Click here to switch to the map view.

The map label for this gene is prlC [H]

Identifier: 91788716

GI number: 91788716

Start: 3009425

End: 3011488

Strand: Direct

Name: prlC [H]

Synonym: Bpro_2855

Alternate gene names: 91788716

Gene position: 3009425-3011488 (Clockwise)

Preceding gene: 91788715

Following gene: 91788717

Centisome position: 57.87

GC content: 62.31

Gene sequence:

>2064_bases
ATGACCAATCCCCTGCTCGACTTCTCCGACCTCCCGCTGTTTGACCGTATCCTGCCCGAGCATGTGGGCCCAGCGGTTGA
CGAATTGCTGGTCAAGGCGGATGCCGCGCTGGAGGAGGTGACAGCGCCCGGCTTCCCGGCCTCCTGGACCGGCATTGCCC
GTGTGCTGGACGTGGCCACCGAGAACCTGGGCCGCGCCTGGGGGGCGGTGAGCCACCTAAACAGCGTGGCCGACACGCCC
GAGTTGCGCGCCGCCTACAACGCTGCCCTGCCGCGCGTGACCGAATTCTGGACACGCCTGGGTGCCGATGAACGCCTTTA
CGCCAAATACAAGGCCATTGATGTGGCCACGCTCAACGCCGAGCAGCGTCAGGCCCACAAAAACGCCATCCGCAACTTTG
TGCTGTCGGGCGCAGAGCTCACCGGTGCCGCCAAGGAACGCTTTGCCAAAATCCAGGAACGCCAGGCCGAACTGAGCCAG
AAATTCAGCGAAAACGCACTGGACGCCACCGACGCCTTCGCCTACTACGCCAGCGCGGATGAAGTGGCCGGCATTCCTGC
CGACGTGCTGCAGACCGCCCGCGCGCAGGCCGAGGCCGAGGGCAAGCCCGGCTACCGCCTCAGCCTGAAGATGCCGAGCT
ACCTGCCCGTCATGCAGTTTGCCCACAGCAGCGCGCTGCGTGAAACTCTCTACAGGGCCTACACCACCCGCGCCAGCGAC
CAGGCGCCAGCGGAATTCGCCCGGTTTGACAACAGCGCCGTCATGCGCGAAATTCTTGCGCTCCGCCTCGAGGAAGCCCA
GTTGCTGGGTTACCGGAATTTCGGCGAAGTGTCGATCGTGCCCAAGATGGCCAAATCCCCCGATGAGGTCATCGGTTTCC
TGCGTGACCTGGCCCGGCGCGCCCGCCCGTATGCCGAAAAAGACGTCGCCGACCTGCGCGCATTTGCGGCCGAAACGTTG
AGCCTGAGCGATCCCCAATCCTGGGACTTCGCCTACATTGGCGAAAAGCTCAAGGAAGCCCGCTATGCCTTCAGCGAGCA
GGAAGTCAAACAGTATTTCACTGCCCCCAAGGTGCTGGCGGGCCTGTTCAAGATAGTCGAGACCCTCTTTGAAGTGACTC
TCCGCAAGGATTCCGCACCTGTCTGGACACCCGGCGTGGCGTTTTATCGCATTGAACGCAACGGCCAGCTGGTAGGCCAG
TTCTACCTGGACCAGCCGGCCCGCACCGGCAAGCGCGGCGGGGCCTGGATGGACGATGTGCGCGCACGCTGGCTGCGCCC
CGACAACGGCAAGCTGCAAACCCCCGTGGCGCATCTGGTCTGCAATTTTGCCGACGGCGTGGGCGGCAAGCCTGCCCTGC
TGACCCATGACGACGCAACCACGCTGTTCCACGAATTCGGCCATGGCCTGCACCACATGCTCACGCAGGTCAACGAGCGT
GACGTTTCGGGCATCAGCGGTGTTGAATGGGATGCGGTGGAGTTGCCCAGCCAGTTCATGGAAAACTTCTGCTGGGAGTG
GGATGTGCTCAAACACATGACATCCCATGTCGAAACGGGCGACCCCCTGCCTCGCGCGCTGTTTGAAAAAATGCTGGCGG
CCAAGAACTTCCAGAGCGGGATGCAGACGCTGCGCCAGGTCGAGTTTTCGCTGTTCGACATGCTCCTGCACACCGCGCAC
AACCCTTCGGACAACCTGATGGACCTGCTCAATGAAGTGCGCAGGGAAGTGGCTGTGATTCCGGCTCCGCTCTACAGCCG
TACCGCACACACCTTCAGTCATATTTTTTCGGGTGGCTATGCAGCGGGTTATTACAGTTACAAATGGGCCGAGGTGCTGT
CGGCTGACGCTTATGCTGCTTTTGAAGAGACCGCGGCCGCGGCGCAAGCCTCAAGCGCGGGCGAGGCCGCAGGCACAACG
ACAGTGACGGTGCAAACGGGTAGAAAATACCGCGAGGCCATTCTGGAAGCCGGCGGAAGCCGCCCAGCCATGGAATCGTT
CAAGGCCTTCAGGGGCCGGGAACCTTCCATTGACGCATTGCTGCGTCATCAAGGCATGGGTTAG

