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The map label for this gene is frzE [H]

Identifier: 91788331

GI number: 91788331

Start: 2573944

End: 2576262

Strand: Direct

Name: frzE [H]

Synonym: Bpro_2466

Alternate gene names: 91788331

Gene position: 2573944-2576262 (Clockwise)

Preceding gene: 91788330

Following gene: 91788332

Centisome position: 49.5

GC content: 61.97

Gene sequence:

>2319_bases
ATGAGCACCAAGGAAGACAACTTTCTCCTGCAACTCCGCGCGACCTTCAAGGTCGAAGCCGAAGAGCATCTGCAGACGAT
CGCGGACGGTTTGCTGGAGCTGGAAAGCACGCCTTCCGCGCAGGCCAAAGGCCAGATCGTGGAGACGGTGTTCCGCGCCG
CGCACAGTCTGAAGGGGGCGGCACGGGCGGTGGGTTTCTCCGAGATCGAGTTGCTGTGCCAGTCGATGGAAGACGTGTTT
GCCAGCTGGAAGCGACAGGAAAGCCTGCCGTCGCCCGATGCACTCGACACACTGCATCGCGTACTCGATGCCATCGCCTC
GGCGCAGGCCGCGCCCGTCGGTTCCGACGGCACCGGTGACCAGCCCGCCTTGTCGTCGTTGCGCCAGGCCTTGCGCCAGT
TGGGAATCGACTCCTCTTTGAGTCCCCGGGAGTCCGCTGCTACCGGGCTGTCGTCCAGCGCCGACGACGCAGCGATGGCA
CCGCCGGTGATCGAAGTTGCGAAGCCTGCTTTACCTTTACCGGTCGCGCCGGAAATCGGCCCCCAGGAAACAGTGCGCGT
CACTGTCTCGAAACTGGAGGCGCGACTACTGGAGGCGGAGGAAATGCTCATGGCCAAACTGACCGTCGGCCAGCGGGTGA
CCGATTTGCGCGAACTGTCTGGCCGCTTTGACGCCTGGCGCAATGCCTGGGGGGAGGTTGAGCCGGAAGCACGCCAGTTG
CGCCTGCTATCCGATCAGCCGGGCTCCCCGACACAGCGGCATTCCTCCGAGGGGCTGGCCCAGGTGCTGGATTTCTTTGA
CTGGAGCATGGACTACGTCAAAATCATGGAGAGCGAGGCCGTGGCACTGGAGCGGACGGCGCAGCACGACCGCTTTGCCA
TTGGCAAACTGGTGGATGACCTGCTGGAGGATTCGAAGCAACTGCTCATGTTGCCGTTTGCCTCGATTTCGGCATCGTTC
CAGAGGCTGGTGCGCGATTTGTGCCGCGATCAGGGCAAGGAGGCTGAGCTCAAGATCTACGGCGAAAACACCGAGATCGA
CAAACGTATTCTGGAGGAGATGAAAGACCCGCTCATTCATTTGCTGCGCAACAGCCTGGATCATGGCATCGAAACCGCGG
CCGAACGCAGGCGGCGCGGCAAACCATCGCGTGCGACGATCGAGCTGGCGGTGACCCAAATCAGCGGCAACAAAGTGCGG
CTGATGCTGTCCGACAACGGCGCCGGCATCGATACCGGGAAGGTCAAAGCGTCGGCAATCAAGCTCGGGCTGATCTCGCC
AGAAGAAGCGGCGCAGCTCAGCGAGCCTGAATCGCAGGCGCTGATTTTCCGCTCCGAAGTGTCTACCAGTCCGATCATCA
CGCAGCTGTCGGGCCGCGGACTGGGACTGGCCATCGTGCGGGAGAAAACCACCAAACTGGGCGGGGAGGTAACGGTTGAC
AGTCAGGCGGGCCTTGGAACCGTTTTCCAGATTGAATTGCCGGCGACGCGTGCAACCTTTCGCGGCATCCTGGTCAAAGC
TGCCGGTCGGCTACTGGTGCTGCCGACCGCCCAGGTTGAGCGCGCCGCGCGCGCCACGCCCGACGACACCCGAACCGTCG
AAGGGCGGGAGACCATCACGTTCGACGGGCGGGCTGTGTCCCTTGTGCGACTGGCCGACGTACTGGAATTGCCGTATGTT
GAGCGCAAGGACATGTTCCCCAGCGGCATACCGGTACTCATTCTCGGCAGCGTCGACCAGCGTGTTGCATTCGCCGTGGA
CGAGGTTCTGGATGAGCAGGAAATTTTAGTCAAGCCGCTGCTCAAGCCCCTGTCACGCGTGCGCAACGTCGCCGCCGCCG
CAGTCCTCAGTAACGGCAAGATCGCAACCATACTCAATGTGGACGACCTGCTTAAATCTGCCAGAAAGGTCGCCCGCACG
GCACCACGGGCAGCCACGGGAACGAAGGCGGTAGAGGCCGGGATGGTACTCATCGCCGAGGACTCCATCACCTCCCGGAT
GCTACTCAAAAGTATCCTGGAATCCGCCGGCTACGACGTCAAAACAGCGGTGGACGGGATGGATGCGTTCACCCTGTTGC
GCGCCGAAAAGTTCGACCTGCTTGTTTCCGATGTTGAAATGCCGCGGCTCAACGGCTTCGACCTGACGGCGAAGATACGC
GCCGACAAAAGACTGGCCGAGCTTCCGGTGGTGCTGGTGACGGCGCTGGAAACGCGGGAGGACCGCGAGCGCGGCATCGA
CGCTGGCGCCAATGCGTATATTGTCAAGAGCAGCTTCGACCAGAGCAACCTGATCGAGGCAGTACGGCGGCTGATTTAA

