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The map label for this gene is cyp18 [H]

Identifier: 91788729

GI number: 91788729

Start: 3023567

End: 3024076

Strand: Direct

Name: cyp18 [H]

Synonym: Bpro_2868

Alternate gene names: 91788729

Gene position: 3023567-3024076 (Clockwise)

Preceding gene: 91788728

Following gene: 91788730

Centisome position: 58.14

GC content: 58.04

Gene sequence:

>510_bases
ATGAGCAACCCGAAAGTAGAACTCCATATCAAGAACTACGGCGTCATCACGCTGGAGCTCGATGCCGCCAAGGCACCCAA
GACCGTCGCCAACTTCCTGAGCTATGTCAACAAGGGCCACTACACCAACACCGTGTTTCACCGCGTGATTCCCGGCTTCA
TGGTGCAGGGTGGCGGCTTTGAAGTCGGCATGAAGCAAAAGCCTACCGACGCCGAGATCGAGAACGAAGCCAGCAACGGC
CTGAAGAACGACAACTACACCGTCGCCATGGCCCGCACCAACGCGCCCCACTCGGCCAGCTCGCAGTTTTTCATCAACGT
GGCAGACAACGGCTTTTTGAACCACACTGCGCCCAGCGCATCAGGTTGGGGCTATGCCGTGTTTGGCAAAGTGGTGGCGG
GCGCCGAGGTCGTTGACAAGATCAAGGCCGTCAAAACCGGCCGCAAGGGCTTTCATGATGACGTGCCCCTCGAAGACGTG
GTGATCGAAAAAGCAGTGGCACTGGCCTGA

Upstream 100 bases:

>100_bases
CCGGCGGCCCCTTCCCCACGGACGTGCCTAAAACGCCCGTTCTCATCAAATCTGCAACCCTCGTCAATTAATCAATTGAC
TCACTGATACAGGAACCACC

Downstream 100 bases:

>100_bases
AGCCCCTTCGGACTGAGCCTGCCCAAGTCCGGCCCGTGACCTCCTCCTTGACCGTGCCCCAGATCGCGGAGCTCCATGCA
CCGCCTTCCTGGCGCACGGT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSNPKVELHIKNYGVITLELDAAKAPKTVANFLSYVNKGHYTNTVFHRVIPGFMVQGGGFEVGMKQKPTDAEIENEASNG
LKNDNYTVAMARTNAPHSASSQFFINVADNGFLNHTAPSASGWGYAVFGKVVAGAEVVDKIKAVKTGRKGFHDDVPLEDV
VIEKAVALA

Sequences:

>Translated_169_residues
MSNPKVELHIKNYGVITLELDAAKAPKTVANFLSYVNKGHYTNTVFHRVIPGFMVQGGGFEVGMKQKPTDAEIENEASNG
LKNDNYTVAMARTNAPHSASSQFFINVADNGFLNHTAPSASGWGYAVFGKVVAGAEVVDKIKAVKTGRKGFHDDVPLEDV
VIEKAVALA
>Mature_168_residues
SNPKVELHIKNYGVITLELDAAKAPKTVANFLSYVNKGHYTNTVFHRVIPGFMVQGGGFEVGMKQKPTDAEIENEASNGL
KNDNYTVAMARTNAPHSASSQFFINVADNGFLNHTAPSASGWGYAVFGKVVAGAEVVDKIKAVKTGRKGFHDDVPLEDVV
IEKAVALA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=152, Percent_Identity=36.8421052631579, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI7706339, Length=170, Percent_Identity=31.7647058823529, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI19557636, Length=169, Percent_Identity=31.3609467455621, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI4758950, Length=158, Percent_Identity=34.1772151898734, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310110104, Length=134, Percent_Identity=36.5671641791045, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=152, Percent_Identity=63.8157894736842, Blast_Score=201, Evalue=2e-53,
Organism=Escherichia coli, GI1789763, Length=155, Percent_Identity=57.4193548387097, Blast_Score=167, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=30.1204819277108, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=32.8767123287671, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=32.8767123287671, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=139, Percent_Identity=33.8129496402878, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=165, Percent_Identity=32.1212121212121, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539496, Length=155, Percent_Identity=30.9677419354839, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=158, Percent_Identity=31.6455696202532, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=32.258064516129, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922912, Length=152, Percent_Identity=35.5263157894737, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19922376, Length=157, Percent_Identity=29.2993630573248, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18150; Mature: 18019

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPKVELHIKNYGVITLELDAAKAPKTVANFLSYVNKGHYTNTVFHRVIPGFMVQGGGF
CCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCCE
EVGMKQKPTDAEIENEASNGLKNDNYTVAMARTNAPHSASSQFFINVADNGFLNHTAPSA
EECCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCC
SGWGYAVFGKVVAGAEVVDKIKAVKTGRKGFHDDVPLEDVVIEKAVALA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SNPKVELHIKNYGVITLELDAAKAPKTVANFLSYVNKGHYTNTVFHRVIPGFMVQGGGF
CCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCCE
EVGMKQKPTDAEIENEASNGLKNDNYTVAMARTNAPHSASSQFFINVADNGFLNHTAPSA
EECCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCC
SGWGYAVFGKVVAGAEVVDKIKAVKTGRKGFHDDVPLEDVVIEKAVALA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]