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The map label for this gene is paaH [H]

Identifier: 91788817

GI number: 91788817

Start: 3117773

End: 3119290

Strand: Direct

Name: paaH [H]

Synonym: Bpro_2957

Alternate gene names: 91788817

Gene position: 3117773-3119290 (Clockwise)

Preceding gene: 91788816

Following gene: 91788818

Centisome position: 59.95

GC content: 64.89

Gene sequence:

>1518_bases
ATGAAACCAATTTACAAAACCGTTGGCATCGTTGGCACGGGTGCCATGGGCCGTGGCATTGCCCAGATTGCGGCGCAAGC
CGGGAGTGTCGTCAAGTTGATGGACAACCAGGCGGGCGCGGCGGAAAAGGCGCGGGAGGCCATCTGCGCGCAGTGGGACA
AGCTGGTGGAAAAAGGCCGGATGGAAACCACCGCTGCGACCAGCCACAAGGCCAGCCTTCTGACGGCCGGCACGCTGGCC
GATCTGGCGGACTGCGATCTGATTGTTGAAGCCATTGTGGAGCGGCTGGACGTCAAGAAAGCCCTGTTCGCCGAACTCGA
GACCATCGTGTCGGCGCAAACCGTGCTTGCCACCAACACCTCGTCGCTGTCCGTGACCGCCATTGCGGCCGCGCTCAAAC
ACCCGGAACGCTTTGCCGGCTACCACTTTTTTAATCCCGTTCCGCTGATGAAGGTGGTGGAGGTCATCGCCGGCCTGAAA
ACTGATGCGGCGGTGTGCAGCGCACTGGCCGACTACGCCCGCCAGATGGGGCACACGCCGGTGCAGGCCCAGGACACTCC
CGGCTTCATCGTCAACCATGCGGGGCGGGGCTATGGCACCGAAGCGCTGCGCATCGTCAGCGAAGGCGTGGCTGATTTCG
CCACCATAGACCGCATCCTGCGGGACCAGGCCGGCTTCAAGCTGGGCCCCTTCGAGTTGATGGACCTGACCGCGCTGGAC
GTATCGCATCCCGTGATGGAGTCCATTTACCACCAGTACTACGAGGAAGCGCGCTACCGCCCCAGCGTGATCACGGCGCA
GCGGCTGGCAGGCGGCATGCTCGGCCGCAAGACCGGCGAAGGCTTTTACCGCTATGCCGACGGTGTGATGCAGCTTCCGG
CCGAAGCACCCGTACCCCGGGTCGCCGAGATGCCGCCGGTCTGGGTGTCACCCAGAGCGTCCCGGCGCTCGGAGTTGCTG
CAATTGCTGAAAAATCTCGGCGCCAAGATCGAAACCGGCCAGTCCGCATCGCCCCAGGCCCTGATGGTGGTGGCGCCCCT
GGGATTTGACATCACCACGGTGGCCGTGGTGGAGCGGCTGGACCCGGCGCGTACCGTGGGTATAGACATGCTGATTGATG
ACGCGGCGACCCGGCGGCGGGTCCTGGCCACCAACCCGGCCACCCGCACCGACATGCGCGACGCCGCCCATGCCCTGTTC
GCCCGGGACGGCAAGGCGGTGAGCGTGATACGGGACAGCGGCGGATTTGTCACGCAGCGCGTCGTGGCCACCATCGTCAA
CATTGCCAGTGATATCTGCCAGCAAGGCATCTGCAGCCCGAAAGATCTTGAAACCGCCGTGACGCTGGGGCTGGGCTACC
CGCTCGGGCCGCTCGCCATGGGCGACCGCTACGGGCCCACCAACGTGCTGGAGGTGCTGTTCAACATGCAAACCGTCTAT
GGCGACCAGCGCTACCGCCCTTCCCCGTGGCTGCGCCGCCGCGGCGCCATTGGCCTGAGCCTGATGCATGAAGAGTGA

Upstream 100 bases:

>100_bases
CGCTATCTTCATCGCGCCAGCCAGCCCGGCCAGATTGATATCAGCCGCTGCGGCGTCTGATACGGTCGCAATGCCGGGCC
CTGCGTAATAATCCATTTCC

Downstream 100 bases:

>100_bases
GACACCCCCTTCGGATGCTCACTTCGTGTAGCACCTTCCCCCCTCCAGGGGGCGGCGCCTGCGGCCTGGCGAAGCCAGTT
CCGCGGCCCCCATTGGTAAG

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MKPIYKTVGIVGTGAMGRGIAQIAAQAGSVVKLMDNQAGAAEKAREAICAQWDKLVEKGRMETTAATSHKASLLTAGTLA
DLADCDLIVEAIVERLDVKKALFAELETIVSAQTVLATNTSSLSVTAIAAALKHPERFAGYHFFNPVPLMKVVEVIAGLK
TDAAVCSALADYARQMGHTPVQAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATIDRILRDQAGFKLGPFELMDLTALD
VSHPVMESIYHQYYEEARYRPSVITAQRLAGGMLGRKTGEGFYRYADGVMQLPAEAPVPRVAEMPPVWVSPRASRRSELL
QLLKNLGAKIETGQSASPQALMVVAPLGFDITTVAVVERLDPARTVGIDMLIDDAATRRRVLATNPATRTDMRDAAHALF
ARDGKAVSVIRDSGGFVTQRVVATIVNIASDICQQGICSPKDLETAVTLGLGYPLGPLAMGDRYGPTNVLEVLFNMQTVY
GDQRYRPSPWLRRRGAIGLSLMHEE

Sequences:

>Translated_505_residues
MKPIYKTVGIVGTGAMGRGIAQIAAQAGSVVKLMDNQAGAAEKAREAICAQWDKLVEKGRMETTAATSHKASLLTAGTLA
DLADCDLIVEAIVERLDVKKALFAELETIVSAQTVLATNTSSLSVTAIAAALKHPERFAGYHFFNPVPLMKVVEVIAGLK
TDAAVCSALADYARQMGHTPVQAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATIDRILRDQAGFKLGPFELMDLTALD
VSHPVMESIYHQYYEEARYRPSVITAQRLAGGMLGRKTGEGFYRYADGVMQLPAEAPVPRVAEMPPVWVSPRASRRSELL
QLLKNLGAKIETGQSASPQALMVVAPLGFDITTVAVVERLDPARTVGIDMLIDDAATRRRVLATNPATRTDMRDAAHALF
ARDGKAVSVIRDSGGFVTQRVVATIVNIASDICQQGICSPKDLETAVTLGLGYPLGPLAMGDRYGPTNVLEVLFNMQTVY
GDQRYRPSPWLRRRGAIGLSLMHEE
>Mature_505_residues
MKPIYKTVGIVGTGAMGRGIAQIAAQAGSVVKLMDNQAGAAEKAREAICAQWDKLVEKGRMETTAATSHKASLLTAGTLA
DLADCDLIVEAIVERLDVKKALFAELETIVSAQTVLATNTSSLSVTAIAAALKHPERFAGYHFFNPVPLMKVVEVIAGLK
TDAAVCSALADYARQMGHTPVQAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATIDRILRDQAGFKLGPFELMDLTALD
VSHPVMESIYHQYYEEARYRPSVITAQRLAGGMLGRKTGEGFYRYADGVMQLPAEAPVPRVAEMPPVWVSPRASRRSELL
QLLKNLGAKIETGQSASPQALMVVAPLGFDITTVAVVERLDPARTVGIDMLIDDAATRRRVLATNPATRTDMRDAAHALF
ARDGKAVSVIRDSGGFVTQRVVATIVNIASDICQQGICSPKDLETAVTLGLGYPLGPLAMGDRYGPTNVLEVLFNMQTVY
GDQRYRPSPWLRRRGAIGLSLMHEE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=40, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=37.785016286645, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI20127408, Length=287, Percent_Identity=30.3135888501742, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI261878539, Length=320, Percent_Identity=28.4375, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI68989263, Length=320, Percent_Identity=28.75, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI115430219, Length=238, Percent_Identity=26.890756302521, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1787661, Length=494, Percent_Identity=38.0566801619433, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1790281, Length=241, Percent_Identity=34.8547717842324, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1788682, Length=269, Percent_Identity=34.5724907063197, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=40.9090909090909, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=285, Percent_Identity=37.5438596491228, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=34.8432055749129, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=30.2816901408451, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=28.7234042553192, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=28.4697508896797, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=28.4697508896797, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=28.4697508896797, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=27.3049645390071, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583077, Length=280, Percent_Identity=28.9285714285714, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24583079, Length=280, Percent_Identity=28.9285714285714, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=29.3286219081272, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI20129993, Length=239, Percent_Identity=26.7782426778243, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54347; Mature: 54347

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIYKTVGIVGTGAMGRGIAQIAAQAGSVVKLMDNQAGAAEKAREAICAQWDKLVEKGR
CCCHHHHHCCEECCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
METTAATSHKASLLTAGTLADLADCDLIVEAIVERLDVKKALFAELETIVSAQTVLATNT
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
SSLSVTAIAAALKHPERFAGYHFFNPVPLMKVVEVIAGLKTDAAVCSALADYARQMGHTP
CCHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
VQAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATIDRILRDQAGFKLGPFELMDLTALD
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VSHPVMESIYHQYYEEARYRPSVITAQRLAGGMLGRKTGEGFYRYADGVMQLPAEAPVPR
HCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
VAEMPPVWVSPRASRRSELLQLLKNLGAKIETGQSASPQALMVVAPLGFDITTVAVVERL
HHCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHC
DPARTVGIDMLIDDAATRRRVLATNPATRTDMRDAAHALFARDGKAVSVIRDSGGFVTQR
CCHHHHHHHHEECCHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
VVATIVNIASDICQQGICSPKDLETAVTLGLGYPLGPLAMGDRYGPTNVLEVLFNMQTVY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GDQRYRPSPWLRRRGAIGLSLMHEE
CCCCCCCCHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MKPIYKTVGIVGTGAMGRGIAQIAAQAGSVVKLMDNQAGAAEKAREAICAQWDKLVEKGR
CCCHHHHHCCEECCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
METTAATSHKASLLTAGTLADLADCDLIVEAIVERLDVKKALFAELETIVSAQTVLATNT
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
SSLSVTAIAAALKHPERFAGYHFFNPVPLMKVVEVIAGLKTDAAVCSALADYARQMGHTP
CCHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
VQAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATIDRILRDQAGFKLGPFELMDLTALD
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VSHPVMESIYHQYYEEARYRPSVITAQRLAGGMLGRKTGEGFYRYADGVMQLPAEAPVPR
HCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
VAEMPPVWVSPRASRRSELLQLLKNLGAKIETGQSASPQALMVVAPLGFDITTVAVVERL
HHCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHC
DPARTVGIDMLIDDAATRRRVLATNPATRTDMRDAAHALFARDGKAVSVIRDSGGFVTQR
CCHHHHHHHHEECCHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
VVATIVNIASDICQQGICSPKDLETAVTLGLGYPLGPLAMGDRYGPTNVLEVLFNMQTVY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GDQRYRPSPWLRRRGAIGLSLMHEE
CCCCCCCCHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]