Upstream 100 bases:

>100_bases
GCGCCAGGCAGTTGGAGGTTGCGGCGCGCAACCTGGATGAGCTGGGCCAGCGGCTCAAGCAGATGGCTGAGCGCTACAAG
GTGTAATCAAAAAGGTCGTC

Downstream 100 bases:

>100_bases
CCGGGTGAACCTTTCATGACCGATGGCAAGATCAACGTACTGGTGGCGGAAGACTCGGCGATCGCACGCGTGCTTCTCGT
GCGCCTGCTCGAATCGGATC

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MSTKEDNFLLQLRATFKVEAEEHLQTIADGLLELESTPSAQAKGQIVETVFRAAHSLKGAARAVGFSEIELLCQSMEDVF
ASWKRQESLPSPDALDTLHRVLDAIASAQAAPVGSDGTGDQPALSSLRQALRQLGIDSSLSPRESAATGLSSSADDAAMA
PPVIEVAKPALPLPVAPEIGPQETVRVTVSKLEARLLEAEEMLMAKLTVGQRVTDLRELSGRFDAWRNAWGEVEPEARQL
RLLSDQPGSPTQRHSSEGLAQVLDFFDWSMDYVKIMESEAVALERTAQHDRFAIGKLVDDLLEDSKQLLMLPFASISASF
QRLVRDLCRDQGKEAELKIYGENTEIDKRILEEMKDPLIHLLRNSLDHGIETAAERRRRGKPSRATIELAVTQISGNKVR
LMLSDNGAGIDTGKVKASAIKLGLISPEEAAQLSEPESQALIFRSEVSTSPIITQLSGRGLGLAIVREKTTKLGGEVTVD
SQAGLGTVFQIELPATRATFRGILVKAAGRLLVLPTAQVERAARATPDDTRTVEGRETITFDGRAVSLVRLADVLELPYV
ERKDMFPSGIPVLILGSVDQRVAFAVDEVLDEQEILVKPLLKPLSRVRNVAAAAVLSNGKIATILNVDDLLKSARKVART
APRAATGTKAVEAGMVLIAEDSITSRMLLKSILESAGYDVKTAVDGMDAFTLLRAEKFDLLVSDVEMPRLNGFDLTAKIR
ADKRLAELPVVLVTALETREDRERGIDAGANAYIVKSSFDQSNLIEAVRRLI

Sequences:

