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The map label for this gene is serA [H]

Identifier: 91788816

GI number: 91788816

Start: 3116173

End: 3117180

Strand: Direct

Name: serA [H]

Synonym: Bpro_2956

Alternate gene names: 91788816

Gene position: 3116173-3117180 (Clockwise)

Preceding gene: 91788815

Following gene: 91788817

Centisome position: 59.92

GC content: 58.43

Gene sequence:

>1008_bases
ATGAATATTGTGATCCTCGATGACTACCAGGATGCAGTGCGAAAACTGAACTGCGCCGCGAAACTGGACGCCTACCCTGC
CAAGGTCTACACCAACACGGTCAAAGGCATAGGCCAGCTGTCCGTCCGGCTCAAGGATGCCGACGTAATCGTGCTGATTC
GCGAACGAACCCAGCTAAACAGGCAGGTGATTGAAAAACTCCCCAAACTCAAGCTGATTGCCCAAACCGGCCGCGTCGGT
AGCCATATCGATGTTGCGGCCTGCACCGAGCGCGGCGTTGCGGTGGCGGAAGGCGTGGGGTCACCAACCGCACCTGCCGA
GCTGACCTGGGCGTTGGTGATGGCCGCGATGCGACGCATTCCCCACTATGTATCGCACTTGAAGCACGGCGCCTGGCAGC
AAGCTGGCCTCAAGGCCGCATCCATGCCCCCCAATTTTGGTATTGGCTCAGTCCTCAAGGGCAAGACATTGGGCGTCTGG
AGCTACGGCAAGATCGGACAAATCATTGCAGGCTATGGCCGGGCGTTTGGCATGCGCGTGATCGTCTGGGGCCGGGAAGC
ATCGCTGGAGCGGGCGCAGGCTGACGGTTTTGAAATTGCCGACAGCAAAGCCGAATTTTTCGAACAAAGTGACGTGCTCA
GTTTGCACCTGCGGCTGCATGATGAAACACGCGGCATCGTGACCCTCGAAGATCTGTCGCGTATGAAACCAACGGCCTTG
TTGGTCAATACCTCACGGGCCGAGCTGATCGAGCCCGAGGCCCTGATTGCCGCGCTGAACCGCGGACGCCCGGGACTGGC
GGCTGTTGATGTCTTTGAGTCCGAACCCATTTTGCAAGGCCACGCACTGCTGCGGCTGGAAAACTGCATCTGCACGCCGC
ACATAGGCTATGTGGAGCAGGACAGTTATGAAATGTATTTCGGGGCGGCCTTTGACAATGTCGTGAACTTCATCAAGGGA
ACCCCGACGAACATCGTCAACCCCGGTGCGCTGCAGGTACGCCGCTGA

Upstream 100 bases:

>100_bases
ATAGCCCGGGCAGGGGGACAGGTTGCCTTCCGATACAAGTTGACGGCTTTCGGGCGCCCCTGTCCGAAGGGAAGAAAAAT
CTTGCAGGCACAATATCGGC

Downstream 100 bases:

>100_bases
TTTTCCCTGATGCCGGGCACCACCGGCTACGGTAAAGCTCAGCAAGGCTGCACCCACACAGGCGATCCGCAGTCGGATGC
AGCTACGCGGCTCGGGCTGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNIVILDDYQDAVRKLNCAAKLDAYPAKVYTNTVKGIGQLSVRLKDADVIVLIRERTQLNRQVIEKLPKLKLIAQTGRVG
SHIDVAACTERGVAVAEGVGSPTAPAELTWALVMAAMRRIPHYVSHLKHGAWQQAGLKAASMPPNFGIGSVLKGKTLGVW
SYGKIGQIIAGYGRAFGMRVIVWGREASLERAQADGFEIADSKAEFFEQSDVLSLHLRLHDETRGIVTLEDLSRMKPTAL
LVNTSRAELIEPEALIAALNRGRPGLAAVDVFESEPILQGHALLRLENCICTPHIGYVEQDSYEMYFGAAFDNVVNFIKG
TPTNIVNPGALQVRR

Sequences:

>Translated_335_residues
MNIVILDDYQDAVRKLNCAAKLDAYPAKVYTNTVKGIGQLSVRLKDADVIVLIRERTQLNRQVIEKLPKLKLIAQTGRVG
SHIDVAACTERGVAVAEGVGSPTAPAELTWALVMAAMRRIPHYVSHLKHGAWQQAGLKAASMPPNFGIGSVLKGKTLGVW
SYGKIGQIIAGYGRAFGMRVIVWGREASLERAQADGFEIADSKAEFFEQSDVLSLHLRLHDETRGIVTLEDLSRMKPTAL
LVNTSRAELIEPEALIAALNRGRPGLAAVDVFESEPILQGHALLRLENCICTPHIGYVEQDSYEMYFGAAFDNVVNFIKG
TPTNIVNPGALQVRR
>Mature_335_residues
MNIVILDDYQDAVRKLNCAAKLDAYPAKVYTNTVKGIGQLSVRLKDADVIVLIRERTQLNRQVIEKLPKLKLIAQTGRVG
SHIDVAACTERGVAVAEGVGSPTAPAELTWALVMAAMRRIPHYVSHLKHGAWQQAGLKAASMPPNFGIGSVLKGKTLGVW
SYGKIGQIIAGYGRAFGMRVIVWGREASLERAQADGFEIADSKAEFFEQSDVLSLHLRLHDETRGIVTLEDLSRMKPTAL
LVNTSRAELIEPEALIAALNRGRPGLAAVDVFESEPILQGHALLRLENCICTPHIGYVEQDSYEMYFGAAFDNVVNFIKG
TPTNIVNPGALQVRR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=295, Percent_Identity=28.135593220339, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=29.6875, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI145580578, Length=302, Percent_Identity=28.8079470198675, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557499, Length=302, Percent_Identity=28.8079470198675, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=29.7709923664122, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=29.7709923664122, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=30.7407407407407, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI87082289, Length=283, Percent_Identity=29.3286219081272, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789279, Length=271, Percent_Identity=30.2583025830258, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787645, Length=292, Percent_Identity=29.1095890410959, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=334, Percent_Identity=28.1437125748503, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=31.7829457364341, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=27.710843373494, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=271, Percent_Identity=26.5682656826568, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=309, Percent_Identity=24.2718446601942, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=269, Percent_Identity=23.7918215613383, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574286, Length=273, Percent_Identity=27.8388278388278, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=31.0483870967742, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19921140, Length=290, Percent_Identity=27.9310344827586, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=25.9541984732824, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574284, Length=262, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36621; Mature: 36621

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVILDDYQDAVRKLNCAAKLDAYPAKVYTNTVKGIGQLSVRLKDADVIVLIRERTQLN
CEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEEEEECCCEEEEEECHHHHH
RQVIEKLPKLKLIAQTGRVGSHIDVAACTERGVAVAEGVGSPTAPAELTWALVMAAMRRI
HHHHHHCCCEEEEECCCCCCCCEEHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHH
PHYVSHLKHGAWQQAGLKAASMPPNFGIGSVLKGKTLGVWSYGKIGQIIAGYGRAFGMRV
HHHHHHHHCCCHHHHCCEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEE
IVWGREASLERAQADGFEIADSKAEFFEQSDVLSLHLRLHDETRGIVTLEDLSRMKPTAL
EEECCCHHHHHHHCCCCEECCCHHHHHCCCCEEEEEEEEECCCCCEEEHHHHHHCCCEEE
LVNTSRAELIEPEALIAALNRGRPGLAAVDVFESEPILQGHALLRLENCICTPHIGYVEQ
EEECCHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHEEECCEECCCCCCCEEC
DSYEMYFGAAFDNVVNFIKGTPTNIVNPGALQVRR
CCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MNIVILDDYQDAVRKLNCAAKLDAYPAKVYTNTVKGIGQLSVRLKDADVIVLIRERTQLN
CEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEEEEECCCEEEEEECHHHHH
RQVIEKLPKLKLIAQTGRVGSHIDVAACTERGVAVAEGVGSPTAPAELTWALVMAAMRRI
HHHHHHCCCEEEEECCCCCCCCEEHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHH
PHYVSHLKHGAWQQAGLKAASMPPNFGIGSVLKGKTLGVWSYGKIGQIIAGYGRAFGMRV
HHHHHHHHCCCHHHHCCEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEE
IVWGREASLERAQADGFEIADSKAEFFEQSDVLSLHLRLHDETRGIVTLEDLSRMKPTAL
EEECCCHHHHHHHCCCCEECCCHHHHHCCCCEEEEEEEEECCCCCEEEHHHHHHCCCEEE
LVNTSRAELIEPEALIAALNRGRPGLAAVDVFESEPILQGHALLRLENCICTPHIGYVEQ
EEECCHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHEEECCEECCCCCCCEEC
DSYEMYFGAAFDNVVNFIKGTPTNIVNPGALQVRR
CCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]