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The map label for this gene is mmsB [H]

Identifier: 91788336

GI number: 91788336

Start: 2585628

End: 2586530

Strand: Reverse

Name: mmsB [H]

Synonym: Bpro_2471

Alternate gene names: 91788336

Gene position: 2586530-2585628 (Counterclockwise)

Preceding gene: 91788337

Following gene: 91788322

Centisome position: 49.74

GC content: 66.33

Gene sequence:

>903_bases
ATGAAAATCGCATTTATAGGCCTCGGCAACATGGGCGCACCCATGGCCCTGAACCTGCACAAGGCGGGCCACCAGGTCGC
CGCCTTTGACCTGTCCGATGAAGCCTGCCAGCGGCTGGGCAACGAGGGCGTGCGCATTGCCGACTCCGCCAGCAATGTGG
TGCGCGGTGTTGAAGTCGTCATCAGCATGTTGCCCGCCAGCCAACATGTGGAGGCACTCTACCTCGGCAATGGTTTGGGC
CATGGACAAGCGGGCCTGCTGAGGCAGTTGCCGGCCGGCACGCTGGTGATTGACTGCAGCACGATTGCCGCGACAAGCGC
CCGCAAGGTCGCTGACGCTGCGGCAAAGTTGCAGATTGCCTGCGTAGACGCGCCGGTGTCCGGCGGCACCGGCGGCGCCA
TCGCCGGCACGCTGACCTTCATGGTGGGCGGCGTGACCCGCGACCTGGAGCGCGCACGACCGCTGCTGGAGACCATGGGG
CAAAACATTTTCCACGCGGGCGAAGCCGGTGCGGGTCAGACCGCCAAGATCTGCAACAACATGCTGCTCGGCATTTTGAT
GATAGGTACCTCGGAAGCGCTGGCCTTGGGCGTGGCCAACGGGCTGGATGCCAAGGTGCTGTCCGAGATCATGCGGCGCA
GCTCGGGCGGCAACTGGGCGCTGGAAAAATACAACCCCCTGCCCGGCGTGATGGAGAACACGCCCGCCTCCCGGGGCTAC
GCCGGCGGCTTTGGCACCGACCTGATGCTGAAAGACCTGGGCCTGGCGCAGGAGAACGCCAGCGCCGTGCGCGCCGCCAC
GCCGCTGGGCGGCCTGGCCCGCAGCCTCTATGCGGCGCACAGCCTGGCCGGCAGCGGCGCGCTGGACTTCTCCAGCGTGA
TCCGGCTGCTGCAGGGCAAATAA

Upstream 100 bases:

>100_bases
AGGTATCGAAGCCTCAGAAGCCTTTCGATACCTCAGGGCGAACGGTCGTGGAGTGCCGATCATGATTCACAGAGCCATTG
ATAAACATAGGAGAAACACA

Downstream 100 bases:

>100_bases
GCACCCGCACTCTGCTACATGTTTGATAGCTGTCAGTGCATGAAGGGGTAATCGTACTTTCGGTGCGGATTGACACGGCC
GTCCCTGAAATGAGTCTAAA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKIAFIGLGNMGAPMALNLHKAGHQVAAFDLSDEACQRLGNEGVRIADSASNVVRGVEVVISMLPASQHVEALYLGNGLG
HGQAGLLRQLPAGTLVIDCSTIAATSARKVADAAAKLQIACVDAPVSGGTGGAIAGTLTFMVGGVTRDLERARPLLETMG
QNIFHAGEAGAGQTAKICNNMLLGILMIGTSEALALGVANGLDAKVLSEIMRRSSGGNWALEKYNPLPGVMENTPASRGY
AGGFGTDLMLKDLGLAQENASAVRAATPLGGLARSLYAAHSLAGSGALDFSSVIRLLQGK

Sequences:

>Translated_300_residues
MKIAFIGLGNMGAPMALNLHKAGHQVAAFDLSDEACQRLGNEGVRIADSASNVVRGVEVVISMLPASQHVEALYLGNGLG
HGQAGLLRQLPAGTLVIDCSTIAATSARKVADAAAKLQIACVDAPVSGGTGGAIAGTLTFMVGGVTRDLERARPLLETMG
QNIFHAGEAGAGQTAKICNNMLLGILMIGTSEALALGVANGLDAKVLSEIMRRSSGGNWALEKYNPLPGVMENTPASRGY
AGGFGTDLMLKDLGLAQENASAVRAATPLGGLARSLYAAHSLAGSGALDFSSVIRLLQGK
>Mature_300_residues
MKIAFIGLGNMGAPMALNLHKAGHQVAAFDLSDEACQRLGNEGVRIADSASNVVRGVEVVISMLPASQHVEALYLGNGLG
HGQAGLLRQLPAGTLVIDCSTIAATSARKVADAAAKLQIACVDAPVSGGTGGAIAGTLTFMVGGVTRDLERARPLLETMG
QNIFHAGEAGAGQTAKICNNMLLGILMIGTSEALALGVANGLDAKVLSEIMRRSSGGNWALEKYNPLPGVMENTPASRGY
AGGFGTDLMLKDLGLAQENASAVRAATPLGGLARSLYAAHSLAGSGALDFSSVIRLLQGK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=44.2567567567568, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI40556376, Length=298, Percent_Identity=25.8389261744966, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=33.7883959044369, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=34.5762711864407, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=32.2147651006711, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789092, Length=303, Percent_Identity=30.3630363036304, Blast_Score=120, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17557316, Length=274, Percent_Identity=46.7153284671533, Blast_Score=240, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24655230, Length=299, Percent_Identity=43.8127090301003, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI19922568, Length=299, Percent_Identity=43.8127090301003, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI28574115, Length=301, Percent_Identity=21.9269102990033, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30559; Mature: 30559

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGLGNMGAPMALNLHKAGHQVAAFDLSDEACQRLGNEGVRIADSASNVVRGVEVV
CEEEEEECCCCCCCEEEEEECCCCEEEEEECCHHHHHHCCCCCCEEECCHHHHHHHHHHH
ISMLPASQHVEALYLGNGLGHGQAGLLRQLPAGTLVIDCSTIAATSARKVADAAAKLQIA
HHHCCCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHEEEEE
CVDAPVSGGTGGAIAGTLTFMVGGVTRDLERARPLLETMGQNIFHAGEAGAGQTAKICNN
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCCCHHHHHHH
MLLGILMIGTSEALALGVANGLDAKVLSEIMRRSSGGNWALEKYNPLPGVMENTPASRGY
HHHHHHHCCCCHHHEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCC
AGGFGTDLMLKDLGLAQENASAVRAATPLGGLARSLYAAHSLAGSGALDFSSVIRLLQGK
CCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGLGNMGAPMALNLHKAGHQVAAFDLSDEACQRLGNEGVRIADSASNVVRGVEVV
CEEEEEECCCCCCCEEEEEECCCCEEEEEECCHHHHHHCCCCCCEEECCHHHHHHHHHHH
ISMLPASQHVEALYLGNGLGHGQAGLLRQLPAGTLVIDCSTIAATSARKVADAAAKLQIA
HHHCCCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHEEEEE
CVDAPVSGGTGGAIAGTLTFMVGGVTRDLERARPLLETMGQNIFHAGEAGAGQTAKICNN
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCCCHHHHHHH
MLLGILMIGTSEALALGVANGLDAKVLSEIMRRSSGGNWALEKYNPLPGVMENTPASRGY
HHHHHHHCCCCHHHEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCC
AGGFGTDLMLKDLGLAQENASAVRAATPLGGLARSLYAAHSLAGSGALDFSSVIRLLQGK
CCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]