>Translated_772_residues
MSTKEDNFLLQLRATFKVEAEEHLQTIADGLLELESTPSAQAKGQIVETVFRAAHSLKGAARAVGFSEIELLCQSMEDVF
ASWKRQESLPSPDALDTLHRVLDAIASAQAAPVGSDGTGDQPALSSLRQALRQLGIDSSLSPRESAATGLSSSADDAAMA
PPVIEVAKPALPLPVAPEIGPQETVRVTVSKLEARLLEAEEMLMAKLTVGQRVTDLRELSGRFDAWRNAWGEVEPEARQL
RLLSDQPGSPTQRHSSEGLAQVLDFFDWSMDYVKIMESEAVALERTAQHDRFAIGKLVDDLLEDSKQLLMLPFASISASF
QRLVRDLCRDQGKEAELKIYGENTEIDKRILEEMKDPLIHLLRNSLDHGIETAAERRRRGKPSRATIELAVTQISGNKVR
LMLSDNGAGIDTGKVKASAIKLGLISPEEAAQLSEPESQALIFRSEVSTSPIITQLSGRGLGLAIVREKTTKLGGEVTVD
SQAGLGTVFQIELPATRATFRGILVKAAGRLLVLPTAQVERAARATPDDTRTVEGRETITFDGRAVSLVRLADVLELPYV
ERKDMFPSGIPVLILGSVDQRVAFAVDEVLDEQEILVKPLLKPLSRVRNVAAAAVLSNGKIATILNVDDLLKSARKVART
APRAATGTKAVEAGMVLIAEDSITSRMLLKSILESAGYDVKTAVDGMDAFTLLRAEKFDLLVSDVEMPRLNGFDLTAKIR
ADKRLAELPVVLVTALETREDRERGIDAGANAYIVKSSFDQSNLIEAVRRLI
>Mature_771_residues
STKEDNFLLQLRATFKVEAEEHLQTIADGLLELESTPSAQAKGQIVETVFRAAHSLKGAARAVGFSEIELLCQSMEDVFA
SWKRQESLPSPDALDTLHRVLDAIASAQAAPVGSDGTGDQPALSSLRQALRQLGIDSSLSPRESAATGLSSSADDAAMAP
PVIEVAKPALPLPVAPEIGPQETVRVTVSKLEARLLEAEEMLMAKLTVGQRVTDLRELSGRFDAWRNAWGEVEPEARQLR
LLSDQPGSPTQRHSSEGLAQVLDFFDWSMDYVKIMESEAVALERTAQHDRFAIGKLVDDLLEDSKQLLMLPFASISASFQ
RLVRDLCRDQGKEAELKIYGENTEIDKRILEEMKDPLIHLLRNSLDHGIETAAERRRRGKPSRATIELAVTQISGNKVRL
MLSDNGAGIDTGKVKASAIKLGLISPEEAAQLSEPESQALIFRSEVSTSPIITQLSGRGLGLAIVREKTTKLGGEVTVDS
QAGLGTVFQIELPATRATFRGILVKAAGRLLVLPTAQVERAARATPDDTRTVEGRETITFDGRAVSLVRLADVLELPYVE
RKDMFPSGIPVLILGSVDQRVAFAVDEVLDEQEILVKPLLKPLSRVRNVAAAAVLSNGKIATILNVDDLLKSARKVARTA
PRAATGTKAVEAGMVLIAEDSITSRMLLKSILESAGYDVKTAVDGMDAFTLLRAEKFDLLVSDVEMPRLNGFDLTAKIRA
DKRLAELPVVLVTALETREDRERGIDAGANAYIVKSSFDQSNLIEAVRRLI

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=678, Percent_Identity=27.5811209439528, Blast_Score=195, Evalue=1e-50,
Organism=Escherichia coli, GI1788713, Length=140, Percent_Identity=34.2857142857143, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=38.2352941176471, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=117, Percent_Identity=34.1880341880342, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI87082012, Length=114, Percent_Identity=32.4561403508772, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=101, Percent_Identity=33.6633663366337, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1787487, Length=121, Percent_Identity=33.8842975206612, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83870; Mature: 83739

