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The map label for this gene is ppiB [H]

Identifier: 91788728

GI number: 91788728

Start: 3022803

End: 3023537

Strand: Direct

Name: ppiB [H]

Synonym: Bpro_2867

Alternate gene names: 91788728

Gene position: 3022803-3023537 (Clockwise)

Preceding gene: 91788727

Following gene: 91788729

Centisome position: 58.13

GC content: 59.73

Gene sequence:

>735_bases
ATGGCATTTGCCAAGCTCGCCATGTCCGCCATGTCCGCCACGTTGACCCCATTCAGCGCGGCTCGCCGCGCAGCGCTCGC
GGCAATGGCTGTCTCTGCCGTCATCACCGGCCTTGCCGGCCCCGCCTCGGCGCAGGGCGCACCCAAGGTGAAGTTTGTCA
CCAGCGAAGGCGATTTCGTGGTCGAGGTCTACCCCGACAAAGCGCCCAAAACGGTCGATAATTTTTTGCAGTACGTCAAG
GACAAGCACTATGACGGCATCATCTTTCACCGGGTCATCAGCAACTTCATGGTGCAGGGCGGTGGCTACGATGCGAAATA
TGCCGAGAAAAAGACCCGCCCCCCGGTGGTCCACGAAGGCCGCGAAGCCCTGGCCAAAGGCGGCGCCAAAAACGTGGTGG
GCACACTGGCCATGGCCCGCACCAGCGACCCCCATTCGGCGTCATCGCAGTTTTTCATCAACGTCAAGGACAACGACTTT
TTGAATCCGACGCTGATCCCGCCGGGCGACCCGGTGCCCCGGTTTGAGTACCAGGGCCAGGTCTATGAAAACACACCACG
CGCGCAACTCGTCAACGCACCCCAACTCTACGGTTACACGGTGTTTGGCAAAGTCATCAGCGGCATGGACGTGGTAAACA
AAATCAAATTGGTTCCCACCGGCCCCGGCGGCCCCTTCCCCACGGACGTGCCTAAAACGCCCGTTCTCATCAAATCTGCA
ACCCTCGTCAATTAA

Upstream 100 bases:

>100_bases
CTGGTCAGGGGCGTTGGAACAGGCCGGACCAGGCACCCGTAGTGGTAGTGGCCCTCGCCGGGGCAGCCAGTGAAAAATAT
TTTCTTGAAGAGGTAATTTG

Downstream 100 bases:

>100_bases
TCAATTGACTCACTGATACAGGAACCACCATGAGCAACCCGAAAGTAGAACTCCATATCAAGAACTACGGCGTCATCACG
CTGGAGCTCGATGCCGCCAA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAFAKLAMSAMSATLTPFSAARRAALAAMAVSAVITGLAGPASAQGAPKVKFVTSEGDFVVEVYPDKAPKTVDNFLQYVK
DKHYDGIIFHRVISNFMVQGGGYDAKYAEKKTRPPVVHEGREALAKGGAKNVVGTLAMARTSDPHSASSQFFINVKDNDF
LNPTLIPPGDPVPRFEYQGQVYENTPRAQLVNAPQLYGYTVFGKVISGMDVVNKIKLVPTGPGGPFPTDVPKTPVLIKSA
TLVN

Sequences:

>Translated_244_residues
MAFAKLAMSAMSATLTPFSAARRAALAAMAVSAVITGLAGPASAQGAPKVKFVTSEGDFVVEVYPDKAPKTVDNFLQYVK
DKHYDGIIFHRVISNFMVQGGGYDAKYAEKKTRPPVVHEGREALAKGGAKNVVGTLAMARTSDPHSASSQFFINVKDNDF
LNPTLIPPGDPVPRFEYQGQVYENTPRAQLVNAPQLYGYTVFGKVISGMDVVNKIKLVPTGPGGPFPTDVPKTPVLIKSA
TLVN
>Mature_243_residues
AFAKLAMSAMSATLTPFSAARRAALAAMAVSAVITGLAGPASAQGAPKVKFVTSEGDFVVEVYPDKAPKTVDNFLQYVKD
KHYDGIIFHRVISNFMVQGGGYDAKYAEKKTRPPVVHEGREALAKGGAKNVVGTLAMARTSDPHSASSQFFINVKDNDFL
NPTLIPPGDPVPRFEYQGQVYENTPRAQLVNAPQLYGYTVFGKVISGMDVVNKIKLVPTGPGGPFPTDVPKTPVLIKSAT
LVN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=203, Percent_Identity=29.5566502463054, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI7657473, Length=203, Percent_Identity=29.5566502463054, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI22547215, Length=203, Percent_Identity=29.5566502463054, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1786736, Length=193, Percent_Identity=45.5958549222798, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789763, Length=222, Percent_Identity=40.990990990991, Blast_Score=148, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17539496, Length=201, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26044; Mature: 25913

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFAKLAMSAMSATLTPFSAARRAALAAMAVSAVITGLAGPASAQGAPKVKFVTSEGDFV
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEE
VEVYPDKAPKTVDNFLQYVKDKHYDGIIFHRVISNFMVQGGGYDAKYAEKKTRPPVVHEG
EEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHCC
REALAKGGAKNVVGTLAMARTSDPHSASSQFFINVKDNDFLNPTLIPPGDPVPRFEYQGQ
HHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCCC
VYENTPRAQLVNAPQLYGYTVFGKVISGMDVVNKIKLVPTGPGGPFPTDVPKTPVLIKSA
EECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECC
TLVN
CCCC
>Mature Secondary Structure 
AFAKLAMSAMSATLTPFSAARRAALAAMAVSAVITGLAGPASAQGAPKVKFVTSEGDFV
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEE
VEVYPDKAPKTVDNFLQYVKDKHYDGIIFHRVISNFMVQGGGYDAKYAEKKTRPPVVHEG
EEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHCC
REALAKGGAKNVVGTLAMARTSDPHSASSQFFINVKDNDFLNPTLIPPGDPVPRFEYQGQ
HHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCCC
VYENTPRAQLVNAPQLYGYTVFGKVISGMDVVNKIKLVPTGPGGPFPTDVPKTPVLIKSA
EECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECC
TLVN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]