Upstream 100 bases:

>100_bases
GCGCAGAAACAGCAGGCGCAATCGCCACGATAGCGACATTCCTGTTGCGCGGACCTGGCGAGCCCTTTAGATTTAAAGCT
TTCGCCCACAGTTAGACACC

Downstream 100 bases:

>100_bases
AAACGTTATAAGCTCTGGACTGAAAAACTTGTACTTGCGACCAACGGGGAAAACATGAGACTCAATGCTGCCAAATCCTT
GATGCCCAACGCTCTCCTGG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MTNPLLDFSDLPLFDRILPEHVGPAVDELLVKADAALEEVTAPGFPASWTGIARVLDVATENLGRAWGAVSHLNSVADTP
ELRAAYNAALPRVTEFWTRLGADERLYAKYKAIDVATLNAEQRQAHKNAIRNFVLSGAELTGAAKERFAKIQERQAELSQ
KFSENALDATDAFAYYASADEVAGIPADVLQTARAQAEAEGKPGYRLSLKMPSYLPVMQFAHSSALRETLYRAYTTRASD
QAPAEFARFDNSAVMREILALRLEEAQLLGYRNFGEVSIVPKMAKSPDEVIGFLRDLARRARPYAEKDVADLRAFAAETL
SLSDPQSWDFAYIGEKLKEARYAFSEQEVKQYFTAPKVLAGLFKIVETLFEVTLRKDSAPVWTPGVAFYRIERNGQLVGQ
FYLDQPARTGKRGGAWMDDVRARWLRPDNGKLQTPVAHLVCNFADGVGGKPALLTHDDATTLFHEFGHGLHHMLTQVNER
DVSGISGVEWDAVELPSQFMENFCWEWDVLKHMTSHVETGDPLPRALFEKMLAAKNFQSGMQTLRQVEFSLFDMLLHTAH
NPSDNLMDLLNEVRREVAVIPAPLYSRTAHTFSHIFSGGYAAGYYSYKWAEVLSADAYAAFEETAAAAQASSAGEAAGTT
TVTVQTGRKYREAILEAGGSRPAMESFKAFRGREPSIDALLRHQGMG

Sequences:

>Translated_687_residues
MTNPLLDFSDLPLFDRILPEHVGPAVDELLVKADAALEEVTAPGFPASWTGIARVLDVATENLGRAWGAVSHLNSVADTP
ELRAAYNAALPRVTEFWTRLGADERLYAKYKAIDVATLNAEQRQAHKNAIRNFVLSGAELTGAAKERFAKIQERQAELSQ
KFSENALDATDAFAYYASADEVAGIPADVLQTARAQAEAEGKPGYRLSLKMPSYLPVMQFAHSSALRETLYRAYTTRASD
QAPAEFARFDNSAVMREILALRLEEAQLLGYRNFGEVSIVPKMAKSPDEVIGFLRDLARRARPYAEKDVADLRAFAAETL
SLSDPQSWDFAYIGEKLKEARYAFSEQEVKQYFTAPKVLAGLFKIVETLFEVTLRKDSAPVWTPGVAFYRIERNGQLVGQ
FYLDQPARTGKRGGAWMDDVRARWLRPDNGKLQTPVAHLVCNFADGVGGKPALLTHDDATTLFHEFGHGLHHMLTQVNER
DVSGISGVEWDAVELPSQFMENFCWEWDVLKHMTSHVETGDPLPRALFEKMLAAKNFQSGMQTLRQVEFSLFDMLLHTAH
NPSDNLMDLLNEVRREVAVIPAPLYSRTAHTFSHIFSGGYAAGYYSYKWAEVLSADAYAAFEETAAAAQASSAGEAAGTT
TVTVQTGRKYREAILEAGGSRPAMESFKAFRGREPSIDALLRHQGMG
>Mature_686_residues
TNPLLDFSDLPLFDRILPEHVGPAVDELLVKADAALEEVTAPGFPASWTGIARVLDVATENLGRAWGAVSHLNSVADTPE
LRAAYNAALPRVTEFWTRLGADERLYAKYKAIDVATLNAEQRQAHKNAIRNFVLSGAELTGAAKERFAKIQERQAELSQK
FSENALDATDAFAYYASADEVAGIPADVLQTARAQAEAEGKPGYRLSLKMPSYLPVMQFAHSSALRETLYRAYTTRASDQ
APAEFARFDNSAVMREILALRLEEAQLLGYRNFGEVSIVPKMAKSPDEVIGFLRDLARRARPYAEKDVADLRAFAAETLS
LSDPQSWDFAYIGEKLKEARYAFSEQEVKQYFTAPKVLAGLFKIVETLFEVTLRKDSAPVWTPGVAFYRIERNGQLVGQF
YLDQPARTGKRGGAWMDDVRARWLRPDNGKLQTPVAHLVCNFADGVGGKPALLTHDDATTLFHEFGHGLHHMLTQVNERD
VSGISGVEWDAVELPSQFMENFCWEWDVLKHMTSHVETGDPLPRALFEKMLAAKNFQSGMQTLRQVEFSLFDMLLHTAHN
PSDNLMDLLNEVRREVAVIPAPLYSRTAHTFSHIFSGGYAAGYYSYKWAEVLSADAYAAFEETAAAAQASSAGEAAGTTT
VTVQTGRKYREAILEAGGSRPAMESFKAFRGREPSIDALLRHQGMG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=627, Percent_Identity=28.548644338118, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI14149738, Length=693, Percent_Identity=28.2828282828283, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI156105687, Length=434, Percent_Identity=25.1152073732719, Blast_Score=136, Evalue=6e-32,
Organism=Escherichia coli, GI1789913, Length=696, Percent_Identity=48.7068965517241, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=704, Percent_Identity=28.125, Blast_Score=216, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI71999758, Length=543, Percent_Identity=23.7569060773481, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI32565901, Length=613, Percent_Identity=21.5334420880914, Blast_Score=92, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=694, Percent_Identity=27.0893371757925, Blast_Score=267, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322715, Length=658, Percent_Identity=23.1003039513678, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21356111, Length=667, Percent_Identity=27.736131934033, Blast_Score=216, Evalue=6e-56,
Organism=Drosophila melanogaster, GI20129717, Length=435, Percent_Identity=26.2068965517241, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76110; Mature: 75978