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKEDNFLLQLRATFKVEAEEHLQTIADGLLELESTPSAQAKGQIVETVFRAAHSLKGA
CCCCCCCEEEEEEEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ARAVGFSEIELLCQSMEDVFASWKRQESLPSPDALDTLHRVLDAIASAQAAPVGSDGTGD
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QPALSSLRQALRQLGIDSSLSPRESAATGLSSSADDAAMAPPVIEVAKPALPLPVAPEIG
CHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
PQETVRVTVSKLEARLLEAEEMLMAKLTVGQRVTDLRELSGRFDAWRNAWGEVEPEARQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RLLSDQPGSPTQRHSSEGLAQVLDFFDWSMDYVKIMESEAVALERTAQHDRFAIGKLVDD
EECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LLEDSKQLLMLPFASISASFQRLVRDLCRDQGKEAELKIYGENTEIDKRILEEMKDPLIH
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LLRNSLDHGIETAAERRRRGKPSRATIELAVTQISGNKVRLMLSDNGAGIDTGKVKASAI
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCEEEEEE
KLGLISPEEAAQLSEPESQALIFRSEVSTSPIITQLSGRGLGLAIVREKTTKLGGEVTVD
EEECCCCHHHHHCCCCCHHEEEEECCCCCCCHHEEECCCCCEEEEEEHHHHHCCCEEEEC
SQAGLGTVFQIELPATRATFRGILVKAAGRLLVLPTAQVERAARATPDDTRTVEGRETIT
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCCEECCCEEEE
FDGRAVSLVRLADVLELPYVERKDMFPSGIPVLILGSVDQRVAFAVDEVLDEQEILVKPL
ECCCHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHHHHHH
LKPLSRVRNVAAAAVLSNGKIATILNVDDLLKSARKVARTAPRAATGTKAVEAGMVLIAE
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEEEEC
DSITSRMLLKSILESAGYDVKTAVDGMDAFTLLRAEKFDLLVSDVEMPRLNGFDLTAKIR
CCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
ADKRLAELPVVLVTALETREDRERGIDAGANAYIVKSSFDQSNLIEAVRRLI
CCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHC
>Mature Secondary Structure 
STKEDNFLLQLRATFKVEAEEHLQTIADGLLELESTPSAQAKGQIVETVFRAAHSLKGA
CCCCCCEEEEEEEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ARAVGFSEIELLCQSMEDVFASWKRQESLPSPDALDTLHRVLDAIASAQAAPVGSDGTGD
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QPALSSLRQALRQLGIDSSLSPRESAATGLSSSADDAAMAPPVIEVAKPALPLPVAPEIG
CHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
PQETVRVTVSKLEARLLEAEEMLMAKLTVGQRVTDLRELSGRFDAWRNAWGEVEPEARQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RLLSDQPGSPTQRHSSEGLAQVLDFFDWSMDYVKIMESEAVALERTAQHDRFAIGKLVDD
EECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LLEDSKQLLMLPFASISASFQRLVRDLCRDQGKEAELKIYGENTEIDKRILEEMKDPLIH
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
LLRNSLDHGIETAAERRRRGKPSRATIELAVTQISGNKVRLMLSDNGAGIDTGKVKASAI
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCEEEEEE
KLGLISPEEAAQLSEPESQALIFRSEVSTSPIITQLSGRGLGLAIVREKTTKLGGEVTVD
EEECCCCHHHHHCCCCCHHEEEEECCCCCCCHHEEECCCCCEEEEEEHHHHHCCCEEEEC
SQAGLGTVFQIELPATRATFRGILVKAAGRLLVLPTAQVERAARATPDDTRTVEGRETIT
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCCEECCCEEEE
FDGRAVSLVRLADVLELPYVERKDMFPSGIPVLILGSVDQRVAFAVDEVLDEQEILVKPL
ECCCHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHHHHHH
LKPLSRVRNVAAAAVLSNGKIATILNVDDLLKSARKVARTAPRAATGTKAVEAGMVLIAE
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEEEEC
DSITSRMLLKSILESAGYDVKTAVDGMDAFTLLRAEKFDLLVSDVEMPRLNGFDLTAKIR
CCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
ADKRLAELPVVLVTALETREDRERGIDAGANAYIVKSSFDQSNLIEAVRRLI
CCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]