGFDTAAIDDVVMGVVSPVGEQGAVIAKVAALRAGWDFR
ASGVQVNRFCASGLEAVNLAAQKVRSGWEDLVVAGGVESMSRVPIGSDGGAWAQDPETNSATLFVPQGIGADLIATIEGF
SRAEVDAFALQSQQRAAAARSAGHFFNSVVPVKDPLGQIILGEDEFIKPHTTLEGLAQLKPAFEQLGAMGFDAVALQRYP
QVERIQHVHHAGNSSGIVDGAAAVLIGSDAAGRTHGLQPRARIVAAALSGADPTIMLTGPMPATRKVLAKAGMTVEQIDL
FEVNEAFAAVVMRFMKEMQVPHEKINVNGGAIAMGHPLGATGAMILGTLVDELHRRQLRYGLATLCVGGGMGIATIVERV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=367, Percent_Identity=36.7847411444142, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=37.6288659793814, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=36.5239294710327, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=33.7349397590361, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4504327, Length=444, Percent_Identity=31.0810810810811, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=49.438202247191, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=41.6075650118203, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=39.7058823529412, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082165, Length=414, Percent_Identity=38.4057971014493, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1788554, Length=416, Percent_Identity=38.9423076923077, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=29.1079812206573, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=374, Percent_Identity=38.7700534759358, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=412, Percent_Identity=31.3106796116505, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25147385, Length=418, Percent_Identity=30.3827751196172, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17551802, Length=453, Percent_Identity=28.2560706401766, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=29.2079207920792, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=406, Percent_Identity=34.2364532019704, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=420, Percent_Identity=29.5238095238095, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=38.3132530120482, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI17648125, Length=415, Percent_Identity=33.7349397590361, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24640423, Length=415, Percent_Identity=31.8072289156626, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=28.5067873303167, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42122; Mature: 41991

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAFIYDAIRTPRGKGKKDGSLHEVKPVNLLAGVLTELQRRNGFDTAAIDDVVMGVVSP
CCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
VGEQGAVIAKVAALRAGWDFRASGVQVNRFCASGLEAVNLAAQKVRSGWEDLVVAGGVES
CCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCHHH
MSRVPIGSDGGAWAQDPETNSATLFVPQGIGADLIATIEGFSRAEVDAFALQSQQRAAAA
HHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RSAGHFFNSVVPVKDPLGQIILGEDEFIKPHTTLEGLAQLKPAFEQLGAMGFDAVALQRY
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
PQVERIQHVHHAGNSSGIVDGAAAVLIGSDAAGRTHGLQPRARIVAAALSGADPTIMLTG
CHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEC
PMPATRKVLAKAGMTVEQIDLFEVNEAFAAVVMRFMKEMQVPHEKINVNGGAIAMGHPLG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCEEEECCCCC
ATGAMILGTLVDELHRRQLRYGLATLCVGGGMGIATIVERV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
TEAFIYDAIRTPRGKGKKDGSLHEVKPVNLLAGVLTELQRRNGFDTAAIDDVVMGVVSP
CCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
VGEQGAVIAKVAALRAGWDFRASGVQVNRFCASGLEAVNLAAQKVRSGWEDLVVAGGVES
CCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCHHH
MSRVPIGSDGGAWAQDPETNSATLFVPQGIGADLIATIEGFSRAEVDAFALQSQQRAAAA
HHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RSAGHFFNSVVPVKDPLGQIILGEDEFIKPHTTLEGLAQLKPAFEQLGAMGFDAVALQRY
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
PQVERIQHVHHAGNSSGIVDGAAAVLIGSDAAGRTHGLQPRARIVAAALSGADPTIMLTG
CHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEC
PMPATRKVLAKAGMTVEQIDLFEVNEAFAAVVMRFMKEMQVPHEKINVNGGAIAMGHPLG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCEEEECCCCC
ATGAMILGTLVDELHRRQLRYGLATLCVGGGMGIATIVERV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]