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLDFSDLPLFDRILPEHVGPAVDELLVKADAALEEVTAPGFPASWTGIARVLDVAT
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ENLGRAWGAVSHLNSVADTPELRAAYNAALPRVTEFWTRLGADERLYAKYKAIDVATLNA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHEEEEECCH
EQRQAHKNAIRNFVLSGAELTGAAKERFAKIQERQAELSQKFSENALDATDAFAYYASAD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH
EVAGIPADVLQTARAQAEAEGKPGYRLSLKMPSYLPVMQFAHSSALRETLYRAYTTRASD
HHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
QAPAEFARFDNSAVMREILALRLEEAQLLGYRNFGEVSIVPKMAKSPDEVIGFLRDLARR
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCHHHHHHHHHHHHHH
ARPYAEKDVADLRAFAAETLSLSDPQSWDFAYIGEKLKEARYAFSEQEVKQYFTAPKVLA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFKIVETLFEVTLRKDSAPVWTPGVAFYRIERNGQLVGQFYLDQPARTGKRGGAWMDDV
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHH
RARWLRPDNGKLQTPVAHLVCNFADGVGGKPALLTHDDATTLFHEFGHGLHHMLTQVNER
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
DVSGISGVEWDAVELPSQFMENFCWEWDVLKHMTSHVETGDPLPRALFEKMLAAKNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MQTLRQVEFSLFDMLLHTAHNPSDNLMDLLNEVRREVAVIPAPLYSRTAHTFSHIFSGGY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
AAGYYSYKWAEVLSADAYAAFEETAAAAQASSAGEAAGTTTVTVQTGRKYREAILEAGGS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCC
RPAMESFKAFRGREPSIDALLRHQGMG
CHHHHHHHHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TNPLLDFSDLPLFDRILPEHVGPAVDELLVKADAALEEVTAPGFPASWTGIARVLDVAT
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ENLGRAWGAVSHLNSVADTPELRAAYNAALPRVTEFWTRLGADERLYAKYKAIDVATLNA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHEEEEECCH
EQRQAHKNAIRNFVLSGAELTGAAKERFAKIQERQAELSQKFSENALDATDAFAYYASAD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH
EVAGIPADVLQTARAQAEAEGKPGYRLSLKMPSYLPVMQFAHSSALRETLYRAYTTRASD
HHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
QAPAEFARFDNSAVMREILALRLEEAQLLGYRNFGEVSIVPKMAKSPDEVIGFLRDLARR
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHCCHHHHHHHHHHHHHH
ARPYAEKDVADLRAFAAETLSLSDPQSWDFAYIGEKLKEARYAFSEQEVKQYFTAPKVLA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFKIVETLFEVTLRKDSAPVWTPGVAFYRIERNGQLVGQFYLDQPARTGKRGGAWMDDV
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHH
RARWLRPDNGKLQTPVAHLVCNFADGVGGKPALLTHDDATTLFHEFGHGLHHMLTQVNER
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
DVSGISGVEWDAVELPSQFMENFCWEWDVLKHMTSHVETGDPLPRALFEKMLAAKNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MQTLRQVEFSLFDMLLHTAHNPSDNLMDLLNEVRREVAVIPAPLYSRTAHTFSHIFSGGY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
AAGYYSYKWAEVLSADAYAAFEETAAAAQASSAGEAAGTTTVTVQTGRKYREAILEAGGS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCC
RPAMESFKAFRGREPSIDALLRHQGMG
CHHHHHHHHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]